Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…Conclusions Our study is the first to reveal that exosomal miR-126-3p, originating from endothelial cells, contributes to ion channel dysfunction by regulating RGS3 signaling in cardiomyocytes. …”
Get full text

Identification of serotype O3b and high-risk clone ST37 of Klebsiella pneumoniae revealed by comparative genomic analysis by Sivaraman Gopalan Krishnan, Sudha Sajeev, Visnuvinayagam Sivam, Raja Swaminathan T., Rakshit Ojha, Bibek Ranjan Shome, Mark Holmes, Thanigaivel Sundaram, Ramesh M. D., Saranya Vinayagam, Suseela Meesala, Tabarak Malik, Tabarak Malik, Pavan Kumar Dara

“…Furthermore, genomes of non-human origin that were submitted from India to the NCBI database were downloaded and included in the comparative analysis.ResultsThe findings showed that many antibiotic-resistant genes (ARGs) are prominent, including acrD, BaeR, cpxA, mdtB, mdtC, CRP, H-NS, KpnE, KpnF, KpnG, KpnH, acrA, acrB, marA, ramB, oqxA, oqxB, LptD, and emrR. …”
Get full text

Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…This study aimed to establish and characterize premalignant CM models from human donor eyes to recapitulate the cell populations at the origin of UM. Results Given the precious value of human donor eyes for studying multiple ocular cell types, we validated a co-isolation protocol of both human NCMs and retinal pigment epithelial (RPE) cells from a single eye. …”
Get full text

Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens by Zhihua Li, Md. Abul Kalam Azad, Chengwen Meng, Xiangfeng Kong, Jue Gui, Wenchao Lin, Yadong Cui, Wei Lan, Qinghua He

“…Abstract Background Meat originating from the spent hen is an important source of poultry meat production; however, multiple factors cause the decline in the meat quality of spent hens. …”
Get full text

Soviet Researchers on the Middle East: Ahead of Their Time by I. D. Zvyagelskaya

“…The theory of socialist orientation was based on original ideas of Marxism founders and further developed by Lenin who insisted that economically underdeveloped countries can with the help of the proletariat from advanced countries go directly to socialism bypassing capitalism.The reality of revolutions without the proletariat and the desire to take advantage of the anti-colonial struggle to establish full-scale presence of the USSR in the Middle Eats made the Soviet leadership more tolerant of scientists' attempts to realistically analyze regional trends and developments.For instance, in the Soviet era, politicians were tempted to explain all conflicts in the regions of the Third world, and particularly in the Middle East exclusively by the workings of imperialism. …”
Get full text

Non-formal encounters between Israeli families and African immigrant families foster lifelong learning competence by Michal Ganz Meishar

“…Everyone is troubled by similar issues of parenting, enjoyment of children, nutritious food and a shared desire to be good citizens while maintaining tolerance, reciprocity and respect. Originality/value – Non-formal encounters are actively performed to create belonging when the “others and we” join together for the community and the children. …”
Get full text

Persistent Gender and Racial Hierarchies: Marriage Migration and Mixedness in Morocco from the French Protectorate to the Present by Catherine Therrien, Catherine Phipps

“…This interdisciplinary approach combines historic data (primarily from a 1949 study into mixed marriages conducted by the colonial government as well as magazines, novels and memoirs) with 52 anthropological semi-structured interviews (conducted in Morocco between 2018 and 2022) with children of mixed couples and some of their parents.We examine first how the demographic make-up of mixed couples and where they choose to settle has shifted, looking at their gender split, their countries of origin, their occupations and where they met. This has diversified considerably throughout the 20th century: the individuals come from a much larger number of countries (no longer primarily Moroccan soldiers who returned from France with French women) and Moroccan women are now more likely to travel abroad. …”
Get full text

Evolution of human genes encoding cell surface receptors involved in the regulation of appetite: an analysis based on the phylostratigraphic age and divergence indexes by E. V. Ignatieva, S. A. Lashin, Z. S. Mustafin, N. A. Kolchanov

“…A large number of exogenous ligands of various origins, including drugs, are known for cell surface receptors, which accounts for interest in them from biomedical researchers. …”
Get full text

Socio-economic assessment of drought impacts in Lesotho: implications for early action by Relebohile Agnes Mojaki, Makoala Vitalis Marake, Evan Easton-Calabria, Joalane Rethabile Marunye, Erin Coughlan de Perez

“…Future humanitarian and policy interventions to prepare for droughts can use this evidence to identify the type of support that would be the most well-received by community members who are preparing for long-term drying trends in their region. Originality/value – The study presents an understanding of people’s opinions of the nature and state of drought impacts, which are key to any effort towards developing and implementing relevant anticipatory action interventions to minimise the impacts of drought.…”
Get full text

Community-based models of care for management of type 2 diabetes mellitus among non-pregnant adults in sub-Saharan Africa: A scoping review. by Emmanuel Firima, Lucia Gonzalez, Fabiola Ursprung, Elena Robinson, Jacqueline Huber, Jennifer M Belus, Fabian Raeber, Ravi Gupta, Gibrilla F Deen, Alain Amstutz, Bailah Leigh, Maja Weisser, Niklaus Daniel Labhardt

“…This model reported a higher linkage and engagement in care at 9 months compared to the corresponding facility model, but only slight reductions of average blood glucose levels at six months compared to baseline. 2) A facility-originated community model where after treatment initiation, a substantial part of follow-up was offered at community level. …”
Get full text

The Exordium of Adébáyọ̀ Fálétí’s Poetry by Adedotun Ogundeji

“…Four of the eleven narrative poems, (‘Ẹ̀là Lọrọ̀ ’, ‘̀ Ṣàṣọrẹ’, ‘Alágbára Ilé àti Alágbára Oko’, and ‘Agbódóro ́ - gun’) are adapted from the Ifá corpus and there are strong evidences that ìjálá (Ogun poetry/hunter’s) is the original source of the story retold in ‘Adébímpé Ojẹ̀dòkun’. …”
Get full text

Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors by Hongwei Zeng, Xiangyu E, Minghe Lv, Su Zeng, Yue Feng, Wenhao Shen, Wenhui Guan, Yang Zhang, Ruping Zhao, Jingping Yu

“…Dosimetric parameters of all OARs were significantly higher than those in the original treatment plan (P < 0.01). The sCT based adaptive LRT boost plan, when combined with CRT, significantly reduced the dose to OARs compared to CRT alone (P < 0.05). …”
Get full text

Un programme d’éducation à l’environnement en RDC : la malle pédagogique « les grands singes et leur habitat », présentation des résultats d’une campagne de sensibilisation en pays... by Louis Ledo, Jean Christophe Bokika Ngawolo, Samy Mankoto, Richard Dumez, Sabrina Krief

“…Les menaces sur cet habitat et sur cette espèce endémique sont toutes d’origine anthropique. L’éducation à l’environnement en sensibilisant les populations locales à leurs rôles dans la conservation apparaît comme un moyen de protéger ces écosystèmes. …”
Get full text

Results of replacing fish meal with insect protein in carp feeds by O. Deren, O. Bernakevych, L. Bobeliak, N. Hrytsyshyna, M. Koryliak

“…At the same time, a tendency for an increase in hemoglobin content and the count of erythrocytes in the blood of the experimental group compared to the control group was recorded. Originality.For the first time, the effectiveness of full or partial replacement of fish meal in carp feeds with black soldier fly meal was investigated according to a comprehensive analysis of productive, individual physiological and biochemical parameters of the fish body in the experimental groups. …”
Get full text

Ekstraksi Knowledge tentang Penyebaran #Ratnamiliksiapa pada Jejaring Sosial (Twitter) menggunakan Social Network Analysis (SNA) by Lyonly Tomasoa, Ade Iriani, Irwan Sembiring

“…The results of this research are the researcher had found the three key actors (creator and influencers) which originated from 5 main actors who spread #RatnaMilikSiapa tweet. …”
Get full text

The impact of attitude towards an e-tax system on tax compliance of Vietnamese enterprises: Adoption of an e-tax system as a mediator by Ha Thi Hai Do, Yen Thi Hai Mac, Hoa Thi Van Tran, Thuy Thi Le Nguyen

“…Besides, the research is conducted in the context of Vietnam, thus, it is a reference for studies in other developing countries having a similar economy or tax administration. ORIGINALITY/VALUE: This study contributes to enhancing research associated with tax compliance, especially investigating the mediating impact of adoption of an e-tax system in the association between attitude towards an e-tax system and tax compliance of enterprises in the context of Vietnam. …”
Get full text

Profil Penderita Penyakit Tuberkulosis Paru BTA Positif yang Ditemukan di BP4 Lubuk Alung periode Januari 2012 – Desember 2012 by Eni Yulvia Susilayanti, Irvan Medison, Erkadius .

“…Most are 21-30 years of age 23.2%. The area of origin mostly from Kab. Padang Pariaman 29.4%. The degree of sputum smear positivity mostly positive three (+3) was 44.2%. …”
Get full text

Magnetic hybrid chitin-horse manure humic acid for optimized Cd(II) and Pb(II) adsorption from aquatic environment by Rahmat Basuki, Yusuf Bramastya Apriliyanto, Elva Stiawan, Adya Rizky Pradipta, Bambang Rusdiarso, Budi Riza Putra

“…Based on Brunauer, Emmett, and Teller's (BET) theory, the HMHA-Ch-Fe3O4 specific surface area (52.26 m2/g) was higher than original HMHA (35.71 m2/g). The average pore size of HMHA-Ch-Fe3O4 (7.33 nm) was within the mesoporous range (2–50 nm). …”
Get full text

Assessing and Enhancing Nutrition and Physical Activity Environments in Early Childhood Education and Care Centers: Scoping Review of eHealth Tools by Joyce Hayek, Kelsi Dickson, Lynne M Z Lafave

“…The tools identified in the gray literature originated in Canada (4 tools, 57%) and the United States (3 tools, 43%). …”
Get full text

Evaluating the Cellophane Production Supply Chain Using Multi-Criteria Decision-Making Approaches by َAhmad Jafarnejad, Amir Mohammad Khani

“…Such efforts aim to safeguard the environment and uphold accountability. Originality/value: This study presented a comprehensive analysis and optimization of the cellophane supply chain using ISM and MCDM approaches. …”
Get full text