Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…The respiratory microbiota from individuals with COVID-19 demonstrated a statistically significant reduction in Shannon diversity and bacterial richness alongside an overall reduction in the prevalence of organisms from a typical healthy respiratory microbiome. …”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…The QOL-E was validated by the European Organization for the Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire – Core 30 (QLQ-C30) and clinical outcomes. …”
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A multidimensional assessment of adverse events associated with paliperidone palmitate: a real-world pharmacovigilance study using the FAERS and JADER databases by Siyu Lou, Zhiwei Cui, Yingyong Ou, Junyou Chen, Linmei Zhou, Ruizhen Zhao, Chengyu Zhu, Li Wang, Zhu Wu, Fan Zou

“…Paliperidone palmitate-associated ADEs encompassed 27 System Organ Classes (SOCs). The top three PTs with the highest reported cases were off-label use, drug ineffective, and hospitalization. …”
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Early Palliative Care Following Aborted Cancer Surgery: Results of a Prospective Feasibility Trial by Jordan M. Cloyd, MD, Rakhsha Khatri, BA, Angela Sarna, BS, Lena Stevens, PhD, Victor Heh, PhD, Mary Dillhoff, MD, Alex Kim, MD, Timothy M. Pawlik, MD, PhD, MPH, Aslam Ejaz, MD, Sharla Wells-Di Gregorio, PhD, Erin Scott, MD, Sachin S. Kale, MD

“…Although resection is generally necessary for curative-intent treatment of most solid organ cancers, surgery is occasionally aborted due to intraoperative findings. …”
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The impact of locus of control on somatic and psychological profiles of patients with irritable bowel syndrome engaging in aerobic exercise by Laura Prospero, Giuseppe Riezzo, Benedetta D’Attoma, Antonia Ignazzi, Antonella Bianco, Isabella Franco, Ritanna Curci, Angelo Campanella, Claudia Beatrice Bagnato, Piero Porcelli, Gianluigi Giannelli, Francesco Russo

“…The present study confirmed the importance of considering both the GI symptoms and the psychological profile when dealing with IBS. AEP organized in walking groups has shown significant improvements for all IBS patients. …”
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Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Hazardous heavy metals, particularly cadmium (Cd), are widely distributed in the environment and cause oxidative stress in various animal and human organs. Clove oil (CLO), a common aromatic spice, has been used as a traditional medication as it has potent anti-inflammatory, antioxidant, and hepatoprotective properties. …”
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Selective expression and significance of ACKR2 in lung aerocytes by Alberto Mantovani, Gianluigi Condorelli, Raffaella Bonecchi, Massimo Locati, Marina Sironi, Roberta Carriero, Francesca Albano, Valeria Mollica Poeta, Lucia Zotti, Alessandra Castagna, Arianna Felicetta, Alessandro Mesaglio, Elisa Zaghen, Arianna Capucetti, Rachele Di Donato, Mattia Laffranchi, Matteo Massara, Silvano Sozzani

“…The serum chemokine levels were studied with a multiplex ELISA.Results The analysis of the reporter mouse revealed that ACKR2 is expressed by lymphatic endothelial cells (LECs) in most murine organs. However, uniquely in the lungs, ACKR2 expression is observed in blood endothelial cells (BECs), specifically in capillaries known as aerocytes specialized for regulating leukocyte trafficking. …”
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Culturally appropriate terminologies in health research: a participatory study with pregnant and breastfeeding mothers in Uganda by Ritah Nakijoba, Adelline Twimukye, Josephine Bayigga, Aida N. Kawuma, Simon Peter Asiimwe, Fredrick Byenume, Jacqueline Kyeyune, Sylvia Nabukenya, Francis Williams Ojara, Francis Williams Ojara, Catriona Waitt, Catriona Waitt

“…Nvivo version 14 software was used to organize and manage the data appropriately based on themes and subthemes.ResultsA consensus on the preferred terminologies to communicate about our research studies involving pregnant and lactating mothers was reached. …”
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The agronomic mechanism of root lodging resistance and yield stability for sweet corn in response to planting density and nitrogen rates at different planting dates by Qinggan Liang, Qinggan Liang, Qinggan Liang, Qinggan Liang, Hailong Chang, Hailong Chang, Hongrong Chen, Hongrong Chen, Qingdan Wu, Qingdan Wu, Yuanxia Qin, Zhuqing Wang, Gang Wang, Xuhui Li, Weiwei Chen, Jiantao Wu, Jiantao Wu, Qinnan Wang, Jianqiang Wang, Jianqiang Wang

“…This further improved the development of plant crown architecture, including stem nodes and ear leaf traits, and further coordinated dry matter dynamics and lignin metabolism between the root and shoot organs. These observations may account for the resistance of the roots to lodging in this treatment. …”
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A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points by Anna Procopio, Annarita Tedesco, Fabrizio Lo Regio, Giuseppe Cesarelli, Leandro Donisi, Carlo Ricciardi, Alessio Merola, Alfonso Maria Ponsiglione, Maria Romano, Francesco Montefusco, Carlo Cosentino, Francesco Amato

“…In this context, the present work proposes a general framework to model the dynamics and describe the behavior of a wide class of multivariable physiological control systems, from the molecular to the whole-organ scale. The framework adopts a structure based on a closed-loop topology taking into account multiple inputs and outputs and with the negative feedback action intrinsically embedded within the model. …”
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The development of a food-group, tree classification method and its use in exploring dietary associations with metabolic dysfunction-associated Steatotic liver disease (MASLD) and... by Amina A. Alawadi, Amrita Vijay, Jane I. Grove, Moira A. Taylor, Guruprasad P. Aithal

“…Results: Significant associations were found for red meat intake with MASLD (OR [CI]: 1.013 [1.001–1.025]) and fibrosis (Beta [SE]: +0.048 [0.013]); intakes of nuts (OR [CI]: 0.951 [0.905–0.999]); and fish (OR [CI]: 0.985 [0.971–0.999]) with MASLD; “Cereals and cereals products”, “salt and gravy” and baked foods with fibrosis (Beta [SE]: +0.018 to +0.057 [0.005–0.23]); white and organ meat (Beta [SE]: −0.04 to −0.61 [0.015–0.249]); diet soda (OR [CI]: +0.01 [1–1.003]) and red meat intakes (OR [CI]:+0.002 [1.002–1.016]) with T2DM; wholegrain wheat, red meat, and semi-skimmed dairy intakes with hypercholesterolemia (ORs [CI]: −0.003 to −0.023 [1–1.043]); “herbs and spices” and wholegrain rice with hypercholesterolaemia (ORs [CI]: −0.08 to −0.98 [0.159–0.989); fresh herbs and boiled foods intakes with hypertension (ORs [CI]: −0.001 to −2.21 [0.013–1]). …”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…Bioinformatic analysis showed signaling pathways relevant to immune cell migration, epithelial cell development, and extracellular structure organization were commonly activated in different models. …”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…Abstract Purpose The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess the effect of landiolol treatment on inflammatory and metabolomic markers. …”
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Factors associated with attention-deficit/hyperactivity disorder among Tunisian children by Asma Guedria, Asma Guedria, Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Manel Ben Fredj, Randaline Ayoub, Randaline Ayoub, Randaline Ayoub, Hela Ben Abid, Hela Ben Abid, Hela Ben Abid, Ahmed Mhalla, Ahmed Mhalla, Ahmed Mhalla, Hela Slama, Hela Slama

“…Univariate then multivariate analyses were conducted to identify factors associated with ADHD.ResultsSeveral factors were more prevalent in children with ADHD than in controls: disturbed family dynamics, low socio-economic status, family history of psychiatric and organic pathologies, and particularly several early environmental factors, including passive smoking during pregnancy, prematurity, fetal distress, caesarean delivery and low birth weight. …”
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Longitudinal immunogenicity cohort study of SARS-CoV-2 mRNA vaccines across individuals with different immunocompromising conditions: heterogeneity in the immune response and cruci... by Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Jacopo Polvere, Simone Lucchesi, Chiara Coppola, Simone Costagli, Gabiria Pastore, Anna Sicuranza, Monica Tozzi, Arianna Lippi, Francesca Panza, Monica Bocchia, Alessandro Bucalossi, Guido Garosi, David Bennett, Sonia Bernazzali, Massimiliano Fabbiani, Francesca Montagnani, Donata Medaglini

“…Methods: In the PatoVac_COV longitudinal prospective single-centre study, the spike-specific B cell and antibody responses to SARS-CoV-2 mRNA vaccination were compared across 5 different groups of individuals with haematological malignancies, hematopoietic stem cell (HCT) or solid organ transplantation (SOT), undergoing haemodialysis, and people living with HIV (PLWH), for a total of 585 participants. …”
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Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

“…In mouse models, ramR L58P and F165L mutants showed lower bacterial burden in organs (spleen, lung, and kidney) 6 h post‐infection, and are fast cleared in 48 h. …”
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Development of a horizontal transmission model to assess the effects of exposure to pathogenic E. cecorum during the hatching phase in broiler chickens by James Higuita, Marcela Arango, Aaron Forga, Mitch Rowland, Jundi Liu, Ross Wolfenden, Danielle Graham

“…These results suggest that horizontal transmission of EC in commercial hatch cabinets could be possible, and that persistent EC colonization and organ involvement may affect performance and disease progression in young broiler chickens depending on the EC strain. …”
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Evaluating the Adequacy of Central Line-Associated Bloodstream Infection As a Quality Measure: A Cross-Sectional Analysis at a Single Tertiary Care Center by Piyush Mathur, MD, FCCM, FASA, FAMIA, Amanda J. Naylor, MD, MPH, Moises Auron, MD, Jean Beresian, MD, Alexandra Tallman, BSN, RN, SANE-A, Allison Griffith, MSN, RN, CCRN, CPHQ, Kathleen Seasholtz, BSN, RN, HACP, Mariel Manlapaz, MD, Katherine Zacharyasz, MSN, RN, CPHQ, Reem Khatib, MD, MBA, FASA, Shreya Mishra, PhD, Kathryn Haller, PA, Thomas Fraser, MD, Katherine Holman, MD

“…For CVC-related cases, Staphylococcus and Candida were the predominant organisms. For the CVC unrelated and unclear groups Enterococcus was most prevalent. …”
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The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken by Yachao Wang, Yilei Liang, Yan Huang, Wei wang, Xiaoyan Long, Li Jiang, Tingting Cheng, Jinfeng Du, Xuegang Luo

“…Results showed that TTO treatment alleviated tissue damage in the thymus, kidneys, spleen, and bursa of Fabricius, and improved the organ index (P < 0.05) compared with the AVG. Serum analysis revealed that TTO lowered levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglycerides(TG), CD3 positive CD4 positive T cells(CD3+CD4+), CD4 positive to CD8 positive Rratio(CD4+/CD8+), and alkaline phosphatase(AKP), while increasing albumin(ALB), globulin(GLO), immunoglobulin A(IgA), and immunoglobulin G(IgG) levels (P < 0.05). …”
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Exploring Dance as a Therapeutic Approach for Parkinson Disease Through the Social Robotics for Active and Healthy Ageing (SI-Robotics): Results From a Technical Feasibility Study by Roberta Bevilacqua, Elvira Maranesi, Marco Benadduci, Gabriella Cortellessa, Alessandro Umbrico, Francesca Fracasso, Giovanni Melone, Arianna Margaritini, Angela La Forgia, Pierpaolo Di Bitonto, Ada Potenza, Laura Fiorini, Carlo La Viola, Filippo Cavallo, Alessandro Leone, Andrea Caroppo, Gabriele Rescio, Mauro Marzorati, Amedeo Cesta, Giuseppe Pelliccioni, Giovanni Renato Riccardi, Lorena Rossi

“…To stimulate engagement, sessions were organized in the shape of exergames where an avatar shows patients the movements they should perform to correctly carry out a dance-based rehabilitation exercise. …”
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