Jinbei oral liquid for idiopathic pulmonary fibrosis: a randomized placebo-controlled trial by Aijun Zhang, Kangkang Han, Fangfang Chen, Xiao Chen, Jun Wang, Yikai Niu, Zhaoqiu Hu, Chunyan Zheng, Liping Han, Zhaoqing Meng, Liangzong Zhang, Qingcui Xu, Cuixiang Yu, Wei Zhang, Quanguo Li, Ningning Tao, Weixiang Kong, Fei Liu, Min Wang, Juanjuan Jiang, Honglin Li, LongBin Pang, Huaichen Li

“…George’s Respiratory Questionnaire (SGRQ) total score, and arterial oxygen partial pressure (PaO2) from baseline to week 26 versus placebo. …”
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Spatial-temporal distribution of phytoplankton HAB species and contamination status of oyster toxins under intensive oyster farming in Jiangmen coasts, the South China Sea by Jian Zou, Yayuan Xiao, Jiaqi Su, Yang Liu, Peng Wu, Teng Wang, Lin Lin, Chunhou Li, Yu Liu, Yong Liu

“…Redundancy analysis showed temperature, dissolved oxygen, silicate and phosphate were the key factors related with variations of HAB species. …”
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Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism by Bayan Alkotub, Lisa Bauer, Ali Bashiri Dezfouli, Khouloud Hachani, Vasilis Ntziachristos, Gabriele Multhoff, Morteza Hasanzadeh Kafshgari

“…Interestingly, FF (50 μM) significantly radiosensitizes U87 cells by inducing DNA double-strand breaks through oxidative stress and impairing mitochondrial membrane integrity, but radioprotects LN18 cells by reducing the production of reactive oxygen species (ROS) and stabilizing the mitochondrial membrane potential. …”
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Three-dimensional direct lithography of stable quantum dots in hybrid glass by Dezhi Zhu, Shangben Jiang, Ying Wang, Dejun Liu, Weijia Bao, Liwei Liu, Junle Qu, Yiping Wang, Changrui Liao

“…Due to the encapsulated QDs within the densely silicon-oxygen molecular networks, the functional structures demonstrate good stability against ultraviolet irradiation, corrosive solutions, and elevated temperatures. …”
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Lena River biogeochemistry captured by a 4.5-year high-frequency sampling program by B. Juhls, A. Morgenstern, J. Hölemann, A. Eulenburg, B. Heim, F. Miesner, F. Miesner, H. Grotheer, H. Grotheer, G. Mollenhauer, G. Mollenhauer, H. Meyer, E. Erkens, E. Erkens, F. Y. Gehde, S. Antonova, S. Chalov, S. Chalov, M. Tereshina, O. Erina, E. Fingert, E. Abramova, T. Sanders, L. Lebedeva, N. Torgovkin, G. Maksimov, V. Povazhnyi, R. Gonçalves-Araujo, U. Wünsch, A. Chetverova, A. Chetverova, S. Opfergelt, P. P. Overduin

“…The dataset comprises 587 sampling events and measurements of various parameters, including water temperature, electrical conductivity, stable oxygen and hydrogen isotopes, dissolved organic carbon concentration and <span class="inline-formula">¹⁴</span>C, colored and fluorescent dissolved organic matter, dissolved inorganic and total nutrients, and dissolved elemental and ion concentrations. …”
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Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice by Wen Yin, Heng Xu, Zhonghao Bai, Yue Wu, Yan Zhang, Rui Liu, Zhangzhao Wang, Bei Zhang, Jing Shen, Hao Zhang, Xin Chen, Danting Ma, Xiaofeng Shi, Lihui Yan, Chang Zhang, Hualiang Jiang, Kaixian Chen, Dean Guo, Wenyan Niu, Huiyong Yin, Weiping J. Zhang, Cheng Luo, Xiangyang Xie

“…Abstract Reactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. …”
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Study on the protective effect of mitochonic acid-5 on septic acute kidney injury and the underlying mechanism by Li Peng-yan, Yan miao, Yang Ding-ping

“…方法细胞实验：将肾小管细胞分为正常组、MA-5（10 µmol/L）组、LPS（10 mg/L）刺激组和LPS+MA-5治疗组，通过细胞计数试剂盒8法评估细胞活力、流式细胞术评估细胞凋亡率；活性氧（reactive oxygen species，ROS）检测试剂盒检测ROS含量；三磷酸腺苷（adenosine triphosphate，ATP）检测试剂盒检测ATP水平；蛋白质印迹法（western blot，Wb）检测沉默信息调节因子3（silence information regulator 3，SIRT3）蛋白、线粒体动力学相关蛋白［动力相关蛋白1（dynamin-related protein 1，DRP1）、视神经萎缩因子1（optic atrophy 1，OPA1）］和细胞凋亡相关蛋白［B细胞淋巴瘤2（B-cell lymphoma-2，Bcl-2）、Bcl-2相关X蛋白（Bcl-2 associated X protein，Bax）］的表达水平。…”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Mechanistic studies indicated that QCT and Mn2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. …”
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The Effect of Corona Dormancy on the Physiological Stress and Main Nutritional Components in the Transport of Trachinotus ovatus During Survival by Siwei LIU, Jiamei ZHONG, Xiuping FAN, Xiaoming QIN, Jian SHEN, Wenqi XU

“…T. ovatus is a warm temperature-loving, omnivorous migratory fish with high oxygen consumption and vigorous metabolism. Fishing exerts high stress on the organism, and they easily die in low temperature environments (< 13 ℃). …”
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Processing tomato (Lycopersicon esculentum Miller) yield and quality in arid regions through micro-nano aerated drip irrigation coupled with humic acid application by Jiaying Ma, Rui Chen, Yue Wen, Jinzhu Zhang, Feihu Yin, Tehseen Javed, Jiliang Zheng, Zhenhua Wang

“…SEM analysis revealed that coupled water-fertilizer-gas drip irrigation directly enhanced soil oxygen content while negatively affecting soil water-filled porosity and evapotranspiration, thus indirectly influencing the growth, yield, and quality of processing tomatoes. …”
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Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress by Xiaomeng Tang, Jingjing Ning, Yilin Zhao, Shuyun Feng, Lujing Shao, Tiantian Liu, Huijie Miao, Yucai Zhang, Chunxia Wang

“…In the in vitro analysis using HepG2 cells, the influence of FGF19 pretreatment on reactive oxygen species (ROS) production and mitochondrial dysfunction was analyzed. …”
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Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…In the discovery cohort, the required level of respiratory support at the time of CXR acquisition (supplemental oxygen or non-invasive ventilation (n=178); invasive-mechanical ventilation (n=234), extracorporeal membrane oxygenation (n=13)) was significantly associated with RALE scores (median (IQR): 20.0 (14.1–26.7), 26.0 (20.5–34.0) and 44.5 (34.5–48.0), respectively, p&lt;0.0001). …”
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Conversion therapy strategy: A novel GPC3-targeted multimodal organic phototheranostics platform for mid-late-stage hepatocellular carcinoma by Fan Wu, Xin Kuang, Sanlin Deng, Shuo Qi, Jian Xiong, Bibo Zhao, Chuanfu Li, Senyou Tan, Qiang Kang, Hao Xiao, Xiaofeng Tan, Gui-long Wu, Qinglai Yang, Guodong Chen

“…IGD NPs target HCC cells through GPC3, releasing heat and reactive oxygen species (ROS) under noninvasive 808 nm laser irradiation to reduce tumor size and achieve downstaging. …”
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Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression by Romain J. Duprat, Kristin A. Linn, Theodore D. Satterthwaite, Yvette I. Sheline, Ximo Liang, Gabriela Bagdon, Matthew W. Flounders, Heather Robinson, Michael Platt, Joseph Kable, Hannah Long, Morgan Scully, Joseph A. Deluisi, Michael Thase, Mario Cristancho, Julie Grier, Camille Blaine, Almaris Figueroa-González, Desmond J. Oathes

“…Single pulses of TMS interleaved with fMRI readouts were administered to these targets to evoke downstream fMRI blood-oxygen-level-dependent (BOLD) responses in the sgACC. …”
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ALDH1L2 drives HCC progression through TAM polarization by Jiajun Li, Chi Zhang, Qingqing Zhou, Qinqin Long, Jiayi Chen, Lili Meng, Wei Tian, Yue Yang, Chao Ge, Yuting Su, Xi-Dai Long, Jun Wu, Hua Tian

“…ALDH1L2 promotes mitochondrial respiration, increases ATP production and protects HCC cells from reactive oxygen species-induced cellular damage via NRF2 stabilization. …”
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Increased spindle-related brain activation in right middle temporal gyrus during N2 than N3 among healthy sleepers: Initial discovery and independent sample replication by Yan Shao, Yupeng Guo, Yun Chen, Guangyuan Zou, Jie Chen, Xuejiao Gao, Panpan Lu, Yujie Tong, Yuezhen Li, Ping Yao, Jiayi Liu, Shuqin Zhou, Jing Xu, Jia-Hong Gao, Qihong Zou, Hongqiang Sun

“…The finding from dataset 1 indicated significantly increased blood-oxygen level-dependent signal in the right middle temporal gyrus during N2 compared with N3, which was well replicated in dataset 2. …”
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True Mass and Atmospheric Composition of the Nontransiting Hot Jupiter HD 143105 b by Luke Finnerty, Yinzi Xin, Jerry W. Xuan, Julie Inglis, Michael P. Fitzgerald, Shubh Agrawal, Ashley Baker, Randall Bartos, Geoffrey A. Blake, Benjamin Calvin, Sylvain Cetre, Jacques-Robert Delorme, Greg Doppmann, Daniel Echeverri, Katelyn Horstman, Chih-Chun Hsu, Nemanja Jovanovic, Joshua Liberman, Ronald A. López, Emily C. Martin, Dimitri Mawet, Evan Morris, Jacklyn Pezzato-Rovner, Jean-Baptiste Ruffio, Ben Sappey, Tobias Schofield, Andrew Skemer, Taylor Venenciano, J. Kent Wallace, Nicole L. Wallack, Jason J. Wang, Ji Wang

“…From these abundances, we place an upper limit on the carbon-to-oxygen ratio for HD 143105 b, C/O < 0.2 at 95% confidence, and find the atmospheric metallicity is approximately 0.1 × solar. …”
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Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases by Ana I. Rojo, Brigitta Buttari, Susana Cadenas, Ana Rita Carlos, Antonio Cuadrado, Ana Sofia Falcão, Manuela G. López, Milen I. Georgiev, Anna Grochot-Przeczek, Sentiljana Gumeni, José Jimenez-Villegas, Jarosław Olav Horbanczuk, Ozlen Konu, Isabel Lastres-Becker, Anna-Liisa Levonen, Viktorija Maksimova, Charalambos Michaeloudes, Liliya V. Mihaylova, Michel Edwar Mickael, Irina Milisav, Biljana Miova, Patricia Rada, Marlene Santos, Miguel C. Seabra, Dubravka Svob Strac, Sandra Tenreiro, Ioannis P. Trougakos, Albena T. Dinkova-Kostova

“…Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. …”
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

“…Mechanistically, we found that S100A8/A9, in conjunction with neutrophil activation and infiltration into the brain, enhances reactive oxygen species (ROS) production within neutrophils, accelerating PAD4-mediated neutrophil extracellular trap (NET) formation, which in turn exacerbates neuroinflammation. …”
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Inhibition of glutathione peroxidase 4 suppresses gastric cancer peritoneal metastasis via regulation of RCC2 homeostasis by Can Hu, Jingli Xu, Yanqiang Zhang, Ruolan Zhang, Siwei Pan, Jiahui Chen, Yan Wang, Qianyu Zhao, Yuqi Wang, Weiwei Zhu, Mengxuan Cao, Shengjie Zhang, Dan Zu, Zhiyuan Xu, Ji Jing, Xiangdong Cheng

“…Furthermore, we demonstrated that the reactive oxygen species (ROS) accumulation induced by GPx4 inhibition or knockdown activated aurora A phosphorylation, leading to RCC2 ubiquitination and degradation, thereby suppressing peritoneal metastasis in GC. …”
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