Enhanced membrane protein production in HEK293T cells via ATF4 gene knockout: A CRISPR-Cas9 mediated approach by Byung-Jo Choi, Ba Reum Kim, Ho Joong Choi, Ok-Hee Kim, Say-June Kim

“…This study aimed to enhance membrane protein production in HEK293T cells by knocking out the ATF4 gene using CRISPR-Cas9 technology. …”
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Perioperative nursing management of transcatheter edge-to-edge repair (经导管二尖瓣缘对缘修复术围手术期护理) by LIU Yuan (刘苑), LAI Jianqing (赖间清), DING Fei (丁菲), HUANG Huifen (黄惠芬)

“…The comprehensive interventions including enhanced recovery after surgery, respiratory exercise, pain control, catheter maintenance and standard health education before discharge were carried out to relieve symptoms of heart failure, improve self-care ability and quality of life of patients after transcatheter edge-to-edge repair. …”
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Assemblies design and modeling analysis of a new fine mesh neutronics/thermal-hydraulics coupling benchmark for plate-type PWR core by Zhigang Li, Wei Lu, Shanfang Huang, Xiafeng Zhou, Yingwei Wu, Bangyang Xia, Junji Chen, Tao He, Guodong Liu, Yangyu Zhong, Zhiying Yue

“…Taking ENDF/B-VII.1 as an example, the maximum deviation of keff in the entire burnup process of all assemblies is −157pcm, the maximum deviation of relative power is −1.13 %, and the maximum power weight error(PWE) is 0.226 %. 2) Compared between KYLIN V2 and the RMC by using ENDF/B-VII.1, the maximum deviation of keff is −468pcm, the maximum deviation of relative power is −1.49 %, and the maximum PWE is 0.316 % when calculating the standard assemblies with all control rod out(ARO) condition and two burnable poison assemblies. …”
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Macrofaunal biopores: Diversity and regeneration rates across diverse pedoclimatic conditions studied with repacked soil cores by Charlotte Védère, Hanane Aroui Boukbida, Yvan Capowiez, Sougueh Cheik, Guillaume Coulouma, Rinh Pham Dinh, Séraphine Grellier, Claude Hammecker, Thierry Henry Des Tureaux, Ajay Harit, Jean Louis Janeau, Pascal Jouquet, Jean Luc Maeght, Pascal Podwojewski, Cornelia Rumpel, Stéphane Sammartino, Norbert Silvera, Siwaporn Siltecho, Lotfi Smaili, Bounsamay Soulileuth, Nicolas Bottinelli

“…Complete regeneration of biopores after 12 months was achieved in seven out of nine sites. Three groups of biopores showed a positive relation with earthworm abundance (r values ranged from 0.69 to 0.90), whereas the other groups of biopores showed no association with any macrofauna taxa. …”
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Design and Analysis of Microstrip Patch Antennas to Support the Implementation of Smart Ports by M. Basuki Rahmat, Yuning Widiarti, Eko Setijadi, Azlina Idris, Aina Julia, Shipun Anuar Hamzah, K S H Putri

“…The simulation was carried out using computer simulation technology (CST) suite studio 2019 software. …”
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Pastoral livestock farming constraints and adaptation strategies in response to institutional reforms in the Sudano-Sahelian zone of West Africa by Basnewindé Ilboudo, Alhassane Zaré, Alhassane Zaré, Innocent Charles Emmanuel Traoré, Innocent Charles Emmanuel Traoré, Loyapin Bondé, Reginald Tang Guuroh, Reginald Tang Guuroh, Reginald Tang Guuroh, Oumarou Ouédraogo

“…In response, some livestock farmers drive their herds out of the country, while others illegally graze in protected areas. …”
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Parental preference for influenza vaccine for children in China: a discrete choice experiment by Gang Chen, Ping Liu, Xiaochen Ma, Hai Fang, Zhiyuan Hou, Hongguo Rong, Xiaozhen Lai, Shunping Li, Tiantian Gong

“…Five attributes were identified based on literature review and qualitative interviews, including protection rate, duration of vaccine-induced protection, risk of serious side effects, location of manufacturer and out-of-pocket cost.Setting Multistage sampling design was used. …”
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Pathogenetic Treatment of Gastritis as a Basis for the Prevention of Gastric Cancer in the Countries of the Commonwealth of Independent States: Literature Review and the Resolution... by V. T. Ivashkin, I. V. Maev, J. V. Gorgun, K. S. Kaliaskarova, M. M. Karimov, A. V. Kononov, T. L. Lapina, N. A. Markaryan, M. S. Moldobaeva, S. I. Pimanov, A. A. Sheptulin

“…Opportunistic screening of H. pylori is carried out by general practitioners, district physicians, gastroenterologists and other specialists. …”
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Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients by Rayra P. Santiago, Magda O. S. Carvalho, Camylla V. B. Figueiredo, Luciana M. Fiuza, Rodrigo M. Oliveira, Sètondji C. M. A. Yahouédéhou, Valma M. L. Nascimento, Isa M. Lyra, Théo Araujo-Santos, Nívea F. Luz, Milena M. Aleluia, Caroline C. Guarda, Valéria M. Borges, Marilda S. Goncalves

“…Hematological and biochemical analyses were carried out using electronic methods. TGF-β1, TIMP-1, and MMP-9 plasma quantifications were performed by ELISA. …”
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The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota by Jingda Zhang, Lin Hou, Shanxiang Lei, Yan Li, Guogang Xu

“…Still, more in vivo and in vitro work should be carried out to validate the precise effect and molecular mechanisms of the gut microbiome.…”
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Adaptive radiotherapy in locally advanced head and neck cancer: The importance of reduced margins by Hedda Enocson, André Haraldsson, Per Engström, Sofie Ceberg, Maria Gebre-Medhin, Gabriel Adrian, Per Munck af Rosenschöld

“…Daily non-adapted D98%,CTV was > 95 % in 890 (5 mm) and 825 (2 mm) out of 902 fractions. All adapted plans achieved D98%,CTV > 95 %. …”
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Protective Effects of Phycobiliproteins from <i>Arthrospira maxima</i> (Spirulina) Against Cyclophosphamide-Induced Embryotoxicity and Genotoxicity in Pregnant CD1 Mice by Yuliana García-Martínez, Amparo Celene Razo-Estrada, Ricardo Pérez-Pastén-Borja, Candelaria Galván-Colorado, Germán Chamorro-Cevallos, José Jorge Chanona-Pérez, Oscar Alberto López-Canales, Hariz Islas-Flores, Salud Pérez-Gutiérrez, Joaquín Cordero-Martínez, José Melesio Cristóbal-Luna

“…<b>Background/Objectives</b>: In recent years the global incidence of cancer during pregnancy is rising, occurring in 1 out of every 1000 pregnancies. In this regard, the most used chemotherapy drugs to treat cancer are alkylating agents such as cyclophosphamide (Cp). …”
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Unraveling the genetic mysteries of spinal muscular atrophy in Chinese families by Shanshan Gao, Duo Chen, Qianqian Li, Xuechao Zhao, Chen Chen, Lina Liu, Miao Jiang, Zhenhua Zhao, Yanhua Wang, Xiangdong Kong

“…Various molecular techniques, including multiplex ligation-dependent probe amplification analysis, long-range polymerase chain reaction (PCR) combined with nested PCR, Sanger sequencing, and whole-exome sequencing were employed to establish a thorough genetic variant profile in 680 Chinese pedigrees with clinically suspected SMA. Results Out of 680 families suspected of having SMA, 675 exhibited mutations in the SMN1 gene, while three families were linked to mutations in the IGHMBP2 gene. …”
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Ammonia Gas Adsorption in Fixed Bed and Fluidized Bed Using Bentonite Particles by Gabriela Muntianu, Ana-Maria Georgescu, Ana-Maria Rosu, Nicoleta Platon, Vasilica Alisa Arus, Cosmin Valeriu Jinescu, Ileana Denisa Nistor

“…To complete the study, ammonia desorption determination was carried out by a thermo-desorption process in order to recover the used particles. …”
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Pre-diagnostic risk factors for brain cancer incidence and survival: insights from the Golestan Cohort Study by Parisa Rezanejad-Asl, Peyvand Parhizkar Roudsari, Negar Rezaei, Maryam Sharafkhah, Gholamreza Roshandel, Hossein Poustchi, Sadaf Sepanlou, Reza Malekzadeh

“…Minimally adjusted and multiple Cox proportional hazards models were used to investigate the association of demographic and behavioral risk factors with brain cancer incidence and survival. Results Out of the 49,783 cancer free participants recruited at baseline, 77 patients were diagnosed with brain cancer and 62 patients were deceased till the end of the follow-up. …”
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Coinfections between Persistent Parasitic Neglected Tropical Diseases and Viral Infections among Prisoners from Sub-Saharan Africa and Latin America by Lilian Da Silva Santos, Hans Wolff, François Chappuis, Pedro Albajar-Viñas, Marco Vitoria, Nguyen-Toan Tran, Stéphanie Baggio, Giuseppe Togni, Nicolas Vuilleumier, François Girardin, Francesco Negro, Laurent Gétaz

“…Our research aimed to study the prevalence rates and coinfections of two neglected tropical diseases, namely, Strongyloides stercoralis and Schistosoma sp. and viral infections among sub-Saharan Africans (SSA) and Latin Americans (LA) in Switzerland’s largest pretrial prison. We carried out a cross-sectional prevalence study using a standardized questionnaire and serological testing. …”
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Automatic GPR detection of grouting defects behind the tunnel shield segments based on wavelet coherence analysis combined with modified Res-RCNN by Dengyi Wang, Ming Peng, Liu Liu, Xiongyao Xie, Zhenming Shi, Yaoying Liang, Jian Shen, Qiyu Wu

“…Through quantitative experiments in both model and synthetic tests, we recommend a trace interval of 15 to avoid the high coherence amplitude caused by two reflections out of same individual rebar.…”
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Classification of management tools in small business organizations for developing a sales funnel by E. R. Tolstova, L. V. Silakova

“…A comparison of various services that help in the development and implementation of a marketing strategy is carried out. There are 4 categories of digital services for working with business automation and sales funnel: information systems and technologies that help to design a business model as a whole, create quality management systems, etc.; programs for business modeling, development of working documentation and requirements; CRM systems designed for planning employee tasks and storing customer data; services that help with promotion in social networks. …”
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The Frequency of <i>DPYD</i> c.557A>G in the Dominican Population and Its Association with African Ancestry by Mariela Guevara, Carla González de la Cruz, Fernanda Rodrigues-Soares, Ernesto Rodríguez, Caíque Manóchio, Eva Peñas-Lledó, Pedro Dorado, Adrián LLerena

“…The implementation of pharmacogenetics in oncology, specifically <i>DPYD</i>, in populations of Afro-Latin American ancestry should include c.557A>G, to be able to carry out the safe and effective treatment of patients treated with fluoropyrimidines.…”
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Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis by Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu, Qingjun Pan

“…Specifically, we knocked out basophilic Atg5 in vivo to investigate its impact on lupus metabolism. …”
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