Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment by Rebecca Sonnino, Gea Ciccarelli, Simona Moffa, Laura Soldovieri, Gianfranco Di Giuseppe, Michela Brunetti, Francesca Cinti, Eleonora Di Piazza, Antonio Gasbarrini, Enrico C. Nista, Alfredo Pontecorvi, Andrea Giaccari, Teresa Mezza

“…Summary: Metabolic syndrome (MetS) and mild cognitive impairment (MCI) are interconnected conditions sharing common pathological pathways, such as inflammation and oxidative stress, leading to the concept of “metabolic-cognitive syndrome.” …”
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Medicinal plants with neuroprotective potential in East African countries: A systematic review by Ibe Michael Usman, Ekom Monday Etukudo, Elna Owembabazi, Wusa Makena, Augustine Oviosun, Makeri Danladi, Vivian Ojiakor, Patrick Maduabuchi Aja, Emeka Anyanwu, Yanurkis Duranones Rosales, Mario Edgar Fernandez Diaz, Josiah Ifie, Ismahil Adekunle Adeniyi, Ilemobayo Victor Fasogbon, Victor Bassey Archibong

“…Key findings included increased levels of glutamine synthetase, Na+/K+ ATPase, calcium ATPase, acetylcholinesterase, catalase, and superoxide dismutase, all of which support enhanced neuronal function and protection against oxidative stress. Conversely, there was a significant decrease in level of malondialdehyde, an important marker of lipid peroxidation, indicating reduced cellular damage from oxidative stress. …”
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Disruption of zinc homeostasis reverses tigecycline resistance in Klebsiella pneumoniae by Jinyu Wang, Jinyu Wang, Cuiping Xia, Cuiping Xia, Zhaoxin Xia, Zhaoxin Xia, Jilu Shen, Jilu Shen

“…The suppression of superoxide dismutase activity and elevation of reactive oxygen species concentration suggest that PBT2 impairs the oxidative stress response of K. pneumoniae, further enhancing its susceptibility to antibiotics. …”
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Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate by Francesca Lazzara, Federica Conti, Grazia Maugeri, Velia D’Agata, Velia D’Agata, Ludovica Sotera, Claudio Bucolo, Claudio Bucolo

“…For instance, the corneal epithelium is sensitive to oxidative stress caused by reactive oxygen species (ROS) or by ultraviolet B (UVB) radiation. …”
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Mechanism of sodium nitroprusside regulating ginseng quality by Wei Zhang, Pengcheng Yu, Wenfei Liu, Liyang Wang, Xiaowen Song, Yao Yao, Xiubo Liu, Xiangcai Meng

“…The Morris water maze (MWM), histopathological analysis and oxidative stress indexes in brain tissues were used to evaluate the anti-aging effect, indicating that the SNP-treated ginseng further ameliorated D-gal-induced the impaired memory function and oxidative stress in mice, implying the efficacy of SNP-treated ginseng was better than untreated ginseng’s. …”
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer by Yuh-Shyan Tsai, Yeong-Chin Jou, Ian Seng Cheong, Hsiu-Ting Tung, Lin-Nei Hsu, Hsin-Tzu Tsai, Tzong-Shin Tzai

“…Phthalate exposure is linked to prostate enlargement through sex hormonal changes and oxidative stress. However, its role and action mechanism in prostate cancer remain unclear. …”
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High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells by Jiajun Lu, Minjie Sheng, Panpan Yao, Chaochao Ran, Hao Liu, Li Chen, Rui Liu, Bing Li

“…High concentration of glucose may induce the formation of ROS which leads to oxidative stress and ER stress in RECEs and even leads to cell apoptosis. …”
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Effects of P1G10 against UVB-induced damage: Reduction of antioxidant stress, inflammation and cell proliferation by Kátia M. Freitas, Emerson S. Veloso, Ênio Ferreira, Marcelo V. Caliari, Carlos E. Salas, Miriam T.P. Lopes

“…Conclusions: These data confirm the lasting protective action of P1G10 by moderating oxidative stress and apoptosis induced by multiple doses of UV-B in the skin, suggesting a potential preventive action against the onset of carcinogenesis.…”
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Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5 by Xi Liu, Yangyang Niu, Xiaoqin Zhang, Yingying Zhang, Ying Yu, Jieli Huang, Jiangtao Li, Chen Yu

“…In the LPS+α-klotho (0.01 mg/kg) group, the levels of apoptosis, inflammation, and oxidative stress were decreased, while the level of endoplasmic reticulum stress was elevated. …”
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The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion by Qian Chen, Elizabeth Eun Jung Kim, Katrina Elio, Christopher Zambrano, Samuel Krass, Jane Chun-wen Teng, Helen Kay, Kerry-Anne Perkins, Sailesh Pershad, Sloane McGraw, Jeffrey Emrich, Jovan S. Adams, Lindon H. Young

“…Reduced nitric oxide (NO) bioavailability and increased oxidative stress are major factors mediating ischemia/reperfusion (I/R) injury. …”
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Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease by Yanan Sun, Cao Ma, Hui Sun, Huan Wang, Wei Peng, Zibo Zhou, Hongwei Wang, Chenchen Pi, Yingai Shi, Xu He

“…Emerging evidence suggests that both oxidative stress and mitochondrial dysfunction are related to amyloid-β (Aβ) pathology. …”
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Aging: A Predisposition to Dry Eyes by Anushree Sharma, Holly B. Hindman

“…In the aging eye, risk factors such as polypharmacy, androgen deficiency, decreased blink rates, and oxidative stress can predispose the patient to developing dry eye that is frequently more severe, has higher economic costs, and leads to worse consequences to the well-being of the patient. …”
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Pathogenesis of Hepatic Encephalopathy by Irena Ciećko-Michalska, Małgorzata Szczepanek, Agnieszka Słowik, Tomasz Mach

“…The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. …”
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Antioxidant Functions of the Aryl Hydrocarbon Receptor by Cornelia Dietrich

“…Increasing evidence points to a protective role of the AhR against carcinogenesis and oxidative stress. Herein, I will highlight data demonstrating a causal role of the AhR in the antioxidant response and present novel findings on potential AhR-mediated antioxidative mechanisms.…”
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Cardio and neuro protection by renin angiotensin aldosterone system-focus inhibition angiotensin converting enzyme: A systematic review by Capritasari Rafiastiana, Akrom, Setianto Arif Budi

“…The presence of risk factors for hyperglycemia or hypertension can result in endothelial nitric oxide (eNOS) dysfunction, thereby causing oxidative stress and vasoconstriction of blood vessels. …”
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Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment by Elizabeth P. Moran, Jian-xing Ma

“…The PPRE is highly conserved, and PPARs thus regulate transcription of an extensive array of target genes involved in energy metabolism, vascular function, oxidative stress, inflammation, and many other biological processes. …”
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The Antioxidant Effect of Erythropoietin on Thalassemic Blood Cells by Johnny Amer, Mutaz Dana, Eitan Fibach

“…Since RBC and platelets of these patients are under oxidative stress, which may be involved in anemia and thromboembolic complications, we investigated Epo as an antioxidant. …”
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Atherogenic Factors and Their Epigenetic Relationships by Ana Z. Fernandez, Andrew L. Siebel, Assam El-Osta

“…Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. …”
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Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy by Motoko Sasaki, Yasuni Nakanuma

“…A suspected causative factor of biliary epithelial senescence is oxidative stress. Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC.…”
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Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases by Ricky Patil, Hui Wang, Matthew Kazaleh, Gorav Ailawadi, Morgan Salmon

“…Mitochondria dysfunction plays a central role in the development of vascular diseases as oxidative stress promotes alterations in mitochondrial morphology and function that contribute to disease progression. …”
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