Therapeutic Potential of <i>Cajanus cajan</i> (L.) <i>Millsp</i>. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease by Mingzhang Lin, Linghua Piao, Zhendong Zhao, Li Liao, Dayong Wang, Haiwen Zhang, Xiande Liu

“…Additionally, the levels of tight junction proteins (ZO-1, Occludin) and oxidative stress enzymes (iNOS, SOD1, CAT) were investigated by qPCR. …”
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Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification by Louna Fruchard, Anamaria Babosan, Andre Carvalho, Manon Lang, Blaise Li, Magalie Duchateau, Quentin Giai Gianetto, Mariette Matondo, Frederic Bonhomme, Isabelle Hatin, Hugo Arbes, Céline Fabret, Enora Corler, Guillaume Sanchez, Virginie Marchand, Yuri Motorin, Olivier Namy, Valérie de Crécy-Lagard, Didier Mazel, Zeynep Baharoglu

“…RsxA displays a codon bias toward tyrosine TAT and overabundance of RsxA leads to decreased expression of genes belonging to SoxR oxidative stress regulon. We also identified conditions that regulate tgt expression. …”
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The Effect of Different Ratio of Methionine-Zinc and Zinc Oxide on Performance Indicators and Diarrhea in Suckling Holstein Calves by Morteza Rezapour, Yadollah Chashnidel, Asadollah Teimoury Yansary, Essa Dirandeh

“…It is thought that the mechanisms of anti-diarrheal effect of zinc element are due to regulation of intestinal fluid transfer and mucosal integrity, strengthening of immunity and modulation of oxidative stress. The purpose of this experiment is to investigate the use of different proportions of organic (methionine-zinc) and inorganic (zinc oxide) sources of zinc to prevent diarrhea, improve the condition of the immune system and performance indicators of suckling calves. …”
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Dose effects of iron on growth, antioxidant potential, intestinal morphology, and intestinal barrier in yellow-feathered broilers by J. Chen, K.W. Lei, S.Y. Li, D.P. Li, Y.L. Wang, X. Wang, X. Bai, Y.L. Huang

“…Chronic iron exposure (≥ 160 mg/kg) can damage the intestinal barrier function, and further increase of Fe supplementation can lead to oxidative stress and even cause growth inhibition for yellow-feathered broilers.…”
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Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens by Mengke Yan, Xin Cong, Hui Wang, Kun Qin, Yuhui Tang, Xiao Xu, Dan Wang, Shuiyuan Cheng, Yulan Liu, Huiling Zhu

“…Aging-related lipid metabolic disorder is related to oxidative stress. Selenium (Se)-enriched Cardamine violifolia (SEC) is known for its excellent antioxidant function. …”
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Preparation, Structural Characterization and Antioxidant Activity of Extracellular Nanovesicles from Hericium erinaceus by Xueli YANG, Ben NIU, Hangjun CHEN, Weijie WU, Guannan WANG, Xiangjun FANG, Honglei MU, Haiyan GAO

“…The in vitro antioxidant activity of HEDENVs was evaluated by determining the DPPH, ABTS+, and O2− radical scavenging capacity. A Caco-2 cell oxidative stress damage model was created using H2O2, and changes in ROS content in cells were measured using laser confocal microscopy. …”
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A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis by Junyue Xing, Xiaohan Ma, Yanan Yu, Yangfan Xiao, Lu Chen, Weining Yuan, Yingying Wang, Keyu Liu, Zhiping Guo, Hao Tang, Kelong Fan, Wei Jiang

“…Previous research has demonstrated a strong correlation between DOX‐induced cardiotoxicity and the activation of oxidative stress pathways. This work introduces a novel antioxidant therapeutic approach, utilizing libraries of tannic acid and N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. …”
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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (<i>Pinus densiflora</i>) in Sprague-Dawley Rats with Loperamide-Induced Constipation by Hee-Jin Song, Ayun Seol, Jumin Park, Ji-Eun Kim, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Su-Jeong Lim, Su-Ha Wang, Ji-Eun Sung, Youngwoo Choi, Heeseob Lee, Dae-Youn Hwang

“…Oxidative stress is the key cause of the etiopathogenesis of several diseases associated with constipation. …”
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Mulberry leaf extract reduces damage by regulating the oxidative response, immune response and intestinal flora of largemouth bass (Micropterus salmoides) under chronic heat stress by Bing Fu, Donglai Zhou, Xiaotong Qiu, Xiaotong Qiu, Jieqiu Zheng, Jieqiu Zheng, Qiong Yang, Yang Xiao, Sentai Liao, Qingrong Li, Dongxu Xing

“…In conclusion, dietary supplementation with 9 g/kg MLE could improve the growth, immunity, and diversity of intestinal flora in heat-stressed largemouth bass, and alleviate hepatic injuries by regulating inflammation, oxidative stress, and apoptosis, providing a theoretical basis for the development of MLE as a treatment against HS.…”
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Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome by Mailén Rojo, Mailén Rojo, Hernán Pérez, Hernán Pérez, Andrea Liliana Millán, Andrea Liliana Millán, María Constanza Pautasso, Alejandra Duarte, Alejandra Duarte, Giselle Adriana Abruzzese, Alicia Beatriz Motta, Alicia Beatriz Motta, Gustavo Daniel Frechtel, Gustavo Daniel Frechtel, Gustavo Daniel Frechtel, Gloria Edith Cerrone, Gloria Edith Cerrone

“…Mitochondrial dysfunction, characterized by oxidative stress and reduced antioxidant capacity, plays a key role in PCOS pathology.MethodsIn our study, we investigated 81 women with PCOS, and 57 control women aged 16 to 46 years old. …”
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Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis by Honglin Xu, Xin Chen, Shangfei Luo, Jintao Jiang, Xianmei Pan, Yu He, Bo Deng, Silin Liu, Rentao Wan, Liwen Lin, Qiaorui Tan, Xiaoting Chen, Youfen Yao, Bin He, Yajuan An, Jing Li

“…Piezo1△Myh6 regulated mitochondrial fusion and fission to improve mitochondrial function and decrease inflammation and oxidative stress in vivo and in vitro. Mechanistically, myocardial Piezo1 knockout alleviated intracellular calcium overload to normalize calpain-associated mitochondrial homeostasis. …”
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Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments by Bowen Yin, Jingyi Ren, Xuanyi Liu, Yadong Zhang, Jinshi Zuo, Rui Wen, Huanting Pei, Miaomiao Lu, Siqi Zhu, Zhenao Zhang, Ziyi Wang, Yanyi Zhai, Yuxia Ma

“…The experimental results show that ASX significantly mitigates DOX-induced myocardial tissue damage, inflammatory response, oxidative stress, and damage to H9C2 cells. Mechanistically, ASX markedly ameliorates levels of ferroptosis and autophagy both in vitro and in vivo. …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…Superoxide dismutase type1 (SOD1) plays an essential role in macrophage polarization, promoting inflammation and oxidative stress, but its association with LP remains unknown. …”
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Role and prognostic value of growth differentiation factor 15 in patient of heart failure with preserved ejection fraction: insights from the PURSUIT-HFpEF registry by Tetsuhisa Kitamura, Shungo Hikoso, Takahisa Yamada, Yoshio Yasumura, Akito Nakagawa, Toshihiro Takeda, Hirota Kida, Akihiro Sunaga, Tomoharu Dohi, Katsuki Okada, Daisaku Nakatani, Yasushi Matsumura, Yasushi Sakata, Shunsuke Tamaki, Takaharu Hayashi, Yoshiharu Higuchi, Masaharu Masuda, Mitsutoshi Asai, Toshiaki Mano, Hisakazu Fuji, Daisaku Masuda, Shizuya Yamashita, Masami Sairyo, Yusuke Nakagawa, Haruhiko Abe, Yasunori Ueda, Kunihiko Nagai, Masamichi Yano, Masami Nishino, Jun Tanouchi, Yoh Arita, Shinji Hasegawa, Takamaru Ishizu, Minoru Ichikawa, Yuzuru Takano, Eisai Rin, Tetsuya Watanabe, Shiro Hoshida, Masahiro Izumi, Hiroyoshi Yamamoto, Hiroyasu Kato, Kazuhiro Nakatani, Mayu Nishio, Keiji Hirooka, Takahiro Yoshimura, Akihiro Tani, Yasushi Okumoto, Yasunaka Makino, Katsuomi Iwakura, Yoshiyuki Kijima, Takashi Kitao, Masashi Fujita, Koichiro Harada, Masahiro Kumada, Osamu Nakagawa, Ryo Araki, Takayuki Yamada, Fusako Sera, Kei Nakamoto, Hidetaka Kioka, Tomohito Ohtani, Nobuyuki Ogasawara, Yukinori Shinoda, Koichi Tachibana, Yohei Sotomi, Taiki Sato, Yuji Yasuga, Toshinari Onishi, Kazunori Kashiwase, Ryu Shutta, Masahiro Seo, Yuki Matsuoka, Yasuhiro Akazawa, Daisuke Sakamoto

“…Background Growth differentiation factor 15 (GDF15) is a cytokine responding to oxidative stress and inflammation, and it regulates appetite and energy balance. …”
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Perfusate Liver Arginase 1 Levels After End-Ischemic Machine Perfusion Are Associated with Early Allograft Dysfunction by Giuseppina Basta, Serena Babboni, Daniele Pezzati, Serena Del Turco, Emanuele Balzano, Gabriele Catalano, Lara Russo, Giovanni Tincani, Paola Carrai, Stefania Petruccelli, Jessica Bronzoni, Caterina Martinelli, Simona Palladino, Arianna Trizzino, Lorenzo Petagna, Renato Romagnoli, Damiano Patrono, Giandomenico Biancofiore, Adriano Peris, Chiara Lazzeri, Davide Ghinolfi

“…Biomarkers linked with oxidative stress, hepatic injury, mitochondrial dysfunction, inflammation, regeneration, and autophagy were measured during NRP, end-ischemic MP, and one week post-transplant. …”
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A combined use of Panax ginseng extract and the probiotic, Lactobacillus plantarum in the diet of Asian seabass, Lates calcarifer: Effects on growth, immunity and survival after ba... by Xiaojie Hou, Jianfeng Zhang, Neda Behmagham, Hamed Ghafarifarsani

“…Supplementation of fish with GINS alone or combined with LAC-P significantly mitigated oxidative stress, as malondialdehyde (MDA) levels decreased in these treatments (P < 0.01). …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…This suggests that potassium phosphite has reduced oxidative stress, thereby impeding the progression of the disease and its associated symptoms. …”
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Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma by Iasmina Marcovici, Iasmina Marcovici, Raul Chioibas, Raul Chioibas, Istvan Zupko, Iulia Pinzaru, Iulia Pinzaru, Alina Moaca, Alina Moaca, Adriana Ledeti, Adriana Ledeti, Lucian Barbu-Tudoran, Lucian Barbu-Tudoran, Andreea Geamantan, Andreea Geamantan, Iasmina Predescu, Iasmina Predescu, Cristina Adriana Dehelean, Cristina Adriana Dehelean

“…Additionally, MEL-NPs accumulated within the intracellular space of CM cells, forming a perinuclear coating, inhibited their motility and clonogenic potential, increased intracellular oxidative stress, targeted the epithelial-to-mesenchymal transition, and induced apoptosis by altering cell morphology, nuclear aspect, F-actin and tubulin distribution, and by modulating the expression of pro- and anti-apoptotic markers. …”
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BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function by Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang

“…Collectively, BPZ exposure significantly impairs early embryo quality by disrupting mitochondrial function, inducing oxidative stress and DNA damage, altering histone modifications, and inhibiting MZT, ultimately resulting in hindered blastocyst formation. …”
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Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi by Ahmed M. Elgendy, Mohamed S. Nafie, Zohour I. Nabil, Nahla S. El-Shenawy, Heba N. Gad El-Hak

“…Objective: Oxidative stress and inflammation play crucial roles in the onset of kidney injury and crystal formation caused by hyperoxaluria. …”
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