Establishment and Evaluation of a Moderate-to-Severe Knee Osteoarthritis Model in Rats Induced by Surgery by SUN Xiaorong, SU Dan, GUI Wenjuan, CHEN Yue

“…Micro-CT observations revealed irregular joint surfaces, osteophyte formation, and signs of osteoporosis in both the 8-week and 20-week model groups, with the 20-week model group showing more loose bodies around the knee joints. …”
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Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene by Yanming Cao, Bin Wang, Ding Wang, Dongxiang Zhan, Caiyuan Mai, Peng Wang, Qiushi Wei, Yamei Liu, Haibin Wang, Wei He, Liangliang Xu

“…The aim of this study is to investigate the involvement of CpG methylation in regulation of SOST expression in patients with primary osteoporosis. Methods. The diagnosis of osteoporosis was established on the basis of dual energy X-ray absorptiometry to measure BMD. …”
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Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study by Juan Wu, Xin-yu Liang, Lei Hu, Ying Li, Liang Ran, Rui-ling She, Xiu-quan Qu, Bai-qing Peng, Kai-nan Wu, Jing Wang, Ling-quan Kong

“…Vitamin D deficiency/insufficiency, osteopenia, and osteoporosis were highly prevalent among newly diagnosed female BC patients. …”
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FOXG1 promotes osteogenesis of bone marrow-derived mesenchymal stem cells by activating autophagy through regulating USP14 by Yiqi Zhang, Long Zhou, Qin Fu, Ziyun Liu

“…Abstract The osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) is key for bone formation, and its imbalance leads to osteoporosis. Forkhead Box Protein G1 (FOXG1) is associated with osteogenesis, however, the effect of FOXG1 on osteogenesis of BMSCs and ovariectomy (OVX)-induced bone loss is unknown. …”
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The Current Role of Osteoclast Inhibitors in Patients with Prostate Cancer by Diomidis Kozyrakis, Dionyssios Paridis, Stefanos Perikleous, Konstantinos Malizos, Anastasios Zarkadas, Antonios Tsagkalis

“…DEN and ZA have proved their efficacy in preventing osteoporosis and bone mass loss in patients treated with hormonal therapy with no proven superiority of one agent over the other. …”
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Bisphophonates in CKD Patients with Low Bone Mineral Density by Wen-Chih Liu, Jen-Fen Yen, Cheng-Lin Lang, Ming-Tso Yan, Kuo-Cheng Lu

“…Patients with chronic kidney disease-mineral and bone disorder (CKD-MBD) have a high risk of bone fracture because of low bone mineral density and poor bone quality. Osteoporosis also features low bone mass, disarranged microarchitecture, and skeletal fragility, and differentiating between osteoporosis and CKD-MBD in low bone mineral density is a challenge and usually achieved by bone biopsy. …”
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A School-Based Exercise Intervention Program Increases Muscle Strength in Prepubertal Boys by Susanna Stenevi-Lundgren, Robin M. Daly, Magnus K. Karlsson

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Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis by Zhencheng Xiong, Ping Yi, Jialiang Lin, Shengfeng Qiu, Li Shu, Chi Zhang

“…Objective. Osteoporosis is an abnormal bone metabolism disease characterized by microstructural degeneration of bone tissue and reduction in bone mass, resulting in increased brittleness of bone tissue and susceptibility to fracture. …”
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RETRACTED ARTICLE: Emodin enhances osteogenesis and inhibits adipogenesis by Feng Yang, Pu-wei Yuan, Yang-Quan Hao, Zheng-Mao Lu

“…Abstract Background It has been suggested that the formation of osteoblasts in bone marrow is closely associated with adipogenesis, and the balance between osteogenesis and adipogenesis differentiation of MSCs (mesenchymal stem cells) is disrupted in osteoporosis. In order to improve the treatment of osteoporosis, available agents with roles of regulating the balance is highly desirable. …”
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Prevalence, comorbidities, and disease-related complications of rheumatoid arthritis in Colombia: a national cross-sectional study based on administrative claims data by Kevin Maldonado-Cañón, Giancarlo Buitrago, Gerardo Quintana-López

“…Lupus (30.04; 95%CI 29.3–30.8), multiple sclerosis (7.18; 95%CI 6.6–7.8), and osteoporosis (5.57; 95%CI 5.5–5.6) provided higher age- and sex-adjusted prevalence ratios. …”
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Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention by Xuan Lu, Ying Chen, Yue Shi, Yi Shi, Xianbin Su, Peijie Chen, Die Wu, Hui Shi

“…We further explore how exerkines combat aging-related diseases, such as type 2 diabetes and osteoporosis. By stimulating the secretion of these exerkines, exercise supports healthy longevity by promoting tissue homeostasis and metabolic balance. …”
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Denosumab-Induced Severe Hypocalcaemia in Chronic Kidney Disease by Ryan Jalleh, Gopal Basu, Richard Le Leu, Shilpanjali Jesudason

“…Hypocalcaemia is increasingly recognized as a complication of denosumab use in Chronic Kidney Disease (CKD) patients with osteoporosis. Despite Therapeutic Goods Administration (TGA) notifications in 2013, we have subsequently encountered several cases of denosumab-induced hypocalcaemia, raising concern about lack of widespread awareness among prescribing practitioners. …”
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Risk Factors for Worsening of Bone Loss in Patients Newly Diagnosed with Inflammatory Bowel Disease by Yi Yin, Xiaofeng Lu, Zhun Li, Song Liu, Lihua Shao, Lei Cao, Rui-Qing Liu, Liang-Yu Huang, Zhen-Xing Zhu, Zhen Guo, Yi Li, Wei-Ming Zhu

“…A total of 639 patients newly diagnosed with IBD that had at least one DXA were included in the cross-sectional study. Osteopenia and osteoporosis were diagnosed in 24.6% and 5.4% of patients, respectively. …”
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Thoracolumbar spine fracture patterns, etiologies, and treatment modalities in Jordan by Ahmad Almigdad, Sattam Alazaydeh, Mohammad Bani Mustafa, Mu'men Alshawish, Anas Al Abdallat

“…However, 70% of spine fractures in women were caused by simple falls, reflecting the high prevalence of osteoporosis among women and the elderly. Therefore, traffic and work safety measures, as well as home safety measures and osteoporosis treatment for the elderly, should be recommended to reduce the risk of spine fractures.…”
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Activated B Lymphocyte Inhibited the Osteoblastogenesis of Bone Mesenchymal Stem Cells by Notch Signaling by Mengxue Pan, Wei Hong, Ye Yao, Xiaoxue Gao, Yi Zhou, Guoxiang Fu, Yuanchuang Li, Qiang Guo, Xinxin Rao, Peiyuan Tang, Shengzhi Chen, Weifang Jin, Guoqiang Hua, Jianjun Gao, Xiaoya Xu

“…Osteoporosis did not happen in SPX rats which is still companied with a high increase of B lymphocytes. …”
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Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone marrow by Elin Svedlund Eriksson, Marta Lantero Rodriguez, Bente Halvorsen, Inger Johansson, Anna K. F. Mårtensson, Anna S. Wilhelmson, Camilla Huse, Thor Ueland, Pål Aukrust, Kaspar Broch, Lars Gullestad, Brage Høyem Amundsen, Geir Øystein Andersen, Mikael C. I. Karlsson, Malin Hagberg Thulin, Alessandro Camponeschi, Dana Trompet, Ola Hammarsten, Björn Redfors, Jan Borén, Elmir Omerovic, Malin C. Levin, Andrei S. Chagin, Tuva B. Dahl, Åsa Tivesten

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Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus by Dian-dian Zhao, Pei-lin Jiao, Jing-jia Yu, Xiao-jing Wang, Lin Zhao, Yan Xuan, Li-hao Sun, Bei Tao, Wei-qing Wang, Guang Ning, Jian-min Liu, Hong-yan Zhao

“…Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. …”
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Improvement of Lumbar Bone Mass after Infliximab Therapy in Crohn’s Disease Patients by Marina Mauro, Vladimir Radovic, David Armstrong

“…BACKGROUND: Patients with Crohn’s disease (CD) have a high risk of developing osteoporosis, but the mechanisms underlying bone mass loss are unclear. …”
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Bone Health by Jacob Young, Jennifer Hillan

“…People who don’t get enough calcium or vitamin D are at risk for osteoporosis: weak bones that are more likely to fracture.” …”
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Bone Health by Jacob Young, Jennifer Hillan

“…People who don’t get enough calcium or vitamin D are at risk for osteoporosis: weak bones that are more likely to fracture.” …”
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