Multifunctional drug delivery nanoparticles for combined chemotherapy/chemodynamic/photothermal therapy against colorectal cancer through synergistic cuproptosis/ferroptosis/apopto... by Xiuzhang Yan, Heshi Liu, Lei Guo, Chang Liu, Shichen Zhang, Xue Wang, Yixin Tang, Rui Zhou, Xin Jiang, Erlei Wang, Shuohui Gao, Caina Xu

“…On the other hand, DFMTCH NPs could produce reactive oxygen species (ROS) and consume glutathione (GSH) by amplifying cellular oxidative stress, while causing intracellular mitochondrial dysfunction, inducing effective cuproptosis/ferroptosis/apoptosis to inhibit tumor growth. …”
Get full text

Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders by Maojun Cheng, Maojun Cheng, Fang Ding, Fang Ding, Liyang Li, Liyang Li, Changmao Dai, Changmao Dai, Xiaolan Sun, Xiaolan Sun, Jia Xu, Jia Xu, Feier Chen, Feier Chen, Mingxiu Li, Xueping Li

“…Curcumin, known for its anti-inflammatory and antioxidant properties, has been shown to enhance cellular antioxidant activity, mitigate oxidative stress, and alleviate lipid metabolism disorders by reducing reactive oxygen species (ROS) accumulation. These effects include decreasing fat deposition, increasing fatty acid uptake, and improving insulin sensitivity. …”
Get full text

O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway by Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li

“…Thus, we generated Ogt1-conditional knockout mice and found that Ogt1 deficiency aggravated ferroptosis, as evidenced by lipid reactive oxygen species (lipid ROS), malondialdehyde (MDA), Fe2+, as well as alterations in critical protein expression glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11). …”
Get full text

Conjugated Polyvinyl Alcohol Modified SnO2 for Efficient Visible Light Photocatalytic Reduction of Cr(VI) by Shaojie Chen, Yuanyuan Luo, Yuhan Xu, Ying Chen, Yinxing Jiang, Zhao Li, Lin Tian, Furong Wang, Yuanyuan Liu, Jing Li

“…A series of testing and characterization results revealed that CPVA was uniformly coated on the surface of SnO2, forming a mesoporous CPVA/SnO2 heterojunction with enhanced crystallinity and reduced oxygen defects, which resulted in an expanded light absorption range towards the red light region. …”
Get full text

The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester-A primary cohort study with a scoping review. by Laura Ormesher, Jessica Catchpole, Linda Peacock, Heather Pitt, Anastasia Fabian-Hunt, Dexter Hayes, Claudia Popp, Jason M Carson, Raoul van Loon, Lynne Warrander, Karli Büchling, Alexander E P Heazell

“…Meta-analysis of three prospective studies investigating maternal haemodynamic effects of prone position found an increase in sBP and maternal heart rate, but no effect on respiratory rate, oxygen saturation or baseline fetal heart rate (though there was significant heterogeneity between studies).…”
Get full text

Needs Assessment and Tailored Training Pilot for Emergency Care Clinicians in the Prehospital Setting in Rwanda by Naz Karim, Jeanne D’Arc Nyinawankusi, Mikaela S. Belsky, Pascal Mugemangango, Zeta Mutabazi, Catalina Gonzalez Marques, Angela Y. Zhang, Janette Baird, Jean Marie Uwitonze, Adam C. Levine

“…For patient outcomes, the total sample size was 572 patients; 324 of these patients were transported to the ED during the pre-training period (56.4%), while 248 were transported post-training. Prehospital oxygen administration for patients with a saturation level of <95% significantly increased pre- to post-training (66.7% to 71.7%; Δ = 5.0%; Δ95% CI 1.9,−8.1%). …”
Get full text

Evaluation of Non-Invasive Hemoglobin Monitoring in Perioperative Patients: A Retrospective Study of the Rad-67^TM (Masimo) by Philipp Helmer, Andreas Steinisch, Sebastian Hottenrott, Tobias Schlesinger, Michael Sammeth, Patrick Meybohm, Peter Kranke

“…<b>Background</b>: Hemoglobin (Hb) is a crucial parameter in perioperative care due to its essential role for oxygen transport and tissue oxygenation. Accurate Hb monitoring allows for timely interventions to address perioperative anemia and, thus, prevent morbidity and mortality. …”
Get full text

JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells by Ling Yan, Shengnan Liu, Chen Wang, Fei Wang, Yingli Song, Nan Yan, Shuhua Xi, Ziyou Liu, Guifan Sun

“…In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extracellular superoxide in microglia. …”
Get full text

Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3&beta;/NRF2 Pathway by Duan M, Yu N, Liu J, Zhao Y, Zhang J, Song S, Wang S

“…The viability and apoptosis rate of SY5Y cells, neurological deficit score, cerebral infarction volume and morphological changes of rat brain cells as well as the protein expression of Bax, Bcl2, Caspase 3, Cleaved-Caspase 3 and the number of TdT-mediated dUTP Nick-End Labeling (TUNEL)-positive cells in the penumbral region were detected. Reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), NRF2, heme oxygenase 1 (HO-1), AKT, P-AKT, GSK-3β, P-GSK-3β protein expression, and nuclear translocation of NRF2 were measured in cell and animal assays.Results: Reduced SY5Y cell viability and increased apoptosis caused by OGD/R injury, elevated neurological deficit scores and cerebral infarct volume induced by brain I/R injury in rats, cerebral cell injury, as well as elevated Bax, Cleaved-Caspase 3, decreased Bcl2, and increased number of TUNEL-positive cells in rat brain tissue were all moderated by remimazolam. …”
Get full text

Effect of cisplatin/gold chitosan nanocomposite on oral squamous cell carcinoma and oral epithelial cells by Basma Abdelrahman Ahmed, Rania Osama M. Mohsen, Marwa Sharaky, Marwa A. Ramadan, Amna H. Faid, Mai Hafez Mohamed

“…The expressions of the reactive oxygen species (ROS) markers; malondialdehyde and nitric oxide were the highest in Cis/AuCh nanocomposite-treated HNO97, while the reduced glutathione expression was the lowest. …”
Get full text

Comparison of sialic acid content in bovine and buffalo milk and meat by Michela Contò, Simona Rinaldi, Sebastiana Failla

“…Neu5Ac differs from Neu5Gc by a single oxygen atom, but humans cannot synthesize the Neu5Gc due to a genetic mutation. …”
Get full text

Effect of Exogenous of Transforming Growth Factor-β1 on Pregnancy Outcome in Mice with Recurrent Pregnancy Loss by Persistent Enhancement of Placental Tissue Indoleamine 2,3-Dioxyg... by Xinghui Wen, Xiaojuan Chen, Mei Li, Jinnian Zhou, Shouli Dao, Shixiang Li, Hui Cheng, Shuyun Zhao, Guanyou Huang

Get full text

Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics by Yujia Shu, Xuanfu Wu, Dongxu Zhang, Shuxia Jiang, Wenqiang Ma

“…Excessive iron supplementation may lead to iron overload and elevated reactive oxygen species (ROS) production in animals, causing cellular damage. …”
Get full text

Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer&rsquo;s Disease by Zhou H, Peng Y, Huo X, Li B, Liu H, Wang J, Zhang G

“…FuRong Laboratory, Changsha, Hunan, 410078, People’s Republic of China, Email ghzhang@hunnu.edu.cn Jian Wang, The Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, 410006, People’s Republic of China, Email 205106@csu.edu.cnBackground: Ferroptosis is a form of programmed cell death triggered by iron-dependent lipid peroxidation, characterized by iron accumulation and elevated reactive oxygen species (ROS), leading to cell membrane damage. …”
Get full text

Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…This study proposed a synthesis method for ultra-small-diameter lentinan Se nanoparticles (LNT-UsSeNPs) with significantly superior reactive oxygen species (ROS) scavenging capabilities compared to conventional lentinan Se nanoparticles (LNT-SeNPs). …”
Get full text

Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats by Ligang Yang, Chao Yang, Zhixiu Song, Min Wan, Hui Xia, Xian Yang, Dengfeng Xu, Da Pan, Hechun Liu, Shaokang Wang, Guiju Sun

“…The 1:1 ratio resulted in a lower postprandial reactive oxygen species (ROS) level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups. …”
Get full text

Metabolomics and transcriptomics analyses revealed overexpression of TaMGD enhances wheat plant heat stress resistance through multiple responses by Dongyun Ma, Haizhou Hu, Jianchao Feng, Beiming Xu, Chenyang Du, Yang Yang, Yingxin Xie, Chenyang Wang

“…Overall, 146 differentially expressed metabolites (DEMs) were identified in MG1516 and wild-type (WT) under heat stress, with MG1516 exhibiting a higher number of upregulated metabolites, particularly glycolipids, organic acids, and organic oxygen compounds. Furthermore, lipid content and unsaturation analysis revealed that the overexpressing wheat line had a higher lipid content and greater saturation than WT under heat stress. …”
Get full text

TaSnRK3.23B, a CBL-interacting protein kinase of wheat, confers drought stress tolerance by promoting ROS scavenging in Arabidopsis by Feiyan Dong, Yide Liu, Huadong Zhang, Yaqian Li, Jinghan Song, Sheng Chen, Shuailei Wang, Zhanwang Zhu, Yan Li, Yike Liu

“…TaSnRK3.23B overexpression in Arabidopsis promoted reactive oxygen species (ROS) scavenging via the accumulation of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) and then conferred significant tolerance to drought. …”
Get full text

Retrospective Analysis of the Prevalence and Risk Factors of Retinopathy of Prematurity in a Single-Center Cohort in Romania and Comparison with National and European Data by Zsuzsánna Simon-Szabó, Sándor Pál, Aliz Pándi, Zsuzsanna Gáll, Hajnal Finta, Zsuzsánna Incze-Bartha, Cristina Maki, Manuela Cucerea

“…Identified risk factors in this cohort, such as respiratory distress syndrome, oxygen therapy, blood transfusion, and intraventricular hemorrhage, are consistent with the existing literature data. …”
Get full text

The Forgotten Hemodynamic (PCO2 Gap) in Severe Sepsis by Zouheir Ibrahim Bitar, Ossama Sajeh Maadarani, AlAsmar Mohammed El-Shably, Ragab Desouky Elshabasy, Tamer Mohamed Zaalouk

“…Central venous-arterial carbon dioxide difference (PCO2 gap) can be a marker of cardiac output adequacy in global metabolic conditions that are less affected by the impairment of oxygen extraction capacity. We investigated the relation between the PCO2 gap, serum lactate, and cardiac index (CI) and prognostic value on admission in relation to fluid administration in the early phases of resuscitation in sepsis. …”
Get full text