Investigation of metabolic features of glioblastoma tissue and the peritumoral environment using targeted metabolomics screening by LC-MS/MS and gene network analysis by N. V. Basov, A. V. Adamovskaya, A. D. Rogachev, E. V. Gaisler, P. S. Demenkov, T. V. Ivanisenko, A. S. Venzel, S. V. Mishinov, V. V. Stupak, S. V. Cheresiz, O. S. Oleshko, E. A. Butikova, A. E. Osechkova, Yu. S. Sotnikova, Y. V. Patrushev, A. S. Pozdnyakov, I. N. Lavrik, V. A. Ivanisenko, A. G. Pokrovsky

“…These reconstructed pathways were integrated into a regulatory gene network comprising 15 genes, 329 proteins, and 389 interactions. Notably, 119 out of the 294 proteins regulating the key enzymes of sphingolipid metabolism were associated with glioblastoma. …”
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Stability of miR-126 in Urine and Its Potential as a Biomarker for Renal Endothelial Injury with Diabetic Nephropathy by Yang Liu, Guangqiang Gao, Chun Yang, Kun Zhou, Baozhong Shen, Hongyan Liang, Xiaofeng Jiang

“…A subgroup analysis was also carried out to compare the urinary miR-126 level in T2DM patients well controlled by the treatment versus those who were not well controlled. …”
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Advances in chromosomal microarray analysis: Transforming neurology and neurosurgery by Wireko Andrew Awuah, Muhammad Hamza Shah, Vivek Sanker, Krishitha Meenu Mannan, Sruthi Ranganathan, Princess Afia Nkrumah-Boateng, Mabel Frimpong, Kwadwo Darko, Joecelyn Kirani Tan, Toufik Abdul-Rahman, Oday Atallah

“…Over the past two decades, genomics has transformed our understanding of various clinical conditions, with Chromosomal Microarray Analysis (CMA) standing out as a key technique. Offering unparalleled sensitivity, CMA detects submicroscopic chromosomal imbalances, enabling the examination of DNA for copy number variations, deletions, duplications, and other structural differences. …”
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Chronic non-communicable diseases in patients and families with retinitis pigmentosa by Raisa Hernández Baguer, Raisa Ivis Beltràn Saìnz, Asunciòn Fortunata Rodrìguez Morris, Dagmara Magdalena Cordero Ruiz, Loida Mevis Savòn George, Bàrbara Cid Vàzquez

“…<br /><strong>Methods:</strong> descriptive, prospective study carried out between March 2016-March 2022, with non-probabilistic and intentional sampling. …”
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Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment. …”
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Improving quality and outcomes of extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest: the Phoenix ECPR project by Michael Taylor, Vasileios Panoulas, Jill Smith, Alex Rosenberg, Mark Mason, Ian McGovern, Majid Akhtar, Sachin Mehta, Waqas Akhtar, Anthony McKay, Sumesh Thiruthalil, Orinta Kviatkovske, Donna Hall, Eftychia Galiatsou, Sofia Pinto, Maria Comanici, Emanuele Gerlando, Timothy Pitt, Joe Hughes, Olaf Maunz, Elia Keating, Julia Gangata, Eleanor Ross, Sophie Avetoom, Jane Durrant, Ciara Collins, Anand Jothidasan, Maria Monteagudo-Vela, Jerry Mitchell, Hatem Soliman Aboumarie, Caroline Bullen, Sundeep Kaul, Clara Hernandez Caballero, Ana Hurtado, Nick Lees

“…A new structured system including a systematic screening process, strict exclusion criteria, assessment of resuscitation adequacy through physiological stop criteria, drilled and standardised cannulation process, post-resuscitation care and neuroprognostication was rolled out on 1 April 2023. A comparison of ECPR performed pre and post was undertaken.Results With the institution of the new system, 13 patients were treated with ECPR over 1 year; of which nine (69.2%) survived with good neurological outcomes at 6 months. …”
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PRA Melting-ICE Project: Svalbard 2022 Expeditions Report [version 1; peer review: 2 approved] by Enrico Maiero, Elisa Baldrighi, Riccardo Cerrato, Delia Segato, Massimiliano Vardè, Mauro Mazzola, Iain Rudnik, James Bradley, Margaret Cramm, Angelina Cordone, Stefano Caliro, Donato Giovannelli, Francesco Montemagno, Carlo Cardellini, Martina Cascone, Elena Manini, Jacopo Pasotti

“…This report describes three specific expeditions performed on the Svalbard archipelago, carried out within the framework of the PRA (Italian Arctic Research Program) project Melting-ICE, performed between February and October 2022, reporting site characteristics and samples collected. …”
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Adaptive High-Performance Optimization Tool for Real-Time Operation of Renewable-Based Virtual Power Plants by Oluwaseun Oladimeji, Alvaro Ortega, Lukas Sigrist, Bogdan Marinescu, Vinu Thomas

“…Real-time implementation of the operation framework is carried out using OPAL-RT real-time simulator, verifying the RVPP&#x2019;s ability to meet the demands of real-time applications effectively. …”
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Impact of the COVID-19 Pandemic on Radiotherapy Supply by Francesco Tramacere, Artor Niccoli Asabella, Maurizio Portaluri, Corinna Altini, Cristina Ferrari, Lilia Bardoscia, Angela Sardaro

“…Among these, 18 cancelled their appointment. 42 patients asked to postpone their procedure. Twenty-seven out of 42 adduced directly or indirectly SARS-CoV-2 infection-related reasons. …”
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Classifying Food Items During an Eating Occasion: A Machine Learning Approach with Slope Dynamics for Windowed Kinetic Data by Ileana Baldi, Corrado Lanera, Mohammad Junayed Bhuyan, Paola Berchialla, Luca Vedovelli, Dario Gregori

“…The performance of the classifiers was expressed in out-of-bag sensitivity and specificity. Results: Acceleration along the x-axis and power show the highest and lowest rates of median variable importance, respectively. …”
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Effect of Temperature on Synthesis of Hydroxyapatite/Chitosan Composite Using the <i>In-Situ</i> Method as a Heavy Metal Adsorbent by Novesar Jamarun, Tri Yupi Amirullah, Syukri Syukri, Arika Prasejati, Wulandari Wulandari, Sintia Caniago, Nabiila Ayyu Tricahyani

“…This research proves that the adsorption of Cu2+ and Pb2+ ions by HAp/CTS composite adsorbent has been successfully carried out.…”
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Research on shale dynamic and static elastic modulus and anisotropy based on pressurization history by Di Zhang, Di Zhang, YaFeng Li, YaFeng Li, YaNan Guo, YaNan Guo, HanLin Xia, HanLin Xia, YanXin Liu, YanXin Liu, JiaShen Yan, JiaShen Yan, Fei Wang, YinTing Wu

“…It is of great practical significance to carry out experiments on dynamic and static elastic parameters of rocks under reservoir conditions and determine the conversion relationship between dynamic and static elastic parameters. …”
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Adapting to ulcerative colitis to try to live a ‘normal’ life: a qualitative study of patients’ experiences in the Midlands region of England by Rachel Cooney, Christel McMullan, Dmitri Nepogodiev, Laura Magill, Thomas D Pinkney, Jonathan M Mathers, Laura L Jones, Shri Pathmakanthan

“…Over time patients test out a variety of non-medical adaptation strategies. …”
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Monitoring Unfractionated Heparin in Adult Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO): ACT, APTT, or ANTI-XA? by Tung Phi Nguyen, Xuan Thi Phan, Dai Quang Huynh, Ha Thi Viet Truong, Yen Nguyen Hai Le, Tuan Manh Nguyen, Quan Quoc Minh Du, Thao Phuong Le, Hai Ngoc Truong, Thi Thi Ho, Thao Thi Ngoc Pham

“…Results. 129 sets of measurements from 37 patients were obtained including ACT, APTT, anti-Xa, antithrombin, and UFH dose measured simultaneously. 102 out of 129 sets of values were interpreted as antithrombin deficiencies. …”
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A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipi... by Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende

“…Here we have characterized six PPP2R5D commercial antibodies for Western Blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. …”
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Health and social care use, costs, and satisfaction among key workers accessing Resilience Hub support during the COVID-19 pandemic by Aleix Rowlandson, Filippo Varese, Linda M. Davies, Paul French, Kate Allsopp, Lesley-Anne Carter, Daniel Hind, Katherine McGuirk, Alan Barrett, Gita Bhutani, Fay Huntley, Joanne Jordan, May Sarsam, Hein Ten Cate, Holly Walker, Ruth Watson, Jack Wilkinson, Jenni Willbourn, Gemma E. Shields

“…Satisfaction was high, with median helpfulness rated 92 (out of 100), and many stating that Hubs either fully (148/299, 49.5%) or partially (54/299, 18.1%) met their needs. …”
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Effect of ecological restoration on physicochemical properties, bacterial and fungal communities of red sand soil in Longquan Mountain forest park by Yan Wang, Yu-Long Zhang, Rui Zhang, Cai-Xia Li, Xian-Jun Lai, Xin-Rong Ma

“…For the construction of Longquan Mountain Forest Park, ecological restoration was carried out, which involved mixing pastoral soil and biochar into the milled shale, introducing earthworms, and phytoremediation. …”
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A novel proficiency test to assess the animal diagnostic investigation process in identifying an unknown toxicant by Andriy Tkachenko, Yang Chen, Marissa Petrey, Scott Fritz, Tim Walsh, David Rotstein, Megan R. Miller, Bruce Williams, Michael Dark, Matthew Kmet, Ravinder Reddy, Gregory Tyson, Sarah M. Nemser

“…Thirteen of 14 VDLs successfully diagnosed lead toxicosis by completing the following stages: (a) correctly identifying histological abnormalities, (b) providing three adequate differential diagnoses, (c) selecting adequate chemistry analyses to rule in or rule out possible causes, (d) accurately detecting lead concentration in the liver, and (e) interpreting the diagnostic significance of their results correctly. …”
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Earth Detecting Earth: At What Distance Could Earth’s Constellation of Technosignatures Be Detected with Present-day Technology? by Sofia Z. Sheikh, Macy J. Huston, Pinchen Fan, Jason T. Wright, Thomas Beatty, Connor Martini, Ravi Kopparapu, Adam Frank

“…., planetary radar) beating out its nearest nonradio competitor by a factor of 10 ^3 in detection distance. …”
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Additive manufacturing of continuous carbon fiber reinforced PETG with ultra-high interlaminar shear strength by Wenbo Wang, Yong Hu, Lei Yang, Yudong Lin, Lei Zhou, Jiayun Ma, Bing Liu, Xuan Cai, Chunze Yan, Yusheng Shi, Xiyong Chen

“…Finally, the mechanism analysis of the above improvement and parameter optimization is carried out by relative density and surface morphology. …”
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