Assessment of Antiretroviral Treatment Adherence among Children Attending Care at a Tertiary Hospital in Southeastern Nigeria by Cletus Akahara, Emeka Nwolisa, Kelechi Odinaka, Seline Okolo

“…There was a significant relationship between adherence and patient educational level (p=0.004), duration of treatment (p=0.001), drug administrator (p=0.005), and orphan status (p=0.001). The motivating factor for adherence was “not falling sick as before” while stigma was the most discouraging factor. …”
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Etude de cas : la bipédie des chimpanzés de la communauté de Sebitoli, Ouganda by Lise Pernel, Brigitte Senut, Dominique Gommery, John Paul Okimat, Edward Asalu, Sabrina Krief

“…In contrast, most (11) of the orphan chimpanzee's bipedal behaviours involved carrying or handling objects. …”
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FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis by Hansle Kim, Sudeep Kumar, Keesook Lee

“…Biosynthesis of testosterone occurs mainly in the testicular Leydig cells. Nur77, an orphan nuclear receptor that is expressed in response to the luteinizing hormone/cyclic adenosine monophosphate (LH/cAMP) signaling pathway, is one of the key factors that regulate steroidogenesis in Leydig cells. …”
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Assessment of genetic variability in oat (Avena sativa L.) germplasm using agro-morphological traits and microsatellite markersParameshwaran Mathavaraj1, Prasanta Kumar Goswami1,... by Parameshwaran Mathavaraj1, Prasanta Kumar Goswami1, Seuji Bora Neog2 and Akhil Ranjan Baruah3

“…We identified 665 potential microsatellites using 1000 contigs from NCBI and designed possible primer pairs to develop PCR-based markers in orphan crop like oats. Validation with a panel of 31 diverse genotypes revealed that seven of ten newly developed markers detected expected alleles, with four being polymorphic. …”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…In this review, I have discussed a limited number of targets including non-oncogene addiction genes such as Sp transcription factors, reactive oxygen species (ROS) or the orphan nuclear receptor 4A (NR4A) sub-family. Thus, the most active compound for these responses could be used only for treating patients that are ROS-inducible or highly express targets such as Sp1 or NR4A sub-family members. …”
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LAMA2 Congenital Muscle Dystrophy: A Novel Pathogenic Mutation in Bulgarian Patient by Ivanka Dimova, Ivo Kremensky

“…The exact molecular and clinical diagnoses, respectively, are a prerequisite for the most effective treatment; sometimes orphan drugs exist for some rare diseases. One of such drugs is Tarix, which was FDA approved and announced in 2016 for treatment of MDC1A. …”
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Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C by Hala O. El-Mesallamy, Nadia M. Hamdy, Hanan H. Rizk, Abdel-Rahman El-Zayadi

“…Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. …”
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Wilson’s Disease: Diagnosis of Wilson’s Disease in Ethiopian Young Sisters by Nebiyu Bekele, Frew Ewnetu, Tigest Hailu, Zerubabel Tegegne, Abilo Tadesse

“…Wilson’s disease, declared to be an orphan disease, requires clinical acumen of physicians and expensive investigation modalities for prompt recognition and is inaccessible as required, lifelong drugs for treatment.…”
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Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review by Patrycja Kurowska, Alix Barbe, Marta Różycka, Justyna Chmielińska, Joelle Dupont, Agnieszka Rak

“…Apelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and immune function were described. …”
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Consejos a la familia para evitar la aparición de la tartamudez by Dailys García Morales, Yanet Morejón Barrueto

“…--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <!…”
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Heterogeneous Network-Based Chronic Disease Progression Mining by Chenfei Sun, Qingzhong Li, Lizhen Cui, Hui Li, Yuliang Shi

“…In this paper, we propose a heterogeneous network-based chronic disease progression mining method to improve the current understanding on the progression of chronic diseases, including orphan diseases. The method also considers the different medication stages of the same chronic disease. …”
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Diverse Molecular Genotypes of Mycobacterium tuberculosis Complex Isolates Circulating in the Free State, South Africa by Anneke Van der Spoel van Dijk, Pakiso M. Makhoahle, Leen Rigouts, Kamaldeen Baba

“…In addition, SpolDB3/RIM assignment of the orphan strains resulted in a further 10 LAM and 13 T families. …”
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Tumor renal by Yarisdey Corrales Hernández, Noelia Castro Ladrón de Guevara

“…--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <!…”
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Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis... by Spyros I. Papamichos, Dimitrios Margaritis, Ioannis Kotsianidis

“…MYEOV represents a Primate Orphan Gene that acquired, via ORF expansion, a human-protein-specific coding potential.…”
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Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice by Hao Liu, Yiwen Li, Yujiao Zhu, Lei Ma, Haibo Xue

“…HE staining, IHC staining, flow cytometry, RT-qPCR, and ELISA were used to evaluate the degrees of thyroiditis, detect the percentage of Th17 cells and measure the expression of retinoic acid-related orphan receptor gamma t (RORγt), interleukin-17A (IL-17A), and the main components of the Notch signaling pathway. …”
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Genome assembly and population analysis of tetraploid marama bean reveal two distinct genome types by Jin Li, Christopher Cullis

“…Abstract Tylosema esculentum (marama bean), an underutilized orphan legume native to southern Africa, holds significant potential for domestication as a rescue crop to enhance local food security. …”
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Protective Effect of Thalidomide on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis in Rats via the Inhibition of T Helper 17 Cells by Ying Xie, Dandan Li, Xiaoshuang Luan, Shuang Jin, Bo Yan, Feng Tian

“…The colonic protein and mRNA expression levels of interleukin-6 (IL-6), IL-17, IL-23, and retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt) were determined using immunohistochemistry, western blot, and qRT-PCR. …”
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Childhood violence exposure and its contributing factors in Indonesia: a secondary data analysis of the National Survey on Children and Adolescents’ Life Experience by Dwi Octa Amalia, Sabarinah Sabarinah, Kemal N Siregar, Ella Nurlaella Hadi

“…The independent variables included gender, education level, occupation, living arrangement, orphan status, witnessing violence, marital status and residence. …”
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Ruptured Noncoronary Sinus of Valsalva Aneurysm by Amaury Dagoberto Martínez Hernández, Dayana Pino Jiménez

“…--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <!…”
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Value contribution of leniolisib in the Treatment of Activated PI3Kδ syndrome (APDS) in Spain using Multi-Criteria Decision Analysis (MCDA) by María Reyes Abad, Carmen Alerany, Luis Ignacio Gonzalez, Olaf Neth, Concepción Payares-Herrera, Carlos Rodríguez-Gallego, Jose Luis Trillo, Kirsten H. Herrmann, Raquel Figueiredo, Alicia Gil

“…An MCDA framework tailored for Orphan Drugs (ODs), consisting of 5 comparative and 2 quantitative non-comparative criteria, was used. …”
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