Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammat... by Wen Zhang, Junke Song, Wan Li, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du

“…A rat middle cerebral artery occlusion/reperfusion (MCAO/R) injury model was established, and an oxygen-glucose deprivation/reoxygenation (OGD/R) injury model was established in PC12 cells. …”
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Inhibition of Mitochondrial Fission Reverses Simulated Microgravity-Induced Osteoblast Dysfunction by Enhancing Mechanotransduction and Epigenetic Modification by Qiusheng Shi, Yaxin Song, Jingqi Cao, Jing Na, Zhijie Yang, Xinyuan Chen, Ziyi Wang, Yubo Fan, Lisha Zheng

“…These mitochondrial alterations are linked to elevated reactive oxygen species levels, a decrease in ΔΨm, and a metabolic shift from oxidative phosphorylation to glycolysis, resulting in decreased adenosine triphosphate production, which are all indicative of mitochondrial dysfunction. …”
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The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense by Shuangzhi Zhao, Ming Lei, Hui Xu, Hailun He, Alexander Suvorov, Junhua Wang, Jiying Qiu, Qingxin Zhou, Jinyu Yang, Leilei Chen

“…The preliminary evaluation of the antioxidant ability of GAMPS was conducted by the oxygen radical absorbance capacity (ORAC). The results showed that the GAMPS was composed of glucose, mannose, and galactose at a molar ratio of 67.62:14.07:7.50, and the weight-average molecular weights were 5.439 × 106 and 1.704 × 105 g/mol by using high-performance gel-permeation chromatography-multiple angle laser scatter (HPGPC-MALS) analysis. …”
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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis by Xiang Li, Gao He, Hui Jin, Xinyu Xiang, Dong Li, Renmiao Peng, Jing Tao, Xinping Li, Kaiyang Wang, Yu Luo, Xiaoan Liu

“…Additionally, a reactive oxygen species (ROS) sensitive linker is used to attach the immunotherapeutic drug PD‐L1 inhibitor (aPD‐L1) to DMSNs via covalent bonds. …”
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New Insights on Continuous Renal Replacement Therapy for Acute Respiratory Distress Syndrome: A Systematic Review and Meta‐Analysis by Siyao Zeng, Shanpeng Cui, Yue Li, Zhipeng Yao, Yunlong Li, Yang Cao, Lianghe Wen, Ming Li, Junbo Zheng, Hongliang Wang

“…Secondary outcome indicators include incidence of ventilator‐associated pneumonia (VAP), ICU length of stay, mechanical ventilation time, oxygenation index (OI) at 24 h (h), OI at 48 h, OI at 72 h, OI at 7 days (d), partial pressure of oxygen (PaO2) at 72 h, Acute Physiology and Chronic Health Evaluation II (APACHE II) score at 24 h, APACHE II score at 48 h, APACHE II score at 72 h, APACHE II score at 7 d, extravascular lung water indexes (EVLWI) at 72 h, TNF‐α at 24 h, TNF‐α at 7 d, IL‐6 at 24 h, IL‐6 at 48 h, IL‐6 at 72 h, and IL‐6 at 7 d. …”
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Comparison of the effectiveness of the helmet interface using flow meters versus the mechanical ventilator for non-invasive ventilation in patients with coronavirus disease 2019. C... by Fernanda dos Reis Ferreira, João Carlos Ferrari Correa, Eduardo Storopoli, Diego Restivo Faria, Karina Cassaro, Natália Feitosa da Hora, Raphael Ritti, Rafael Akira Becker, Simone Dal Corso, Ivan Peres Costa, Luciana Maria Malosá Sampaio

“…Our study included participant selection, blood gas analysis, assessment of respiratory rate, peripheral oxygen saturation, modified Borg scale scores, and a visual analog scale. …”
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Difference Analysis of Organic Matter Enrichment Mechanisms in Upper Ordovician-Lower Silurian Shale from the Yangtze Region of Southern China and Its Geological Significance in Sh... by Ming Wen, Zhenxue Jiang, Kun Zhang, Yan Song, Shu Jiang, Chengzao Jia, Weiwei Liu, Yizhou Huang, Tianlin Liu, Xuelian Xie, Yue Sun, Shichao Fan, Xiangni Cao, Lin Zhu, Chuanxun Zhou

“…The sedimentary water body is divided into an oxygen-rich upper water layer that has higher paleoproductivity and a strongly reducing lower water that is conducive to the preservation of sedimentary organic matter. …”
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Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation by Chen Y, Li Y, Song H, Liu X, Zhang H, Jiang J, Liu H, Zhuo R, Cheng G, Fang J, Xu L, Qi Y, Sun D

“…The incorporation of ZIF-8@Cur confers the hydrogel with exceptional antibacterial properties and the capability to eliminate reactive oxygen species (ROS). Moreover, the pH-responsive MCC@ZIF-8@Cur hydrogel continuously releases Cur and Zn2+, mitigating inflammation, inducing M2 polarization of macrophages, and promoting angiogenesis. …”
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Antioxidant Properties of Tonsil-Derived Mesenchymal Stem Cells on Human Vocal Fold Fibroblast Exposed to Oxidative Stress by Sung-Chan Shin, Hyung-Sik Kim, Yoojin Seo, Cho Hee Kim, Ji Min Kim, Hyun-Keun Kwon, Jin-Choon Lee, Eui-Suk Sung, Byung-Joo Lee

“…Cell viability and reactive oxygen species (ROS) production were assessed to examine the progression of oxidative stress in vitro. …”
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Germline Single-Nucleotide Polymorphism <i>GFI1-36N</i> Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acu... by Jan Vorwerk, Longlong Liu, Theresa Helene Stadler, Daria Frank, Helal Mohammed Mohammed Ahmed, Pradeep Kumar Patnana, Maxim Kebenko, Eva Dazert, Bertram Opalka, Nikolas von Bubnoff, Cyrus Khandanpour

“…Since we have demonstrated that GFI1 plays an active role in metabolism, in this study, we investigated whether increased levels of reactive oxygen species (ROS) could contribute to the accumulation of genetic damage in <i>GFI1-36N</i> leukemic cells. …”
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Thermosensitive Porcine Myocardial Extracellular Matrix Hydrogel Coupled with Proanthocyanidins for Cardiac Tissue Engineering by José Luis Hidalgo-Vicelis, Angélica Raquel Rivera-Contreras, Beatriz Hernández-Téllez, Gabriela Piñón-Zárate, Katia Jarquín-Yáñez, Tatiana Fiordelisio-Coll, José Manuel Saniger-Blesa, Gertrudis Hortensia González-Gómez, María Alicia Falcón-Neri, María Margarita Canales-Martínez, Andrés Eliú Castell-Rodríguez

“…Injectable hydrogels are a treatment option because they may replace the damaged extracellular matrix and, in addition, can be administered minimally invasively. Reactive oxygen species generated by ischemia-reperfusion damage can limit the therapeutic efficacy of injectable hydrogels. …”
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Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…Moreover, these results also showed that EMO, contrary to the effects of ML385, suppressed the ferroptosis response, which manifested as up-regulated glutathione (GSH) and GPX4 levels in vivo and in vitro and down-regulated malondialdehyde (MDA), superoxide dismutase (SOD), Fe2+, and reactive oxygen species (ROS) levels. Conclusions Our results demonstrated that EMO effectively inhibited ferroptosis both in vivo and in vitro, while also modulating the Nrf2/HO-1/GPX4 signaling pathway to provide protection against SAP-ALI.…”
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Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation by Tingyi Luo, Yujing Tang, Wangcheng Xie, Zhilong Ma, Jian Gong, Yonggui Zhang, Tingsong Yang, Xuyang Jia, Jia Zhou, Zhengyu Hu, Lin Han, Qigang Wang, Zhenshun Song

“…Abnormally elevated calcium levels and reactive oxygen species (ROS) overproduction by damaged mitochondria are key factors in the inflammatory cascade in SAP. …”
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CMPK2 promotes NLRP3 inflammasome activation via mtDNA‐STING pathway in house dust mite‐induced allergic rhinitis by YaoMing Zheng, YaDong Xie, JiaYing Li, YuJie Cao, Min Li, Qing Cao, MiaoMiao Han, HongFei Lou, YiLai Shu, Hui Xiao, HuaBin Li

“…Additionally, mitochondrial reactive oxygen species (mtROS) production following HDM exposure contributed to mitochondrial dysfunction and the release of mitochondrial DNA (mtDNA), which activated the cyclic GMP‐AMP synthase (cGAS)‐STING pathway. …”
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CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor by Francisco Aguirre, Franco Tacchi, Mayalen Valero-Breton, Josué Orozco-Aguilar, Sabrina Conejeros-Lillo, Josefa Bonicioli, Renata Iturriaga-Jofré, Daniel Cabrera, Jorge A. Soto, Mauricio Castro-Sepúlveda, Marianny Portal-Rodríguez, Álvaro A. Elorza, Andrea Matamoros, Felipe Simon, Claudio Cabello-Verrugio

“…We showed increased reactive oxygen species (ROS) production and carbonylated proteins, denoting oxidative stress induced by CCL5. …”
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Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles by Galindo-Padrón AG, Lorenzo-Anota HY, Rueda-Munguía M, García-Carrasco A, Gaitán López M, Vázquez-Garza E, Campos-González E, Lozano O, Cholula-Díaz JL

“…Moreover, the effect of the metal-based nanoparticle exposure on healthy and hypertrophic H9c2 cells was measured by analyzing the cellular vitality, the loss of mitochondrial membrane potential (∆Ψm), and the production of mitochondrial reactive oxygen species (mROS).Results: The Au:Ag NPs did not affect the cell vitality of healthy or metabolically activated macrophages. …”
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Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels by Junyuan Du, Junyuan Du, Zhiyi Wu, Zhiyi Wu, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Feike Zhao, Feike Zhao, Binghu Fang, Binghu Fang

“…The multifunctional electronic enzyme marker was used to determine intracellular reduced glutathione/oxidized glutathione (GSH/GSSG), ferrous iron on (Fe2+), and reactive oxygen species (ROS) levels. The expression of glutathione and stress genes was determined using real-time quantitative PCR.ResultWe confirmed that exogenous cystine increased the lethal effect of gentamicin against strain S. enterica Typhimurium (ATCC 14028) and other clinically resistant Salmonella serotypes. …”
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Nano-Zinc Oxide Can Enhance the Tolerance of Apple Rootstock M9-T337 Seedlings to Saline Alkali Stress by Initiating a Variety of Physiological and Biochemical Pathways by Jietao Zhai, Xulin Xian, Zhongxing Zhang, Yanxiu Wang

“…ZnO NPs can balance the osmotic adjustment system by increasing the contents of soluble protein (SP), soluble sugar (SS), proline (Pro) and starch, and can also enhance the activities of enzymatic (SOD, POD, and CAT) and non-enzymatic antioxidant enzymes (APX, AAO, GR, and MDHAR) to enhance the scavenging ability of reactive oxygen species (H₂O₂, O₂^•−), ultimately reducing oxidative damage; ZnO NPs promoted the growth of M9-T337 seedlings under saline alkali stress by synergistically responding to auxin (IAA), gibberellin (GA₃), zeatin (ZT) and abscisic acid (ABA). …”
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Volatile components, total phenolic compounds, and antioxidant capacities of worm-infected Gomphidius rutilus by Libin Sun, Wei He, Guang Xin, Pengju Cai, Yin Zhang, Zhiyong Zhang, Yunyun Wei, Bingxin Sun, Xiaowen Wen

“…ABTS radical cation scavenging activity, FRAP ferric reducing antioxidant capacity (FRAP) radical scavenging activity, and oxygen radical absorbance capacity (ORAC) were investigated to screen the antioxidant properties of extracts. …”
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On the feasibility of monitoring the content of phenolic compounds in transformer oil by M. N. Lyutikova, S. V. Nekhoroshev, V. M. Muratova, P. R. Semenyuk, A. S. Gadzhiyeva

“…The formation of 2,6-DTBP in oil can serve as an indicator of accelerated aging of the oil as a result of its prolonged contact with atmospheric oxygen. Changes in additive concentrations during oil aging are controlled using a new technique developed by us, based on IR spectroscopy. …”
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