Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Through the whole exome and transcriptome sequencing analysis of the fresh blood and tumour tissues of the enrolled patients, the 20 25-33aa antigen peptides with the highest mutation scores of the patients will be screened out, and the corresponding new antigen peptides will be synthesised and prepared. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Multiple sequence, genetic, structural and disease phenotype analyses were applied in this study.ResultsAnalysis revealed that out of 130 mutations, approximately 8.5% of these mutations were classified as pathogenic. …”
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Prenatal malaria exposure and risk of adverse birth outcomes: a prospective cohort study of pregnant women in the Northern Region of Ghana by Akbar Fotouhi, Masud Yunesian, Hawawu Hussein, Mansour Shamsipour, Mohammad Sadegh Hassanvand, Percival Delali Agordoh, Mashoud Alabi Seidu

“…The purpose of this study was to assess the relationship between malaria and adverse birth outcomes among prenatal women in the Northern Region of Ghana.Design This is a prospective cohort study of singleton pregnancies at 28 weeks of gestational age and above recruited between July 2018 and May 2019 from four public hospitals in the Northern Region of Ghana.Outcome measures Low birth weight (LBW), preterm birth and perinatal death.Results A total of 1323 pregnant women completed the study out of the 1626 recruited, with an average age of 27.3±5.2 years. …”
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Computerised cognitive training tools and online nutritional group counselling for people with mild cognitive impairment: study protocol of a completely digital, randomised, contro... by Stephanie Book, Elmar Graessel, Julia Schneider, Michael Jeitler, Petra Scheerbaum, Michael Jank, Etienne Hanslian, Melanie DellO’ro, Julia-Sophia Scheuermann, Sophia Bösl, Christian Kessler

“…The CCT can be carried out independently at home on a computer, laptop, or tablet. …”
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Vesicoureteral Reflux in Children with Accidental Diagnosis of Unilateral Small Size Kidney by Mohsen Mohammadi, Khadijeh Ebrahimi, Soraya Khafri, Maryam Nikpour, Hadi Sorkhi

“…Results: The mean age of the children with small-size kidneys was 5.52 ± 3.70 years, and 58.1% were boys. Out of the 86 children, 28 (32.6%) were found to have VUR, with approximately 71.4% of them being boys. …”
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Cardiopulmonary resuscitation coaching for resuscitation teams: A systematic review by Kasper G. Lauridsen, Emma Bürgstein, Sabine Nabecker, Yiqun Lin, Aaron Donoghue, Jonathan P. Duff, Adam Cheng

“…Overall, 6 were randomized studies involving pediatric resuscitation of which 4 studies were secondary analyses of one simulation-based trial, and one was an observational study on adult out-of-hospital cardiac arrest. Reported outcomes were: CPR performance in a simulated setting (n = 3), workload in a simulated setting (n = 2), adherence to guidelines in a simulated setting (n = 1), team communication in a simulated setting (n = 1), and clinical CPR performance (n = 1). …”
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Body composition and physical performance of mountain bike athletes by Rayane Carvalho de Moura, Crislane de Moura Costa, Cirley Pinheiro Ferreira, Bruna Lorena Soares Cavalcante Sousa, Leandra Caline dos Santos, Michelly da Silva Pinheiro, Sérgio Luís Galan Ribeiro, Sandro Soares Almeida, Joseline Lima e Silva Pinho, Naíza Monge Lages, Maria Flávia de Sousa, Iago Alves Costa, Glêbia Alexa Cardoso, Acácio Salvador Veras Silva, Alisson Alves Silva, Jefferson Cruz dos Santos Leite, Felipe Machado Brito, Lailson Henrique Oliveira dos Santos, Rubens Lima Rodrigues, Jairo da Costa Souza, Marcos Antonio Pereira dos Santos

“…Body composition assessment was carried out using bioimpedance analysis. Participants performed the standing long jump and handgrip strength tests, to assess their strength of the lower and upper limbs, respectively. …”
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Predictors of Poor Outcome of Anti-MDA5-Associated Rapidly Progressive Interstitial Lung Disease in a Chinese Cohort with Dermatomyositis by Yuhui Li, Yimin Li, Jian Wu, Miao Miao, Xiaojuan Gao, Wenxin Cai, Miao Shao, Xuewu Zhang, Yan Xu, Lu Cong, Jing He, Xiaolin Sun

“…Kaplan-Meier, chi-square test, univariate, and multivariate data analyses were used. Results. Out of 213 patients with DM and clinically amyopathic dermatomyositis (CADM), 20.7% (44/213) of patients were identified as aMDA5-DM. …”
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Follicular Occlusion Syndrome — a Possible Option of Follicular-Retension Origin of Pilonidal Sinus by D. D. Shlyk, M. N. Pikuza, Yu. E. Kitsenko, A. S. Pirogova, N. B. Paramonova, R. T. Rzaev, N. P. Teplyuk, P. V. Tsarkov

“…Hidradenitis suppurativa of axillary and inguinal areas was found in 5 out of 7 patients. Acne conglobata, as one of the components of FOS, was noted in three patients. …”
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Development and validation of a food-related quality of life questionnaire (CANUT-QVA) for cancer patients by Kenza Drareni, Catherine Mercier, Reisya Rizki Riantiningtyas, Anestis Dougkas, Benjamin Riche, Pascale Roux, Chantal Fingal, Hélène Labrosse, Fadila Farsi, David Dayde, Mélanie Roche, Julie Anne Nazare, Arnaud Fournel, Delphine Maucort-Boulch, Moustafa Bensafi, Véronique Mourier, Amandine Bruyas, Agnès Giboreau

“…Analysis of test-retest reliability was also performed to evaluate reproducibility. Results: Out of the 46 items, 39 items showed significant differences between patients and healthy controls. …”
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Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study by Yvonne Böttcher, Michael Stumvoll, Kees Straatman, Matthias Raschpichler, Matthias Leopold Schroeter, Katrin Arelin, Haiko Schlögl, Dominik Fritzsch, Meinhard Mende, André Pampel, Arno Villringer, Karsten Mueller

“…Moreover, we aimed to investigate whether these effects change with age.Design Cross-sectional, exploratory.Setting University Clinic, Integrative Research and Treatment Centre.Participants We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by the city's registration office, subdivided into two age groups: young-to-mid-age (n=51, 20–45 years of age, mean BMI=24.9, 24 women) versus old (n=49, 65–70 years of age, mean BMI=27.0, 18 women).Main outcome measures VAT, BMI, subcutaneous abdominal adipose tissue, brain structure (grey matter density), functional brain architecture (eigenvector centrality, EC).Results We discovered a loss of cerebellar structure with increasing VAT in the younger participants, most significantly in regions involved in motor processing. …”
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Navigating the future of agri-food supply chain: A conceptual framework using bibliometric review by Abdul Kafi, Nizamuddin bin Zainuddin, Mohd Fitri Mansor, Mohamed Najib Bin Salleh, Adam bin Mohd Saifudin, Nurhaizal Azam Arif, Syairah Aimi Shahron, Ravi Ramasamy, Ibrahim Hassan mohamud

“…A rigorous inclusion and exclusion process was carried out by using articles whose titles contained only 'agri-food' and 'supply chain' terms. …”
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Exploring the Impact of Citric Acid on Mitigating Sweet Potato Soft Rot and Enhancing Postharvest Quality by Yixi Chen, Linjiang Pang, Jiacheng Bai, Wenbao Yu, Yueming Zhu, Melvin Sidikie George, Zunfu Lv, Guoquan Lu

“…In vivo experiments were carried out using “Xinxiang” sweet potato varieties and the application of a 0.5% (<i>w</i>/<i>v</i>) CAC solution as a pretreatment. …”
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Biological and Molecular Characterization of Moroccan Isolates of <i>Spiroplasma citri</i> by Tourya Sagouti, Ikram Legrifi, Naima Rhallabi, Zineb Belabess, Moussa El Jarroudi, Said Amiri, Essaid Ait Barka, Abdessalem Tahiri, Rachid Lahlali

“…Biological indexing through reverse inoculation revealed that seven out of ten isolates caused moderate to intense symptoms within 8 to 10 weeks, with symptom severity varying across citrus cultivars and regions. …”
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Efficacy and safety of intermittent fasting for type 2 diabetes mellitus: A systematic review and meta-analysis of randomized trials by Joshua Chadwick, Lavanya Ayyasamy, Madhanraj Kalyanasundaram, Ganeshkumar Parasuraman, Bhavani Shankara Bagepally, Jeyashree Kathiresan, Lokesh Shanmugam

“…We performed a sensitivity analysis to assess the robustness of the result. Results: Out of the 24 studies identified, nine were deemed suitable for inclusion. …”
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Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)—Two-Year Follow-Up Study by Leila Yazdanpanah, Hajieh Shahbazian, Iraj Nazari, Hamid Reza Arti, Fatemeh Ahmadi, Seyed Ehsan Mohammadianinejad, Bahman Cheraghian, Saeed Hesam

“…This study was carried out to assess the incidence and risk factors of diabetic foot ulcer (DFU). …”
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Burn wound healing using adipose-derived mesenchymal stem cells and manganese nanoparticles in polycaprolactone/gelatin electrospun nanofibers in rats by Azin Shahmohammadi, Hadi Samadian, Saeed Heidari Keshel, Khodabakhsh Rashidi, Amir Kiani, Masoud Soleimani, Farjam Goudarzi

“…The wound closure rate, IL-1β, and IL-6 level, hydroxyproline, and glycosaminoglycans content were measured, and the hematoxylin and eosin, Masson’s trichrome, and immunohistochemistry stainings were carried out. Results: Based on the results, in Mn+S (ADSCs+PCL/Gel/5%MnO2-NPs nanofiber) and N+S (ADSCs+PCL/Gel nanofiber) groups, the IL-6 and IL-1β levels were reduced, and the percentage of wound closure, glycosaminoglycans, and hydroxyproline content were increased compared to the control group (P<0.05). …”
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Implementation of patient-reported outcome dashboards within the electronic health record to support shared decision-making in serious chronic illness by Glyn Elwyn, Sheetal M Kircher, Eugene Nelson, David Cella, Lisa Hirschhorn, Cynthia Barnard, Vikram Aggarwal, Jeffrey Linder, Sofia F Garcia, Aricca Van Citters, Mary O'connor, Laura M Perry, Nisha A Mohindra, Ava Coughlin, Katy Bedjeti, Devin Peipert, Melissa Weitzel, Victoria Morken, Elijah Patten, Jissell Torres, Susan Metzger, Alesia O’daniel, Ryan Chmiel, Reena Modi, Michelle Munroe, Stavroula Xinos

“…Clinicians (n=7) and patients (n=30) responded to a 6-month survey that included appropriateness, acceptability, adoption and sustainability.Results Out of 1450 eligible patients, 748 (52%) completed at least one PRO invitation (reach). 37% of PRO questionnaire invitations (1421/3882) were completed (fidelity to PRO completion), with higher rates occurring when more implementation strategies were adopted. …”
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Prognostic factors of thalamic and thalamopeduncular low-grade gliomas in children: A systematic review and recommendations for surgical management by Jana Táborská, Adéla Bubeníková, Petr Skalický, Jakub Táborský, David Horváth, Michal Zápotocký, Ondřej Bradáč, Vladimír Beneš, 3rd

“…Results: The study selection process resulted in the inclusion of 14 articles out of the initial pool of 876 references. These 14 articles encompassed data from 446 patients. …”
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Emergence and polyclonal dissemination of NDM-5/OXA-181 carbapenemase-producing Escherichia coli in the French Indian Ocean territories by Thibaut Vedani, Matthieu Pot, Thomas Garrigos, Loïk Sababadichetty, Marion Daniel, David Wilkinson, Thierry Benoit-Cattin, Olivier Belmonte, Patrick Mavingui, Laurent Dortet, Guillaume Miltgen

“…Genotypic analysis of the isolates was carried out using WGS to determine the clonality relationship between the isolates and the genetic support of the carbapenemase-encoding genes. …”
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