Overexpression of SFPQ Improves Cognition and Memory in AD Mice by Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

“…Additionally, synaptic and memory-associated proteins, as well as antioxidant proteins like glutathione S-transferase (GST) and heme oxygenase-1 (HO-1), were upregulated. The ratio of antiapoptotic protein Bcl-2 to proapoptotic protein Bax also increased. …”
Get full text

Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 by Xiao-hui Li, Xia Gong, Li Zhang, Rong Jiang, Hong-zhong Li, Meng-jiao Wu, Jing-yuan Wan

“…Notably, PD upregulated the expression and activity of heme oxygenase (HO-)1 in lung tissue of septic mice. Further, the protective effects of PD on sepsis were abrogated by ZnPP IX, a specific HO-1 inhibitor. …”
Get full text

Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice by Seung Hee Choi, Jaechan Leem, In-Kyu Lee

“…In addition, gemigliptin increased the protein expression of heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) in the kidneys of cisplatin-treated mice. …”
Get full text

Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway by Huabing Yang, Pengjun Zhao, Shiliu Tian

“…INN reduced TNFα-induced reactive oxygen species (ROS) generation and time-dependently prompted the expression and activity of heme oxygenase 1 (HO-1). Cellular glutathione (GSH) levels were augmented by INN. shHO-1 blocked the INN suppression of TNFα-induced HL-60 cell adhesion. …”
Get full text

Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats by Seungae Park, Na-Young Park, Giuseppe Valacchi, Yunsook Lim

“…HFCR reduced lipid peroxidation and decreased the expression levels of inducible nitric oxide synthetase, cyclooxygenase-2, NF-E2-related factor, and heme oxygenase-1 in the liver. Moreover, HFCR suppressed the expression levels of C- reactive protein and manganese superoxide dismutase in the adipose tissue in the HF group. …”
Get full text

Canagliflozin alleviates acetaminophen-induced renal and hepatic injury in mice by modulating the p-GSK3β/Fyn-kinase/Nrf-2 and p-AMPK-α/STAT-3/SOCS-3 pathways by Abeer Bishr, Bassant M. El-Mokadem, Asmaa A. Gomaa

“…Alternatively, Cana dampened the expression of STAT-3 and Fyn-kinase genes with a subsequent increase in the contents of suppressor of cytokine signaling (SOCS)-3 and also boosted the contents of the nuclear factor erythroid related factor 2 (Nrf-2)/heme oxygenase (HO)-1/ NADPH quinone oxidoreductase (NQO)-1 axis. …”
Get full text

Butein Inhibits Oxidative Stress Injury in Rats with Chronic Heart Failure via ERK/Nrf2 Signaling by Peng Liu, Quanli Pan

“…Importantly, butein activated the ERK1/2 pathway, which contributed to Nrf2 activation and subsequent heme oxygenase-1 (HO-1) and glutathione cysteine ligase regulatory subunit (GCLC) induction. …”
Get full text

Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1 by Mardi M. Algandaby

“…These effects were associated with increased levels of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) in renal tissue. …”
Get full text

15-Deoxy-Δ12,14-prostaglandin J2 Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction by Line Nilsson, Fredrik Palm, Rikke Nørregaard

“…Protein and RNA expression were examined using immunoblotting and qPCR. 15d-PGJ2 increased NF-E2-related nuclear factor erythroid-2 (Nrf2) protein expression in response to UUO, and heme oxygenase 1 (HO-1), a downstream target of Nrf2, was induced by 15d-PGJ2. …”
Get full text

Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries by Olivia Lenoir, François Gaillard, Hélène Lazareth, Blaise Robin, Pierre-Louis Tharaux

“…Indirect evidence suggests a role for heme oxygenase-1 (HO-1) in limiting diabetic vasculopathy. …”
Get full text

Role of HO/CO in the Control of Peripheral Circulation in Humans by David Sacerdoti, Despina Mania, Paola Pesce, Silvia Gaiani, Angelo Gatta, Massimo Bolognesi

“…Experimental studies show that the heme oxygenase/carbon monoxide system (HO/CO) plays an important role in the homeostasis of circulation and in the pathophysiology of hypertension. …”
Get full text

Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury by Wen-Chung Huang, Shu-Ju Wu, Ya-Ling Chen, Chwan-Fwu Lin, Chian-Jiun Liou

“…Furthermore, tomatidine enhanced the production of heme oxygenase-1, decreased the secretion of inflammatory cytokines and chemokines in LPS-stimulated lung epithelial cells, and attenuated THP-1 monocyte adhesion. …”
Get full text

Implementation Nutrigenomic of Vitamin D in Periodontitis by Hervina Hervina, I Dewa Made Sukrama, I Made Jawi

“…VDR signaling can build transcription of genes encoding proactive cytokines, bypassing the cyclo-oxygenase-2 (COX-2) and prostaglandin pathway, and can inhibit matrix metalloproteinase production. …”
Get full text

Quercetin Protects Primary Human Osteoblasts Exposed to Cigarette Smoke through Activation of the Antioxidative Enzymes HO-1 and SOD-1 by Karl F. Braun, Sabrina Ehnert, Thomas Freude, José T. Egaña, Thilo L. Schenck, Arne Buchholz, Andreas Schmitt, Sebastian Siebenlist, Lilianna Schyschka, Markus Neumaier, Ulrich Stöckle, Andreas K. Nussler

“…Quercetin increased the expression of the anti-oxidative enzymes heme-oxygenase- (HO-) 1 and superoxide-dismutase- (SOD-) 1. …”
Get full text

Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Susu M. Zughaier, Brandon B. Stauffer, Nael A. McCarty

“…We also show that ER stress combined with inflammation synergistically upregulated the expression of the iron carrier protein NGAL and the stress-inducible heme degrading enzyme heme oxygenase-1 (HO-1) leading to iron liberation. This is the first report to show that inflammation and ER stress downregulate the expression of BDH2 in human THP-1 macrophages.…”
Get full text

Pterostilbene protects against lipopolysaccharide-induced inflammation and blood–brain barrier disruption in immortalized brain endothelial cell lines in vitro by Yan Zhou, Yifan Yang, Rui Tian, Wai San Cheang

“…Additionally, pterostilbene exhibited antioxidant effects by activating heme oxygenase 1 (HO-1). These findings indicated that pterostilbene protected against lipopolysaccharide (LPS)-induced inflammation, oxidative stress and blood–brain barrier (BBB) disruption in bEnd.3 cells.…”
Get full text

Analysis of the Renal Protection and Antioxidative Stress Effects of Panax notoginseng Saponins in Diabetic Nephropathy Mice by Wei Mi, Min Yu, Shuying Yin, Yuhan Ji, Tala Shi, Ning Li

“…ELISA and western blotting were carried out to quantify the levels of OS indexes and inflammatory factors (IFs) in mouse kidney tissues and the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), respectively. Results. The weight of DN mice decreased first compared with control animals and then gradually increased after different doses of PNS treatment. …”
Get full text

Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway. by Jing Zhang, Xuefeng Chen, Shilin Lv, Qingqing Hao

“…Protein expression levels of nuclear factor E2-related factor 2(Nrf2), heme oxygenase-1(HO-1), glutathione peroxidase 4(Gpx4) were detected by Western blot.…”
Get full text

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases by Xueyan Zhang, Yihan Yu, Hanyu Lei, Yufeng Cai, Jie Shen, Ping Zhu, Qingnan He, Mingyi Zhao

“…Nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) is a protein found in all cells of the human body. …”
Get full text

Protective mechanisms of exogenous melatonin on chlorophyll metabolism and photosynthesis in tomato seedlings under heat stress by Wangwang An, Guangzheng Wang, Jianhua Dou, Yonghai Zhang, Qing Yang, Yongmei He, Zhongqi Tang, Jihua Yu, Jihua Yu

“…Photosynthetic parameters, including key enzyme activities [sedoheptulose-1,7-bisphosphatase (SBPase), ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), and NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (NADP-GAPDH)], photochemical efficiency [Fv/Fm and Y(II)], and photochemical quenching (Qp), were significantly improved, restoring the OJIP curve and enhancing photosynthesis. …”
Get full text