Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia by Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma

“…Significant differences were observed in the increase in mucin production and the expression of S100P in PanIN-1 and the expression of p53 in PanIN-3, when compared with those in BilIN of a corresponding grade. …”
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CRISPR/Cas9-Based Protocol for Precise Genome Editing in Induced Pluripotent Stem Cells by Avinash Singh, Swathy Babu, Marcus Phan, Shauna Yuan

“…In our study, we observed that combining p53 inhibition with pro-survival small molecules yields a homologous recombination rate of over 90% when using CRISPR in human iPSCs. …”
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Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…Additionally, LNP-M effectively delivered DNA-encoded antigens, such as mouse PD-L1 and p53R172H, or monoclonal antibodies targeting mouse PD1 and human p53R282W. …”
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Analysis of tumoral, stromal and glycolitic markers in the response basal cell carcinoma and Bowen disease to photodynamic therapy in real life by L Bernal-Masferrer, T Gracia-Cazaña, L Najera-Botello, MC Gomez-Mateo, P Cerro, MC Matei, M Gallego-Rentero, S González, A Juarranz, Y Gilaberte

“…Immunohistochemical analysis revealed that p53 positivity was associated with better treatment outcomes, while increased β-catenin and cytoplasmic GLUT1 expression correlated with resistance to PDT. …”
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ERRATA REFERENTE AS REFERÊNCIAS BIBLIOGRÁFICAS PUBLICADA NA REVISTA BRASILEIRA DE ATIVIDADE FÍSICA E SAÚDE, V.7, N.2, 2002, PÁGINA 60 E 61 by Roberto Simão, Marcos Doederlein Polito, Luís Viveiros, Paulo de Tarso Veras Farinatti

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Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation by Satish Kumar, Joanne E. Curran, David C. Glahn, John Blangero

“…Here, we report a new optimized LCL-to-iPSC reprogramming protocol using episomal plasmids encoding pluripotency transcription factors and mouse p53DD (p53 carboxy-terminal dominant-negative fragment) and commercially available reprogramming media. …”
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Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305 by Victoria Chagoya de Sánchez, Lidia Martínez-Pérez, Rolando Hernández-Muñoz, Gabriela Velasco-Loyden

“…Liver homogenate, mitochondria, and nucleus were used to measure cyclins, CDKs, and cell cycle regulatory proteins PCNA, pRb, p53, E2F, p21, p27, HGF, liver ATP, and mitochondrial function. …”
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Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 by Huizhen Fan, Chunyan Jiang, Baoyuan Zhong, Jianwen Sheng, Ting Chen, Qingqing Chen, Jingtao Li, Hongchuan Zhao

“…Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine’s mechanism. …”
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Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma by Shu-Qin Jia, Jian-Jun Ren, Pei-De Dong, Xing-Kai Meng

“…In 107 specimens, 40.2% (43/107) HCC tissues expressed p53 protein, lower than that of the HPCs around the tumor nodules (46.7%, 50/107) and much higher than that of the HPCs around the paracirrhosis nodules (8.41%, 9/107). …”
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Cinnamaldehyde impacts key cellular signaling pathways for induction of programmed cell death in high-grade and low-grade human glioma cells by Yoo Na Kim, Ketki Patil, S. Balakrishna Pai

“…Gliomas comprise high-grade gliomas like glioblastoma multiforme (GBMs), many of which have mutation in the tumor suppressor p53 gene and low-grade gliomas (LGGs). LGGs can progress to GBMs due to various factors. …”
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辅酶Q₁₀抑制过氧化氢诱导的血小板线粒体功能紊乱 by 施译琳, 杨奥林, 王锐杰, 牙甫礼, 陈彦球, 杨燕

“…结论CoQ₁₀抑制H₂O₂诱导的血小板线粒体功能紊乱，并且抑制p53磷酸化及升高Bcl-2家族抗凋亡蛋白表达。…”
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Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4 by Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks

“…Furthermore, our data demonstrate that the combined knockdown of FBXO4 and E6AP not only rescues the protein levels of E6 but also induces high levels of cell death in a p53-dependent manner in the HPV-positive cervical cancer cell line, HeLa. …”
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Deciphering the dose-dependent effects of thymoquinone on cellular proliferation and transcriptomic changes in A172 glioblastoma cells. by Rachana Pandey, Purushothaman Natarajan, Umesh K Reddy, Wei Du, Cristian Sirbu, Moussa Sissoko, Gerald R Hankins

“…., SPRY4, BEX2). TQ also affected p53 downstream targets, maintaining p53 levels. …”
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microRNA16可能通过调控Wip1抑制U87细胞增殖和侵袭

“…过表达miR16后，U87 细胞增殖和侵袭能力下降，早期凋亡率增加，且Wip1蛋白表达明显减少，P53蛋白的表达增加。【结论】miR16可能通过调控靶基因Wip1抑制U87细胞的增殖和侵袭。…”
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Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice by Dunia Waked, Gabriel Henrique Rodella Guedes, Raissa Macedo, Paulo Hilário Nascimento Saldiva, Mariana Matera Veras, Ana Paula Cremasco Takano

“…Cardiac hypertrophy, fibrosis, and markers of cellular senescence (p53, p21, p-H2AX, and lipofuscin) in the myocardium were evaluated in the experimental groups. …”
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Modulation of Apoptosis and ER Stress Markers in Hepatocellular Carcinoma Cells by Irinotecan, Hesperidin, and Piperine by Serkan Sen, Kardelen Kocaman Kalkan, Canan Yilmaz, Sefa Celik

“…Results: Irinotecan significantly upregulated the expression of Bad, Bax, and p53 genes, as well as ER stress markers such as ATF4, CHOP, and GRP78. …”
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Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperati... by Juliano Coelho de Oliveira Zakir, Luiz Augusto Casulari, José Wilson Corrêa Rosa, João Willy Corrêa Rosa, Paulo Andrade de Mello, Albino Verçosa de Magalhães, Luciana Ansaneli Naves

“…Ki-67 (p=0.23) and c-erbB2 (p=0.71) had no significant relation to tumor progression status. P53 (p=0.003), parasellar invasion (p=0.03), and classification, grade 2B (p=0.01), were associated with worse clinical outcome. …”
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ABA enhances the apoptotic effect of docetaxel in the multidrug-resistant DU145 prostate cancer cell line by Şumnulu Deniz, Doğanlar Zeynep Banu

“…RT-PCR analysis showed that treatment of resistant cells with 50.07 nM docetaxel and 500 μM ABA (ABA) resulted in the following changes in gene expression: heat shock protein (HSP) 70 (0.63-fold), glucose-regulated protein 94 (GRP94) 0.33-fold, inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) 1.62-fold, ER degradation- enhancing alpha-mannosidase-like 1 (EDEM1) 1.77-fold, X-box binding protein 1 (XBP1) 1.53-fold, p21 (2.53-fold), cellular tumor antigen p53 (p53) 2.49-fold, bcl-2-like protein 4 (Bax) 2.7-fold, and tumor necrosis factor (TNF-α) 6.35-fold. …”
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Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs by Kitra Cates, Luorongxin Yuan, Yan Yang, Andrew S. Yoo

“…Among the predicted regulators, we identify TP53 (p53), whose inhibition is sufficient to enhance neuronal conversion even in post-mitotic cells. …”
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Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats by Yachao Zhao, Zhiwei Jia, Shanshan Huang, Yaohong Wu, Longgang Liu, Linghan Lin, Deli Wang, Qing He, Dike Ruan

“…Differences in morphology, proliferation, colony formation, multilineage differentiation, cell cycle, and expression of β-galactosidase (SA-β-gal) and senescent markers (p53, p21, and p16) were compared between groups. …”
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