A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells by Zhao Zhang, Lianfeng Zhao, Tinghui Huang, Zhengliang Chen, Zhengliang Chen, Yaoyao Zhao, Yaoyao Zhao, Junqing Liang, Xudong Ao, Xiaoqiong Jia, Lei Kang, Linghui Kong, Qi Jing, Jianhua Hu, Lili Gu, Feiyan Pan, Zhigang Hu, Lingfeng He, Muya Zhou, Jiannan Chen, Zhigang Guo

“…Anti-CD70 UCAR-T cells were then generated by knocking out TRAC, B2M, and HLA-DRA. To address the limitations of UCAR-T therapy, we developed an 'all-in-one' self-activated and protective (SAP) module, integrated into the CAR scaffold. …”
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Effectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study by Lauren D'Mello-Guyett, Ruwan Ratnayake, Andrew S Azman, Yap Boum, Francesco Checchi, W John Edmunds, Placide Okitayemba Welo, Nicolas Peyraud, Iza Ciglenecki, Etienne Gignoux, Maria Lightowler, Primitive Gakima, Jean Patrick Ouamba, Joseph Amadomon Sagara, Rollin Ndombe, Nana Mimbu, Alexandra Ascorra, Elisabeth Mukamba Musenga, Berthe Miwanda, Francisco Luquero, Klaudia Porten, Flavio Finger, Miriam Alia, Bachir Assao, Catherine Bachy, Rob D'hondt, Karl Njuwa Fai, Caroline Henry-Ostian, Abdoul-Moumouni Issa-Soumana, Danish Malik, Herbert Mutubuki, Rodrigue Ntone, Isabella Panunzi, Issaka Soumana, Oumar Touré, Mamady Traore

“…As with most real-world interventions, there will be delays to response as the strategy is rolled out. We will compare the cumulative incidence among rings as a function of response delay, as a proxy for performance. …”
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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Histological, immunohistochemical, genetic, and transcriptomic comparisons of patient and patient-derived xenograft (PDX) tumors were carried out. Results: Higher tumor grade, peritoneal implantation, and RAS/RAF mutation were associated with successful tumor engraftment. …”
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Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affects the Systemic Expression of Pro- and Anti-Inflammatory Genes by Rafael Nepomuceno, Bárbara Scoralick Villela, Sâmia Cruz Tfaile Corbi, Alliny De Souza Bastos, Raquel Alves Dos Santos, Catarina Satie Takahashi, Silvana Regina Perez Orrico, Raquel Mantuaneli Scarel-Caminaga

“…Blood analyses of lipid and glycemic profiles were carried out. The expression of genes, including IL10, JAK1, STAT3, SOCS3, IP10, ICAM1, IFNA, IFNG, STAT1, and IRF1, was investigated by RT-qPCR. …”
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Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in Magnaporthe oryzae by Chang Liu, Yi Wei, Yuejia Dang, Wajjiha Batool, Xiaoning Fan, Yan Hu, Zhengquan He, Shihong Zhang

“…In this study, we describe D-erythroascorbic acid-mediated OA synthesis and its metabolic and clearance pathways in rice blast fungus. By knocking out the D-arabino-1,4-lactone oxidase gene (Moalo1), one-third of oxalic acid remained in M. oryzae, indicating a main pathway for oxalic acid production. …”
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Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population by L. Kimura, C. B. Angeli, M. T. B. M. Auricchio, G. R. Fernandes, A. C. Pereira, J. P. Vicente, T. V. Pereira, R. C. Mingroni-Netto

“…Methods. Analyses were carried out using a family-based design in a sample of 652 participants (97 families). …”
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The Bioethics-CSR Divide by Caio Caesar Dib

“… Photo by Sean Pollock on Unsplash ABSTRACT Bioethics and Corporate Social Responsibility (CSR) were born out of similar concerns, such as the reaction to scandal and the restraint of irresponsible actions by individuals and organizations. …”
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Le mobilier en cuir antique et médiéval du boulevard Dr Henri-Henrot à Reims/Durocortorum by Martine Leguilloux

“…Most of the sandals have decorated soles (20 soles out of 29 pieces identified): the surface in contact with the foot presents patterns of palmettes or eyespots (ocelles), applied by pressure with stamping machines. …”
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Constructing Identities: Amos Tutuola and the Ibadan Literary Elite in the wake of Nigerian Independence by Mackenzie Finley

“…Tutuola explained, “As much as I could [in my novels], I tried my best to bring out for the people to see the secrets of my tribe—I mean, the Yoruba people—and of Nigerian people, and African people as a whole. …”
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De l’agglomération antique de Cassinomagus au village de Chassenon (Charente) : un bilan des connaissances by Lucie Carpentier, Sandra Sicard

“…Beyond documenting these territorial changes in the light of the political and administrative forces at play, the work carried out based on archival sources makes it possible to specify the different types of occupations present within the commune of Chassenon until the 19th c., when the locality assumed its present limits1.…”
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Editorial by Michael Rose, Jonathan M. Hoffmann

“…Moreover – sounding the same horn as Hoffmann – he points out that in political practice, the citizens’ interests brought into political decision-making are not individualised anyway. …”
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Penerapan Importance Performance Analysis (IPA) pada Evaluasi Keberlanjutan Penggunaan e-filing untuk Pelaporan Pajak Perorangan by Imelda Saluza, Dewi Sartika

“…This is conducted to enhance customer experience. To get the most out of e-filing as a method of uploading individual tax returns (SPT). …”
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Le sanctuaire romain du Vigneau à Pussigny (Indre-et-Loire) : un lieu de mémoire, de vie et d’accueil by Arnaud Coutelas, Sébastien Lepetz

“…The installation was therefore carried out at the bottom, in the axis of the slope, with a natural orientation towards the valley.In this orientation, the complex known as the “Western buildings” was developed. …”
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An HST Transmission Spectrum of the Closest M Dwarf Transiting Rocky Planet LTT 1445Ab by Katherine A. Bennett, David K. Sing, Kevin B. Stevenson, Hannah R. Wakeford, Zafar Rustamkulov, Natalie H. Allen, Joshua D. Lothringer, Ryan J. MacDonald, Nathan J. Mayne, Guangwei Fu

“…We do, however, confidently rule out ≤100× solar metallicity atmospheres. Although stellar contamination retrievals cannot fit the IR features well, the overall spectrum is consistent with stellar contamination from hot or cold spots. …”
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Multi-environmental traits selection and farmer's participatory assessment of mean performance and stability of orange-fleshed sweet potato genotypes in Benin by Idrissou Ahoudou, Nicodeme V. Fassinou Hotegni, Dêêdi E.O. Sogbohossou, Tania L.I. Akponikpè, Charlotte O.A. Adjé, Françoise Assogba Komlan, Ismail Moumouni-Moussa, Enoch G. Achigan-Dako

“…Nine OFSP genotypes were evaluated through a multi-environment trial (MET) carried out in 14 environments and in a complete randomised block (RCB) design to select the best genotypes based on the multi-trait mean performance and stability index (MTMPS) and participatory variety selection (PVS). …”
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Repairbads: An automatic and adaptive method to repair bad channels and segments for OPM-MEG by Fulong Wang, Yujie Ma, Tianyu Gao, Yue Tao, Ruonan Wang, Ruochen Zhao, Fuzhi Cao, Yang Gao, Xiaolin Ning

“…Repairbads employs Riemannian Potato combined with joint decorrelation to project out artifact components, achieving automatic bad segment repair. …”
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Phytogeographic Transition Areas Hide Floristic Diversity in Hyper-Arid Environments (Sharaan Natural Reserve, NW-Saudi Arabia) by Mohamed Djamel Miara, Sami Youssef, Yassine Fendane, Louise Marris, Robin Sallio, Hassan Boukcim, Sami D. Almalki, Shauna K. Rees, Benjamin P. Y.-H. Lee, Abdalsamad Aldabaa, Ahmed H. Mohamed

“…The floristic studies carried out in the vegetation season from 2022 to 2024 led to the identification of 166 plant taxa belonging to 38 botanical families. …”
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Field Deployment of a Mobile Biosafety Laboratory Reveals the Co-Circulation of Dengue Viruses Serotype 1 and Serotype 2 in Louga City, Senegal, 2017 by Idrissa Dieng, Maryam Diarra, Moussa Moïse Diagne, Martin Faye, Marie Henriette Dior Ndione, Yamar Ba, Mamadou Diop, El Hadji Ndiaye, Paolo Marinho de Andrade Zanotto, Boly Diop, Mamadou Ndiaye, Abdoulaye Bousso, Ndongo Dia, Mawlouth Diallo, Aliou Barry, Gamou Fall, Cheikh Loucoubar, Amadou Alpha Sall, Ousmane Faye, Oumar Faye

“…Serotyping, sequencing of complete E gene, and phylogenetic analysis were also performed. Out of 960 suspected cases, 131 were confirmed dengue cases. …”
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Spatial and temporal variability in sea surface temperatures and monsoon dynamics in the northwestern Arabian Sea during the last 43 kyr by J. Maier, J. Maier, N. Burdanowitz, N. Burdanowitz, G. Schmiedl, G. Schmiedl, B. Gaye, B. Gaye

“…Importantly, the Last Glacial Maximum stands out owing to the absence of intense cooling at the core site which clearly diverges from previously known SST patterns. …”
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Soft computing approaches of direct torque control for DFIM Motor's by Zakariae Sakhri, El-Houssine Bekkour, Badre Bossoufi, Nicu Bizon, Mishari Metab Almalki, Thamer A.H. Alghamdi, Mohammed Alenezi

“…Results show that DTC-ANN and DTC-SVM stand out for their ripple reduction performance, making them particularly suitable for applications requiring high precision. …”
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