Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality by Emmerson C. F. de Farias, Luciana M. P. P. do Nascimento, Manoel J. C. Pavão Junior, Dalila C. A. Pavão, Ana P. S. Pinheiro, Andreza H. O. Pinheiro, Marília C. B. Alves, Kíssila M. M. M. Ferraro, Larisse F. Q. Aires, Luana G. Dias, Mayara M. M. Machado, Michaelle J. D. Serrão, Raphaella R. Gomes, Sara M. P. de Moraes, Gabriela C. L. Pontes, Railana D. F. P. Carvalho, Cristiane T. C. Silva, Carla M. A. das Neves, Joyce C. L. dos Santos, Adriana M. B. de Sousa, Leda L. da Silva, Mary L. F. M. F. de Mello, Patricia B. Carvalho, Renata de B. Braga, Kathia de O. Harada, Maria C. A. Justino, Iran B. Costa, Igor Brasil-Costa, Marta C. Monteiro, Gleice Clemente, Maria Teresa Terreri

“…The ROC (Receiver Operating Characteristic) curve analysis was performed.Results and conclusionsA total of 41 patients out of 109 patients admitted at PICU with suspected MIS-C during the study period were included, of which 33 (80.5%) were male, 9 (22%) were under one year old, and 30 (73.2%) presented comorbidities. …”
Get full text

Have the COVID-19 pandemic and lockdown affected children’s mental health in the long term? A repeated cross-sectional study by Alan Johnson, Sayan Mukherjee, Sushant Mane, Manas Pustake, Ajit Bhagwat, Mohammad Arfat Ganiyani, Misba Sayed, Varada Mithbavkar, Zaid Memon, Abdus Samad Momin, Krishna Deshmukh, Ayush Chordia, Sabyasachi Parida, Sanket Warghade, Deepankar Varma

“…Objective The study aimed to evaluate the impact of the COVID-19 pandemic on levels of anxiety and depressive symptoms in children and adolescents.Design Cross-sectional surveys were carried out on the mental health of children; one survey was conducted before the COVID-19 pandemic and one into the pandemic, 15 months after the school closures and implementation of lockdown and social distancing. …”
Get full text

Exploring the experiences of healthcare professionals in South Africa and Uganda around communicating with children about life-threatening conditions: a workshop-based qualitative... by Sue Ziebland, Julia Ambler, Julia Downing, Alan Stein, Elizabeth Namukwaya, Elizabeth Nabirye, Louise Walker, Elizabeth Rapa, Jeffrey R Hanna, Louise J Dalton, Teresa Pollard, Stephanie Santos-Paulo, Yasmin Gogay, David Kavuma, Ruth Mary Kemigisha, Juliet Namyeso, Tracey Brand, Beverley G Neethling

“…Objectives This study aimed to explore how published communication frameworks could be amended to ensure applicability and cultural appropriateness for professionals to support family-centred conversations by investigating’ healthcare professionals’ (1) experiences of providing support to families when a caregiver or a dependent child (<18 years old) has a life-threatening condition, (2) perceived challenges for caregivers and healthcare professionals in communicating with children about illness, (3) perceptions of how clinicians could be equipped to facilitate conversations between caregivers and children about an adult or the child’s own life-threatening condition and (4) suggestions for amendments to previously published guidelines to ensure cultural relevance in South Africa and Uganda.Design A qualitative study involving two 2-day workshops with embedded focus group discussions, break out rooms and consensus discussions.Setting Health and social care and third sector organisations in South Africa and Uganda.Participants Thirty-two professionals providing care to families affected by life-threatening conditions in South Africa or Uganda who were aged 18 years or older and able to converse in English.Results Participants identified obstacles to having conversations with caregivers about children and to telling children about serious illness during consultations. …”
Get full text

High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretrov... by Shabani Iddi, Caroline A. Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R. Kidenya, Stephen E. Mshana, Mariam M. Mirambo

“…A cross-sectional study involving a total of 230 sera from HIV seropositive patients from different regions of the Lake Victoria zone was carried out in July 2017. All samples with required variables/parameters such as age, sex, ART regimen, and residence were serially included in the study. …”
Get full text

Precise Detection of Gene Mutations in Fine-Needle Aspiration Specimens of the Papillary Thyroid Microcarcinoma Using Next-Generation Sequencing by Feng-xia Yu, Min-xia Hu, Han-xue Zhao, Li-juan Niu, Xue-yu Rong, Wei-hua Li, Qiang Zhu, Jian-ming Ying, Ning Lyu

“…A total of 135 FNA samples out of 135 patients with suspected PTMC were submitted for mutation testing using NGS. …”
Get full text

Productivity potential of maize hybrids developed at the P.P. Lukyanenko National Grain Center for deep grain processing by V. G. Goldshtein, A. I. Suprunov, P. M. Bogdan, V. V. Sherstobitov, V. I. Khoreva, L. P. Nosovskaya, L. V. Adikaeva, E. B. Khatefov

“…Actual extraction of native starch was implemented using the “plant-on-the-table” method developed at the All-Russian Research Institute of Starch Products, and breeding trials of maize hybrids were carried out in the steppe zone of Kabardino-Balkaria in 2020/2021.Results. …”
Get full text

Clinical results of autologous fat transfer for basal thumb arthritis with a minimum of three years’ follow-up by Elisabeth M. Haas-Lützenberger, Iana Emelianova, Moritz C. Bader, Sinan Mert, Nicholas Moellhoff, Wolfram Demmer, Ursula Berger, Riccardo Giunta

“…Wilcoxon tests compared data from pre-intervention, and at one and three years post-intervention. Results: Out of 136 treated joints, the study involved 87 patients (37 patients were loss to follow-up, and 12 patients (9%) who underwent resection arthroplasty) with a median follow-up of 4.9 years (IQR 5.4 to 5.9). …”
Get full text

Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial by Mohamed Abdelrahman, Neil Cowan, Meera Ramcharn, Bassel H Al Wattar, William Parry-Smith, Sarah McRobbie, Michael Rimmer, Nagla Elfaki, Cheryl Dunlop, Damien Coleburt, Olivia Raglan, Jhia Jiat Teh, Maria Fisher, Nilaani Murugesu, Yazid Jibrel, Matthew Wood

“…We will report secondarily on the feasibility and acceptability of the JCs using Likert scale questionnaires. Assuming a 30% drop-out rate, we aim to enrol 75 participants to detect a 20% improvement in knowledge acquisition at 80% power and 5% significance. …”
Get full text

Management of CAR-T cell therapy in patients with multiple myeloma: a systematic review and expert consensus in Australia by P. Joy Ho, Hang Quach, M. Hasib Sidiqi, M. Hasib Sidiqi, Cindy H. Lee, Jason Butler, Andrew Spencer, Kenneth Micklethwaite, Kenneth Micklethwaite, Kenneth Micklethwaite, Kenneth Micklethwaite, Jingya Li, Elissa Cusson, Robert Bagnall, Simon J. Harrison

“…The Delphi panel reached consensus on practices related to patient referral, screening, selection, prioritization, treatments requiring wash-out, bridging therapy, lymphodepletion, infusion, and post-infusion monitoring and management. …”
Get full text

Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…An in silico study was carried out to predict underlying mechanisms. Results: The HPLC analysis revealed gallic acid, cinnamic acid, and naringenin as major phenolics of the carob pod aqueous extract. …”
Get full text

Characteristics and contributing factors of adverse drug reactions: an analytical study of patients with tuberculosis receiving treatment under the National TB Program of India [ve... by Jay Patel, Priya Bhavsar, Harsh Shah, Sandul Yasobant, Deepak Saxena, Anish Sinha, Somen Saha, Yogesh Patel

“…Binomial logistic regression was carried out to describe the association between various variables and occurrence of ADRs. …”
Get full text

Self-reported determinants for subjective financial distress: a qualitative interview study with German cancer patients by Eva Winkler, Katja Mehlis, Bastian Surmann, Wolfgang Greiner, Andrea Züger, Viktoria Mathies, Sophie Pauge, Luise Richter, Thomas Ernst, Natalja Menold

“…The self-reported determinants can be classified into material (savings, good salary, shared rent through shared living, employed partner, paid-off house, potential financial support from family and friends, work-related specifics, consumer restrictions, out-of-pocket-costs and anticipated financial changes), social (social support from friends and family), systemic (administrative hurdlers and insurance cover) and inner personal determinants (coping strategies, change of attitude, character traits).Conclusion Subjective financial distress depends not only on material but also on social, systemic and inner personal determinants. …”
Get full text

Does syndromic surveillance assist public health practice in early detecting respiratory epidemics? Evidence from a wide Italian retrospective experience by Giovanni Corrao, Andrea Stella Bonaugurio, Giorgio Bagarella, Mauro Maistrello, Olivia Leoni, Danilo Cereda, Andrea Gori

“…Signals that occurred during periods labelled as free from epidemics were used to measure positive predictive values (PPV) and false negative values (FNV) in anticipating the epidemic wave. Results: Out of the 156 weeks of interest, 70 (45 %) were affected by epidemic waves. …”
Get full text

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…This allowed the effective isolation of novel neoantigen-reactive TCRs. Out of the 25 consecutive TIL samples, neoantigenic stimulation enabled the identification of 16 unique reactivities and 42 TCRs, while conventional TIL expansion identified 9 reactivities and 14 TCRs. …”
Get full text

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…Interestingly, the combination of CD4.BBz with CD8.28z CAR-T cells resulted in the lowest toxicity, without impacting antitumor efficacy.Conclusions Taken together, these data point out that the rational design of improved adoptive T-cell therapies should consider the biological features of CD4 CAR-T cells, which emerged as crucial for maintaining long-term responses but also endowed by a higher toxic potential.…”
Get full text

Nature and Origin of Mineralizing Fluids in Hyperextensional Systems: The Case of Cretaceous Mg Metasomatism in the Pyrenees by Benoît Quesnel, Marie-Christine Boiron, Michel Cathelineau, Laurent Truche, Thomas Rigaudier, Gérard Bardoux, Pierre Agrinier, Michel de Saint Blanquat, Emmanuel Masini, Eric C. Gaucher

“…Stable isotope analyses (δ13C, δ18O, δD, and δ37Cl) and Cl/Br ratio measurements in fluid inclusions and their host minerals were carried out in order to determine the origin of the fluid(s) involved in the formation of the ore deposit. …”
Get full text

Effectiveness of an electronic clinical decision support system in improving the management of childhood illness in primary care in rural Nigeria: an observational study by Marek Kwiatkowski, Rodolfo Rossi, Torsten Schmitz, Fenella Beynon, Capucine Musard, Marco Landi, Daniel Ishaya, Jeremiah Zira, Muazu Muazu, Camille Renner, Edwin Emmanuel, Solomon Gideon Bulus

“…Children attending for routine care or nutrition visits (eg, immunisation, growth monitoring), physical trauma or mental health problems were excluded.Interventions The ALMANACH intervention package (CDSS implementation with training, mentorship and data feedback) was rolled out across Adamawa’s PHC facilities by the Adamawa State Primary Health Care Development Agency, in partnership with the International Committee of the Red Cross and the Swiss Tropical and Public Health Institute. …”
Get full text

ANTHROPOLOGICAL PROBLEMS IN THE PHILOSOPHICAL WORKS OF RUSSIAN SPIRITUAL ACADEMIES’ TEACHERS OF THE EARLY 20TH CENTURY by M. A. Ershova

“…Representation and analysis of anthropologic problematics in philosophical and religious papers of the Russian ecclesiastical education stage of development signify essential agreement among Russian and Western sophists; they had been discussing the same problem – a human being. The author points out that their discussions were not absolutely the same, but it gives the reason to regard the anthropology of the early 20th century as modern Philosophy; and this difference allows academic anthropology to avoid classic and non-classic types of philosophy. …”
Get full text

Neural tube defects in a war-torn Tigray regional state of Ethiopia: a retrospective study of 54,626 deliveries by Birhane Alem Berihu, Afework Mulugeta, Tony Magana, Masresha Tessema, Tafere Gebreegziabher, Yibrah Berhe, Abadi Leul Welderufael, Hayelom Kebede Mekonen

“…The results were systematically presented in both textual, tabular, graph formats to facilitate understanding and interpretation. Results Out of 54,626 delivery records, 1,612 cases of NTDs were identified (1,434 NTD cases and 178 isolated hydrocephalus cases). …”
Get full text

Clinical outcomes of COVID-19 in patients with liver cirrhosis - a propensity-matched analysis from a multicentric Brazilian cohort by Luanna Silva Monteiro Menezes, Pedro Ferrari Sales da Cunha, Magda Carvalho Pires, Lucas Rocha Valle, Flávia Carvalho Cardoso Costa, Maria Angélica Pires Ferreira, Milton Henriques Guimarães Júnior, Saionara Cristina Francisco, Marcelo Carneiro, Daniel Vitório Silveira, Fernando Graça Aranha, Rafael Lima Rodrigues de Carvalho, Teresa Cristina de Abreu Ferrari, Milena Soriano Marcolino

“…Abstract Background Cirrhosis has been pointed out as a clinical entity that leads to worse clinical prognosis in COVID-19 patients. …”
Get full text