Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…Methods: Wild-type KCNQ2 or K556E variant were expressed in Chinese Hamster Ovary (CHO) cells (with or without KCNQ3) and their biophysical properties assessed using patch clamp recordings. …”
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Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carbo... by Michelle Lockley, Kathy Robinson, Rowan Miller, Charlie Gourley, Nicholas Counsell, Iain Mcneish, Trevor Graham, Uma Anne Mukherjee, Helen Hockings, Apini Patel, Priya Narayanan, Katie Wilkinson, Harjot Dhanda, Alexander R A Anderson

“…Introduction Adaptive ChemoTherapy for Ovarian cancer (ACTOv) is a phase II, multicentre, randomised controlled trial, evaluating an adaptive therapy (AT) regimen with carboplatin in women with relapsed, platinum-sensitive high-grade serous or high-grade endometrioid cancer of the ovary, fallopian tube and peritoneum whose disease has progressed at least 6 months after day 1 of the last cycle of platinum-based chemotherapy. …”
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Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…After the experimental characterization of variants’ functional properties in transiently transfected Chinese Hamster Ovary (CHO) cells, we identified drugs to be used as pharmacological approaches. …”
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Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations by Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos, Simon Fischer

“…PS represents a critical surfactant stabilizing the active pharmaceutical ingredients, which are produced by recombinant Chinese hamster ovary (CHO) cell lines. While the list of potential PS-degrading CHO host cell proteins (HCPs) has grown over the years, tangible data on industrially relevant HCPs are still scarce. …”
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Localization and expression of C1QTNF6 in chicken follicles and its regulatory effect on follicular granulosa cells by Chong Li, Qi Li, Xing Wu, Zihao Zhang, Jing Li, Ruirui Jiang, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Zhuanjian Li, Donghua Li, Yadong Tian

“…In this study, the full-length coding sequence (CDS) of chicken C1QTNF6 was cloned from adult chicken ovary. We demonstrated that the putative C1QTNF6 protein shares a highly conserved amino acid sequence with known bird homologs. …”
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Administration of Sex Hormone Preparations as a Risk Factor in the Development of Intrahepatic Cholestasis of Pregnancy and Biliary Sludge in Pregnant Women by Yu. B. Uspenskaya, I. V. Kuznetsova, A. A. Sheptulin, N. V. Goncharenko, A. N. Gerasimov, M. M. Amiraslanova

“…Prognostic factors in the insufficient effectiveness of BS treatment: the use of sex hormone preparations during pregnancy, the presence of the polycystic ovary syndrome (PCOS) in the anamnesis, an older age at the time of pregnancy and conception after ART.Conclusion. …”
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Lipoleiomyoma of the uterus in a woman of reproductive age (clinical case) by V.V. Talash, Ya.V. Palyokha, A.M. Gromova, V.V. Talash, V.B. Martynenko, N.O. Prylutska, N.I. Mityunina

“…The peculiarity of this clinical case is that sonographically uterine lipoleiomyoma was hidden under the "mask" of a dermoid cyst of the right ovary. Macroscopically, it differed from a typical lipoleiomyoma by the purple-bluish color of its outer surface and soot-colored, fine-lobed spongy structure on the section. …”
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Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…Methods: We designed a multi-centre, non-blinded, open-label phase II basket trial with each of the following 8 rare cancers considered a separate phase II trial: salivary carcinoma, carcinoma of unknown primary (CUP) with tumour infiltrating lymphocytes and/or expressing PD-L1, mucosal melanoma, acral melanoma, osteosarcoma, undifferentiated pleomorphic sarcoma, clear cell carcinoma of the ovary (CCCO) or squamous cell carcinoma of the anal canal (SCCA). …”
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Evaluation of karamunting Melastoma malabathricum L leaf extract on gonad development and growth performance of tilapia Oreochromis niloticus by Ermianus Samalei, Muhammad Zairin Jr., Odang Carman, Muhammad Agus Suprayudi

“…The final histological results (D112) showed that the 1 g/kg diet obtained the highest inhibition level of the testis and ovary developments, which were still in stage II compared to 0.5 g/kg diet (stage III) and control (stage IV and V). …”
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MiR-9-z/zp2, miR-3154-y/zp2, and miR-3533-y/zp3 participated in ovarian development and adaptation to salinity stress in spotted scat (Scatophagus argus) by Zhuoying Leng, Xinghua Lin, Yi Zhai, Hongjuan Shi, Dongneng Jiang, Mouyan Jiang, Huapu Chen, Tianli Wu, Siping Deng

“…The result of qRT-PCR demonstrated that both zp2 and zp3 exhibited the highest expression levels in the ovary. The expression levels of zp2, zp3, miR-9-z, miR-3154-y, and miR-3533-y were higher in phase Ⅴ than in other phases of ovarian development. …”
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Gonadal Histology and Expression Analysis of Sex Characteristic Genes in Grass Carp at Different Ages by Bo QI, Shengjie LI, Jinxing DU, Xiaofang XIAO, Dongyun ZHANG, Tao ZHU, Caixia LEI, Zhijun LIU, Hongmei SONG

“…The fluorescence quantitative results showed that the expression level of the female characteristic gene cyp19a1a in the ovary showed an overall trend of first increasing, then decreasing, and then increasing again. …”
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Connecting The Dots: The Impact Of Subclinical Hypothyroidism On Female Subfertility And Obesity by Naila Ashfaq, Warda Hussain, Mugheera Hussain, Neelam Saba, Asma Muddasir, Jawairiah Liaqat

“…Subclinical hypothyroidism is not a risk factor for polycystic ovary syndrome in obese women of reproductive age. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Overall test sensitivity and specificity reported below [95% confidence interval (CI) shown in brackets] are not directly comparable across different MCED tests, owing to differences in the number of cancer types each test can detect: Galleri (three studies) Sensitivity: 20.8% (14.0% to 29.2%) to 66.3% (61.2% to 71.1%) Specificity: 98.4% (98.1% to 98.8%) to 99.5% (99.0% to 99.8%) CancerSEEK (two studies) Sensitivity: 27.1% (18.5% to 37.1%) to 62.3% (59.3% to 65.3%) Specificity: 98.9% (98.7% to 99.1%) to 99.1% (98.5% to 99.8%) SPOT-MAS (two studies) Sensitivity: 72.4% (66.3% to 78.0%) to 100% (54.1% to 100%) Specificity: 97.0% (95.1% to 98.4%) to 99.9% (99.6% to 100%) Trucheck (one study) Sensitivity: 90.0% (55.5% to 99.7%) Specificity: 96.4% (95.9% to 96.8%) CDA (one study) Sensitivity: 40.0% (12.2% to 73.8%) Specificity: 97.6% (96.8% to 98.2%) AminoIndex Cancer Screenings for individual cancers separately; sensitivity ranged from 16.7% (3.0% to 56.4%) for ovary/uterus cancer to 51.7% (34.4% to 68.6%) for gastric cancer. …”
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Validating the reproductive tract score (RTS) technique in pre-service buffalo heifers by Freddys Escalona-Ramírez, Jessenia Mercado-Carrillo, Balbino A. Jaimes-Vazques, Antonio Landaeta-Hernández

“…Using rectal palpation, the RTS (scale 1-5) assign the following scores: 1=flabby uterus and ovaries both <10 mm of diameter with no detectable follicles; 2=flabby uterus and ovaries both 10-15mm of diameter with <8 mm follicles; 3=soft tone uterus and ovaries both <15-20 mm of diameter with 8-10 mm follicles; 4=good tone uterus with 20-25 mm of diameter, ovaries >20mm with >10 mm follicles; 5= good tone uterus >25 mm of diameter, ovaries >20mm with evident luteal tissue. …”
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Ovarian development of female mud crab, Scylla serrata supplemented with cholesterol and injected with serotonin by Betsy J. Pattiasina, M. Zairin Junior, I. Mokoginta, R. Affandi, W. Manalu

“…Kata-kata kunci: Kolesterol, serotonin, perkembangan ovari, Scylla serrata …”
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Metastatic Uterine Leiomyosarcoma Involving Bilateral Ovarian Stroma without Capsular Involvement Implies a Local Route of Hematogenous Dissemination by Monica Dandapani, Brandon-Luke L. Seagle, Amer Abdullah, Bryce Hatfield, Robert Samuelson, Shohreh Shahabi

“…Here we present an unusual case of a large, high-grade uLMS with metastatic disease internal to both ovaries without capsular involvement or other abdominal diseases, and discovered in a patient with distant metastases to the lungs, suggesting likely hematogenous dissemination of uLMS to the ovaries in this case. …”
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THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS by Adam Fajar, Mohammad Rizal Chaidir, Dicky Mulyadi, Ahmad Ramdan, Yoyos Dias Ismiarto

“…Meanwhile, Independent T-test was used to compare β-CrossLaps expression in 3rd taken blood sample between Ovari and Ovari+Zinc, Ovari and Ovari+Zinc+Rise showed p is less than 0.05 (p<0.05), which indicated that there are significant difference in the mean between variable 2 groups. …”
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Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring by Xiu Cheng, Yue Xue, Houpeng Wang, Zhangqiang Ma, Na Hu, Chenchen Zhang, Yu Gao, Ruihong Fan, Liaoliao Hu, Jia Li, Dalei Zhang, Jian Huang, Sitian Fang, Runting Xiao, Yuanqiao He, Tao Luo, Liping Zheng

“…Furthermore, a significant reduction in transzonal projections (TZPs) was noted in the ovaries of adult offspring mice in PS-NPs group. RNA sequencing of the ovaries from adult offspring female mice revealed that the TZPs related genes may be linked to CAMKIIβ, with a corresponding downregulation in expression levels. …”
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GENETIC AND MOLECULAR ANALYSIS OF COMPLEMENTATION OF THE FLAMENCO AND PIWI LOCI IN DROSOPHILA MELANOGASTER by F. A. Urusov, L. N. Nefedova, A. R. Lavrenov, N. I. Romanova, A. I. Kim

“…It has been revealed that transcription of gypsy is differently regulated in testis and ovaries of strains SS and MS, apparently owing to the different activity of piRNA clusters in these tissues. …”
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Invasive micropapillary carcinoma of the breast and bilateral ovarian mature cystic teratoma with benign Brenner tumor in a postmenopausal woman – An uncommon occurrence by Pavithra Ayyanar, Suvradeep Mitra, Mohammed Imaduddin, Dillip K. Muduly

“…However, following the radical surgical excision of the right breast and bilateral ovaries, the right breast showed invasive micropapillary carcinoma (IMPC) while the ovaries showed mature cystic teratoma (MCT) with benign Brenner tumor. …”
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