Accumulation of advanced oxidative protein products exacerbate satellite glial cells activation and neuropathic pain by Chen Tu, Shi-Cheng Wang, Meng-Xuan Dai, Si-Qi Lai, Zhi-Wei Huang, Yong-Peng Yu, Yun-Biao Chen, Ji-Huan Zeng, Liang Wang, Zhao-Ming Zhong

“…Exogenous AOPPs activated SGCs, increased reactive oxygen species and inflammatory response, upregulated the RAGE, and activated NF-κB signaling. …”
Get full text

An Atypical Case of Taravana Syndrome in a Breath-Hold Underwater Fishing Champion: A Case Report by Andrea Cortegiani, Grazia Foresta, Giustino Strano, Maria Teresa Strano, Francesca Montalto, Domenico Garbo, Santi Maurizio Raineri

“…A magnetic resonance imaging of the brain disclofsed a cortical T1-weighted hypointense area in the temporal region corresponding to infarction with partial hemorrhage. An early hyperbaric oxygen therapy led to prompt resolution of neurological findings. …”
Get full text

Overlooking the Obvious during the COVID-19 Pandemic: Dyspnoea with Asymmetric Breath Sounds in a Toddler by Heli Salmi, Heini Harve-Rytsälä, Paula Rautiainen, Sari Pyörälä, Johanna Hästbacka

“…An ambulance was called, and he was taken to a tertiary hospital’s paediatric emergency department, where his condition and oxygen saturation fluctuated. He had mildly elevated temperature and petechiae on his trunk, showed asymmetrical radiographic and auscultatory pulmonary findings, and did not tolerate any exertion. …”
Get full text

Contribution of individual phospholipase A2 enzymes to the cleavage of oxidized phospholipids in human blood plasma by Philipp Jokesch, Olga Oskolkova, Maria Fedorova, Bernd Gesslbauer, Valery Bochkov

“…The rate of degradation of full-length OxPLs depended on the degree of oxygenation. Species containing 1 to 3 oxygen atoms were relatively stable to degradation in plasma, while OxPLs containing > 3 extra oxygens were degraded but at significantly slower rate than truncated species. …”
Get full text

Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK‐fusion‐positive lung cancer... by Koh Furugaki, Takaaki Fujimura, Narumi Sakaguchi, Yasutaka Watanabe, Ken Uchibori, Eisaku Miyauchi, Hidetoshi Hayashi, Ryohei Katayama, Shigeki Yoshiura

“…GPX4 was found to be upregulated in DTP cells and to promote cell survival by suppressing reactive oxygen species (ROS) accumulation; GPX4 inhibitors blocked this upregulation and facilitated ROS‐mediated cell death. …”
Get full text

Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

“…Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide. Elevated reactive oxygen species (ROS) followed by oxidative stress, apoptosis, inflammatory changes and suppressed immunity are considered the key biomarkers observed during mastitis. …”
Get full text

Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…Protective effects were assessed by measuring cell viability, malondialdehyde (MDA), and superoxide dismutase (SOD) levels, along with detecting intracellular reactive oxygen species (ROS) using 2, 7-dichlorodihydrofluorescein diacetate (DCFH-DA) and dihydroethidine (DHE) probes. …”
Get full text

SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1 by Xinjie Fan, Qichu Zhu, Chengzhuo Du, Jinlai Chen, Yingming Su

“…The intracellular levels of total iron and Fe2+ were detected using Iron Assay Kits. Reactive oxygen species (ROS) levels were evaluated using a DCFH-DA probe and flow cytometry. …”
Get full text

1-Methylcyclopropene Delays Browning and Maintains Aroma in Fresh-Cut Nectarines by Rui Zhang, Ze Miao, Shuang Xie, Jiao Li, Sheng Tao, Yuqian Jiang, Lingling Pang, Lihua Duan, Xihong Li

“…Compared with the control, 1-MCP pre-cutting treatment maintained the ultrastructural integrity of the cell wall in fresh-cut nectarines, which also showed reduced malondialdehyde (MDA) content and reactive oxygen species (ROS) and enhanced the 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) radical scavenging activities. …”
Get full text

Comparing standard treatment of moderate to severe obstructive sleep apnoea to add-on acetazolamide treatment: An open-label randomised controlled trial by Anurag Tripathi, Ved Prakash, Hemant Kumar, Mohammad Arif, Atul Tiwari, Sachin Kumar, Mrityunjaya Singh, Deepak Sharma, Shubhra Srivastava

“…Following four weeks of intervention, the outcomes measured involved changes in AHI (apnea hypopnoea index), sleep architecture, ODI (oxygen desaturation Index), and other sleep parameters. …”
Get full text

Synthetic Hydrogel Dilutes <i>Serratia plymuthica</i> Growth— Promoting Effect on <i>Brassica napus</i> L. Under Drought Conditions by Grażyna B. Dąbrowska, Daniel Krauklis, Milena Kulasek, Magdalena Nocny, Marcel Antoszewski, Agnieszka Mierek-Adamska, Beata Kaliska

“…The seed viability test, reactive oxygen species accumulation, and SOD activity showed no adverse effects of applying hydrogel to canola seeds. …”
Get full text

Antimicrobial Activity of the Synthesized of Copper Chalcogenide Nanoparticles by N. G. Mbewana-Ntshanka, M. J. Moloto, P. K. Mubiayi

“…The sensitivity of copper oxide nanoparticles is attributed to the smaller size of oxygen atom which strongly affects its reactivity and stability and hence very stable and highly reactive compared to sulfur and selenium.…”
Get full text

Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway by Xiaoyu Zhang, Ping Zhu, Xiuying Zhang, Yina Ma, Wenguang Li, Ji-Mei Chen, Hui-Ming Guo, Richard Bucala, Jian Zhuang, Ji Li

“…Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco. Reactive oxygen species (ROS) is a critical factor involved in modulating cardiac stress response signaling during ischemia and reperfusion. …”
Get full text

Prophylactic Theophyline reduces birth asphyxia related renal injury in term neonates by Salma Aziz, Syeda Maimoona Qudrat, Tanzeela Rani, Qurat-ul-Ain Chughtai, Misbah Aziz, Rai Muhammad Asghar

“… BACKGROUND INTRODUCTION: Birth Asphyxia (Perinatal Asphyxia) in newborn is a condition caused by the inadequate supply of oxygen before, during, or just after birth. Kidney is the most damaged organ in asphyxiated full-term infants. …”
Get full text

The Metallogeny of the Tieling Cu-Mo Porphyry Deposit in Eastern Tianshan, NW China: New Insights from Zircon U-Pb, Fluid Inclusion, and H-O-S Stable Isotope Analyses by Ping Li, Ting Liang, Fan Huang, Tongyang Zhao, Zhixin Zhu, Yong Li, Jing Feng, Lei He

“…., respectively. The hydrogen and oxygen isotope data indicate that the ore-forming fluids of the Tieling deposit were originally derived from magmatic hydrothermal fluids and then mixed with meteoric water. …”
Get full text

Preparation, structural property, and antioxidant activities of a novel pectin polysaccharide from the flowers of Hibiscus syriacus Linn. by Jialong Chen, Chaojun Ye, Lu Zhang, Zhiliang Xie, Jianjun Zhu, Zhi Zhang

“…IntroductionOxidative stress, triggered by an imbalance between reactive oxygen species (ROS) production and cellular antioxidant defense mechanisms, is implicated in various pathological conditions. …”
Get full text

Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing by Mengyang Liu, Manisha Sharma, Guoliang Lu, Zhiwen Zhang, Wenting Song, Jingyuan Wen

“…<b>Background:</b> Skin ageing, driven predominantly by oxidative stress from reactive oxygen species (ROS) induced by environmental factors like ultraviolet A (UVA) radiation, accounts for approximately 80% of extrinsic skin damage. …”
Get full text

Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis by Yao Wang, Lin Sun, Zhenglin Dong, Tianyu Zhang, Leining Wang, Yihui Cao, Hui Xu, Chenglei Liu, Bo Chen

“…This study demonstrates the activation of ferroptosis and reactive oxygen species (ROS)-related pathways in the bone marrow mesenchymal stem cells (BMSCs) of SROP mice. …”
Get full text

Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway by Yuanyang Chen, Sihao Zheng, Zhiwei Wang, Xin Cai, Yanjia Che, Qi Wu, Shun Yuan, Xiaohan Zhong

“…In addition, cell experiments were conducted to determine the changes in expression of surface maturation markers of BMDC and changes in intracellular reactive oxygen species after LPS stimulation. Finally, western blot analysis was performed to determine the levels of endoplasmic reticulum stress-related proteins (CHOP/ATF4/PERK). …”
Get full text

Motor Learning Deficits in a Neonatal Mouse Model of Hypoxic-Ischemic Injury by Maria Marlicz, Weronika Matysik, Emily Zucker, Sarah Lee, Hannah Mulhern, Jennifer Burnsed

“…Methods: We induced HI in postnatal day (p)10 C57/Bl6 mice through unilateral carotid ligation followed by 60 min of 8% oxygen exposure, or a sham procedure. At p30, we assessed complex motor performance and learning using the accelerating rotarod and complex running wheel tasks. …”
Get full text