Role of Vitamin D in Cardiometabolic Diseases by Chaoxun Wang

“…Low vitamin D levels have long been associated with bone diseases, such as rickets in children and osteomalacia and osteoporosis in adults. However, it has become apparent in recent years that adequate vitamin D levels are also important for optimal functioning of many organs and tissues throughout the body, including the cardiovascular system. …”
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Sarcopenia and Its Implications for Metabolic Health by Gary R. Hunter, Harshvardhan Singh, Stephen J. Carter, David R. Bryan, Gordon Fisher

“…Sarcopenia not only affects the ability to lead an active lifestyle but also contributes to increased obesity, reduced quality of life, osteoporosis, and metabolic health, in part due to reduced locomotion economy and ease. …”
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans by Michela Palmieri, Spyridoula Maraka, Horace J. Spencer, Jeff D. Thostenson, Katherine Dishongh, Micheal Knox, Betty Ussery, Jesse Byrd, Jacqueline K. Kuipers, Sanaz Abedzadeh-Anaraki, Chitharanjan Duvoor, Yuanjie Mao, Lakshmi Menon, James S. Williams, Stavros C. Manolagas, Robert L. Jilka, Elena Ambrogini

“…These results raise the possibility that higher levels of anti-PC IgM in patients with lower BMD reflect exposure to higher levels of PC-OxPLs, which are known to affect bone mass, and could be a novel risk marker for osteoporosis.…”
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Melatonin Rescued Reactive Oxygen Species-Impaired Osteogenesis of Human Bone Marrow Mesenchymal Stem Cells in the Presence of Tumor Necrosis Factor-Alpha by Xianjian Qiu, Xudong Wang, Jincheng Qiu, Yuanxin Zhu, Tongzhou Liang, Bo Gao, Zizhao Wu, Chengjie Lian, Yan Peng, Anjing Liang, Peiqiang Su, Dongsheng Huang

“…Accordingly, these findings provide more evidence that melatonin can be used as a candidate drug for the treatment of osteoporosis.…”
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T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis by Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D

“…Our data underscore the substantive role of T cell-derived ApoEVs to treat osteoporosis, thus providing new ideas for the development of ApoEVs-based therapies in tissue regeneration. …”
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TZDs and Bone: A Review of the Recent Clinical Evidence by Ann V. Schwartz

“…Research is needed to better understand the mechanisms of bone loss with TZDs, to identify factors that influence susceptibility to TZD-induced osteoporosis, and to test treatments for its prevention.…”
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Application of bone turnover markers in skeletal and extra-skeletal conditions in children and adults by Agnieszka Postępska, Przemysław Sikora

“…BTMs have found applications as research and clinical tools in a wide range of skeletal and extra-skeletal conditions, including diagnosis and treatment of osteoporosis. Unfortunately, their utility in routine clinical practice, especially in children, is still limited due to heterogenous methodo­logy, intra- and inter patient variability, and a paucity of accurate reference ranges and approved guidelines. …”
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Sarcopenia in Type 2 Diabetes Mellitus: A Cross-Sectional Observational Study by L. M. Pechmann, T. H. Jonasson, V. S. Canossa, H. Trierweiler, G. Kisielewicz, R. R. Petterle, C. A. Moreira, V. Z. C. Borba

“…Patients with T2DM presenting with albuminuria, osteoporosis, and increased %TF were more likely to have sarcopenia. …”
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Risk Factors for Fracture in Patients with Coexisting Chronic Kidney Disease and Type 2 Diabetes: An Observational Analysis from the CREDENCE Trial by Tamara K. Young, Nigel D. Toussaint, Gian Luca Di Tanna, Clare Arnott, Carinna Hockham, Amy Kang, Aletta E. Schutte, Vlado Perkovic, Kenneth W. Mahaffey, Rajiv Agarwal, George L. Bakris, David M. Charytan, Hiddo J. L. Heerspink, Adeera Levin, Carol Pollock, David C. Wheeler, Hong Zhang, Meg J. Jardine

“…Fracture prediction was not improved by models built on alternative pathophysiology hypotheses compared with traditional osteoporosis predictors.…”
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Sarcopenia: ¿Otra epidemia silenciosa? by Margarita Duarte

“…En la Reumatología, el concepto de sarcopenia se utiliza desde hace varias décadas en la evaluación del paciente con alto riesgo de fracturas, relacionándolo casi siempre con una de las epidemias silenciosas de más alto impacto en la calidad de vida en las personas de la tercera edad, que es la osteoporosis. Sin embargo, en los últimos años, la sarcopenia se ha erigido por su propio peso en una entidad independiente, que puede presentarse a cualquier edad, y cuyos alcances superan ampliamente la salud musculoesquelética. …”
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Safety of proton pump inhibitors by Ye. A. Losik

“…The interrelation between PPI intake and osteoporosis development is of special interest. Cases of the PPIassociated acute interstitial nephritis are presented. …”
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The Practice of Scottish Urologists in the Assessment and Management of Fracture Risk in the Ageing Male being Treated for Prostate Cancer by Wee Sing Ngu, Derek J. Byrne

“…Various methods were used in the prophylaxis and treatment of osteoporosis, including avoidance of castration type therapy and the use of bisphosphonates and bicalutamide along with castration-type therapy. …”
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Contemporaneous Insufficiency Fractures of Bilateral Femoral Necks in an Older Patient Taking Bisphosphonate: A Case Report and Literature Review by Hiroaki Tagomori, Nobuhiro Kaku, Shota Sato, Tsuguaki Hosoyama, Hiroshi Tsumura

“…A 74-year-old woman with osteoporosis was taking raloxifene hydrochloride and bisphosphonate for approximately 5 and 3 years, respectively. …”
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In Vitro Assay to Examine Osteoclast Resorptive Activity Under Estrogen Withdrawal by Cara Fiorino, Safia Omer, Nisha Gandhi, Rene Harrison

“…Hyperactivation of the bone-degrading cells, the osteoclasts (OCs), occurs in disease conditions and hormonal changes in females, resulting in osteoporosis, a disease characterized by altered microarchitecture of the bone tissue, and increased bone fragility. …”
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Denosumab as the Treatment of Recalcitrant Tuberculous Pleural Effusion-Associated Hypercalcemia by Afdhal Afiq Abd Jalil, Sharifah Faradila Wan Muhamad Hatta, Aimi Fadilah Mohamad, Mohammed Fauzi Abdul Rani

“…It has mainly been used in the treatment of osteoporosis for a variety of causes especially in situations refractory to bisphosphonates or when kidney function is impaired. …”
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Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology by Stefano Lello, Andrea Cavani

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Blockchain-enabled digital twin system for brain stroke prediction by Venkatesh Upadrista, Sajid Nazir, Huaglory Tianfield

“…The application can be extended to monitor other pathologies such as heart attacks, cancers, osteoporosis, and epilepsy with minimal configuration changes.…”
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Haemothorax and Thoracic Spine Fractures in the Elderly by Michael A. Masteller, Aakash Chauhan, Harsha Musunuru, Mark M. Walsh, Bryan Boyer, Joseph A. Prahlow

“…In this paper, we discuss two cases where seemingly insignificant low-energy trauma precipitated massive haemothoraces in elderly patients with underlying osteoporosis, ultimately resulting in their immediate causes of death. …”
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Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells by Aofei Yang, Chaochao Yu, Qilin Lu, Hao Li, Zhanghua Li, Chengjian He

“…Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. …”
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Possible Health Implications and Low Vitamin D Status during Childhood and Adolescence: An Updated Mini Review by Dimitrios Papandreou, Pavlos Malindretos, Zacharoula Karabouta, Israel Rousso

“…While insufficiency of vitamin D is a significant contributing factor to risk of rickets in childhood, it is possible that a more marginal deficiency of vitamin D during life span contribute to osteoporosis as well as potentially to the development and various other chronic diseases such as cardiovascular disease, cancer and diabetes. …”
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