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1841
Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation
Published 2025-01-01“…The disease’s pathology is characterized by heightened inflammation and oxidative stress, culminating in chronic pain and the loss of joint functionality. …”
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1842
Cardamom extract alleviates tamoxifen-induced liver damage by suppressing inflammation and pyroptosis pathway
Published 2025-02-01“…Serum levels of liver enzymes including alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were elevated, along with hepatic oxidative stress, as shown by increased lipid peroxidation with lower levels of reduced glutathione. …”
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1843
Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process
Published 2018-01-01“…Oxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). …”
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1844
Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury
Published 2022-01-01“…To achieve the protective impact of PG the following was required: (1) stimulating PPARγ; (2) decreasing oxidative stress; (3) decreasing nuclear factor kappa B (NF-κB), interleukin 6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and C-C motif chemokine ligand 20 (CCL20) expression; (4) limiting the increase in the number of activated microglia; and (5) reducing mitochondrial dysfunction. …”
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1845
The relative biologic effectiveness versus linear energy transfercurve as an output-input relation for linear cellular systems
Published 2009-05-01“…Although multiple biochemical parts may well be involved, the shape of the RBE-LET curve is reproduced when only three system parameters are related to three biochemical parts: the molecular machinery for DNA double strand break repair; the molecular pathways for handling oxidative stress; and the radiolytic products of the cellular water. …”
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1846
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway
Published 2025-01-01“…The study systematically evaluated the effects of hyperoxia on oxidative stress, mitochondrial damage, ferroptosis, and inflammation of intestinal epithelial cells both in vitro and in vivo. …”
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1847
Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach
Published 2025-01-01“…Evidently, it is related to leaky gut, oxidative stress, and several diseases such as inflammatory bowel disease and cancers. …”
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1848
Association of moderate beer consumption with the gut microbiota
Published 2024-11-01“…Alcoholic beverages alter the composition of the gut microbiota, which in turn causes oxidative stress brought on by alcohol, increases intestinal permeability to luminal bacterial products. …”
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1849
Allocation of Secondary Metabolites, Photosynthetic Capacity, and Antioxidant Activity of Kacip Fatimah (Labisia pumila Benth) in Response to CO2 and Light Intensity
Published 2014-01-01“…The production of secondary metabolites displayed a significant negative relationship with maliondialdehyde indicating lowered oxidative stress under high CO2 and low irradiance improved the production of plant secondary metabolites that simultaneously enhanced the antioxidant activity (DPPH), thus improving the medicinal value of Labisia pumila under this condition.…”
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1850
Lessons Learned from Experimental Human Model of Zinc Deficiency
Published 2020-01-01“…Zinc supplementation improves cell-mediated immunity, decreases oxidative stress, and decreases generation of chronic inflammatory cytokines in humans. …”
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1851
Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection
Published 2025-01-01“…They are mainly related to the increase in oxidative stress in neuronal cells, which leads to higher levels of pro-inflammatory cytokines as IL-1β, IL-6 and TNF-α, enzymatic activity as GST, GPx, CAT and SOD and neurotransmitter dysfunction (5-HT, serotonin, dopamine and GABA). …”
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1852
Proanthocyanidin from Grape Seed Extracts Protects Indomethacin-Induced Small Intestinal Mucosal Injury
Published 2014-01-01“…Proanthocyanidin (grape seed proanthocyanidin extracts, GSPEs) is an antioxidant and scavenges free radicals. Excessive oxidative stress and free radical production are major components in the pathogenesis of NSAID-induced small intestinal injury. …”
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1853
An Adverse Outcome Pathway Linking Organohalogen Exposure to Mitochondrial Disease
Published 2019-01-01“…Pathway 1 details the downstream consequences of oxidative stress, which include mitochondrial DNA damage, protein aggregation, and depolarization of the mitochondrial membrane. …”
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1854
The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies
Published 2024-12-01“…Obesity leads to a chronic inflammatory state throughout the body, with increased infiltration of immune cells and inflammatory factors in skeletal muscle tissue, and, at the same time, the level of intracellular mitochondrial oxidative stress rises. Meanwhile, obesity is closely related to the development of skeletal muscle fibrosis and can affect the metabolic function of skeletal muscle, triggering metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D). …”
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1855
Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats
Published 2022-12-01“…Conclusion: The study showed that jamblang leaf extract can reduce hydrogen peroxide levels in Wistar rats treated with lead acetate, indicating its ability to address oxidative stress. …”
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1856
Consumption of a High-Fat Diet Alters Perineuronal Nets in the Prefrontal Cortex
Published 2018-01-01“…PNNs contribute to synaptic stabilization, protect against oxidative stress, regulate the ionic microenvironment within cells, and modulate regional excitatory output. …”
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1857
The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications
Published 2022-01-01“…Type 2 diabetes mellitus (T2DM), especially hyperglycemia, is associated with increased glucose cell toxicity and oxidative stress that can lead to irreversible damage in the kidney such as diabetic nephropathy (DN). …”
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1858
Antioxidant capacity in leaves of pear cultivars during the summer season
Published 2023-07-01“…To stop the development of oxidative stress, plants activate their antioxidant enzyme system. …”
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1859
Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19.
Published 2023“…Respiratory manifestations of SARS-CoV-2 infection such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) leads to hypoxia, oxidative stress, and sympatho-activation and in severe cases leads to sympathetic storm (SS). …”
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1860
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis
Published 2025-01-01“…Indicators such as hepatic function, oxidative stress, inflammatory factors, as well as the histopathology of liver tissue were evaluated to assess liver damage and synthetic function (AOE). …”
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