A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods by Nikaeta Sadekar, Holger Peter Behrsing, Tanja Hansen, Vivek Patel, Hazel Paulo, Alex Rae, Detlef Ritter, Katharina Schwarz, Anne Marie Api

“…Cytotoxicity, cytokine release, epithelial resistance, oxidative stress, and mitochondrial membrane potential were measured. …”
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Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway by Hong Wei, Rui Bu, Qinghui Yang, Jing Jia, Tao Li, Qiuping Wang, Yanjun Chen

“…In an effort to understand the signaling mechanisms underlying the antipyroptotic property of Exendin-4, we found that blockade of AMPK, an oxidative stress sensor, activity diminished the antipyroptotic property of Exendin-4. …”
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In vitro evaluation of anthelmintic activity of biocompatibile carbon quantum dot nanocomposite against egg and larval stages of equine strongyles by Armin Fakheri, Bijan Esmaeilnejad, Hamid Akbari, Rahim Molaei

“…Both CQDs and Cu@CQDs induced oxidative stress, indicated by decreased TAS and increased MDA, PCO, and oxidative DNA damage. …”
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Effect of Lipoxin A4 on Lipopolysaccharide-Induced Endothelial Hyperpermeability by Huayan Pang, Pan Yi, Ping Wu, Zhuoya Liu, Zhongjie Liu, Jianming Gong, Hua Hao, Lei Cai, Duyun Ye, Yinping Huang

“…Excessive oxidative stress, decreased antioxidant capacity, and enhanced cellular calcium levels are initial factors that cause endothelial cell (EC) hyperpermeability, which represents a crucial event in the pathogenesis of pre-eclampsia. …”
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From contamination to detection: The growing threat of heavy metals by Basma Hossam Abdelmonem, Lereen T. Kamal, Rana M. Elbaz, Mohamed R. Khalifa, Anwar Abdelnaser

“…Cognitive and cardiovascular functions are particularly affected by exposure to heavy metals even at low concentrations through the induction of oxidative stress. Various analytical techniques are used in measuring heavy metals in different environmental and biological samples. …”
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GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells by Jiahui Meng, Linlin Xu, Bingchun Ma, Chaoju Hao, Yanning Guo, Jinglei Wang, Jiaxiang Chen

“…Our study reveals that ACR markedly triggers oxidative stress-mediated autophagy and upregulates the expression of GABAA-receptor-associated protein like-1 (GABARAPL1). …”
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Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures by Yán Wāng

“…The mechanisms of PM2.5 toxicity, encompassing oxidative stress, inflammatory responses, and metabolic imbalances, are described in detail. …”
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Combined Effects of Microgravity and Chronic Low-Dose Gamma Radiation on <i>Brassica rapa</i> Microgreens by Sara De Francesco, Isabel Le Disquet, Veronica Pereda-Loth, Lenka Tisseyre, Stefania De Pascale, Chiara Amitrano, Eugénie Carnero Diaz, Veronica De Micco

“…An analysis of the harvested microgreens revealed that growth was moderately reduced under chronic irradiation combined with altered gravity, likely due to oxidative stress, primarily concentrated in the roots. …”
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Astaxanthin Inhibits Interleukin-6 Expression in Cerulein/Resistin-Stimulated Pancreatic Acinar Cells by Min Seung Kwak, Joo Weon Lim, Hyeyoung Kim

“…Cerulein, a cholecystokinin analog, induces calcium (Ca2+) overload, oxidative stress, and IL-6 expression in pancreatic acinar cells, which are hallmarks of acute pancreatitis. …”
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A review of Psoralea corylifolia L.: a valuable plant with profound biological significance by Anni Yang, Lingping Kong, Zhibo You, Xinyu Li, Jian Guan, Fengjin Li, Lingyun Zhong, Hai Jiang

“…The expression mechanisms of these pharmacological effects are closely related to the regulation of the immune system, the inhibition of oxidative stress, and the induction of apoptosis. This paper summarizes the latest research on the ethnobotany, phytochemistry, processing technology, pharmacology, and hepatotoxicity of PCL. …”
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Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms by Sheng Li, Yinling Wei, Zhenzhen Liang, Lingli Guo, Xiaojiang Hao, Yu Zhang

“…Especially with the widespread use of DSs, DSs containing polyphenols, alkaloids, terpenes, polysaccharides and other bioactive components can prevent AD by reducing Aβ deposition, inhibiting tau protein hyperphosphorylation, reconstructing synaptic dysfunction, weakening cholinesterase activity, regulating mitochondrial oxidative stress, neuronal inflammation and apoptosis. …”
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Physical exercise improves the premature muscle aging and lifespan reduction induced by high-salt intake and muscle CG2196(salt) overexpression in Drosophila by Dengtai Wen, Yiling Chen, Xu Tian, Wenqi Hou

“…Therefore, current results indicated that high-salt stress accelerated muscle aging by decreasing muscular NAD+/dSir2/dFOXO pathway activity and increasing oxidative stress. Physical exercise protected muscle from accelerated aging induced by high-salt stress through activating muscle NAD+/dSir2/dFOXO pathway and enhancing muscle oxidation resistance. …”
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Exploring Amanita muscaria (L.) Lam.: Cytotoxic, proapoptotic and antiferroptotic effect of acetone extract on JAR choriocarcinoma cell line by Milojević Sara D., Nikodijević Danijela D., Milutinović Milena G., Kosanić Marijana M., Petrović Nevena N., Jovanović-Krivokuća Milica G., Nacka-Aleksić Mirjana M.

“…Both the proapoptotic and antiferroptotic effects were achieved regardless of the induction of oxidative stress._ This is the first report on A. muscaria acetone extract indicating proapoptotic and antiferroptotic effects on choriocarcinoma cells.…”
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Toxicity and antioxidant assessment of ethanol leaf extract of Hibiscus surattensis in Wistar rats: hepatotoxicity evaluation by Israel Kevin Umana, Tobechukwu Anthony Tochukwu, Enoluomen Ehigiator, Chinedu Joseph Ikem, Godswill James Udom, Akinyele Olubiyi Akinsola

“…Behavioural changes, haematological and liver function parameters, in-vivo oxidative stress markers and histological changes were then evaluated. …”
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Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern by Pao-Hwa Lin, Jason D. Allen, Yi-Ju Li, Miao Yu, Lillian F. Lien, Laura P. Svetkey

“…Early natriuresis and reductions in oxidative stress cannot be ruled out. Future studies are needed to verify these findings, assess the possibility of earlier effects, and examine other potential mediators.…”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…Genistein protects normal cells by its potent antioxidant effect that reduces oxidative stress and mitigates radiation-induced apoptosis and inflammation. …”
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Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia by Vilen Molotov-Luchanskiy, Altynbek Nukhuly, Larissa Muravlyova, Ryszhan Bakirova, Aruna Kossybayeva, Dmitry Klyuyev, Ludmila Demidchik, Irina Beinikova

“…We study the indices of oxidative stress and oxidized-modified proteins of neutrophils in CAP patients, depending on the degree of severity, and also compare the detection frequency of neutrophil extracellular traps in the progression of pneumonia. …”
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Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management by Ge Ban, Yuanjie Chen, Yingbing Liang, Xiaona Wang, Dan Ding, Rui Liu, Jingjing Jia, Ran Zhao, Chenxia Wang, Na Li

“…This condition engenders a cascade of cellular oxidative stress via the activation of bioavailable silica, culminating in the generation of reactive oxygen species (ROS). …”
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Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients by Kevin D. Ballard, Eunice Mah, Yi Guo, Richard S. Bruno, Beth A. Taylor, Jo Ellen Beam, Donna M. Polk, Paul D. Thompson

“…Acute cholesterol reduction by LDL apheresis does not alter VEF, oxidative stress, or NO homeostasis in patients treated chronically for hypercholesterolemia.…”
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Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy by Joselyn Rojas, Valmore Bermudez, Jim Palmar, María Sofía Martínez, Luis Carlos Olivar, Manuel Nava, Daniel Tomey, Milagros Rojas, Juan Salazar, Carlos Garicano, Manuel Velasco

“…They also include the action of proinflammatory cytokines, the production of reactive oxygen species, DNA fragmentation (typical of necroptosis in type 1 diabetic patients), excessive production of islet amyloid polypeptide with the consequent endoplasmic reticulum stress, disruption in autophagy mechanisms, and protein complex formation, such as the inflammasome, capable of increasing oxidative stress produced by mitochondrial damage. Summary. …”
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