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1961
Analgesic Mechanism of Sinomenine against Chronic Pain
Published 2020-01-01“…Sinomenine may alter the unbalanced neuroimmune interaction and inhibit neuroinflammation, oxidative stress, and central sensitization in chronic pain states. …”
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1962
NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats
Published 2016-01-01“…NOX2, 8-OHdG, and NF-κB expression in the thyroid tissue was evaluated by immune-histochemical staining. Oxidative stress and inflammatory cytokines were detected. …”
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1963
Effect of Glycyrrhiza glabra L. on Broiler Growth Performance, Slaughter and Carcass Characteristics, Blood biochemistry, and Hematological Parameters: A Systematic Review
Published 2025-01-01“…Notably, licorice exhibited potential antioxidant properties by reducing malondialdehyde levels, in-dicating decreased oxidative stress. The review highlighted diverse outcomes across growth performance, slaughter traits, car-cass parameters, and blood biochemistry due to licorice supplementation. …”
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1964
Harnessing multivariate insights coupled with susceptibility indices to reveal morpho-physiological and biochemical traits in heat tolerance of cotton
Published 2025-01-01“…Biochemical assays underlined the elevated activities of antioxidant enzymes superoxide dismutase (SOD), peroxidase (POD), total free amino acids (TFA), total soluble sugars (TSS), proline content and declined production of total soluble proteins (TSP), which is indicative of oxidative stress. Physiological traits such as photosynthetic rate and cell membrane stability% decreased severely under stress conditions. …”
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1965
Management of patients with dry eye syndrome with systemic autoimmune and infectious diseases
Published 2018-07-01“…The common pathogenetic processes of development of DES in patients with systemic infectious and non-infectious diseases allows to consider the reduction of oxidative stress as the main direction of the drug therapy. …”
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1966
YTHDF1-mediated m6A modification of GBP4 promotes M1 macrophage polarization in acute lung injury
Published 2025-01-01“…Abstract Background Acute lung injury (ALI) is a severe condition with multifaceted causes, including inflammation and oxidative stress. This research investigates the influence of m6A (N6-methyladenosine) modification on GBP4, a protein pivotal for macrophage polarization, a critical immune response in ALI. …”
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1967
The role of M1/M2 macrophage polarization in the pathogenesis of obesity-related kidney disease and related pathologies
Published 2025-01-01“…In addition, macrophage-induced oxidative stress is a key feature of CKD as it also promotes cell damage and inflammation. …”
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1968
Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice
Published 2024-01-01“…Parameters inherent to body mass, glucose tolerance, evaluation of liver enzymes, percentage of hepatic steatosis, oxidative stress, the process of cell death with the apoptotic biomarkers (Bax, Bcl2, and Cytochrome C), and the ultrastructure of hepatocytes were analyzed. …”
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1969
The Effect of Exogenous Melatonin on the Photosynthetic Characteristics of <i>Rhododendron simsii</i> Under Cadmium Stress
Published 2025-01-01“…Furthermore, MT significantly decreased malondialdehyde (MDA) content, a marker of oxidative stress, and enhanced the activity of antioxidant enzymes, including superoxide dismutase (SOD) and guaiacol peroxidase (POD). …”
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1970
Sex-based disparities in the association between uric acid levels and anxiety: a cross-sectional analysis of nationwide data in Korea
Published 2025-01-01“…Conclusions This study indicates that low serum uric acid levels are associated with a higher prevalence of anxiety symptoms only in females, suggesting involvement of oxidative stress in anxiety disorders and its sex-based variation.…”
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1971
INVESTIGATING THE BIOCHEMICAL PROFILE AND NUTRITIONAL COMPOSITION OF VERNONIA AMYGDALINA LEAVES: A STUDY ON ANTIOXIDANT PROPERTIES, PHYTOCHEMICAL COMPOSITION, ENZYME INHIBITION, AN...
Published 2024-05-01“…The extract also demonstrated a significant 49.01% inhibition of lipid peroxidation, highlighting its potential in mitigating oxidative stress. Phytochemical analysis revealed the presence of flavonoids, alkaloids, phenols, saponins, and tannins, further emphasizing the therapeutic potential of Vernonia amygdalina. …”
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1972
Sulforaphane acutely activates multiple starvation response pathways
Published 2025-01-01“…SFN treatment (i) increased mitochondrial mass and resistance to oxidative stress, (ii) acutely suppressed markers of mTORC1/2 activity via inhibition of insulin signaling, (iii) upregulated autophagy and further amplified autophagic flux induced by rapamycin or nutrient deprivation while concomitantly promoting lysosomal biogenesis, and (iv) acutely decreased glucose uptake and lactate secretion followed by an adaptive rebound that coincided with suppressed protein levels of thioredoxin-interacting protein (TXNIP) due to early transcriptional down-regulation. …”
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1973
The ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino rats
Published 2025-01-01“…Abstract Background Recently, silver nanoparticles (Ag-NPs) were shown to provoke oxidative stress through the release of reactive oxygen species and consequently induce cell damage. …”
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1974
The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts
Published 2013-01-01“…Moreover, most of the experimental data on atherosclerosis-prone animals benefiting from antioxidant treatment points towards a link between oxidative stress and atherosclerosis. The evidence coming from cohort studies demonstrating an association between oxidized LDLs and cardiovascular events, notwithstanding some discrepancies, seems to point towards a role of oxidized LDLs in atherosclerotic plaque development and destabilization. …”
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1975
Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway
Published 2016-01-01“…In conclusion, these results demonstrated that curcumin attenuated high glucose-induced cardiomyocyte apoptosis by inhibiting NADPH-mediated oxidative stress and this protective effect is most likely mediated by PI3K/Akt-related signalling pathway.…”
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1976
Inhibition of high glucose-induced cardiac fibroblast activation: an effective treatment for diabetic cardiomyopathy using Chinese herbal medicine
Published 2025-01-01“…In this review, we first introduced the physiology and function of CFs and discussed the conditions for the pathological activation of CFs in the process of diabetes, and then systematically summarized the effects of CHM on the activation of CFs by controlling the production of advanced glycosylation end products, oxidative stress and inflammation. This review will illustrate the potential of CHM to inhibit the activation of CFs and provide new ideas for the treatment of DCM.…”
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1977
Biochemical and anatomical characteristics associated with browning of Bambusa lako Widjaja (Poaceae) in vitro shoot explants
Published 2025-02-01“…To understand the browning process in this species, we investigated whether the browning of in vitro nodal explants was linked to the accumulation of phenolic compounds, polyphenol oxidase activity, and oxidative stress as indicated by the presence of malondialdehyde. …”
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1978
Manipulating Intracellular Oxidative Conditions to Enhance Porphyrin Production in <i>Escherichia coli</i>
Published 2025-01-01“…Our findings highlight the potential of both antioxidant supplementation and strain engineering to mitigate ROS-induced oxidative stress and redirect more dissimilated carbon flux toward the biosynthesis of type-III porphyrins in <i>E. coli</i>. …”
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1979
Costus afer: A Systematic Review of Evidence-Based Data in support of Its Medicinal Relevance
Published 2019-01-01“…Based on these evident data, it is concluded that the plant could be used as an alternative and complementary therapy for many oxidative stress-related diseases, provided further scientific studies on the toxicological and pharmacological aspects are carried out.…”
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1980
Autophagy activation alleviates annulus fibrosus degeneration via the miR-2355-5p/mTOR pathway
Published 2025-01-01“…Methods AFCs were exposed to H2O2 to model oxidative stress-induced degeneration. Protein expression levels of collagen I, collagen II, MMP3, and MMP13 were quantified. …”
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