Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis. by Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li

“…More importantly, we observed TGF-β-SMAD3 pathway activation, mitochondrial dysfunction, decreased antioxidant capacity, oxidative stress, and an enhanced inflammatory response in the model group, consistent with renal interstitial fibrosis in elderly individuals. …”
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Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro by Sun yingfei, Yang feng, Ma haoning

“…The results showed that heatstroke reduced the cell activity of chondrocytes and triggered a decrease in mitochondrial membrane potential and oxidative stress response. Further biochemical analysis showed that heatstroke caused chondrocyte PANoptosis. …”
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Impact of Vitamin D on Skin Aging, and Age-Related Dermatological Conditions by Sankalya S. Ambagaspitiya, Gayan A. Appuhamillage, Sunil J. Wimalawansa

“…Vitamin D, in turn, protects the skin from oxidative stress, inflammation, and DNA damage, thereby delaying both chronological and photo-aging. …”
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Protective Effect of Melatonin on Nonylphenol-Induced Reproductive and Behavioral Disorders in First-Generation Adult Male Rats by Mahsa Tavakoli, Ali Akbar Moghadamnia, Fereshteh Pourabdolhossein, Mohammad Hossein Asghari, Sohrab Kazemi

“…Nonylphenol (NP), as an environmental pollutant, has adverse effects on the reproductive and nervous systems through disrupting the endocrine system and inducing oxidative stress. This study was aimed at investigating the protective effect of melatonin (MLT) on NP-induced reproductive and behavioral disorders in first-generation adult male rats. …”
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Astaxanthin as a potential therapeutic agent for knee osteoarthritis: A review of mechanisms and clinical evidence by Sidra Sabir, AHM Mahmudur Rahman, Abdul Haseeb Bhutta

“…Results: The review identified several key mechanisms by which astaxanthin exerts its therapeutic effects, including reducing oxidative stress, attenuating inflammation, and preserving cartilage integrity. …”
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Atrial Cardiomyopathy: From Diagnosis to Treatment by Zheyu Liu, Tao Liu, Gang Wu

“…Chronic inflammation, oxidative stress response, lipid accumulation, and fibrosis leading to ACM form the foundation for AF. …”
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Carcinogenic and anticancer activities of microbiota-derived secondary bile acids by Mobina Kouhzad, Friedrich Götz, Tahereh Navidifar, Elahe Taki, Mahsa Ghamari, Roghayeh Mohammadzadeh, Maryam Seyedolmohadesin, Narjess Bostanghadiri

“…The carcinogenic activities of SBAs include DNA damage, promotion of oxidative stress, and modulation of signaling pathways that drive tumorigenesis. …”
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Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention by Liang Chen, Meng Shi, Chenghao Lv, Ying Song, Yuanjie Wu, Suifei Liu, Zhibing Zheng, Xiangyang Lu, Si Qin

“…It has attracted considerable attention from consumers due to its beneficial properties including anticancer, antioxidative, and anti-inflammatory activities. Continuous oxidative stress caused by intracellular redox imbalance can lead to chronic inflammation, which is intimately associated with the initiation, promotion, and progression of cancer. …”
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Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions by Igor Belenichev, Olena Popazova, Nina Bukhtiyarova, Victor Ryzhenko, Sergii Pavlov, Elina Suprun, Valentyn Oksenych, Oleksandr Kamyshnyi

“…Disruptions in mitochondrial function, driven by factors such as oxidative stress, excitotoxicity, and altered ion balance, lead to neuronal death and contribute to cognitive impairments in several brain diseases. …”
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Effect of Transient Nicotine Load Shock on the Performance of Pseudomonas sp. HF-1 Bioaugmented Sequencing Batch Reactors by Dong-sheng Shen, Li-jia Wang, Hong-zhen He, Mei-zhen Wang

“…Though the dramatic increase of activities of ROS, MDA, SOD, and CAT suggested that transient nicotine shock loads could induce oxidative stress on microorganisms in activated sludge, a decrease to control level demonstrated that most of the microorganisms could resist 500–1500 mg/L of transient nicotine shock under the protection from strain HF-1. …”
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Medical foods in Alzheimer’s disease by Klaus W. Lange, Jianjun Guo, Shigehiko Kanaya, Katharina M. Lange, Yukiko Nakamura, Shiming Li

“…Improvements in symptomatology and regional brain atrophy in AD have been claimed for several medical foods, for example, those providing ketone bodies as alternative energy supply to neurons, those containing precursors believed to improve synaptic function, and those addressing oxidative stress related to memory loss. Many methodological shortcomings render the interpretation of the available findings of medical food trials in AD difficult. …”
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Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity by Romina Tanideh, Omid Farshad, Akram Jamshidzadeh, Aida Iraji

“…Several locomotor activity indices, as well as biomarkers of oxidative stress, were monitored in the brain tissue of Mn-exposed animals. …”
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Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation by Shuang Lin, Shanshan Dai, Jiahui Lin, Xiaohe Liang, Weiqi Wang, Weijian Huang, Bozhi Ye, Xia Hong

“…Continuous activation of the renin-angiotensin-aldosterone system (RAAS) contributes to the development of myocardial remodeling greatly, and angiotensin II (Ang II), its main constituent, can directly lead to cardiac remodeling through an inflammatory response and oxidative stress. Since Ang II-induced myocardial remodeling is closely related to inflammation, we tried to explore whether the anti-inflammatory drug oridonin (Ori) can reverse this process and its possible mechanism. …”
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Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration by Jialiu Zeng, Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo, Chih Hung Lo

“…Inflammatory states within the brain can lead to insulin resistance, mitochondrial dysfunction, autolysosomal dysfunction, and increased oxidative stress. These disruptions impair normal neuronal function and subsequently lead to cognitive decline and motor deficits, similar to the pathologies observed in major neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease. …”
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Pinitol Improves Diabetic Foot Ulcers in Streptozotocin-Induced Diabetes Rats Through Upregulation of Nrf2/HO-1 Signaling by Jinsick Kim, Min Young Go, Chae Young Jeon, Jung Un Shin, Mujun Kim, Hye Won Lim, Dong Wook Shin

“…Our findings indicated that pinitol enhanced cell migration, proliferation, and wound healing by activating Nrf2, thereby mitigating oxidative stress and inflammatory responses at the wound site. …”
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Assessing fertility preservation strategies: A scoping review by Chaimaa Hilali, Chafika Nadifi, Modou Mamoune Mbaye, Nouama Bouanani, Kettani Halabi Mohamed, Noureddine Louanjli, Moncef Benkhalifa, Fatima Azzahra Lahlou

“…Lastly, plant-based alternatives, including extracts and essential oils, have demonstrated potential in reducing oxidative stress, improving sperm motility, and supporting oocyte development, thus providing a promising complementary approach to conventional methods. …”
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Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus by Le Dai, Qing Wang

“…Due to the weak antioxidant capacity of β-cells, they are susceptible to cytotoxic stimuli such as oxidative stress (OS), and are therefore susceptible to ferroptosis. …”
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Metabolic Basis for Thyroid Hormone Liver Preconditioning: Upregulation of AMP-Activated Protein Kinase Signaling by Luis A. Videla, Virginia Fernández, Pamela Cornejo, Romina Vargas

“…This is achieved by mechanisms involving direct allosteric activation and reversible phosphorylation of AMPK, in response to signals such as energy status, serum insulin/glucagon ratio, nutritional stresses, pharmacological and natural compounds, and oxidative stress status. Reactive oxygen species (ROS) lead to cellular AMPK activation and downstream signaling under several experimental conditions. …”
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SELENOF gene as a quintessential target in oral squamous cell carcinoma by Ramya Ramadoss, Monal Yuwanati, Abigail Viola E, Pradeepkumar Yadalam, Pratibha Ramani, Sindhu Ramesh

“…Selenium substantially suppressed cell proliferation of cancerous cells in vitro and they could effectively produce oxidative stress and trigger apoptosis in oral cancer cells, hence inhibiting the oral cancer to some extent. …”
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Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins by Malihe Soltani, Majid Rahmati, Mohammad Reza Nikravesh, Shahin Saeedi Nejat, Mahdi Jalali

“…Autophagy is influenced by oxidative stress, disturbances of calcium homeostasis, and hyperthermia conditions. …”
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