Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration by Bysani Chandrasekar, Srinivas Mummidi, Vincent G. DeMarco, Yusuke Higashi

“…Persistent oxidative stress and inflammation contribute causally to smooth muscle cell (SMC) proliferation and migration, the characteristic features of vascular proliferative diseases. …”
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Editorial: Hypertension in obese women: gender-specific challenges and solutions by Santiago Cuevas, Jussara M. Do Carmo, Rodrigo O. Marañón

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Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Human immortalized keratinocyte cell lines (HaCaT) were treated with CCRE in healthy and UVB-induced conditions to assess their impact on oxidative stress and aging. Results demonstrated a significant reduction in mitochondrial superoxide anion levels without affecting mitochondrial membrane potential, indicating enhanced cellular resilience to oxidative stress. …”
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miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

“…Additionally, AFB1 induced oxidative stress and DNA damage. RT-qPCR showed reduced expression of certain Phase I/II metabolic detoxification enzymes and GR. …”
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Exploring Azithromycin’s Neuroprotective Role in Traumatic Brain Injury: Insights into Cognitive and Motor Recovery and Neuroinflammatory Modulation by Mohannad A. Almikhlafi, Nehad A. Abdallah, Aakash Kumar, Tarun Sharma, Zuber Khan, Haifa A. Fadil, Sultan Althagfan, Ahmed K. B. Aljohani, Sara A. Almadani, Samar F. Miski, Tahani Saeedi, Rayan S. Alharbi, Abdulrahman M. Al-Harthe, Mohammed H. Alsubhi, Hanaa Wanas, Ahmed Aldhafiri, Sidharth Mehan, Hossein M. Elbadawy

“…Background: Traumatic brain injury (TBI) is a leading cause of mortality worldwide and often results in substantial cognitive, motor, and psychological impairments, triggering oxidative stress, neuroinflammation, and neurodegeneration. …”
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Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…Oxidative stress induced by the overproduction of reactive oxygen species (ROS) during the interaction between titanium (Ti) surfaces and cells commonly results in delayed or compromised osteogenic differentiation. …”
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Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Colitis in Mice via the Modulation of NF-κB and Nrf2/HO-1 Pathways by Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Yifan Wang, Fengyun Wang, Xudong Tang

“…Conclusion: MGQD alleviated UC by suppressing inflammation and oxidative stress via the modulation of NF-κB and Nrf2/HO-1 pathways, suggesting that MGQD may be a candidate therapy for UC.…”
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Total Antioxidant Capacity and Its Dietary Sources and Seasonal Variability in Diets of Women with Different Physical Activity Levels by Człapka-Matyasik Magdalena, Ast Katarzyna

“…Increased physical activity induces oxidative stress and utilization of dietary antioxidants. …”
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Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis by Yinuo Fan, Zhiwen Chen, Haixing Wang, Mengyu Jiang, Hongduo Lu, Yangwenxiang Wei, Yunhao Hu, Liang Mo, Yuhao Liu, Chi Zhou, Wei He, Zhenqiu Chen

“…Abstract The death of osteoblasts induced by glucocorticoid (GC)-mediated oxidative stress plays a crucial role in the development of steroid-induced osteonecrosis of the femoral head (SIONFH). …”
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Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits by Dina Sibouakaz, Khira Othmani-Mecif, Amirouche Fernane, Abdennour Taghlit, Yasmina Benazzoug

“…Our goal is to study the influence of a HFD on biochemical, oxidant stress parameters, and the cardiac ultrastructure in both male and female prepubertal models. …”
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Inhibitory Effect of Lactobacillus delbrueckii subsp. bulgaricus KSFY07 on Kappa-Carrageenan-Induced Thrombosis in Mice and the Regulation of Oxidative Damage by Pan Wang, Fang Tan, Jianfei Mu, Hongjiang Chen, Xin Zhao, Yanan Xu

“…These results indicate that LDSB-KSFY07 was able to inhibit mouse thrombosis and reduce liver oxidative stress damage in thrombus mice and show that high concentrations of LDSB-KSFY07 provided a better response similar to that of the drug heparin.…”
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Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study by Yunyi Yan, Nozomi Kondo, Kentaro Oniki, Hiroshi Watanabe, Tadashi Imafuku, Yuki Sakamoto, Takuro Shigaki, Akari Maruyama, Hitomi Nakazawa, Tetsuya Kaneko, Ayami Morita, Akira Yoshida, Hitoshi Maeda, Toru Maruyama, Hideaki Jinnouchi, Junji Saruwatari

“…Moreover, the HbA1c-SD and HbA1c-AUC were also associated with oxidized human serum albumin (HSA), an oxidative stress marker. Conclusions. Visit-to-visit variability of HbA1c was an independent risk factor of microalbuminuria in association with oxidative stress among type 2 diabetes mellitus patients. …”
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The Protective Effect of Docosahexaenoic Acid on Mitochondria in SH-SY5Y Model of Rotenone-Induced Toxicity by Britta Eggers, Jennifer Stepien, Anne-Katrin Reker, Svenja Esser, Kathy Pfeiffer, Magdalena Pawlas, Katalin Barkovits, Katrin Marcus

“…<b>Methods:</b> We utilized the most common neuronal cell line (SH-SY5Y) and induced mitochondrial oxidative stress through the addition of rotenone. To study the potential protective effect of DHA, the cells were additionally pre-treated with DHA prior to rotenone administration. …”
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Circulating miR-574–5p shows diagnostic and prognostic significance and regulates oxygen-glucose deprivation (OGD)-induced inflammatory activation of microglia by targeting ATP2B2... by Xia Yin, Chunlei Zhang

“…The regulation of inflammation, oxidative stress, and proliferation of microglia by miR-574–5p were assessed by cell transfection. …”
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N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy by Sheng Wang, Chunyan Wang, Fuxia Yan, Tingting Wang, Yi He, Haobo Li, Zhengyuan Xia, Zhongjun Zhang

“…Excessive autophagy is a major mechanism of myocardial ischemia reperfusion injury (I/RI) in diabetes with enhanced oxidative stress. Antioxidant N-acetylcysteine (NAC) reduces myocardial I/RI. …”
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Glucagon-Like Peptide-1 Triggers Protective Pathways in Pancreatic Beta-Cells Exposed to Glycated Serum by Alessandra Puddu, Roberta Sanguineti, Arianna Durante, Alessio Nencioni, François Mach, Fabrizio Montecucco, Giorgio L. Viviani

“…The results showed that GS increased oxidative stress, reduced protein expression of all investigated factors through proteasome activation, and decreased proinsulin content. …”
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Virgin coconut oil lessens trichloroacetic acid assault on the stomach and intestine of rats via enhancement of Nrf2 but inhibition of TNF-α, IL1β/NF-kB signalling pathway by OO Oladokun, KO Ajeigbe, MA Adelakun

“…Background: Trichloroacetic acid (TCA), a known environmental toxicant, causes organ damage via oxidative stress and activation of pro-inflammatory cytokines. …”
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Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rat... by Tahia H. Saleem, Nagwa Abo El-Maali, Mohammed H. Hassan, Nahed A. Mohamed, Nashwa A. M. Mostafa, Emaad Abdel-Kahaar, Azza S. Tammam

“…Both PA and PH induce oxidative stress in rat liver within their therapeutic doses. …”
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Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level by Devran Coşkun, Rahmi Canbar, Yasemin Korkmaz, Burak Dik, Ayşe Er, Enver Yazar

“…<p> <b>Conclusion: </b>It can be stated that danofloxacin administration to sheep for 14 days does not cause systemic oxidative stress and does not cause seriously effects to the function of heart, liver, kidney and bone marrow.…”
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Evaluating Dose- and Time-Dependent Effects of Vitamin C Treatment on a Parkinson’s Disease Fly Model by Huynh Man Anh, Dao My Linh, Vuu My Dung, Dang Thi Phuong Thao

“…It is difficult to develop an effective treatment, since the PD onset mechanism of PD is still unclear. Oxidative stress is considered as a major cause of neurodegenerative diseases, and there is increasing evidence for the association between PD and oxidative stress. …”
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