PCSK9 affects vascular senescence through the SIRT1 pathway by Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong

“…The senescent state of mice was delayed under PCSK9 inhibitor treatment, and the expression of P16, P21, and P53 proteins in senescent cells was increased because LPS induction stimulated PCSK9 activation. …”
Get full text

Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity by Ziqi Liu, Huan Gao, Guoliang Li, Yongjiang Yu, Mengxing Cui, Honghao Peng, Xinchao Guan, Xue Zhang, Zhihan Zhang, Xiaoyu Shen, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Lili Liu, Qing Wang

“…Further investigations revealed that E2F1 promotes apoptosis by activating the p53 signaling pathway and upregulating pro-apoptotic genes, such as BAK and BAX. …”
Get full text

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…The expression levels of SERPINE1, GATA2, p53, and p21 were determined by real-time quantitative PCR and Western blot. …”
Get full text

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication by Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamnia

“…Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. Aluminum poisoning can affect blood content, musculoskeletal system, kidney, liver, and respiratory and nervous system, and the extent of poisoning can be diagnosed by assaying aluminum compounds in blood, urine, hair, nails, and sweat. …”
Get full text

Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines by Jiandong Li, Yanxin Hu, Jiayao Zhang, Weiguang Zhang, Jianhua Yu, Baochun Lu

“…We then explored potential resistance mechanisms and found that pathways and targets such as epithelial-mesenchymal transition, PI3K/Akt, p53R2, and IGF-1R did not show a significant correlation with ICC resistance. …”
Get full text

Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness by DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong

“…This article introduces the action mechanism and metabolic processes of lysosomes and elaborates the activation pathways of lysosomal membrane permeabilization through reactive oxygen species (ROS), sphingosine, B-cell lymphoma-2 (Bcl-2) and p53 proteins. Furthermore, it explores the pathway for the involvement of lysosomes in apoptosis, and summarizes the regulatory mechanism of lysosomes on muscle tenderization from the perspectives of the release of cathepsins and Ca2+, caspase activation and iron-induced oxidative stress. …”
Get full text

Reviewing the Impact of Generative AI on ‎Language Learning and Teaching: A Synthesis of Potentials and Pitfalls by Hewa Fouad Ali, Zahra Abdulmutalib Muhammed

Get full text

TWEAK/Fn14 axis may promote vascular smooth muscle cell senescence via p38 signaling pathway: preliminary evidence by Chunyang Wei, Xiaoying Liu, Zhuang Miao, Hua Zhang, Yanfu Wang, Guoxian Qi

“…TWEAK activated the p38 phosphorylation pathway and promoted the SA-β-gal staining and P53 expression.Conclusion These preliminary findings suggest that the TWEAK/Fn14 axis may play a crucial role in promoting VSMC senescence.…”
Get full text

Interactions between key genes and pathways in prostate cancer progression and therapy resistance by Fan Wu, Hengsen Zhang, Miaomiao Hao

“…Key genetic and pathway alterations include the amplification and/or mutation of the androgen receptor, the loss of Rb, PTEN, and p53, the activation of the WNT signaling pathway, and the amplification of the MYC oncogene. …”
Get full text

Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer by Gonzalo Carrasco, Alejandro H. Corvalan

“…The epigenetic bases of chronic gastritis, mainly DNA methylation, are presented through examples such as (i) the methylation of the promoter region of E-cadherin in HP-induced chronic gastritis and its reversion after HP eradication and (ii) the association of methylation of the promoter region of Reprimo, a p53-mediated cell cycle arrest gene, with aggressive HP strains in high risk areas for GC. …”
Get full text

Lung Cancer Prediction Using Neural Network Ensemble with Histogram of Oriented Gradient Genomic Features by Emmanuel Adetiba, Oludayo O. Olugbara

“…These machine learning classifiers were trained to predict lung cancer using samples of patient nucleotides with mutations in the epidermal growth factor receptor, Kirsten rat sarcoma viral oncogene, and tumor suppressor p53 genomes collected as biomarkers from the IGDB.NSCLC corpus. …”
Get full text

Effects of Fluorescein Staining on Laser In Vivo Confocal Microscopy Images of the Cornea by Christine W. Sindt, D. Brice Critser, Trudy K. Grout, Jami R. Kern

“…Density of dendritic immune cells was statistically similar between the unstained and contralateral stained eyes of 24 contact lens wearers (P=.72) and of 10 nonwearers (P=.53). Overall, the results indicated that fluorescein staining did not interfere with laser confocal microscopy of corneal epithelium, subbasal nerves, or dendritic immune cells.…”
Get full text

Transmembrane Amino Acid Transporters in Shaping the Metabolic Profile of Breast Cancer Cell Lines: The Focus on Molecular Biological Subtype by Elena I. Dyachenko, Lyudmila V. Bel’skaya

“…In addition to the main signaling pathway PI3K/Akt/mTOR, the activity of the oncogene c-Myc, HIF, p53, GATA2, NF-kB and MAT2A have a direct effect on the amino acid metabolism of cancer cells, their growth and proliferation, as well as the maintenance of homeostatic equilibrium. …”
Get full text

Dual EMCV-IRES-integrated dengue virus can express an exogenous gene and cellular Mdm2 integration suppresses the dengue viral replication by Tadahisa Teramoto

“…It was also revealed that a cellular gene, Mdm2, which antagonizes tumor suppressor protein p53 (TP53), could terminate the viral replication in BHK21 cells. …”
Get full text

Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature by Ngoc Bao Vu, Ngoc Tuyen Le, Risa Chaisuparat, Pasutha Thunyakitpisal, Ngoc Minh Tran

“…Immunohistochemical analysis exhibited a positive result for Cytokeratin (CK) 19 and overexpression of p53 and Ki67. The patient underwent right hemimandibulectomy and neck dissection. …”
Get full text

Characterization of a pleomorphic rhabdomyosarcoma cell line by Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton

“…Results of the novel functional BH1522 tests corroborate published tumor sequencing data that demonstrated alterations in receptor tyrosine kinase/MAPK, PI3K/AKT and mutated p53 as suspected drivers of malignant growth.…”
Get full text

Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine by Ewelina Wawryk-Gawda, Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Kamila Bulak, Barbara Jodłowska-Jędrych

“…Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic apoptosis pathway. …”
Get full text

Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line by Faeze Vali, Vahid Changizi, Majid Safa

“…To investigate the apoptotic effect of experimental groups PI-flow cytometry was used and expression of apoptotic proteins (caspase-7, caspase-9, PARP, and p53) was studied by western blot. Results. This study revealed that the combined therapy of 0.01µmol/mL paclitaxel and 2.5 mg/mL crocin after 48 h could cause IC50 for MCF-7 cell line. …”
Get full text

The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer by J. L. Schwartz, A. N. Shajahan, R. Clarke

“…IRF1 is a tumor suppressor that mediates cell fate by facilitating apoptosis and can do so with or without functional p53. Expression of IRF1 is downregulated in endocrine-resistant breast cancer cells, protecting these cells from IRF1-induced inhibition of proliferation and/or induction of cell death. …”
Get full text

Aging and tumors: a dynamic interaction by Yudi Zhang, Siqiang Zhu, Zhaodong Liu, Yonghao Hu, Yongjian Zhang, Liang Shang, Leping Li

“…Concurrently, the study explores the expression levels of senescence-associated markers, such as p16, p53, and mTOR, in the context of tumor development. …”
Get full text