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2061
Novel soybean peptide iglycin ameliorates insulin resistance of high-fat diet fed C57BL/6J mice and differentiated 3T3L1 adipocytes with improvement of insulin signaling and mitoch...
Published 2022-11-01“…These data suggested that iglycin ameliorated insulin resistance via activation of insulin signaling, which was associated with inhibition of oxidative stress, adipocyte apoptosis, and improvement of mitochondrial function.…”
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2062
Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis
Published 2023-09-01“…Furthermore, scoulerine treatment was found to decrease oxidative stress factors in ovarian cancer mice model. …”
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2063
Diagnosis and treatment of obstructive sleep apnea
Published 2025-01-01“…These episodes trigger sympathetic activation, oxidative stress, and systemic inflammation, contributing to daytime sleepiness, road traffic accidents, and a spectrum of cardiovascular and metabolic comorbidities such as hypertension, arrhythmias, coronary artery disease, stroke, and diabetes mellitus. …”
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2064
Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco
Published 2025-03-01“…Moreover, their antiglycation effects, marked by the prevention of advanced glycation end products and protein damage, highlight their potential in maintaining cellular integrity.These findings suggest that Sonchus oleraceus and Lobularia maritima extracts possess promising antioxidant, antidiabetic, and anti-inflammatory properties, paving the way for their therapeutic application in managing diabetes, oxidative stress, and related conditions.…”
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2065
Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from <i>Taenia solium</i> Using Computational and Bioinformatics Tools
Published 2024-12-01“…Glutathione S-transferases (GSTs) are promising pharmacological targets for developing antiparasitic agents against helminths, as they play a key role in detoxifying cytotoxic xenobiotics and managing oxidative stress. Inhibiting GST activity can compromise parasite viability. …”
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2066
Gallic acid: a dietary metabolite’s therapeutic potential in the management of atherosclerotic cardiovascular disease
Published 2025-01-01“…It alleviates the entire process of atherosclerosis (AS) by reducing oxidative stress, improving endothelial dysfunction, and inhibiting platelet activation and aggregation. …”
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2067
Effects of Enterobacter cloacae extract, selenium nanoparticles and methyl jasmonate on shoot liquid cultures of Sarcocornia fruticosa under salinity stress
Published 2025-01-01“…Growth parameters, photosynthetic pigments, ion accumulation, osmolyte content, oxidative stress marker, enzyme activity, phenolic compound levels, and isorhamnetin production were analyzed to determine the impact of salinity and elicitor treatments on S. fruticosa for 14 days. …”
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2068
Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh
Published 2022-12-01“…These findings reveal that co-exposure to TRAP PM2.5 and high-dose glucose causes more serious health effects, while tempeh could modulate oxidative stress which ameliorated TRAP PM2.5-induced and hyperglycemia-induced toxicological effects.…”
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2069
Composition of Anthocyanins in Colored Grains and the Relationship of Their Non-Acylated and Acylated Derivatives
Published 2019-03-01“…Colored grains are rich sources of anthocyanins that could play an important role in the prevention of various diseases associated with oxidative stress. Bearing in mind that cereals are widely grown crops, anthocyanins-rich colored grains could be used as a functional food ingredient that provide health benefits to a large part of human world's population. …”
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2070
Evaluation of Total Phenolic Content, HPLC Analysis, and Antioxidant Potential of Three Local Varieties of Mushroom: A Comparative Study
Published 2022-01-01“…The results indicate that the mushroom species tested in this study could serve as a potential source of natural antioxidants in the development of nutraceuticals and herbal drugs for the management of oxidative stress-associated diseases as well as infectious diseases.…”
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2071
Antiaging and Antioxidant Bioactivities of Asteraceae Plant Fractions on the Cellular Functions of the Yeast Schizosaccharomyces pombe
Published 2021-01-01“…Interestingly, all treatment solutions promoted the stress tolerance phenotype of S. pombe to strong H2O2-induced oxidative stress conditions. Moreover, compared with the treatments without plant extract/fraction, all extract and fraction treatments, except the chloroform fractions of A. conyzoides, promoted yeast cell longevity. …”
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2072
HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide
Published 2025-01-01“…HSP60 is implicated in many biological functions and plays a key role in maintaining oxidative stress and preserving mitochondrial integrity. …”
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2073
A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation
Published 2025-01-01“…The effects of Apelin-13@ROS-hydrogel on macrophage polarization, inflammatory mediators and oxidative stress were assessed in LPS-pre-treated microglia BV2 cells and an SCI rat model. …”
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2074
tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination
Published 2025-01-01“…In this study, we identified that the transfer RNA-Asp-GTC derived fragment (tRF-AspGTC) is highly expressed in the IA tissues of both humans and mice. tRF-AspGTC promotes IA formation by facilitating the phenotypic switching of vascular smooth muscle cells, increasing of matrix metalloproteinase 9 expression, and inducing of oxidative stress and inflammatory responses. Mechanistically, tRF-AspGTC binds to galectin-3, inhibiting tripartite motif 29-mediated ubiquitination and stabilizing galectin-3. …”
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2075
RETRACTED: The role of biofield energy treatment on psychological symptoms, mental health disorders, and stress‐related quality of life in adult subjects: A randomized controlled c...
Published 2023-05-01“…Proinflammatory cytokines (TNF‐α, IL‐1β, IL‐6, and IL‐8) and oxidative stress biomarkers (isoprostane and oxidized LDL) were reduced in treatment group compared with placebo. …”
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2076
Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis.
Published 2024-12-01“…Copper (Cu) is essential for respiration, neurotransmitter synthesis, oxidative stress response, and transcription regulation, with imbalances leading to neurological, cognitive, and muscular disorders. …”
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2077
Oligomeric procyanidins combined with Parabacteroides distasonis ameliorate high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and bile aci...
Published 2024-09-01“…In this study, PPC treatment was found to significantly decrease atherosclerotic lesion, as well as alleviate the lipid metabolism disorder, inflammation and oxidative stress injury in ApoE-/- mice. Surprisingly, targeted metabolomics demonstrated that PPC intervention altered the BA profile in mice by regulating the ratio of secondary BAs to primary BAs, and increased fecal BAs excretion. …”
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2078
The Gut–Kidney Axis in Chronic Kidney Diseases
Published 2024-12-01“…Mechanisms like endotoxemia, immune activation and oxidative stress worsen renal damage by activating pro-inflammatory and oxidative pathways. …”
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2079
The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment
Published 2025-01-01“…Abstract Heavy metals (HMs) may cause the generation of reactive oxygen species (ROS), which results in oxidative stress and eventually leads to an increase in cardiovascular diseases (CVD). …”
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2080
Impact of fluoxetine exposure on Lymnaea stagnalis and its developing eggs: integrating untargeted lipidomics, targeted metabolomics, and classical risk assessment
Published 2025-02-01“…Moreover, the dose-dependent increase in choline, along with PC and oxidized PC, indicated oxidative stress and lipid peroxidation in the CNS and exposed eggs of Lymnaea stagnalis. …”
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