PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways by Yves Lecarpentier, Victor Claes, Jean-Louis Hébert

“…Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress. In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium. …”
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Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals by Vivek Kumar Gupta, Shweta Singh, Anju Agrawal, Nikhat Jamal Siddiqi, Bechan Sharma

“…These free radicals produced in excess have been shown to create an imbalance between the oxidative and antioxidative systems leading to emergence of oxidative stress, which may cause necrosis, DNA damage, and many neurodegenerative disorders. …”
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Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…However, an imbalance in metal ions, whether excessive or insufficient, is detrimental and can contribute to neuronal death through oxidative stress, ferroptosis, cuproptosis, cell senescence, or neuroinflammation. …”
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Effect of Vitamins A, C, and E Supplementation in the Treatment of Metabolic Syndrome in Albino Rats by L. S. Bilbis, S. A. Muhammad, Y. Saidu, Y. Adamu

“…Obesity and metabolic syndrome increase the risk of cardiovascular morbidity and mortality. Oxidative stress seems to be involved in the path physiology of cardiovascular complications of metabolic syndrome. …”
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Bioinformatic analysis of ferroptosis related biomarkers and potential therapeutic targets in vitiligo by Linli Liu, Lingli Deng, Li Guan, Yuan Hu, Qianying Li, Chunshui Yu

“…Functional enrichment analysis revealed that these DE-FRGs are significantly involved in oxidative stress, immune regulation, and vitiligo-associated signaling pathways. …”
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Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage by Xinyi Liu, Yukun Song, Shasha Cheng, Mingqian Tan

“…In addition, the HPPGAL-CUR delivery system possessed liver targeting property due to the existence of GAL, which could effectively alleviate the alcohol-induced liver damage and the inflammation indexes by inhibiting the oxidative stress. Therefore, HPP-GAL-CUR nanoparticles might be a potential candidate system for the prevention of alcoholic liver damage in the future.…”
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Mitophagy in ischemic heart disease: molecular mechanisms and clinical management by Shujuan Xu, Zihan Wang, Fan Guo, Yehao Zhang, Han Peng, Huiyu Zhang, Zixin Liu, Ce Cao, Gaojie Xin, Yuan Yuan Chen, Jianhua Fu

“…We conclude that mitophagy affects ischemic heart disease by promoting cardiomyocyte hypertrophy and fibrosis, the progression of oxidative stress, the development of inflammation, and cardiomyocyte death, and that the specific mechanisms of mitophagy are worthy of further investigation.…”
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Taurine prevents mitochondrial dysfunction and protects mitochondria from reactive oxygen species and deuterium toxicity by Stephanie Seneff, Anthony M. Kyriakopoulos

“…Moreover, taurine’s derivatives, N-chlorotaurine (NCT) and N-bromotaurine (NBrT), produced through spontaneous reaction of taurine with hypochlorite and hypobromite, have fascinating regulatory roles to protect from oxidative stress and beyond. We describe how taurine could potentially alleviate deuterium stress, primarily through metabolic collaboration among various gut microflora to produce deuterium depleted nutrients and deuterium depleted water, and in this way protect against leaky gut barrier, inflammatory bowel disease, and colon cancer.…”
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Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…The pathogenic characteristics encompass the existence of amyloid plaques outside the cells, neurofibrillary tangles inside the cells, neuroinflammation, oxidative stress, and the loss of synapses. The altered brain endocannabinoid system (ECS) has been linked to the progression of AD. …”
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Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines by Manfredi Tesauro, Maria Paola Canale, Giuseppe Rodia, Nicola Di Daniele, Davide Lauro, Angelo Scuteri, Carmine Cardillo

“…Obesity and MetS affect renal physiology and metabolism through mechanisms which include altered levels of adipokines such as leptin and adiponectin, oxidative stress, and inflammation. Secretory products of adipose tissue also deeply and negatively influence endothelial function. …”
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The impact of environmental factors on the immunopathogenesis of osteoporosis: A systematic review by Prabowo Nurhasan Agung, Soetrisno, Nurwati Ida, Ardyanto Tonang Dwi, Poncorini Eti, Nurudhin Arief, Dirgahayu Paramasari

“…The review's findings indicate that exposure to environmental pollutants triggers systemic inflammation and oxidative stress, contributing to an imbalance between bone formation and resorption. …”
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Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy by Xinglin Chen, Tongtong Zhang, Xiangyang Zhan, Xinyue Zang, Xinyu Zhai, Zhong Wan, Minyao Ge, Mingyue Tan, Jianyi Gu, Dongliang Xu

“…Finally, the pathways enrichment analysis revealed that response to oxidative stress, cyclin binding, programmed cell death, and immune response are the most enriched pathways in CCND1. …”
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Assessment of Some Heavy Metals and Trace Elements in a Sample of Patients with Viral Hepatitis in Baghdad by Najlaa Fattah-Allah Rasheed, Hind Salman Jassim, Ahmad Saadi Hassan

“…Impairment of liver functions disrupts trace element metabolism, causing oxidative stress, which subsequently leads to liver inflammation and fibrosis. …”
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Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology by Kenneth Maiese, Jinling Hou, Zhao Zhong Chong, Yan Chen Shang

“…Oxidative stress significantly impacts multiple cellular pathways that can lead to the initiation and progression of varied disorders throughout the body. …”
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Bioactive constituents from the leaves of Quercus phillyraeoides A. Gray for α-glucosidase inhibitor activity with concurrent antioxidant activity by Anastasia Wheni Indrianingsih, Sanro Tachibana

“…Furthermore, the significant antioxidant activities were evaluated using several assays, such as the DPPH radical scavenging, hydrogen peroxide radical scavenging, reducing power, and β-carotene-linoleate bleaching assays, and the results suggested that the isolated constituents showed their possible application for treating the hyperglycemia-induced oxidative stress. The results of the present study showed the potential of Q. phillyraeoides as a rich source of natural antidiabetic medicine.…”
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Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease by Mengjiao Xu, Peng Feng, Peng Feng, Jun Yan, Lei Li

“…Mitochondrial dysfunction plays a pivotal role in the pathogenesis of COPD, contributing toinflammatory response, oxidative stress, cellular senescence. However, therapeutic strategies targeting mitochondria remain underexplored. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…Conclusions Together, MEF2C dysregulation by the enhancer mutation leads to mitochondrial dysfunction and oxidative stress, which are prevalent features in motor neuronal damage and ALS pathogenesis. …”
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Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis by Shasha Huang, Wanqi Li, Dengke Wang, Huiwen Feng, Bo Wang, Xinyu Dong, Wei Zhao, Dan Liu, Yuan Wang

“…Exposure to DM can lead to iron metabolism disorder, oxidative stress and learning and memory dysfunction. In our study, pregnant Wistar rats were randomly divided into four groups and gavaged at doses of 0, 1, 4 or 10 mg/kg/d DM from gestational day (GD) 0 to postnatal day (PND) 21. …”
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Associations between milk infrared-predicted plasma biomarkers of stress resilience and fertility in dairy cattle: Insights for enhancing breeding programs and herd management by Alessio Cecchinato, Hugo Toledo-Alvarado, Lucio Flavio Macedo Mota, Vittoria Bisutti, Erminio Trevisi, Riccardo Negrini, Sara Pegolo, Stefano Schiavon, Luigi Gallo, Giovanni Bittante, Diana Giannuzzi

“…The blood metabolites (15 blood biomarkers related to hepatic damage and function, oxidative stress, inflammation, and innate immunity) were predicted using milk Fourier-transform mid-infrared (MIR) spectroscopy. …”
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Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…This article provides a detailed review of the multiple roles of hypoxia-inducible factor-1α in the pathogenesis of diabetic kidney disease, including: regulating angiogenesis, increasing the expression of erythropoietin, modulating oxidative stress through the PI3K/AKT and HIF-1α/HO-1 pathways, promoting inflammatory cell infiltration and the release of inflammatory factors to induce inflammatory responses, facilitating epithelial-mesenchymal transition, pathological angiogenesis, and promoting the release of fibrotic factors, ultimately leading to renal fibrosis. …”
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