Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota by Xiaoxia He, Xiaofeng Yuan, Qilin Shu, Yayang Gao, Youli Chen, Yao Liu, Yao Liu, Yao Liu, Jian Xu, Jian Xu, Jian Xu, Yongping Zhang, Yongping Zhang, Yongping Zhang, Guoqiong Cao, Guoqiong Cao, Guoqiong Cao

“…They were also compared in terms of indices of intestinal barrier permeability, inflammation and oxidative stress, brain metabolites as well as composition of the gut microbiota and their metabolites. …”
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PCSK9 affects vascular senescence through the SIRT1 pathway by Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong

“…PCSK9 overexpression accelerated cell senescence, activated a large number of oxidative stress pathways, and increased the expression of senescence-related genes (including P16, P21, and P53). …”
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Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…The results documented in this study will be valuable leads in the development of therapeutic candidates for diabetes and oxidative stress.…”
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Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication by Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamnia

“…Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. …”
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The Pathology of T Cells in Systemic Lupus Erythematosus by Anselm Mak, Nien Yee Kow

“…Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. …”
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Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness by DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong

“…Furthermore, it explores the pathway for the involvement of lysosomes in apoptosis, and summarizes the regulatory mechanism of lysosomes on muscle tenderization from the perspectives of the release of cathepsins and Ca2+, caspase activation and iron-induced oxidative stress. We hope that this review can provide a theoretical reference for improving meat tenderness.…”
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Obesity as a Major Risk Factor for Cancer by Giovanni De Pergola, Franco Silvestris

“…Various novel candidate mechanisms have been proposed: chronic inflammation, oxidative stress, crosstalk between tumour cells and surrounding adipocytes, migrating adipose stromal cells, obesity-induced hypoxia, shared genetic susceptibility, and the functional defeat of immune function. …”
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Pharmacognostic evaluation of Lasimorpha senegalensis schott leaves (Araceae) by Ginikachukwu MaryRose Okoh, Obinna Sabastin Onugwu, Obodike Christopher Ezugwu

“… The leaves of Lasimorpha senegalensis Schott (Araceae) have long been utilized in conventional medicine to treat conditions like diabetes, inflammation, malaria, oxidative stress, and fever. However, its properties have not been standardized to prevent adulteration. …”
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The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants by Dala N. Daraghmeh, Rafik Karaman

“…When pro-oxidant activity exceeds antioxidative capacity, oxidative stress occurs, leading to cytotoxicity. This type of stress has been linked to various pathologies, including hemolytic anemia. …”
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Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Viviani

“…In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. …”
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Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats by Ariani Zaltin Okvenda, Eti Yerizel, Raveinal

“…Hyperglycemia in diabetes mellitus is known to trigger oxidative stress. The activity of glutathione peroxidase (GSH-Px) is decreased in diabetic conditions. …”
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Endophytes: Colonization, Behaviour, and Their Role in Defense Mechanism by Anteneh Ademe Mengistu

“…However, they have to survive the oxidative environments, and endophytes like Enterobacter sp. encode superoxide dismutases, catalases, and hydroperoxide reductases to cope up the oxidative stress during colonization. On the contrary, others produce subtilomycin which binds with flagella to affect flg22-induced plant defense. …”
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Influence of Oxidants on the Stability of Tocopherol in Model Nanoemulsions: Role of Interfacial Membrane Organized by Nonionic Emulsifiers by Jinhyuk Kim, Ha Youn Song, Seung Jun Choi

“…The α-tocopherol concentration remaining after 3 weeks of storage at 25°C depended greatly on the type of oxidative stress, which indicated that the environment surrounding the oil droplets could determine the stability of α-tocopherol in nanoemulsions. α-Tocopherol was gradually degraded by radical-mediated oxidation over storage, and approximately 60% of its initial concentration remained after 3 weeks of storage. …”
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Administration of Traditional Chinese Blood Circulation Activating Drugs for Microvascular Complications in Patients with Type 2 Diabetes Mellitus by Lisha He, Han Wang, Chengjuan Gu, Xinhui He, Linhua Zhao, Xiaolin Tong

“…Furthermore, we summarized the effects and mechanism of TCM on improving blood rheology, inhibiting aggregation of platelet, forming advanced glycation end products (AGEs), regulating oxidative stress, reducing blood fat, and improving lipid metabolism. …”
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NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication by Hyeonseo Park, Tejal V. Patil, Jieun Lee, Hojin Kim, Seong-Jun Cho, Ki-Taek Lim

“…Upon exposure to near-infrared (NIR) light, the scaffolds exhibited a significant photothermal activity, oxidative stress and effectively damaging key bacterial components, such as biofilm, bacterial membranes, and proteins. …”
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Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats by Balan Rajan, Rajendran Ravikumar, Thandavamoorthy Premkumar, Thiruvengadam Devaki

“…DEN is an egregious toxin, present in numerous environmental factors, which enhances chemical driven liver damage by inducing oxidative stress and cellular injury. Administration of DEN (200 mg/kg bodyweight, I.P) to rats results in elevated marker enzymes (in both serum and tissue). …”
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Zinc Supplementation against Eimeria acervulina-Induced Oxidative Damage in Broiler Chickens by Nedyalka V. Georgieva, Margarita Gabrashanska, Ventsislav Koinarski, Zvezdelina Yaneva

“…The observed deviations in the studied enzymes and nonenzymatic parameters evidence the occurrence of oxidative stress following the infection and impaired antioxidant status of chickens, infected with Eimeria acervulina. …”
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Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease by Jianshe Wei, Gilbert Ho, Yoshiki Takamatsu, Eliezer Masliah, Makoto Hashimoto

“…Indeed, there are some reports describing that αS prevents apoptosis and mitochondrial alteration under the oxidative stress conditions, notwithstanding myriads of papers on the neuropathology of αS. …”
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Sympathoexcitation Associated with Renin-Angiotensin System in Metabolic Syndrome by Takuya Kishi, Yoshitaka Hirooka

“…In the animal studies, SNS activation is regulated by the AT1R-induced oxidative stress in the brain. We have also demonstrated that orally administered ARBs cause sympathoinhibition independent of the depressor effects in dietary-induced hypertensive rats. …”
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Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications by Sonal Sharma, Geeta Pandey

“…The findings suggest that triazoles might negatively affect female fertility and embryonic development through multiple mechanisms including inhibition or interference with key enzymes such as CYP17A1 and CYP19A1 (aromatase) involved in steroid hormone synthesis, endocrine disruption, oxidative stress, disruption of signaling pathways, and apoptosis. …”
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