Evaluation of efficacy and safety of generic tacrolimus (Suprotac®) compared to reference tacrolimus (Prograf^®) in kidney transplantation: a phase IV study by Behzad Einollahi, Mohsen Nafar, Mohammad Javanbakht, Amirhesam Alirezaei, Jalal Azmandian, Abbas Etminan, Mohammad Reza Ardalan, Jalal Etemadi, Roghayeh Akbari, Vahid Pourfarziani, Seyed Sadraddin Rasi Hashemi, Seyed Maryam Rahbar, Shahrzad Shahidi, Javid Safa, Hamid Tayyebi Khosroshahi, Sima Abedi Azar, Shahrzad Ossareh, Abdolamir Atapour, Bahareh Marghoob, Fatemeh Nazemian, Hamidreza Kafi, Araz Sabzvari

“… Background Transplant recipients are given an immunosuppressive regimen such as tacrolimus to prevent organ rejection. Suprotac® is a generic tacrolimus that is utilized in kidney transplantation regimen in Iran. …”
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Morphological and Chemical Changes in the Hemolymph of the Wax Moth <i>Galleria mellonella</i> Infected by the Entomopathogenic Fungus <i>Conidiobolus coronatus</i> by Mieczysława Irena Boguś, Agata Kaczmarek, Anna Katarzyna Wrońska, Mikołaj Drozdowski, Lena Siecińska, Ewelina Mokijewska, Marek Gołębiowski

“…Hemolymph enables communication between organs in insects and ensures necessary coordination and homeostasis. …”
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Diagnosis and treatment of thyroblastoma: a case report and review of literature by Xiting Chen, Xiting Chen, Lijuan Xiong, Lijuan Xiong, Hongling Liu, Haoqiang Wang, Donghai Cheng, Wei Wang, Wenyuan He, Bo Xie, Juan Zhou

“…Background and objectiveThe diagnosis of thyroblastoma initially identified as a thyroid malignant teratoma was subsequently classified as a distinct entity by the World Health Organization (WHO) in 2022. This classification was based on the observation that the tumor presents with independent primitive multilineage elements and is frequently associated with DICER1 hotspot mutations.The objective of this study was to explore and investigate the clinicopathologic characteristics, molecular features and treatment strategies of patients with thyroblastoma, followed by a review of the previous relevant literature.MethodsThe clinical manifestations, pathological characteristics, molecular features and treatment strategies of the initial case of thyroblastoma pathologically confirmed in China were analyzed.ResultsThe tumor was revealed to have high invasive potential, rapid disease progression, and primitive multilineage elements of pathology, including immature thyroid epithelium, spindled mesenchymal proliferations, and neuroepithelial blastema. …”
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Nutritive Parameters and Antioxidant Quality of Minimally Processed "Cime di Rapa" ( Brassica rapa subsp. sylvestris ) Vary as Influenced by Genotype and Storage Time by Donato Giannino, Giulio Testone, Chiara Nicolodi, Lucia Giorgetti, Lorenza Bellani, Maria Gonnella, Marco Ciardi, Paolo Cappuccio, Stefano Moscatello, Alberto Battistelli, Vincenzo Longo

“…The characterization of shoots and composing organs at post-cut stage included contents of dietary fibre (DF), glycaemic carbohydrates (GC), antioxidant compounds (ACC) and capacity (AOC), which were determined by chromatographic methods and spectrophotometric assays. …”
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Search for signals of positive selection of circadian rhythm genes <i>PER1</i>, <i>PER2</i>, <i>PER3</i> in different human populations by A. I. Mishina, S. Y. Bakoev, A. Y. Oorzhak, A. A. Keskinov, Sh. Sh. Kabieva, A. V. Korobeinikova, V. S. Yudin, M. M. Bobrova, D. A. Shestakov, V. V. Makarov, L. V. Getmantseva

“…To identify selection signals in different population groups, the PER1, PER2 and PER3 genes that are involved in the coordination of thermogenic functions and regulation of circadian rhythms, which is directly reflected in the adaptive abilities of the organism, were investigated. Data were analyzed using publicly available data from the 1000 Genomes Project for 23 populations. …”
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Exploring factors of physicians’ preferences for continuing medical education by Ruzica Nikolic Mandic, Vesna Bjegovic-Mikanovic, Zoran Bukumiric, Zorica Terzic-Supic, Jovana Todorovic, Sandra Grujicic, Dejan Nesic, Ulrich Laaser

“…This can help physicians and program organizers focus on essential competencies and exclude non-evidence-based ones.…”
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Characteristics of Medical Care During in-hospital Cardiopulmonary-cerebral Resuscitation by Viviana de la Concepción García Escudero, Liset Fuentes Santana, Víctor René Navarro Machado, Aymara Marcia Hernández Cardoso, Yanisleidys Chacón Blay, Camilo Rodríguez Pérez

“…<strong>Background:</strong> cardiopulmonary-cerebral resuscitation is the set of maneuvers to ensure oxygenation of organs when blood circulation stops. In-hospital cardiopulmonary-cerebral resuscitation is a life-saving intervention. …”
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Characterization of Complex Image Spatial Structures Based on Symmetrical Weibull Distribution Model for Texture Pattern Classification by Jinping Liu, Jiezhou He, Zhaohui Tang, Pengfei Xu, Wuxia Zhang, Weihua Gui

“…Visually, the visual appearance of the complex spatial structure (CSS) of texture pattern (TP) generally depends on the random organization (or layout) of local homogeneous fragments (LHFs) in the imaged surface. …”
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Amyloid-β and heart failure in Alzheimer’s disease: the new vistas by Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Sohaib G. Mohammed, Ali I. Al-Gareeb, Ali K. Albuhadily, Retaj A. Dawood, Amer Al Ali, Mohammed H. Abu-Alghayth

“…Interestingly, AD is regarded as a systemic disease that causes systemic inflammation and oxidative stress, which in turn affects peripheral organs, including the heart. Aβ through deranged BBB can be transported into the systemic circulation from the brain and accumulated in the heart, leading to the development of HF. …”
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Factors influencing breast milk donation to a human milk bank in Iran: implications for policymakers and planners by Leila Doshmangir, Maryam Naghshi, Kamal Gholipour, Ayat Ahmadi, Hosein Azizi, Vladimir Sergeevich Gordeev

“…Abstract Background The World Health Organization (WHO) actively promotes breastfeeding as the optimal source of nourishment for infants and young children. …”
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Characterizing PM2.5 Secondary Aerosols via a Fusion Strategy of Two-stage Positive Matrix Factorization and Robust Regression by Chun-Sheng Huang, Ho-Tang Liao, Chia-Yang Chen, Li-Hao Young, Ta-Chih Hsiao, Tsung-I Chou, Jyun-Min Chang, Kuan-Lin Lai, Chang-Fu Wu

“…To overcome this limitation, we employed a two-stage PMF modeling approach with adjustments of the species weighting, which was fused with a robust regression model to better characterize the sources of PM2.5 secondary aerosols. Additionally, organic molecular tracers were incorporated into PMF for source identification. …”
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Direct and Indirect Methods for Studying Human Gut Microbiota by V. T. Ivashkin, O. S. Medvedev, E. A. Poluektova, A. V. Kudryavtseva, I. R. Bakhtogarimov, A. E. Karchevskaya

“…Integration of the data obtained by gut microbiota studies at the genome, transcriptome and metabolome levels would allow a comprehensive analysis of microbial community function and its interaction with the human organism. This approach may increase our understanding of the pathogenesis of various diseases as well open up new opportunities for prevention and treatment.…”
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Induced Defense in Ryegrass–Epichloë Symbiosis Against <i>Listronotus bonariensis</i>: Impact on Peramine Levels and Pest Performance by Manuel Chacón-Fuentes, Gunnary León-Finalé, Marcelo Lizama, Gastón Gutiérrez-Gamboa, Daniel Martínez-Cisterna, Andrés Quiroz, Leonardo Bardehle

“…Therefore, this study assessed the feeding of the ASW on ryegrass carrying endophytic fungus and peramine levels in aerial organs and its effects on pest performance. Argentine stem weevil adults and larvae were placed on ryegrass leaves and stems to assess feeding. …”
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Olfactory Impairment and Recovery in Zebrafish (<i>Danio rerio</i>) Following Cadmium Exposure by Chiara Maria Motta, Rosa Carotenuto, Chiara Fogliano, Luigi Rosati, Pabitra Denre, Raffaele Panzuto, Rossana Romano, Gianluca Miccoli, Palma Simoniello, Bice Avallone

“…While the toxic effects of cadmium on the organs and tissues of aquatic species are well-documented, little is known about its impact on sensory systems crucial for survival. …”
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Accumulation Mechanism of Marine Shale Gas Reservoir in Anticlines: A Case Study of the Southern Sichuan Basin and Xiuwu Basin in the Yangtze Region by Kun Zhang, Yan Song, Shu Jiang, Zhenxue Jiang, Chengzao Jia, Yizhou Huang, Ming Wen, Weiwei Liu, Pengfei Wang, Xin Li, Tianlin Liu, Xuelian Xie, Chang’an Shan, Xiaoxue Liu, Xin Wang

“…The stratification plane and the organic pores form the migration channel of natural gas that is horizontal to the stratification plane in shale. …”
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Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications by Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, Garrett Wong, Isha Dey, Spencer Holmes, Abigail Dockey, Lindsay Bailey-Steinitz, Lina Zheng, Weizhong Li, Vivek Chandra, Jakhan Nguyen, Jason Sharp, Erik Willems, Mark Kennedy, Matthew R. Dallas, David Kuninger

“…Abstract Tumoroids, sometimes referred to as cancer organoids, are patient-derived cancer cells grown as 3D, self-organized multicellular structures that maintain key characteristics (e.g., genotype, gene expression levels) of the tumor from which they originated. …”
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Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells by Qi-Ming Huang, You-Qiong Zhuo, Zhong-Xin Duan, Yin-lin Long, Jia-Nan Wang, Zhou-hang Zhang, Shao-Yong Fan, Yong-Ming Huang, Ke-Yu Deng, Hong-Bo Xin

“…Aims: Mesenchymal stem cells (MSCs) are usually cultured in a normoxic atmosphere (21%) in vitro, while the oxygen concentrations in human tissues and organs are 1% to 10% when the cells are transplanted in vivo. …”
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Using Blockchain in the Registration and Authentication of a Carpooling Application: From Review to Proposal by Lina Sofía Cardona Martínez, Cesar Andrés Sandoval Muñoz, Ricardo Salazar-Cabrera, Álvaro Pachón de la Cruz, Juan Manuel Madrid Molina

“…The findings from the review were organized and assessed to identify key aspects for improving user authentication in a system based on intelligent transportation systems (ITSs) and utilizing blockchain, recognized for its security and data integrity. …”
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Continuously relapsing (for two years) course of diarrheal variant of IBS (<i>Clinical case</i>) by Ye. A. Poluektova, S. Yu. Kuchumova, A. A. Kurbatova, A. A. Sheptulin, O. S. Shifrin, V. T. Ivashkin

“…In the clinic differential diagnosis between organic diseases of gastro-intestinal tract was carried out (erosive-ulcerative lesion of the upper parts of GIT, celiac disease, inflammatory bowel diseases), functional gastro-intestinal disorder, thyroid gland hyperfunction). …”
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Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey by Jun Lu, Dongmei Hong, Qian Wu, Yinghui Xia, Guozhong Chen, Tie Zhou, Cheng Li

“…Purpose Heavy metal exposure can cause impaired or reduced pathology in the kidneys, lungs, liver, and other vital organs. However, the relationship between heavy metal exposure and kidney stones has not been determined. …”
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