γ-Gammaglutamyl transferase predicts all-cause mortality within three-year intervals in patients undergoing peritoneal dialysis by Yan-Bing Chen, Xiao-Jiang Zhan, Jun Xiao, Heng-Mei Zhu

“…Objectives Peritoneal dialysis (PD) serves as a vital renal replacement therapy for patients with end-stage kidney disease (ESKD). γ-Gamma-glutamyl transferase (γ-GGT) is a recognized predictor of oxidative stress and mortality. This study aimed to assess the prognostic significance of γ-GGT in predicting all-cause and cardiovascular mortality among PD patients.Methods A retrospective study was conducted, enrolling 640 PD patients from a single center. …”
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Enhancing Miscanthus floridulus remediation of soil cadmium using Beauveria bassiana FE14: Plant growth promotion and microbial interactions by Ying Wang, Sha Xiang, Rui Chen, Liang Chen, Wendi Lan, Jun Fang, Yunhua Xiao

“…Results revealed that B. bassiana FE14 significantly enhanced the growth of M. floridulus, substantially decreased Cd content in soil by 79.39 %, and modified enzyme activities (superoxide dismutase, peroxidase, and catalase) to alleviate Cd-induced oxidative stress in plants, determined by the physical and chemical indicators and enzyme activities of soil and plant. …”
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Protein and metabolite acclimations to temperature variability in a calcareous green macroalga Halimeda macroloba by Hao Zhang, Yuyu Wang, Lingshuai Zhang, Zhiqin Wang, Zejun Zhu, Lijuan Long, Lijuan Long

“…At the sub-optimal temperature of 25°C, the alga modulated its fatty acid composition to maintain membrane fluidity and accumulated selenium-containing metabolites to mitigate oxidative stress. At the supra-optimal temperature of 31°C, despite reduced photosynthetic performance, the alga maintained high metabolic activity to facilitate growth and calcification by increasing the abundance of proteins involved in light-harvesting, photosystems, and carbon fixation, while redistributing substantial carbon into sugars and fatty acids. …”
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Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis by Wenchang Yang, Yaxin Wang, Peng Zhang, Tao Wang, Chengguo Li, Xin Tong, Xiangyu Zeng, Yuping Yin, Kaixiong Tao, Ruidong Li

“…In conclusion, our study indicated that OI alleviated Con A-induced hepatic damage by reducing inflammatory response, oxidative stress, and apoptosis.…”
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The Role of Phosphatidylethanolamine-N-methyltransferase (PEMT) Gene rs12449964 Polymorphism in the Development of Acute Pancreatitis and its Complications by T. A. Samgina, Yu. E. Azarova, Yu. V. Kanishchev, V. A. Lazarenko, P. M. Nazarenko, A. V. Polonikov

“…The disruption of phosphatidylethanolamine methylation processes increases the sensitivity of cells to oxidative stress, which can lead to the development of acute pancreatitis.…”
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Selective Vulnerability of the Cochlear Basal Turn to Acrylonitrile and Noise by B. Pouyatos, C. A. Gearhart, A. Nelson-Miller, S. Fulton, L. D. Fechter

“…The mechanism by which acrylonitrile promotes NIHL includes oxidative stress as antioxidant drugs can partially protect the cochlea from acrylonitrile+noise. …”
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The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms by Jing Zhang, Na Sun, Wanhao Zhang, Wenjie Yue, Xiaochen Qu, Xiaochen Qu, Zhonghai Li, Zhonghai Li, Gang Xu, Gang Xu

“…Mechanisms linking SU to musculoskeletal disorders include oxidative stress, MSU (monosodium urate) crystal deposition, inflammation, and other factors. …”
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Mitochondrial chaperonin DNAJC15 promotes vulnerability to ferroptosis of chemoresistant ovarian cancer cells by Stefano Miglietta, Manuela Sollazzo, Iacopo Gherardi, Sara Milioni, Beatrice Cavina, Lorena Marchio, Monica De Luise, Camelia Alexandra Coada, Marco Fiorillo, Anna Myriam Perrone, Ivana Kurelac, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Ghelli, Anna Maria Porcelli

“…DNAJC15 is a mitochondrial TIMM23-related co-chaperonin known for its role in regulating oxidative phosphorylation efficiency, oxidative stress response and lipid metabolism. Recently, it has been proposed that the loss of DNAJC15 correlates with cisplatin (CDDP)-resistance onset in ovarian cancer (OC), suggesting this protein as a potential prognostic factor during OC progression. …”
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Leptin Modifies the Rat Heart Performance Associated with Mitochondrial Dysfunction Independently of Its Prohypertrophic Effects by Edna Berzabá-Evoli, Cecilia Zazueta, Jarumi Hishel Cruz Hernández, Nancy Patricia Gómez-Crisóstomo, Isela Esther Juárez-Rojop, Erick Natividad De la Cruz-Hernández, Eduardo Martínez-Abundis

“…In our results, leptin induced an increased rate-pressure product as a result of increased heart rate and contraction force, as well oxidative stress. In addition, mitochondrial dysfunction expressed as a loss of membrane potential, decreased ability for calcium transport and retention, faster swelling, and less respiratory control was observed. …”
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New perspectives on DNA methylation modifications in ocular diseases by Fei-Fei Zong, Da-Dong Jia, Guang-Kun Huang, Meng Pan, Hao Hu, Shi-Yi Song, Liang Xiao, Ru-Weng Wang, Liang Liang

“…In addition, inflammation, oxidative stress and lipid metabolism, which abnormal DNA methylation is closely related to, are also considered to be major factors in eye diseases. …”
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Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion by Zhao-Hui Yao, Xiao-li Yao, Shao-feng Zhang, Ji-chang Hu, Yong Zhang

“…Low cerebral blood flow (CBF) during CCH leads to disturbances in the homeostasis of hemodynamics and energy metabolism, which in turn results in oxidative stress, astroglia overactivation, and synaptic protein downregulation. …”
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Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1 by Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang

“…In vitro, Pue pretreatment significantly alleviated A/R-induced damage by decreasing LDH levels, increasing cellular activity, inhibiting autophagic lysosomal overactivation, inhibiting oxidative stress (ROS, LIP ROS, MDA), increasing antioxidant defense (SOD, GSH-Px), and increasing P62 protein expression while decreasing LC3II/I ratio. …”
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The combination of polystyrene microplastics and di (2-ethylhexyl) phthalate promotes the conjugative transfer of antibiotic resistance genes between bacteria by Yu Li, Xiaomei Liu, Saisai Guo, Lan Wang, Jingchun Tang

“…Transcriptome analysis indicated that the transfer of ARGs affects bacterial ion binding, oxidative stress, and energy metabolism processes, while the expression of genes related to cell membrane permeability, DNA repair, bacterial drug resistance, and quorum sensing also increase. …”
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Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications by Lyubomir Gaydarski, Kristina Petrova, Ivan Angushev, Stancho Stanchev, Alexandar Iliev, Nikola Stamenov, Vidin Kirkov, Boycho Landzhov

“…The NO/NOS system, integral to vascular and renal homeostasis, also exhibits altered activity in DKD, with reduced bioavailability linked to oxidative stress and inflammation. This review underscores the intricate interplay between these pathways in DKD, revealing both challenges and opportunities in their therapeutic targeting. …”
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Effector proteins of Funneliformis mosseae BR221: unravelling plant-fungal interactions through reference-based transcriptome analysis, in vitro validation, and protein‒protein doc... by Pratima Vasistha, Pushplata Prasad Singh, Divya Srivastava, Leena Johny, Sadhana Shukla

“…These interactions are multifaceted in modulating host physiological and defense mechanisms, including immune suppression, hydration, nutrient uptake, and oxidative stress modulation. Conclusions These findings of the current study provide a foundational understanding of fungal-host molecular interactions and open avenues for exploring pathways influenced by these effectors. …”
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Age-Related Macular Degeneration: Insights into Inflammatory Genes by Raffaella Cascella, Michele Ragazzo, Claudia Strafella, Filippo Missiroli, Paola Borgiani, Francesco Angelucci, Luigi Tonino Marsella, Andrea Cusumano, Giuseppe Novelli, Federico Ricci, Emiliano Giardina

“…AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, family history, dietary habits, oxidative stress, and hypertension). In particular, ageing and cigarette smoking (including oxidative compounds and reactive oxygen species) have been shown to significantly increase susceptibility to the disease. …”
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Cardiac manifestation of phenylketonuria in adulthood by Péter Homródi, Emese Tóth-Zsámboki, Róbert Gábor Kiss, Orsolya Lovász, Gábor Zoltán Duray

“…It is associated with several cardiovascular risk factors (hyperlipidemia, hypertension, increased oxidative stress), and has a high rate of cardiovascular complications. …”
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Antituberculosis Drugs (Rifampicin and Isoniazid) Induce Liver Injury by Regulating NLRP3 Inflammasomes by Qiang Su, Wei Kuang, Weiyi Hao, Jing Liang, Liang Wu, Chunmei Tang, Yali Wang, Tao Liu

“…Treatment with the antituberculosis drugs caused significant liver injuries, induced inflammatory responses and oxidative stress (OS), activated NLRP3 inflammasomes, reduced the activity of drug-metabolizing enzymes, and altered the antioxidant defense system in rats and hepatic cells. …”
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The Effects of Polystyrene Microplastics and Copper Ion Co-Contamination on the Growth of Rice Seedlings by Huiyu Jin, Guohe Lin, Mingzi Ma, Lin Wang, Lixiang Liu

“…Both PS-MPs and Cu significantly reduced peroxidase (POD) activity in root, stem, and leaf, indicating oxidative stress and disrupted antioxidant defenses. Notably, in the combined treatment, PS-MPs mitigated Cu toxicity by adsorbing Cu²⁺ ions, reducing their bioavailability, and limiting Cu accumulation in rice tissues. …”
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Salivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetes by Diana Samodova, Evelina Stankevic, Mathilde Sonne Søndergaard, Naiyu Hu, Tarunveer S. Ahluwalia, Daniel R. Witte, Daniel Belstrøm, Anniek Frederike Lubberding, Pratik D. Jagtap, Torben Hansen, Atul S. Deshmukh

“…Bioinformatic analysis revealed host signatures of altered immune-, lipid-, and glucose-metabolism regulatory systems, increased oxidative stress, and possible precancerous changes in T2D saliva. …”
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