Pseudodominant Nanophthalmos in a Roma Family Caused by a Novel PRSS56 Variant by Lubica Dudakova, Pavlina Skalicka, Olga Ulmanová, Martin Hlozanek, Viktor Stranecky, Frantisek Malinka, Andrea L. Vincent, Petra Liskova

“…The change was absent from the gnomAD dataset, but two out of 118 control Roma individuals were also shown to be heterozygous carriers. …”
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Biofilmed-PGPR: Next-Generation Bioinoculant for Plant Growth Promotion in Rice under Changing Climate by Jeberlin Prabina Bright, Hemant S. Maheshwari, Sugitha Thangappan, Kahkashan Perveen, Najat A. Bukhari, Debasis Mitra, Riyaz Sayyed, Andrea Mastinu

“…Therefore, a pot culture experiment with the CBB formulations was carried out, and different growth and yield parameters were recorded. …”
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Trends and factors associated with delays in the first prenatal consultation in Guinea by Tiany Sidibe, Mamadou Dioulde Balde, Sadan Camra, Ramata Diallo, Bienvenu Salim Camara, Karifa Kourouma, Madeleine Toure, Kaba Saran Keita, Fanta Barry, Maimouna Balde

“…Results: This study shows that in Guinea, out of 14 546 women, the overall proportion of the delay in performing the ANC1 between 2007 and 2018 was 73%. …”
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Incidence and Clinical Outcomes of Hip Fractures Involving Both the Subcapital Area and the Trochanteric or Subtrochanteric Area by Takayuki Tani, Hiroaki Kijima, Natsuo Konishi, Hitoshi Kubota, Shin Yamada, Hiroshi Tazawa, Norio Suzuki, Keiji Kamo, Yoshihiko Okudera, Masashi Fujii, Ken Sasaki, Tetsuya Kawano, Yosuke Iwamoto, Itsuki Nagahata, Naohisa Miyakoshi, Yoichi Shimada

“…The failure rate was defined as the incidence of internal fixator cut-out or telescoping >10 mm. Results. Types 1-2-3 and 1-2-3-4 fractures accounted for 1.72%. …”
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Causal associations of ambient particulate matter 10 and Alzheimer’s disease: result from a two-sample multivariable Mendelian randomization study by Zehan Huang, Guodong He, Shuo Sun, Yingqing Feng, Yuqing Huang

“…Sensitivity analyses included MR-Egger regression, weighted median, weighted mode and leave-one-out methods. The multivariable MR model adjusted for education. …”
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Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus by Rangi Kandane-Rathnayake, Sang-Cheol Bae, Zhanguo Li, Shereen Oon, Vera Golder, Mandana Nikpour, Masayoshi Harigai, Zhuoli Zhang, Eric Morand, Chak Sing Lau, Worawit Louthrenoo, Alberta Hoi, Sandra Navarra, Sean O’Neill, Shue-Fen Luo, Yanjie Hao, Yasuhiro Katsumata, Dominique Milea, Aisha Lateef, Laniyati Hamijoyo, Sargunan Sockalingam, Madelynn Chan, Jiacai Cho, Leonid Zamora, Fiona Goldblatt, Yeong-Jian Jan Wu, Xiaomeng Xu, Aldo A Navarro Rojas

“…Multivariable, multifailure survival analyses were carried out to quantify the association between flares and damage accrual.Results 1556 patients with SLE with a median (IQR) of 5.7 (3.9, 7.0) years of follow-up were studied. 39.5% (n=614) of patients had damage at enrolment, and 31.9% (n=496) accrued damage during the study observation period. …”
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Seasonality of host-seeking Ixodes ricinus nymph abundance in relation to climate by Hoch, Thierry, Madouasse, Aurélien, Jacquot, Maude, Wongnak, Phrutsamon, Beugnet, Fréderic, Bournez, Laure, Cosson, Jean-François, Huard, Frédéric, Moutailler, Sara, Plantard, Olivier, Poux, Valérie, René-Martellet, Magalie, Vayssier-Taussat, Muriel, Verheyden, Hélène, Vourc’h, Gwenaël, Chalvet-Monfray, Karine, Agoulon, Albert

“…To this end, a seven-year longitudinal study, with monthly collections of I. ricinus host-seeking nymphs, was carried out in France, in six locations corresponding to different climates. …”
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Evaluation of storage stability of refrigerated buffalo meat coated with hydrothermally treated potato starch incorporated with thyme (Thymus vulgaris) and ginger (Zingiber officin... by Sangam Dahal, Basanta Kumar Rai, Anish Dangal, Kishor Rai, Prekshya Timsina, Ramesh Koirala, Sanjay Chaudhary, Pankaj Dahal, Tanka Bhattarai, Angelo Maria Giuffrè

“…The present study was carried out to prepare thyme essential oil (TEO) and ginger essential oil (GEO)-incorporated edible starch coating on buffalo meat to extend its refrigerated shelf-life. …”
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Mechanism of Coal Bump among Mine Group under the Control of Large Geological Body: A Case Study of Yima Mining Area, China by Yizhe Li, Shankun Zhao, Qingxin Qi, Pengzhi Pan, Xiangzhi Wei, Yin Wang, Ningbo Zhang, Yang Zhao, Haitao Chai, Qilin Hao

“…Then, the deep-ground and whole-space measurement is carried out in the 13230 working face of Gengcun mine and 21121 working face of Qianqiu mine. …”
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A new phase of China-ASEAN health cooperation: the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies by Jie Qiao, Siyan Zhan, Minghui Ren, Haijun Wang, Yangmu Huang, Zhenyu Zhang, Yanan Luo, Hui Yin, Zhongwei Jia, Wei Huang, Hong Zhou, Jue Liu, Xiaoyun Liu, Qiudan Sun, Xiaojia Li, Jing Bai, Fangjing Liu, Yihong Liu, Yinzi Jin, Ming Xu, on behalf of China-ASEAN Science and Technology Cooperation Center for Public Health

“…The Center held the Second Annual Forum on China-ASEAN Cooperation in Public Health on June 26–28, 2024, and the participants reached consensus on launching the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies, which calls on China and ASEAN countries to carry out the following actions: (1) Establish a more effective, open, and inclusive cooperation mechanism for health product innovation towards a China-ASEAN innovation ecosystem; (2) Enhance R&D capabilities by targeting new technologies, methods and appropriate and affordable health products for key populations and addressing diseases prevalent in China and ASEAN; (3) Establish a China-ASEAN Collaboration Center for Health Product Innovation, coordinate regional development plans, and enhance equitable access to pharmaceutical products at the regional level; (4) Accelerate regulatory harmonization in the region by optimizing and improving regulatory modalities of China and ASEAN Countries; and (5) Strengthen cross-sectoral cooperation to build resilient health system and achieve sustainable development of innovation cooperation. …”
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Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study by Stanislav Rejchrt, Milos Hroch, Rudolf Repak, Tomas Fejfar, Tomas Douda, Darina Kohoutova, Eva Peterova, Jan Bures

“…A total of 73 patients entered the study: 7 subjects with benign biliary stenosis (6 men, 1 woman; 68±13 years old), 21 with malignant biliary stenosis (15 men, 6 women; 72±14 years old), and 45 patients without biliary stenosis (22 men, 23 women; 70±13 years old); out of those, 25 subjects have and 20 do not have choledocholithiasis. …”
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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer by Peter Jung, Stefan P. Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian Martin, Christoph Albrecht, Barbara Drobits-Handl, Sathanandam S. Anand, Srinath Kasturirangan, Francesca Trapani, Norbert Schweifer, Joseph R. Marszalek, Ulrike Tontsch-Grunt, Mark Pearson, Timothy P. Heffernan, Norbert Kraut, Christopher P. Vellano, Juan Manuel García-Martínez

“…We demonstrate target-dependent TR2/CDH3 BAB anti-tumor activity in CRISPR/Cas9-engineered TRAILR2 or CDH3 knock-out cells. By utilizing the cell line screening platform PRISM, we found selective TR2/CDH3 BAB efficacy in various cancer types, such as pancreatic, gastric, colorectal, and triple negative breast cancer. …”
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Advancements in lamb wave high-frequency devices using diamond-like carbon (DLC) coatings by Jatinder Pal Singh, Ajay Kumar Sao, Babita Sharma, Satyam Garg, Anjali Sharma, Reema Gupta, Lokesh Rana, Mallika Verma, Akhilesh Pandey, Archibald Theodore Nimal, Upendra Mittal, Amit Kumar Vishwakarma, Monika Tomar, Arijit Chowdhuri

“…The patterning of aluminium electrodes for the fabrication of Lamb wave devices was carried out using lithography. The frequency response of the Lamb wave devices prepared without and with DLC coatings was studied and it was found that the Lamb wave devices without DLC coatings showed a return loss of -27.97 dB at a frequency of 286 MHz. …”
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Preclinical evaluation of avutometinib and defactinib in high‐grade endometrioid endometrial cancer by Tobias Max Philipp Hartwich, Miranda Mansolf, Cem Demirkiran, Michelle Greenman, Stefania Bellone, Blair McNamara, Shuvro P. Nandi, Ludmil B. Alexandrov, Yang Yang‐Hartwich, Silvia Coma, Jonathan Pachter, Alessandro D. Santin

“…Results WES results demonstrated multiple EAC cell lines to harbor genetic derangements in the RAS/MAPK pathway including KRAS/PTEN/PIK3CA/BRAF/ARID1A, potentially sensitizing to FAK and RAF/MEK inhibition. Five out of five of the EAC cell lines demonstrated in vitro sensitivity to FAK and/or RAF/MEK inhibition. …”
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Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…This study aims to report the current status of thalassaemia in Malaysia and provide a comprehensive understanding of the disease through data obtained from the Malaysian Thalassaemia Registry.Design Data were extracted from the Malaysian Thalassaemia Registry, a web-based system accessible to enrolled users through www.mytalasemia.net.my.Setting The Malaysian Thalassaemia Registry data was recorded from reports obtained from 110 participating government and university hospitals in Malaysia.Participants The patients were those attending the 110 participating hospitals for thalassaemia treatment.Intervention Data were collected from the Malaysian Thalassaemia Registry from 2007 until the fourth quarter of 2018.Primary outcome measure 7984 out of 8681 patients with thalassaemia registered in the Malaysian Thalassaemia Registry were reported alive.Results Majority of the patients were reported in the state of Sabah (22.72%); the largest age group affected was 5.0–24.9 years old (64.45%); the largest ethnic group involved was Malay (63.95%); and the major diagnosis was haemoglobin E/β-thalassaemia (34.37%). …”
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Isolation of competent actinomycetes strains from soil planted with three species of mint irrigated with olive mill wastewater by Oumaima Beroigui, Lahsen El Ghadraoui, Faouzi Errachidi

“…Microbiological analysis of OMWW was carried out to determine the presence of total aerobic mesophilic flora (FMAT), yeasts, and molds. …”
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Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients by Pandji Irani Fianza, Anita Rahmawati, Sri Hudaya Widihastha, Shofura Afifah, Mohammad Ghozali, Andre Indrajaya, Dilli Marayuzan Akbar Pratama, Dimmy Prasetya, Teddy Arnold Sihite, Mas Rizky A. A. Syamsunarno, Djatnika Setiabudi, Suthat Fucharoen, Ramdan Panigoro

“…Transfusion-dependent thalassemic (TDT) outpatients (n = 66; mean age, 21.5 ± 7.2 years) were carried out for the complete assessment consisting of blood test including liver enzyme and serum ferritin, followed by electrocardiography (ECG) and echocardiography. …”
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Evaluation of the planting performance for planting substrate using the SQI-CRITIC combination model based on the least squares method by Ning Wang, Dong Xia, Dong Xia, Dong Xia, Xiaoming Duan, Bingqin Zhao, Bingqin Zhao, Wennian Xu, Wennian Xu

“…BackgroundTo improve the scientificity of the evaluation results of the planting performance of the Yellow River sediment based on planting substrate.MethodsThis study replaced the natural soil with Yellow River sediment, used cement as the cementing material, added different proportions of organic matter and amendment of habitat material to prepare planting substrate based on the Yellow River sediment, and carried out experiments by using oats and proposed a combined SQI-CRITIC combined weighting calculation method based on the least square method for its evaluation.ResultsThe results showed that (1) different proportions of cement and amendment of habitat material led to significant variations in the planting performance of the planting substrate based on Yellow River sediment: among the 5# mix ratio, the plant height (12.5 cm) and biomass (3.06 g) of oats reached extreme values. …”
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The impact of an educational intervention on undergraduate students’ knowledge, acceptability, and willingness to pay for dapivirine vaginal ring in Nigeria's first indigenous univ... by Abdulmuminu Isah, Gabriel Ezenri, Ogechi Obi, Nnamdi A. Okibe, Hadiza Usman Ma’aji, Ezinwanne J. Ugochukwu, Cynthia C. Eze, Chisom M. Amoke, Augustus Ezeodimegwu, Charles C. Idabor, Mustapha Muhammed Abubakar, Francis Iloabuchi, Ikenna John Ugwu, Chukwuebuka M. Asogwa, Chinwe V. Ukwe, Blessing Onyinye Ukoha-kalu

“…Most of the students were willing to pay less than one dollar out-of-pocket for the ring.…”
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Accumulation conditions and target area evaluation of coalbed methane in eastern uplift of Junggar Basin by Qixiang YU, Mi TIAN, Yu LUO, Fan YANG, Yan'e CHEN, Feng WANG, Yuqiao GAO, Tao GUO

“…Utilizing well logging data, core analysis test results, and seismic data, well-seismic calibration and seismic profile interpretation were carried out. Connecting-well profiles and thickness distribution maps for coal seams in the Jurassic Xishanyao and Badaowan formations were compiled. …”
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