Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Additionally, we identified unique immune signatures associated with smoking, obesity, and diseases such as osteoporosis, heart failure, and gout. Interpretation: This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. …”
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Effect of Chloroform Extraction Site of Jiangu Granule on Obteoblast Differentiation <italic>in Vitro</italic> via BMP2/Smad1/Runx2/Osterix Signaling Pathway by ZHOU Fen, SUN Yuqing, SUN Pan, ZHANG Chutian, YANG Juan, LIN Yanping

“…It suggested that the chloroform extraction site of Jiangu Granules could promote the differentiation of osteoblasts by regulating the BMP2/Smad1/Runx2/Osterix pathway, so as to prevent and treat postmenopausal osteoporosis.…”
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Circulating Baseline CXCR3+Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis by Julia M. Scheffler, Christina Drevinge, Catharina Lindholm, Inger Gjertsson, Kristina Lend, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Tuulikki Sokka‐Isler, Dan Nordström, Kim Hørslev‐Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Ronald vanVollenhoven, Hans Carlsten, Mattias Lorentzon, Anna‐Karin Hultgård Ekwall, Anna Rudin, Ulrika Islander

“…Objective The high prevalence of osteoporosis in rheumatoid arthritis (RA) is due to inflammation that stimulates differentiation of osteoclasts, a process involving circulating monocytes and T cell–derived factors. …”
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Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast by Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu’e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu

“…Exposure to perfluorooctane sulfonate (PFOS) has been associated with lower bone density and the occurrence of osteoporosis in human studies, but the effects and mechanisms of PFOS induces bone loss is not well understood. …”
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Recent advances in the role of high-salt diet in anti- and pro-cancer progression by Shiwei Tang, Juan Xu, Ping Wan, Ping Wan, Ping Wan, Shumen Jin, Ying Zhang, Ying Zhang, Linting Xun, Linting Xun, Jinli Wang, Jinli Wang, Mei Luo, Mei Luo, Wenjie Chen, Wenjie Chen, Zan Zuo, Zan Zuo, Zan Zuo, Hui Tang, Hui Tang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi

“…Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosis. However, recent studies have uncovered a novel aspect of HSD, suggesting that HSD may inhibit tumor growth in specific pathological conditions by modulating the activity of immune cells that infiltrate tumors and enhancing the effectiveness of PD-1 immunotherapy. …”
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Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration by Peisheng Liu, Hao Guo, Xiaoyao Huang, Anqi Liu, Ting Zhu, Chenxi Zheng, Fei Fu, Kaichao Zhang, Shijie Li, Xinyan Luo, Jiongyi Tian, Yan Jin, Kun Xuan, Bingdong Sui

“…Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. Collectively, our findings provide insights into Golgi regulation in stem cell senescence and bone aging, which further highlight CA-EVs as a potential rejuvenative approach for aging bone regeneration.…”
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Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study by Johan Burisch, Lene Terslev, Mikkel Østergaard, Annette Bøjer Jensen, Frank Krieger Jensen, Flemming Bendtsen, Charlotte Wiell, Mohamed Attauabi, Klaus Theede, Viktoria Fana, Hartwig Roman Siebner, Henrik S Thomsen, Jakob M Møller, Simon Francis Thomsen, Gorm Roager Madsen, Anne Vibeke Wewer, Rune Wilkens, Johan Ilvemark, Nora Vladimirova, Sanja Bay Hansen, Yousef Jesper Wirenfeldt Nielsen, Helene Andrea Sinclair Ingels, Trine Boysen, Jacob T Bjerrum, Christian Jakobsen, Maria Dorn-Rasmussen, Sabine Jansson, Yiqiu Yao, Ewa Anna Burian, Frederik Trier Møller, Kristina Bertl, Andreas Stavropoulos, Jakob B Seidelin

“…Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.Ethics and dissemination This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). …”
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