Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease by Tommaso Mello, Simone Polvani, Andrea Galli

“…The increased ethanol metabolism, in turn, leads to alteration of the redox balance of the cells and impairment of RXR/PPAR functions by direct and indirect effects of acetaldehyde, resulting in deranged lipid metabolism, oxidative stress, and release of proinflammatory cytokines. …”
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The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of Development of Diabetic... by Subhasish Pramanik, Kaustav Banerjee, Lakshmi Kanta Mondal

“…Excessive intracellular glucose in insulin-independent tissues including nerve, nephron, lens, and retina invites mishandling of metabolism of glucose resulting in a background of increased oxidative stress, advanced glycation end products (AGE) formation, lipid peroxidation, and failure of antioxidant defense systems in type 2 diabetes mellitus (T2DM). …”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…Novel pharmacological interventions targeting metabolism, calcium homeostasis, oxidative stress, extracellular matrix remodeling, endothelial function, and inflammation are needed to address RVF effectively. …”
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The impact of antioxidant-ciprofloxacin combinations on the evolution of antibiotic resistance in Pseudomonas aeruginosa biofilms by Doaa Higazy, Marwa N. Ahmed, Oana Ciofu

“…Abstract The evolution of antimicrobial resistance (AMR) in biofilms, driven by mechanisms like oxidative stress, is a major challenge. This study investigates whether antioxidants (AOs) such as N-acetyl-cysteine (NAC) and Edaravone (ED) can reduce AMR in Pseudomonas aeruginosa biofilms exposed to sub-inhibitory concentrations of ciprofloxacin (CIP). …”
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Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry by Manuel David Peris-Díaz, Artur Krężel, Perdita Barran

“…Several studies have reported that oxidative stress weakens the p53-DNA binding affinity for certain promoters depending on the oxidation mechanism. …”
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Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy by Shinji Kume, Takashi Uzu, Keiji Isshiki, Daisuke Koya

“…Furthermore, data from murine models suggest that PPAR agonists also have independent renoprotective effects by suppressing inflammation, oxidative stress, lipotoxicity, and activation of the renin-angiotensin system. …”
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Liposomal Antioxidants for Protection against Oxidant-Induced Damage by Zacharias E. Suntres

“…This paper focus on the use of liposomes for the delivery of antioxidants in the prevention or treatment of pathological conditions related to oxidative stress.…”
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The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes by M. C. Thomas, K. A. Jandeleit-Dahm, C. Tikellis

“…Over and above action on metabolic control and effects on blood pressure, PPAR agonists also appear to have independent effects on a number of critical pathways that are implicated in the development and progression of diabetic kidney disease, including oxidative stress, inflammation, hypertrophy, and podocyte function. …”
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Nanoparticles-mediated delivery of herbal extract: Impact on inhibition advanced glycation end-product (AGEs): A systematic review by Astuti Febriana, Akrom, Mustofa

“…The outcomes indicate that these nanocomplexes not only foster enhanced delivery and bioavailability of the herbal extracts but also significantly decrease inflammatory biomarkers and blood glucose levels, enhance antioxidant responses, and protect against cellular damage caused by oxidative stress. This review emphasizes the potential of nanoparticles to augment the therapeutic properties of herbal medicines for preventing and managing diabetic complications through the inhibition of AGEs formation.…”
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Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications by Bobby Nossaman, Edward Pankey, Philip Kadowitz

“…In pathophysiologic states, NO formation and bioavailability can be impaired by oxidative stress and that tolerance to NO donors develops with continuous use. …”
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Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes by Masafumi Ihara, Hidekazu Tomimoto

“…The purpose of this paper is to provide a comprehensive summary of the achievements made with the model that shows good reproducibility of the white matter changes characterized by blood-brain barrier disruption, glial activation, oxidative stress, and oligodendrocyte loss following chronic cerebral hypoperfusion. …”
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Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress by Phillip W. Gold, Rodrigo Machado-Vieira, Maria G. Pavlatou

“…Aspects such as depression subtypes, inflammation, insulin resistance, oxidative stress, and prothrombotic states in critical brain circuits and periphery are critically appraised. …”
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Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure by Takuya Kishi, Yoshitaka Hirooka

“…Recently, the abnormalities in the central regulation of sympathetic nerve activity mediated by brain renin angiotensin system-oxidative stress axis and/or proinflammatory cytokines have been focused. …”
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Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse by Peng-Fei Wang, Ke Xie, Yun-Xing Cao, An Zhang

“…Studies have found that the overproduction of reactive oxygen species (ROS) is the major cause of oxidative stress, which is the main pathogenic factor for the progression of septic liver injury. …”
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Exploring environmental factors contributing to Parkinson’s disease in AfrAbian populations by Wael Mohamed

“…In addition, we will investigate how these variables disrupt processes such as excitotoxicity, oxidative stress, and neuroinflammation, all of which are strongly linked to Parkinson’s disease (PD). …”
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To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents by Isaac Arbeláez-Quintero, Mauricio Palacios

“…Most experiments done in the cerebral ischemia model, via middle cerebral artery occlusion in rodents (MCAO), had positive results favoring metformin’s neuroprotective role and involve several cellular pathways like oxidative stress, endothelial nitric oxide synthase activation, activation of angiogenesis and neurogenesis, autophagia, and apoptosis. …”
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The crucial role of 5hmC in neuroprotection and repair after cerebrovascular injury by Yanina Tsenkina

“…The discussion delves into the dynamic interaction between hydroxymethylation and important pathways in neuroprotection, such as the modulation of excitotoxicity and cellular metabolism, resolution of inflammation, and mitigation of oxidative stress. Additionally, it explores emerging evidence suggesting that 5hmC contributes to neurorepair by promoting neurogenesis, axonal regeneration, angiogenesis, and synaptic plasticity. …”
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Alcoholism and Inflammatory Response: Implications for Liver and Cardiovascular Disease by Christian Gabriel Acosta Ricachi, Sheila Ivette Quinapanta Serrano, Álvaro Paúl Moina Veloz

“…Among the main mechanisms that cause these injuries are: alterations in the immune response, increased oxidative stress and methylation alterations. Among the multiple conditions it can cause are: cardiovascular disease, stroke, cancer, diabetes mellitus, fetal alcohol syndrome, liver and immune system disorders. …”
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Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats by Foncham Evans Ngwenah, Kada Sanda Antoine, Salah Martin, Tume Christopher, Oumar Mahamat

“…Also, it was observed that the extract increased dose-dependent total oxidative stress and thymus index. Finally, the crude polysaccharide-rich extract showed nitrite and hydrogen peroxide scavenging activity in a concentration-dependent manner. …”
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Factors influencing glycocalyx degradation: a narrative review by Jing Wang, Lan Ma, Yu Fang, Tengteng Ye, Hongbo Li, Peng Lan

“…This review summarizes factors leading to the reduction of the glycocalyx in detail, including inflammatory factors, ischemia-reperfusion, oxidative stress, lipids, glucose, high sodium, female sex hormones and others. …”
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