Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats by Qingqing Li, Fengrong Zhang, Xianyu Li, Qing Wang

“…The differential protein expression profile was analyzed using Liquid Chromatography—Tandem Mass Spectrometry (LC-MS/MS) whole blood proteomics.ResultsZZZGene Ontology (GO) analysis revealed that, compared to ginkgo biloba extract (EGb), the proteins differentially expressed under NA intervention were predominantly involved in oxidative stress response and calcium-dependent adhesion processes. …”
Get full text

New Therapeutic Targets for Mood Disorders by Rodrigo Machado-Vieira, Giacomo Salvadore, Nancy DiazGranados, Lobna Ibrahim, David Latov, Cristina Wheeler-Castillo, Jacqueline Baumann, Ioline D. Henter, Carlos A. Zarate

“…These include: (1) glycogen synthase kinase-3 (GSK-3) and protein kinase C (PKC), (2) the purinergic system, (3) histone deacetylases (HDACs), (4) the melatonergic system, (5) the tachykinin neuropeptides system, (6) the glutamatergic system, and (7) oxidative stress and bioenergetics. The paper reviews data on new compounds that have shown antimanic or antidepressant effects in subjects with mood disorders, or similar effects in preclinical animal models. …”
Get full text

Hybridization of Aminoadamantanes with Cinnamic Acid Analogues and Elucidation of Their Antioxidant Profile by Maya Chochkova, Almira Georgieva, Tsvetelina Ilieva, Madlena Andreeva, Georgi Pramatarov, Nejc Petek, Petranka Petrova, Martin Štícha, Yavor Mitrev, Jurij Svete

“…Thus, these promising antioxidants could have beneficial effects in various pathological conditions, where oxidative stress is implicated.…”
Get full text

Evaluation of the Cytotoxicity of Aqueous Extract and Oleo-Essential Oil of Dorema ammoniacum Plant Oleo-Gum Resin in Some Human Cancer Cell Lines by Pardis Mohammadi Pour, Spideh Bidad, Gholamreza Bahrami, Leila Hosseinzadeh, Mahdi Mojarrab, Mohammad Hosein Farzaei

“…Based on results, the cytotoxic effect of essential oil of D. ammoniacum can induce apoptosis toward A549 cell line via induction of oxidative stress, MMP depletion, and caspase-3 activation, which is independent to mitochondrial cytochrome c release and caspase-9 function.…”
Get full text

Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects by Hesti Lina Wiraswati, Ilma Fauziah Ma’ruf, Nur Akmalia Hidayati, Julia Ramadhanti, Daniela Calina, Javad Sharifi-Rad

“…Key mechanisms underlying these effects include oxidative stress modulation, suppression of pro-metastatic factors, and synergistic interactions with established drugs like doxorubicin and paclitaxel. …”
Get full text

Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer by Hyun Ju Lee, Janice M. Bahr, Pincas Bitterman, Sanjib Basu, Sameer Sharma, Jacques S. Abramowicz, Animesh Barua

“…Chronic inflammation and long-standing oxidative stress are potential predisposing factors for developing malignancies, including ovarian cancer (OVCA). …”
Get full text

Effect of Bacillus subtilis JZXJ-7, a Strain Isolated from Shrimp Paste, on Colonic Function and Microbial Community in Mice Infected with Vibrio parahaemolyticus by ZHOU Kui, WANG Rundong, GONG Mengxue, MOU Jingyuan, DENG Yijia, LI Xuepeng, ZHANG Yuhao, LI Jianrong

“…Disease activity index (DAI), Vp load in the intestine tract (including the ileum, cecum, and colon), colonic pathological alterations, colonic cytokine contents, oxidative stress resistance, and changes in intestinal microbial community composition were detected in all groups. …”
Get full text

Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies by Blessing A. Obafemi, Isaac A. Adedara, Cássia Pereira Delgado, Olabisi T. Obafemi, Michael Aschner, Joao B.T. Rocha

“…Studies have also shown that neurotoxicity due to FB1 involves dysregulation of several biochemical events in the brain, such as induction of oxidative stress and inflammation, mitochondrial dysfunction and associated programmed cell death, inhibition of acetylcholinesterase and alteration of neurotransmitter levels, decreased activity of Na+K+ ATPase, as well as disruption of blood-brain barrier. …”
Get full text

The Relationship between Serum Bilirubin and Inflammatory Bowel Disease by Xiaojing Zhao, Linzhen Li, Xueting Li, Jiajia Li, Di Wang, Hongjie Zhang

“…Increased reactive oxygen species production in IBD is likely to be responsible for increased consumption of bilirubin in patients with IBD, leading to further intestinal injury. Reducing oxidative stress may be therapeutic for these patients.…”
Get full text

Association of oxidative balance score with all-cause and cardiovascular mortality in overweight and obese by Shuxin Ying, Hongyan Ding, Yanjin Chen, Su Zheng

“…BackgroundThe oxidative balance score (OBS) combines diverse dietary components with lifestyle factors to comprehensively evaluate oxidative stress. The investigation focuses on the link between the OBS and mortality outcomes, including cardiovascular and all-cause deaths, in overweight and obese individuals.MethodsThe analysis utilized data from the National Health and Nutrition Examination Survey (NHANES), covering the period from 1999 to 2018. …”
Get full text

A Simple Ex Vivo Semiquantitative Fluorescent Imaging Utilizing Planar Laser Scanner: Detection of Reactive Oxygen Species Generation in Mouse Brain and Kidney by Rie Hosoi PhD, Sota Sato BS, Miho Shukuri PhD, Yuka Fujii BS, Kenichiro Todoroki PhD, Yasushi Arano PhD, Toshihiro Sakai PhD, Osamu Inoue PhD

“…Objective: Oxidative stress plays an important role in the onset of many neuronal and peripheral disorders. …”
Get full text

Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives by Menghua Liu, Rumeng Chen, Zhiwei Zheng, Shuling Xu, Chunyan Hou, Yining Ding, Mengling Zhang, Meihua Bao, Binsheng He, Sen Li

“…Hypertension involves the activation of the renin-angiotensin system (RAS) alongside oxidative stress-induced endothelial dysfunction and local inflammation mediated by T cells. …”
Get full text

Alterations in mRNA level of proteins related to redox state and mitochondria in an Alzheimer’s disease animal model: Promising targets in neuroprotection by Sylwia Żulińska, Przemysław L. Wencel, Kinga Czubowicz, Joanna B. Strosznajder

“…Oxidative stress and disturbances of mitochondrial function in the brain play a crucial role in Alzheimer’s disease (AD). …”
Get full text

Metformin delays the decline in thermogenic function of brown adipose tissue in a mouse model of Hutchinson-Gilford progeria syndrome by Xin Xiang, Yuyue Feng, Hongcheng Li, Wenbo Li, Jia Li, Zhu Xia, Hua Pang, Zhengjie Wang

“…We found that progeroid mice, after receiving metformin treatment, showed significant improvement in the senescent state of brown adipocytes through the activation of SIRT1, and effectively reduced mitochondrial oxidative stress. Additionally, metformin slowed the age-related decline in UCP1 expression levels in brown adipose tissue, thereby maintaining the thermogenic capacity of the progeroid mice. …”
Get full text

Insights into the toxic impact of long-term exposure to diethyl phthalate on commercially important species Catla (Labeo catla) by Satabdi Ganguly, Basanta Kumar Das, Anupam Adhikari, Subir Kumar Nag

“…DEP-induced changes in oxidative stress, histopathological changes (liver, kidney and brain) and bioaccumulation in fish muscle were also evaluated. …”
Get full text

The Impact of Root Temperature on Photosynthesis and Isoprene Emission in Three Different Plant Species by Mauro Medori, Lucia Michelini, Isabel Nogues, Francesco Loreto, Carlo Calfapietra

“…Most of the perennial plant species, particularly trees, emit volatile organic compounds (BVOCs) such as isoprene and monoterpenes, which in several cases have been demonstrated to protect against thermal shock and more generally against oxidative stress. In this paper, we show the response of three strong isoprene emitter species, namely, Phragmites australis, Populus x euramericana, and Salix phylicifolia exposed to artificial or natural warming of the root system in different conditions. …”
Get full text

Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway by Chenlong Wang, Chuangjiang Chen, MengYa Wang, Sajid Ur Rahman, Bin Wei, Hongyan Ding, Wanyue Huang, Xichun Wang

“…When porcine ESCs were co-cultured with the addition of Rutin and ZEA following p53 gene silencing via siRNA transfection, Rutin significantly mitigated ZEA-induced mitochondrial damage, oxidative stress, and Fe2 + content through the p53 pathway. …”
Get full text

The effects of oleuropein on lung and heart injury in cecal ligation and puncture - induced sepsis by Hüseyin Serkan Erol, Tuba Aydın, Serkan Yıldırım, İsmail Can, Mesut Bünyami Halıcı

“…<b>Aim:</b> Sepsis is a fatal serious clinical disorder. The oxidative stress in sepsis plays an important role in the inflammation. …”
Get full text

Smart estimation of protective antioxidant enzymes’ activity in savory (Satureja rechingeri L.) under drought stress and soil amendments by Amin Taheri-Garavand, Mojgan Beiranvandi, Abdolreza Ahmadi, Nikolaos Nikoloudakis

“…An ANN model with a 3-10-6 topology was found to be the best model to predict polyphenols (PHE), proline (PRO), peroxidase (POX), catalase (CAT), ascorbate peroxidase (APX) levels, and indicator of oxidative stress malondialdehyde (MDA). The model’s efficiency was established using the R-value as the statistical parameter, and simulated GA-ANN data were highly correlated with experimental findings. …”
Get full text

Different Associations of Trunk and Lower-Body Fat Mass Distribution with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and Women by Bin Wu, Jingshan Huang, Keisuke Fukuo, Kazuhisa Suzuki, Gen Yoshino, Tsutomu Kazumi

“…Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and systemic oxidative stress marker. Arterial properties were indicated by cardio-ankle vascular index (CAVI) and intima-media thickness (IMT) of the common carotid artery. …”
Get full text