Poor outcome despite modern treatments: A retrospective study of 99 patients with primary and secondary plasma cell leukemia by Camille Tessier, Richard LeBlanc, Jean Roy, Sabrina Trudel, Julie Côté, Marc Lalancette, Jean‐Samuel Boudreault, Émilie Lemieux‐Blanchard, Rayan Kaedbey, Michel Pavic

“…Finally, our data suggested that sPCL originates from a high‐risk multiple myeloma (MM) population with a short OS (median 30.2 months), early relapse after stem cell transplant (median 11.9 months) and a high proportion of patients with multiple cytogenetic abnormalities (36% with ≥2 abnormalities). …”
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Using Dose-Effect Relationship for Optimising Systemic Corticosteroid Dosage in Treatment of Inflammatory Bowel Diseases by O. P. Alekseeva, S. V. Krishtopenko, A. A. Alekseeva

“…The dose-effect relationship for prednisone was constructed using an original method. The method realises an adequate statistical transformation of primary clinical data in form of a quantitative expression of factual doses and registered alternative responses established with endpoint criteria into a visual efficacy function graph suitable for downstream analyses. …”
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From Trinidad to Cyberspace: Reconsidering Ernst Toch’s “Geographical Fugue” by Carmel Raz

“…Finally, the afterlife of these features is explored in various contemporary remixes of Toch’s work on YouTube, and the ways in which contemporary possibilities of musical creation enable the work to return to a state that evokes its original context of technological experimentation. …”
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Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort by Jakob Höppner, Christoph Maier, Anne Schlegtendal, Anna Hoffmann, Astrid Petersmann, Thomas Lücke, Nicole Toepfner, Folke Brinkmann

“…In a subgroup (n = 259) SARS-CoV-2 antibody serology was further investigated. 789 participants of the original CorKID study cohort (n = 2.121; 37.2%) were included. 67.9% reported at least one SARS-CoV2 infection. 46.6% had received one or more SARS-CoV-2 vaccinations. …”
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Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017) by Mohammad Sajed Dehghan Banadaki, Vahid Rahmanian, Saeed Hosseini, Seyyed Mohammad Hossein Hosseini, Narjes Hazar

“…ABSTRACT Introduction An uncommon and diverse class of cancers originating from mesenchymal tissues is designated as soft tissue sarcoma (STS). …”
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Cultural adaptation of ENABLE (Educate, Nurture, Advise, Before Life Ends) an early palliative care model for Iranian patients with heart failure and their caregivers: a qualitativ... by Arvin Mirshahi, Ali Khanipour-Kencha, Marie Bakitas, J. Nicholas Odom, Rachel Wells, Arpi Manookian

“…Abstract Background ENABLE (Educate, Nurture, Advise, Before Life Ends) is a model of nurse-led, early palliative care that was originally developed for U.S. patients with advanced cancer and their family caregivers and then adapted for patients with heart failure. …”
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A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…In addition, we investigate which peculiar evolutionary forces could have acted at different loci given the genetic profile observed in populations. This gives us an original focus on MHC evolution and its mechanisms and helps us to understand the specificities of the human and chimpanzee lineages, respectively.…”
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OWN GOAL: COMPARISON OF MEDIAMETAPHORS IN UKRAINIAN AND POLISH JOURNALISM by Tetiana Faichuk, Іlona Myroshnichenko, Iryna Stohnii, Alla Vilchynska

“…The relevance of the topic is determined by the fact that metaphorical expressions, having a common origin in different languages, acquire unique shades of meaning depending on the context and national characteristics. …”
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Reconstrucción histórico-material y virtual para la conservación del retablo renacentista de San Juan Bautista (Antequera, España) by Beatriz Prado-Campos, Antonio-J. Sánchez-Fernández

“…El deficiente estado de conservación, tanto del muro al que se adosaba como de la predela, propició su desmontaje y almacenamiento a la espera de una restauración y remontaje posterior en su ubicación original. Al inicio de la investigación, el retablo desmembrado se hallaba fragmentado, disperso y descontextualizado de su entorno, teniendo algunos fragmentos destinos divergentes en lo que refiere a su historia material. …”
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Impact of invasive infections on clinical outcomes in acute pancreatitis: early predictive factors and implications for prophylactic anti-infective therapy by Fabienne Bender, Theresa König, Matthias Hecker, Moritz Fritzenwanker, Jacqueline Braun, Joern Pons-Kühnemann, Matthias Wolff, Andreas Hecker, Martin Reichert

“…Thus, an aggressive, early anti-infective strategy against pathogens of intestinal origin should be considered in these cases and may improve patient outcomes.…”
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Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence of Acinetobacter baumannii Isolates from Malaysia by Mohan Rao, Fairuz A. Rashid, Surianti Shukor, Rohaidah Hashim, Norazah Ahmad

“…The spread of this pathogen is largely due to its ability to acquire various resistance genes of intrinsic and extrinsic origins that confer unpredictable susceptibility to β-lactams. …”
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High speciation in the cryptic Pristimantis celator clade (Anura: Strabomantidae) of the Mira river basin, Ecuador-Colombia by Mario H. Yánez-Muñoz, Juan P. Reyes-Puig, Carolina Reyes-Puig, Gabriela Lagla-Chimba, Christian Paucar-Veintimilla, Miguel A. Urgiles-Merchán, Julio C. Carrión-Olmedo

“…Through detailed analyses of type material and expanded molecular sampling, we found that the original description actually included specimens representing two additional species, which are described herein. …”
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Development of a Solar-Powered Edge Processing Perimeter Alert System with AI and LoRa/LoRaWAN Integration for Drone Detection and Enhanced Security by Mateo Mejia-Herrera, Juan Botero-Valencia, José Ortega, Ruber Hernández-García

“…The evaluation results show notable progress in the acoustic detection of helicopters and drones under controlled conditions. Finally, all the original data presented in the study are openly available in an OSF repository.…”
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Linking employee voice to service recovery performance in the hotel sector: The mediating role of tacit knowledge sharing and employee innovation by Sultan Alzyoud, Waed Ensour, Ayman Harb

“…Furthermore, hotel managers are advised to establish clear expectations for employees regarding the significance of their opinions and insights, and recognize and reward innovative ideas that can hopefully enhance hotels’ performance. ORIGINALITY AND VALUE: This research provides new insights and contributes to the understanding of the role of employee voice, tacit knowledge sharing, and employee innovation in enhancing service recovery performance, particularly in acontext that has received little attention from researchers, which is the hotel sector, and in adeveloping country, Jordan. …”
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Spatial Distribution of Tsetse Flies and Trypanosome Infection Status in a Vector Genetic Transition Zone in Northern Uganda by Robert Opiro, Okello Allele Moses, Robert Opoke, Francis A. Oloya, Esther Nakafu, Teresa Iwiru, Richard Echodu, Geoffrey M. Malinga, Joel L. Bargul, Elizabeth A. Opiyo

“…The infection rate was not significantly associated with the sex of the fly (generalized linear model (GLM), χ2=0.051, p=0.821, df=1,n=477) and district of origin (χ2=0.611, p=0.434, df=1, n=477). However, trypanosome infection was highly significantly associated with the fly’s age based on wing fray category (χ2=7.56, p=0.006, df=1, n=477), being higher among the very old than the young. …”
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Mechanism of <italic>Hindu Datura</italic> in the Treatment of Rheumatoid Arthritis from the Perspective of Network Pharmacology by Changlong FU, Yangyang MEI, Xihai LI, Zhiwei QIU, Changxing CHEN, Chunsong ZHENG

“…Objective:To construct the active component target of <italic>Hindu datura</italic> and the disease target of rheumatoid arthritis by using network pharmacology, to predict the specific molecular signal and pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis, and to analyze its potential therapeutic target and molecular mechanism.Methods:All the chemical components of <italic>hindu datura</italic> were summarized and screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)database, retrieval was performed with the preset oral bioavailability(OB)≥30%and drug like(DL)≥0.18.Uniprot database was used to screen the entire correlation basis of the effective chemical compound.After screening the disease target with"rheumatoid arthritis"as the retrieval word using GeneCards and OMIM database, the superimposed target area between the drug target of <italic>hindu datura</italic> and the disease target of rheumatoid arthritis was summarized and analyzed, and it could be used as the prediction target gene of <italic>hindu datura</italic> for treating rheumatoid arthritis.Network targets were constructed and analyzed for the exported data based on Cytoscape 3.7.1 software and STRING 7.8 database.Finally, GO functional enrichment analysis and KEGG signal pathway analysis were performed to further screen the main targets and signal pathways.Results:①Through screening and analysis, 27 effective compounds, 318 corresponding target genes and 125 predicted target genes were obtained for the treatment of rheumatoid arthritis.②The core genes in PPI network mainly included JUN, AKT1, RELA, MAPK1, etc.③GO functional enrichment analysis showed that the biological process(BP)for the treatment of rheumatoid arthritis by <italic>hindu datura</italic> mainly involves response to lipopolysaccharide, response to lipopolysaccharide, response to molecule of bacterial origin, response to metalion, response to oxidative stress, response to steroid hormone, cellular response to oxidative stress, reactive oxygen species metabolic process, response to oxygen levels, etc..The cell component(CC)consisted of membrane raft, membrane region, plasma membrane raft and presynaptic membrane; molecular functions(MF)mainly involved the nuclear receptor activity, transcription factor activity(direct ligand regulated sequence-specific DNA binding), steroid hormone receptor activity, cytokine receptors, cytokine activity, DNA-binding transcription activator activity, RNA polymeraseⅡtranscription factor binding, kinase regulator activity, receptor ligand activity, etc.The analysis of KEGG signaling pathway showed that the obvious pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis may involve IL-17 signaling pathway, TNF signal pathway, HIF-1signalpathway, Toll-like receptor signal pathway, etc.Conclusion:The potential mechanism of <italic>hindu datura</italic> for the treatment of rheumatoid arthritis is to exert anti-inflammatory, analgesic and antioxidant effects, which involve a number of interactive signal pathways.…”
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D. I. BLOKHINTSEV – SCIENTIST AND TEACHER. THE SPIRITUAL FOUNDATIONS OF SCIENTIFIC WORK by V. N. Pervushin

“…Blokhintsev had the special, original point of view on spiritual bases of scientific creativity that was directly reflected in his research and pedagogical activity.There are two fundamental aspects of pedagogics. …”
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Characteristics and Source-specific Health Risks of Ambient PM2.5-bound PAHs in an Urban City of Northern Taiwan by Yu-Chieh Ting, Chun-Hung Ku, Yu-Xuan Zou, Kai-Hsien Chi, Jhy-Charm Soo, Chin-Yu Hsu, Yu-Cheng Chen

“…We utilized a positive matrix factorization (PMF) model, diagnostic ratios, and potential source contribution function (PSCF) to identify the origins of PM2.5-bound PAHs. The annual concentration of total PAHs (TPAH) was 0.79 ± 0.67 ng m−3 (range = 0.11–3.27 ng m−3). …”
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Top health service concerns: a data mining study of the Shanghai health hotline by Lili Shi, Tong Zhao, Shimiao Shi, Tianyu Tan, Aksara Regmi, Yuyang Cai

“…The findings of this study will provide a reference to relevant government departments and assist the government in optimizing the allocation of health resources.MethodsOur research utilized 16,962 original work orders from the 12,320 health hotline, collected since 2015. …”
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Social Media Potential and Impact on Changing Behaviors and Actions in Skin Health Promotion: Systematic Review by Justyna Martyna Brzozowska, Joanna Gotlib

“…The following qualification criteria were used: original research; research conducted on social media; and research topics regarding educational activities in skin health promotion, skin care, skin health, skin diseases, and skin protection. …”
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