Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration by Andrea Barragán-Cárdenas, Daniel Castellar-Almonacid, Yerly Vargas-Casanova, Claudia Parra-Giraldo, Adriana Umaña-Pérez, Joel López-Meza, Zuly Rivera-Monroy, Javier García-Castañeda

“…Evaluation of mechanism associated to the cytotoxic effect were carried out by flow cytometry, RT-qPCR, wound healing, transwell and zymography. …”
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High-Fiber Extruded Purple Sweet Potato ( Ipomoea batatas ) and Kidney Bean ( Phaseolus vulgaris ) Extends the Feeling of Fullness by Eny Palupi, Naufal Muharam Nurdin, Ghina Mufida, Fadhilah Nur Valentine, Ricter Pangestika, Rimbawan Rimbawan, Ahmad Sulaeman, Dodik Briawan, Fitry Filianty

“…Optimization of the formula was carried out using four levels of purple sweet potato flour substitution with kidney bean flour: 0, 20, 30, and 40% (w/w ). …”
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Use of an observer tool to enhance learning of anaesthesia resident’s non-technical skills during high-fidelity simulation: a randomised controlled trial by Caroline Havard, Viridiana Jouffroy, Agnès Le Gouez, Marie Bruyère, Samy Figueiredo, Philippe Roulleau, Dan Benhamou, Aurore Margat, Antonia Blanié

“…The primary outcome was NTS performance, assessed by an evaluator using the Anaesthesia Non-Technical Skills score (ANTS score out of 16) on video recording. Secondary outcomes were results of score items, satisfaction, team performance, and professional impact. …”
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Factors influencing health service utilization among 19,869 China’s migrant population: an empirical study based on the Andersen behavioral model by Yalin Song, Jingru Liu, Shuming Yan, Mingze Ma, Clifford Silver Tarimo, Clifford Silver Tarimo, Yiyang Chen, Yanhong Lai, Xinghong Guo, Jian Wu, Beizhu Ye

“…This study addresses the gap in health service utilization among migrants, specifically examining their engagement with basic public health services and the factors that impact these interactions.MethodsIn the year 2023, a cross-sectional survey was carried out among 19,869 migrants in China, employing a multi-stage stratified sampling technique for participant recruitment. …”
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Potentiality of algorithms and artificial intelligence adoption to improve medication management in primary care: a systematic review by Gianfranco Damiani, Antonio Oliva, Gerardo Altamura, Massimo Zedda, Mario Cesare Nurchis, Giovanni Aulino, Aurora Heidar Alizadeh, Francesca Cazzato, Gabriele Della Morte, Matteo Caputo, Simone Grassi, Maria Teresa Riccardi, Martina Sapienza, Giorgio Sessa

“…The methodological quality of included studies was appraised adopting the Quality Assessment of Controlled Intervention Studies of the National Institute of Health for randomised controlled trials.Results Studies reported in different ways the effective reduction of medication error. Ten out of 14 included studies, corresponding to 71% of articles, reported a reduction of medication errors, supporting the hypothesis that AI is an important tool for patient safety.Conclusion This study highlights how a proper application of AI in primary care is possible, since it provides an important tool to support the physician with drug management in non-hospital environments.…”
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Pseudomonas azotoformans and Pseudomonas putida: Novel kiwifruit-native biological control agents against Pseudomonas syringae pv. actinidiae by Cristiana Correia, Antonio Cellini, Irene Donati, Panagiotis Voulgaris, Adebayo Ebenezer Obafemi, Elia Soriato, Elodie Vandelle, Conceição Santos, Francesco Spinelli

“…Overall, these results open new perspectives to develop commercial products for Psa management based on kiwifruit-native bacteria, well-adapted to common orchard management practices, with a high efficiency of host plant colonization, at Psa-conducive temperatures, and point out possible mechanisms of action for these two BCA candidates, supporting further steps to assess their effectiveness in orchard conditions.…”
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Mirizzi Syndrome: Diagnosis and Management of a Challenging Biliary Disease by Gennaro Clemente, Andrea Tringali, Agostino M. De Rose, Elena Panettieri, Marino Murazio, Gennaro Nuzzo, Felice Giuliante

“…The aim of this study is to point out some particular aspects of diagnosis and treatment of this condition. …”
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Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei by Samhita Das, Tanaya Unhale, Carine Marinach, Belsy del Carmen Valeriano Alegria, Camille Roux, Hélène Madry, Badreddine Mohand Oumoussa, Rogerio Amino, Shiroh Iwanaga, Sylvie Briquet, Olivier Silvie

“…To illustrate the versatility of this new tool, we conditionally knocked out the essential gene encoding the claudin-like apicomplexan micronemal protein (CLAMP) in P. berghei and confirmed the role of CLAMP during invasion of erythrocytes.…”
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SF1-specific deletion of the energy sensor AMPKγ2 induces obesity by Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López

“…Complete metabolic phenotyping and molecular analyses in brown adipose tissue (BAT), white adipose tissue (WAT) and liver were carried out. Results: Our findings reveal that, in contrast to the obesity-protective effect of the genetic deletion of AMPKα subunits, the loss of AMPKγ2 in SF1 neurons leads to a sex-independent and feeding-independent obesity-prone phenotype due to decreased thermogenesis in brown adipose tissue (BAT) and reduced browning of WAT, resulting in lower energy expenditure. …”
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Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway by Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu

“…In silico prediction demonstrates that 70 active compounds of RSTF were filtered out through ADME screening and 84 putative targets correlated with different diseases. …”
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Using a region-specific ice-nucleating particle parameterization improves the representation of Arctic clouds in a global climate model by A. B. Gjelsvik, R. O. David, T. Carlsen, F. Hellmuth, S. Hofer, Z. McGraw, Z. McGraw, H. Sodemann, H. Sodemann, T. Storelvmo, T. Storelvmo

“…In this study, INP observations were carried out at Andenes, Norway, in March 2021. These observations were used as a basis for an Arctic-specific and purely temperature-dependent INP parameterization, which was implemented into the Norwegian Earth System Model (NorESM). …”
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Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP by Yi Wang, Weiwei Qiu, Stace Kernodle, Carly Parker, Marc-Antonio Padilla, Jiaao Su, Abigail J. Tomlinson, Stephanie Oldham, Joss Field, Elise Bernard, David Hornigold, Christopher J. Rhodes, David P. Olson, Randy J. Seeley, Martin G. Myers, Jr

“…Not only does the artificial activation of NTSPrlh cells decrease feeding, but also the expression of Prlh (which encodes the neuropeptide PrRP) and neurotransmission by NTSPrlh neurons contributes to the restraint of food intake and body weight, especially in animals fed a high fat diet (HFD). We set out to determine roles for putative PrRP receptors in the response to NTS PrRP and exogenous PrRP-related peptides. …”
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The success rate of infrazygomatic mini-implants placed with and without surgical guides: a historical control study by Lixian Yuan, Ruifeng Zhao, Jingjing Liu, Rui Tang, Shizhu Bai, Xin Liu

“…Results After implantation, 2 out of the 62 mini-implants fell off and a success rate of 96.8% was indicated in the surgical guide group. …”
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Original Personalized Reconstruction Method for Certain Large Tumors of the Lower Lip (Not Including Oral Commissures) by Ovidiu Dan Grigorescu, Marius Irimie, Nadinne Roman, Roxana Steliana Miclaus, Maria-Cristina Cîmpeanu, Bogdan-Radu Necula, Christian-Gabriel Strempel, Simona Grigorescu, Marius Alexandru Moga, Dana Gabriela Festila

“…Unfortunately, the majority involve the use of both local and regional flaps, which either lack labial structure or disorganize the oral commissures as nodal oral function points. We set out to design a new reconstruction method that is not burdened by any of the above disadvantages, starting from the necessity to reconstruct large lower lip defects by exclusively using local and/or regional labial flaps belonging only to the healthy upper lip and the remaining structures of the lower lip after surgical tumor removal. …”
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Socioeconomic correlates of mental health in Moldova: A nationally representative door-to-door survey by J.M. van Baar, C. Ciofu, F. Thompson, A.I. Luik, O. Mereanu, J. Kramer, F. Schouten, V. Condrat, L. Voorham, J. Chihai, L. Shields-Zeeman

“…Average well-being was 69.6 out of 100. Women reported higher prevalence of depression and anxiety symptoms, more loneliness, and lower well-being than men. …”
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Factors Affecting Treatment Adherence Among Patients with Tuberculosis in Indonesia: Literature Review by Fahrul Islam, Haeranah Ahmad, Nurbaya, Masnaeni Ahmad, Ansar, Kadar Ramadhan, Muhammad Syukri, Syafran Arrazy, Agung Aji Perdana, Deborah Siregar, Nining Ade Ningsih, Ikes Dwi Astuti, St. Kadijah Hamid, Asrul Hamonangan Pasaribu

“…Article selection was carried out using the method "Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and analyzed using descriptive analysis techniques. …”
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Experimental Study of Thoracoabdominal Injuries Suffered from Caudocephalad Impacts Using Pigs by Sishu Guan, Zhikang Liao, Hongyi Xiang, Xiyan Zhu, Zhong Wang, Hui Zhao, Peng Liu, Xinan Lai

“…The functional change examination and the autopsies were carried out, with which the injuries were evaluated from the Abbreviated Injury Scale (AIS) and the Injury Severity Score (ISS). …”
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Factors affecting patient satisfaction during endoscopic procedures by Maryam Ghazala, E-Hinna Rashk, Sardar Saman, Khan Jahangir, Isram Javaria, Hassan Fayyaz

“…Methods: A cross-sectional study was conducted with 409 participants, out of which 212 responses were included for analysis. …”
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Multimodal low-opioid anesthesia as a factor in reducing the activation of the proinflammatory response in cardiac surgery by S.R. Maruniak, O.A. Loskutov, O.M. Druzhyna, I.R. Malysh, V.G. Kolesnikov, N.O. Korotchuk

“…The determination of the level of interleukin-6 in the blood was carried out before and after the completion of cardiopulmonary bypass by enzyme-linked immunosorbent assay. …”
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Regulation of ofloxacin resistance in Escherichia coli strains causing calf diarrhea by quorum-sensing acyl-homoserine lactone signaling molecules by Zi Wang, Zi Wang, Zi Wang, Miao Sun, Yongqiang Wang, Yongqiang Wang, Jinchuan Shi, Wei Gao, Dongxu Han, Fanjun Zeng, Sanren, Liyin Du, Liyin Du, Hongxia Ma, Kai Liu, Kai Liu, Kai Liu

“…In this study, a type I quorum sensing AHL, N-Octanoyl-L-Homoserine lactone (C8), was added to E. coli growth medium to investigate its regulatory functions in drug resistance. After screening out the strains of E. coli that showed an obvious regulatory effect to the drug ofloxacin (OFX), transcriptomic sequencing was performed on the E. coli strains from the sub-inhibitory concentration group that concentration plus C8 group, and the control group. …”
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