Effects of Intrathecal Bupivacaine with Adjuvants Midazolam versus Magnesium Sulphate in Tibia Fibula Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Aanal Sha, Dushyant Chavda, Dinesh K Chauhan

“…The primary objective was to observe Heart Rate (HR), Blood Pressure (BP), Oxygen Saturation (SpO2) and Respiratory Rate (RR). …”
Get full text

Short- and long-term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-crank exercise capacity in individuals with a spinal cord injury... by Samuel J E Lucas, Tom E Nightingale, Jet J C S Veldhuijzen van Zanten, Shin-Yi Chiou, Alex J Wadley, Rebekah A I Lucas, Daniel D Hodgkiss, Shane J T Balthazaar, Joseph F Welch, Phoebe A Cox

“…All participants will perform 48 min of ACE twice per week (at workloads corresponding to 73–79% peak oxygen uptake), over a period of 8 weeks, either with (CV-TSCS) or without (SHAM-TSCS) cardiovascular-optimised stimulation. …”
Get full text

CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct t... by Mercedes Zubiaur, Laura C. Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-del Jesús, Luz María Canet-Antequera, María M. Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez, Sonia Pérez-Cabrera, Nerea Bello-Iglesias, Antonio Alcina, Ana-Clara Abadía-Molina, Fuencisla Matesanz, Esther Zumaquero, Ramón Merino, Jaime Sancho

“…Last, we have shown an intense metabolic reprogramming toward oxidative phosphorylation in PECs and SPC from cGVHD WT mice, which may reflect an increased cellular demand for oxygen consumption, in contrast to PECs and SPC from cGVHD Cd38-/- mice, which showed a short-lived metabolic effect at the transcriptomic level. …”
Get full text

Synergistically S/N self-doped biochar as a green bifunctional cathode catalyst in electrochemical degradation of organic pollutant by Xuechun Wang, Huizhong Wu, Jiana Jing, Ge Song, Xuyang Zhang, Minghua Zhou, Raf Dewil

“…Herein, we illustrated the morphological fates of waste leaf-derived graphitic carbon (WLGC) produced from waste ginkgo leaves via pyrolysis temperature regulation and used as bifunctional cathode catalyst for simultaneous H2O2 electrochemical generation and organic pollutant degradation, discovering S/N-self-doping shown to facilitate a synergistic effect on reactive oxygen species (ROS) generation. Under the optimum temperature of 800 °C, the WLGC exhibited a H2O2 selectivity of 94.2% and tetracycline removal of 99.3% within 60 min. …”
Get full text

Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect by Yunfei Zuo, Pei Li, Wen‐Jin Wang, Changhuo Xu, Shuting Xu, Herman H. Y. Sung, Jianwei Sun, Guorui Jin, Weiping Wang, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang

“…TQ‐HA generates reactive oxygen species (ROS) under light irradiation, enabling the simultaneous induction and monitoring of apoptosis and ferroptosis in tumor cells. …”
Get full text

Mulberry leaf extract reduces damage by regulating the oxidative response, immune response and intestinal flora of largemouth bass (Micropterus salmoides) under chronic heat stress by Bing Fu, Donglai Zhou, Xiaotong Qiu, Xiaotong Qiu, Jieqiu Zheng, Jieqiu Zheng, Qiong Yang, Yang Xiao, Sentai Liao, Qingrong Li, Dongxu Xing

“…HS significantly decreased the final body weight, specific growth rate, intestinal villus length, muscular layer thickness, ACE and Chao1 indices, and lipase, trypsin, total superoxide dismutase (T-SOD), glutathione peroxidase (GPx), alkaline phosphatase (AKP), and lysozyme (LZM) activities, but significantly increased the feed conversion rate, aspartate aminotransferase (AST) activity, reactive oxygen species (ROS), malondialdehyde (MDA), complement 3 (C3) contents, and the relative abundances of Proteobacteria and Plesiomonas. …”
Get full text

Torrefaction of bamboo pellets using a fixed counterflow multibaffle reactor for renewable energy applications by W. Hidayat, B.A. Wijaya, B. Saputra, I.T. Rani, S. Kim, S. Lee, J. Yoo, B.B. Park, L. Suryanegara, M.A.R. Lubis

“…The ultimate analysis showed increased carbon and reduced nitrogen, hydrogen, and oxygen, improving solid fuel quality, energy density, and combustion emissions. …”
Get full text

Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the... by Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo

“…To assess cellular senescence, we performed a senescence-associated β-galactosidase (SA-β-gal) assay, measured reactive oxygen species (ROS) levels, and examined the expression of P16, P21, and γH2AX. …”
Get full text

Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma by Soniya Bastola, Marat S. Pavlyukov, Neel Sharma, Yasmin Ghochani, Mayu A. Nakano, Sree Deepthi Muthukrishnan, Sang Yul Yu, Min Soo Kim, Alireza Sohrabi, Natalia P. Biscola, Daisuke Yamashita, Ksenia S. Anufrieva, Tatyana F. Kovalenko, Grace Jung, Tomas Ganz, Beatrice O’Brien, Riki Kawaguchi, Yue Qin, Stephanie K. Seidlits, Alma L. Burlingame, Juan A. Oses-Prieto, Leif A. Havton, Steven A. Goldman, Anita B. Hjelmeland, Ichiro Nakano, Harley I. Kornblum

“…In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support to GBM cells via paracrine signaling. …”
Get full text

Preparation of Composite Films Based on Methyl Cellulose/Polyvinyl Alcohol-loaded Nanosilver (AgNPs@PVA/MC) and Its Effect on Storage Quality of Ougan by Shuaishuai DAI, Weijie WU, Xiangjun FANG, Hangjun CHEN, Jun HUANG, Ruiling LIU, Huizhi CHEN, Ben NIU, Haiyan GAO

“…Among them, the composite film with 0.1% AgNPs content had the best comprehensive performance, its tensile strength reached 12.45 MPa, elongation at break was 6.47%, water vapor permeability was 21.03×10−6 g·mm/(m2·s·Pa), and oxygen permeability was 2.31×10−6 cm3/(cm2·s·Pa). …”
Get full text

Associations between milk infrared-predicted plasma biomarkers of stress resilience and fertility in dairy cattle: Insights for enhancing breeding programs and herd management by Alessio Cecchinato, Hugo Toledo-Alvarado, Lucio Flavio Macedo Mota, Vittoria Bisutti, Erminio Trevisi, Riccardo Negrini, Sara Pegolo, Stefano Schiavon, Luigi Gallo, Giovanni Bittante, Diana Giannuzzi

“…Specifically, increasing levels of ceruloplasmin, total reactive oxygen metabolites, and advanced oxidation protein products resulted in a relevant decrease in the HR of cows becoming pregnant. …”
Get full text

Injectable Autocatalytic Hydrogel Triggers Pyroptosis to Stimulate Anticancer Immune Response for Preventing Postoperative Tumor Recurrence by Zhiping Rao, Yutong Zhu, Zhuang Chen, Yi Luo, Zuo Yang, Weijing Liu, Chaoqiang Qiao, Yuqiong Xia, Peng Yang, Dong‐Man Ye, Zhongliang Wang

“…Following injection of the CP@Gel, the sustained release of CP leads to the autocatalytic generation of reactive oxygen species, resulting in caspase‐3 activation, and the pre‐administered DAC inhibits the methylation of Gsdme to elevate the GSDME protein levels, leading to intense pyroptosis and anti‐tumor immune responses. …”
Get full text

ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…Ferroptosis indicators, including levels of reactive oxygen species, were used to detect the combined effect of CAR-T cells and ferroptosis-inducing drugs. …”
Get full text

Optimization of salinity range for rearing glass eel Anguilla bicolor bicolor by Ade Yulita Hesti Lukas, Daniel Djokosetiyanto, Tatag Budiardi, Agus Oman Sudrajat, Ridwan Affandi

“…Physical and chemical parameters included temperature, dissolved oxygen, and pH which were measured daily, while ammonia and alkalinity were measured every seven days. …”
Get full text

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby cou... by Wenxin Zhang, Wenxin Zhang, Hongbo Teng, Hongbo Teng, Tianyi Zhao, Tianyi Zhao, Roberts I. Eglitis, Xv Wang, Xv Wang, Zhengxuan Yu, Shurong Qu, Shurong Qu, Haijing Wang, Haijing Wang, Yaru Zhao, Yaru Zhao, Bowen Fan, Bowen Fan, Shuangli Liu, Shuangli Liu, Yan Zhao, Yan Zhao

“…Compound 19 treatment increased autophagy levels, thereby alleviating mitochondrial dysfunction and reducing the accumulation of reactive oxygen species (ROS).In-depth studies have found that the autophagy inhibitor 3-methyladenine (3-MA) weakens the regulatory effect of compound 19 on autophagy and inhibits the clearance of damaged cells, resulting in oxidative stress damage, apoptosis and necrosis. …”
Get full text

Comparative Study of the Chemical Composition Disparities Between Fast-twitch and Slow-twitch Muscles in Marine Teleost Fishes by Huan WANG, Shufang LIU

“…Finally, the mineral element analysis revealed that slow-twitch muscles possess higher iron and zinc concentrations, which are critical in oxygen transportation and catalyzation of oxidation processes. …”
Get full text

A Comparative Study of Health Efficacy Indicators in Subjects with T2DM Applying Power Cycling to 12 Weeks of Low-Volume High-Intensity Interval Training and Moderate-Intensity Con... by Jun Li, Wei Cheng, Haifeng Ma

“…HIIT involved one-minute power cycling (80%–95% maximal oxygen uptake (VO2max)), one-minute passive or active rest (25%–30% VO2max), and two-minute rounds of eight groups. …”
Get full text

BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function by Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang

“…Consequently, BPZ-exposed embryos exhibit elevated levels of reactive oxygen species, superoxide anions, and oxidative DNA damage. …”
Get full text

Improving Growth Performance, Biochemical Parameters and Reducing Mortality due to Ascites in Broilers by Propranolol Inclusion by Shahriar Saidian, Somaya Farahmand, Mokhtar Fathi, Salar Saifi

“…In addition, reactive oxygen species (ROS) reduce the half-life of nitric oxide (vasodilating agent), causing a decrease in the ability of vasodilation and providing the basis for the occurrence of ascites. …”
Get full text

Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats by Justin Stadler, Justin Stadler, Justin Stadler, Lucas G. Garmo, Lucas G. Garmo, Lucas G. Garmo, David Doyle, David Doyle, David Doyle, Chin-I. Cheng, Garrett Richardson, Garrett Richardson, Zain Waheed, Zain Waheed, Tim Tofan, Bhairavi Srinageshwar, Bhairavi Srinageshwar, Bhairavi Srinageshwar, Ajit Sharma, Robert B. Petersen, Gary L. Dunbar, Gary L. Dunbar, Gary L. Dunbar, Julien Rossignol, Julien Rossignol, Julien Rossignol

“…IntroductionIschemic stroke is a devastating neurovascular condition that occurs when cerebral tissue fails to receive an adequate supply of oxygen. Despite being a leading cause of death and disability worldwide, therapeutic interventions are currently limited. …”
Get full text