Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities by Hanzun Zhang, Shipeng Dong, Hongwei Shan, Chao Yang, Fang Wang

“…Subsequently, tissues including the eyestalk, posterior gill, hepatopancreas, and ovary were sampled from crabs in both the freshwater control group and the 18 ‰ salinity treatment group for transcriptional and metabolomic analysis. …”
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Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases by Xing Li, Mingyu Liao, Rufei Shen, Linlin Zhang, Hua Hu, Jun Wu, Xiuli Wang, Hua Qu, Shaodong Guo, Min Long, Hongting Zheng

“…However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM) and PCOS has not been thoroughly elucidated to date. …”
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Impact of heavy metal pollution on the use of fishing pond land, a former site of used battery smelting by E. Riani, N.A. Butet, M. Ansori, M.R. Cordova

“…Contaminating heavy metals also cause various damage to fish organs, namely, edema in the kidneys, melano-macrophage centers in the spleen and liver, edema and hyperplasia in the epithelial gills, and fatty degeneration in the liver and its lysed ovary cells.CONCLUSION: Consequently, land in Cinangka Village is still categorized as hazardous, and toxic waste and should not be converted into a fishing pond because the soil is a point source of pollution that contaminates fish with high concentrations of heavy metals and damages their organs. …”
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Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse by Sara Carmela Credendino, Nicole Lewin, Miriane de Oliveira, Swaraj Basu, Barbara D’Andrea, Elena Amendola, Luigi Di Guida, Antonio Nardone, Remo Sanges, Mario De Felice, Gabriella De Vita

“…We examine the whole expression level of Klhl14-AS in a panel of adult mouse tissues, showing that it is expressed in the thyroid, lung, kidney, testis, ovary, brain, and spleen, although at different levels. …”
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Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes by Sirima Sangkapat, Rattiporn Boonnop, Jeerawat Pimta, Napason Chabang, Bodee Nutho, Promsuk Jutabha, Sunhapas Soodvilai

“…<b>Methods</b>: The interactions of pinocembrin on drug transporters were determined in the Madin–Darby canine kidney (MDCK) cells overexpressing human (h)OAT1 or hOAT3 and in the Chinese hamster ovary (CHO-K1) cells overexpressing hOCT1, hOCT2, hMATE1, or hMATE2. …”
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Alleviating heat stress on broiler breeder hens: Effect of dietary antioxidant supplementation on reproductive performance, egg quality, offspring growth, and antioxidant capacity by Phocharapon Pasri, Chayanan Pukkung, Pascal Mermillod, Nadine Gérard, Orapin Jantasaeng, Merisa Sirisopapong, Supattra Okrathok, Thanatat Thiabching, Sitthipong Rakngam, Kanokwan Kamkajon, Yongcai Zhu, Sutisa Khempaka

“…The results showed that either synthetic or phytogenic antioxidants can improve the Haugh unit and maintain ovary weight, and large and small yellow follicles (P < 0.05). …”
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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…Methods: Wild-type KCNQ2 or K556E variant were expressed in Chinese Hamster Ovary (CHO) cells (with or without KCNQ3) and their biophysical properties assessed using patch clamp recordings. …”
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Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…After the experimental characterization of variants’ functional properties in transiently transfected Chinese Hamster Ovary (CHO) cells, we identified drugs to be used as pharmacological approaches. …”
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Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations by Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos, Simon Fischer

“…PS represents a critical surfactant stabilizing the active pharmaceutical ingredients, which are produced by recombinant Chinese hamster ovary (CHO) cell lines. While the list of potential PS-degrading CHO host cell proteins (HCPs) has grown over the years, tangible data on industrially relevant HCPs are still scarce. …”
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Localization and expression of C1QTNF6 in chicken follicles and its regulatory effect on follicular granulosa cells by Chong Li, Qi Li, Xing Wu, Zihao Zhang, Jing Li, Ruirui Jiang, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Zhuanjian Li, Donghua Li, Yadong Tian

“…In this study, the full-length coding sequence (CDS) of chicken C1QTNF6 was cloned from adult chicken ovary. We demonstrated that the putative C1QTNF6 protein shares a highly conserved amino acid sequence with known bird homologs. …”
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Administration of Sex Hormone Preparations as a Risk Factor in the Development of Intrahepatic Cholestasis of Pregnancy and Biliary Sludge in Pregnant Women by Yu. B. Uspenskaya, I. V. Kuznetsova, A. A. Sheptulin, N. V. Goncharenko, A. N. Gerasimov, M. M. Amiraslanova

“…Prognostic factors in the insufficient effectiveness of BS treatment: the use of sex hormone preparations during pregnancy, the presence of the polycystic ovary syndrome (PCOS) in the anamnesis, an older age at the time of pregnancy and conception after ART.Conclusion. …”
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Lipoleiomyoma of the uterus in a woman of reproductive age (clinical case) by V.V. Talash, Ya.V. Palyokha, A.M. Gromova, V.V. Talash, V.B. Martynenko, N.O. Prylutska, N.I. Mityunina

“…The peculiarity of this clinical case is that sonographically uterine lipoleiomyoma was hidden under the "mask" of a dermoid cyst of the right ovary. Macroscopically, it differed from a typical lipoleiomyoma by the purple-bluish color of its outer surface and soot-colored, fine-lobed spongy structure on the section. …”
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Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…Methods: We designed a multi-centre, non-blinded, open-label phase II basket trial with each of the following 8 rare cancers considered a separate phase II trial: salivary carcinoma, carcinoma of unknown primary (CUP) with tumour infiltrating lymphocytes and/or expressing PD-L1, mucosal melanoma, acral melanoma, osteosarcoma, undifferentiated pleomorphic sarcoma, clear cell carcinoma of the ovary (CCCO) or squamous cell carcinoma of the anal canal (SCCA). …”
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Evaluation of karamunting Melastoma malabathricum L leaf extract on gonad development and growth performance of tilapia Oreochromis niloticus by Ermianus Samalei, Muhammad Zairin Jr., Odang Carman, Muhammad Agus Suprayudi

“…The final histological results (D112) showed that the 1 g/kg diet obtained the highest inhibition level of the testis and ovary developments, which were still in stage II compared to 0.5 g/kg diet (stage III) and control (stage IV and V). …”
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MiR-9-z/zp2, miR-3154-y/zp2, and miR-3533-y/zp3 participated in ovarian development and adaptation to salinity stress in spotted scat (Scatophagus argus) by Zhuoying Leng, Xinghua Lin, Yi Zhai, Hongjuan Shi, Dongneng Jiang, Mouyan Jiang, Huapu Chen, Tianli Wu, Siping Deng

“…The result of qRT-PCR demonstrated that both zp2 and zp3 exhibited the highest expression levels in the ovary. The expression levels of zp2, zp3, miR-9-z, miR-3154-y, and miR-3533-y were higher in phase Ⅴ than in other phases of ovarian development. …”
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Connecting The Dots: The Impact Of Subclinical Hypothyroidism On Female Subfertility And Obesity by Naila Ashfaq, Warda Hussain, Mugheera Hussain, Neelam Saba, Asma Muddasir, Jawairiah Liaqat

“…Subclinical hypothyroidism is not a risk factor for polycystic ovary syndrome in obese women of reproductive age. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Overall test sensitivity and specificity reported below [95% confidence interval (CI) shown in brackets] are not directly comparable across different MCED tests, owing to differences in the number of cancer types each test can detect: Galleri (three studies) Sensitivity: 20.8% (14.0% to 29.2%) to 66.3% (61.2% to 71.1%) Specificity: 98.4% (98.1% to 98.8%) to 99.5% (99.0% to 99.8%) CancerSEEK (two studies) Sensitivity: 27.1% (18.5% to 37.1%) to 62.3% (59.3% to 65.3%) Specificity: 98.9% (98.7% to 99.1%) to 99.1% (98.5% to 99.8%) SPOT-MAS (two studies) Sensitivity: 72.4% (66.3% to 78.0%) to 100% (54.1% to 100%) Specificity: 97.0% (95.1% to 98.4%) to 99.9% (99.6% to 100%) Trucheck (one study) Sensitivity: 90.0% (55.5% to 99.7%) Specificity: 96.4% (95.9% to 96.8%) CDA (one study) Sensitivity: 40.0% (12.2% to 73.8%) Specificity: 97.6% (96.8% to 98.2%) AminoIndex Cancer Screenings for individual cancers separately; sensitivity ranged from 16.7% (3.0% to 56.4%) for ovary/uterus cancer to 51.7% (34.4% to 68.6%) for gastric cancer. …”
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Validating the reproductive tract score (RTS) technique in pre-service buffalo heifers by Freddys Escalona-Ramírez, Jessenia Mercado-Carrillo, Balbino A. Jaimes-Vazques, Antonio Landaeta-Hernández

“…Using rectal palpation, the RTS (scale 1-5) assign the following scores: 1=flabby uterus and ovaries both <10 mm of diameter with no detectable follicles; 2=flabby uterus and ovaries both 10-15mm of diameter with <8 mm follicles; 3=soft tone uterus and ovaries both <15-20 mm of diameter with 8-10 mm follicles; 4=good tone uterus with 20-25 mm of diameter, ovaries >20mm with >10 mm follicles; 5= good tone uterus >25 mm of diameter, ovaries >20mm with evident luteal tissue. …”
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Ovarian development of female mud crab, Scylla serrata supplemented with cholesterol and injected with serotonin by Betsy J. Pattiasina, M. Zairin Junior, I. Mokoginta, R. Affandi, W. Manalu

“…Kata-kata kunci: Kolesterol, serotonin, perkembangan ovari, Scylla serrata …”
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Metastatic Uterine Leiomyosarcoma Involving Bilateral Ovarian Stroma without Capsular Involvement Implies a Local Route of Hematogenous Dissemination by Monica Dandapani, Brandon-Luke L. Seagle, Amer Abdullah, Bryce Hatfield, Robert Samuelson, Shohreh Shahabi

“…Here we present an unusual case of a large, high-grade uLMS with metastatic disease internal to both ovaries without capsular involvement or other abdominal diseases, and discovered in a patient with distant metastases to the lungs, suggesting likely hematogenous dissemination of uLMS to the ovaries in this case. …”
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