Sex-biased gene expression across tissues reveals unexpected differentiation in the gills of the threespine stickleback by Sylvestre, Florent, Aubin-Horth, Nadia, Bernatchez, Louis

“…Understanding patterns of sex-biased gene expression across organisms is important for gaining insight into the evolution of sexual dimorphism and sex chromosomes. …”
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Attention Deficits in Stroke Patients: The Role of Lesion Characteristics, Time from Stroke, and Concomitant Neuropsychological Deficits by Simona Spaccavento, Chiara Valeria Marinelli, Roberto Nardulli, Luigi Macchitella, Umberto Bivona, Laura Piccardi, Pierluigi Zoccolotti, Paola Angelelli

“…In keeping with the hierarchical organization of attention functions, results confirm the important role of the right hemisphere for the intensive components of attention, also highlighting the involvement of left hemisphere functioning for the selective aspects, possibly indicating a role of its linguistic functions.…”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…Abstract Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. Macrophage polarization plays a critical role in pathogenesis of sepsis, and the influence of B lymphocyte-induced maturation protein-1 (Blimp-1) on this polarization is an underexplored yet pivotal aspect. …”
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Application of Novel Amino-Functionalized NZVI@SiO2 Nanoparticles to Enhance Anaerobic Granular Sludge Removal of 2,4,6-Trichlorophenol by Zeyu Guan, Jinquan Wan, Yongwen Ma, Yan Wang, Yajie Shu

“…A novel amino-functionalized silica-coated nanoscale zerovalent iron (NZVI@SiO2-NH2) was successfully synthesized by using one-step liquid-phase method with the surface functionalization of nanoscale zerovalent iron (NZVI) to enhance degradation of chlorinated organic contaminants from anaerobic microbial system. …”
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Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage by Marin Kuntić, Ivana Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Dilja Krueger-Burg, Huige Li, Sebastian Steven, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber

“…At least 20% of the European Union’s population lives in noise-polluted areas with exposure levels exceeding the recommended limits of the World Health Organization, which is considered unhealthy by the European Environment Agency. …”
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Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…The close connection and interaction between the cardiac and the liver functions are well-known, as cirrhotic cardiomyopathy is an important clinical entity which best describes the mutual pathogenical influence between these two organs. Due to the fact that cardiac dysfunction in patients with chronic hepatic disorders is oligosymptomatic or even asymptomatic, an early diagnosis represents a challenge for every physician. …”
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Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome by Pedro Perez, Wilson Sze, Daniel Lozeau, Dipa Avichal, Joshua Miller

“…Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a serious, sometimes lethal, immunological reaction to drug metabolites involving multiple organ systems. Some of the common causative agents of DRESS include allopurinol, minocycline, sulfasalazine, azathioprine, antiepileptic drugs, and hydroxychloroquine. …”
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Morphophysiological alterations caused by insertional mutagenesis of contactin 5 (Cntn5) gene in transgenic mice by A. V. Smirnov, N. A. Feofanova, G. V. Kontsevaya, M. V. Anisimova, I. I. Kovrigin, I. A. Serova, M. P. Moshkin, L. A. Gerlinskaya, N. R. Battulin

“…We studied Cntn5 expression with RT-PCR and discovered that its expression in the brain, the primary organ of Cntn5 activity, was unperturbed. However, transgenic animals had less Cntn5 transcripts in other tissues such as the kidney and heart. …”
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Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss by Jiali Liu, Haisen Peng, Yuehui Liu, Chunhua Li, Wen Xie

“…Results: Growth differentiation factor 15 (GDF15) and sirtuin 1 (SIRT1) expression was significantly decreased in hydrogen peroxide (H2O2)-induced House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and the cochlea of ARHL rats. …”
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In-Hospital Macro-, Meso-, and Micro-Drivers and Interventions for Antibiotic Use and Resistance: A Rapid Evidence Synthesis of Data from Canada and Other OECD Countries by Rosa Stalteri Mastrangelo, Anisa Hajizadeh, Thomas Piggott, Mark Loeb, Michael Wilson, Luis Enrique Colunga Lozano, Yetiani Roldan, Hussein El-Khechen, Anna Miroshnychenko, Priya Thomas, Holger J. Schünemann, Robby Nieuwlaat

“…To cast a wider net, we searched OECD organization websites and screened reference lists from systematic reviews. …”
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Biocontrol efficacy of Bacillus licheniformis and Bacillus amyloliquefaciens against rice pathogens by Mohsin Tariq, Mehvish Zahoor, Tahira Yasmeen, Tahir Naqqash, Muhammad Abdul Rehman Rashid, Muhammad Abdullah, Abdul Rafay Rafiq, Marriam Zafar, Iqra Irfan, Ijaz Rasul

“…Antagonistic microorganisms or their derivatives specifically target the plant pathogens while minimizing the harm to non-target organisms. Bacterial blight and brown spot are the major rice diseases caused by Xanthomonas oryzae pv. oryzae (Xoo) and Bipolaris oryzae (Bo), respectively. …”
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HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“…A significant association between female gender and the necessity for packed cell volume and fresh frozen plasma transfusion was observed (OR (95% CI: 10.26 (2.23 – 96.24), p =0.0005).The significant risk factors for mortality were: presence of ascites, pleural effusion, organ dysfunction, need for PCV, FFP and platelet megaunit transfusion. …”
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Intraoperative haemodynamic optimisation using the Hypotension Prediction Index and its impact on tissular perfusion: a protocol for a randomised controlled trial by Javier Ripollés-Melchor, Ane Abad-motos, Juan Victor Lorente, Ignacio Jimenez, Alejandra Becerra, Wilbert Wesselink, Francesca Reguant, Irene Mojarro, Maria de los Angeles Fuentes, Elizabeth Agudelo, Francisco Herrero-Machancoses, Paula Callejo, Joan Bosch, Manuel Ignacio Monge

“…This study aims to determine whether a treatment protocol based on the prevention of arterial hypotension using the HPI algorithm reduces the duration and severity of intraoperative hypotension compared with the recommended goal-directed fluid therapy strategy and may improve tissue oxygenation and organ perfusion.Methods and analysis We will conduct a multicentre, randomised, controlled trial (N=80) in high-risk surgical patients scheduled for elective major abdominal surgery. …”
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Students’ Perspectives on Learning Practical Nursing Skills: A Focus Group Study in Norway by A. G. Gregersen, M. T. Hansen, S. E. A. Brynhildsen, V. A. Grøndahl, A. C. Leonardsen

“…Students experienced that practical skills did not only include technical aspects but also the ability to establish a relationship to the patient and to organize their working day. Supervising was assumed as essential both when training in the simulation center and in clinical placement, as well as planning of the training, respectively. …”
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Impact of the COVID-19 Pandemic on Acute Ischemic Stroke Presentation, Treatment, and Outcomes by Timothy G. White, Gabriela Martinez, Jason Wang, Michele Gribko, Artem Boltyenkov, Rohan Arora, Jeffrey M. Katz, Henry H. Woo, Pina C. Sanelli

“…Introduction. The World Health Organization declared COVID-19 a global pandemic last year. …”
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Data mining and safety analysis of voriconazole in patients with a hematological malignant tumor based on the FAERS database: differences between children and adults by Hao Li, Hao Li, Manxue Jiang, Manxue Jiang, Xiaona Pan, Lingti Kong, Lingti Kong, Lingti Kong

“…Then, they were classified using the preferred terminology (PT) and system organ category (SOC) in the Medical Dictionary for Regulatory Activities. …”
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Effect of diabetes mellitus on levels of insulin-like growth factors and their carrier proteins in Guerin’s carcinoma and it’s perifocal tissue in rats by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, N. D. Cheryarina, P. S. Kachesova, L. A. Nemashkalova

“…In males, induced DM downregulated levels of glucose, IGF-II and IGFBP2 in the carcinoma by 8.4, 3.1 and 1.7 (p < 0.05) times, respectively, and increased levels of IGF-I and IGFBP2 by 1.4 and 1.3 times (p < 0.05) in the perifocal area without changing glucose levels; as a result, tumor volumes exceeded the values in the standard growth, without metastasizing into visceral organs.Conclusion. We revealed gender differences in changing levels of glucose and IGF both in the tumor and in it's perifocal tissue in rats with Guerin's carcinoma growing in presence of DM; these differences could determine different tumor growth dynamics in male and female rats.…”
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THE DIGITAL FRONTIER: STRATEGIES AND TOOLS FOR CULTIVATING EDUCATIONAL-STRATEGIC COMPETENCE  FOR PRE-SERVICE TEACHERS by Vira Svyrydiuk, Ostap Bodyk, Larysa Kalinina, Nataliya Prokopchuk, Nina Khrystych

“… Digital tools constitute an integral component in the organization of contemporary foreign language environment. …”
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Liver cystic echinococcosis: A retrospective study on the demographics and clinical profile of patients managed at a single tertiary institution in central Eastern Cape Province, S... by A Govindasamy, P R Bhattarai, J van Niekerk, J John

“…CE is caused by the tapeworm Echinococcus granulosus sensu lato, with the liver being the most commonly affected organ. In South Africa (SA), there is a paucity of data on liver CE demographics and management. …”
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Evaluation of twin-arginine translocation substrate proteins as potential antigen candidates for serodiagnosis of brucellosis by Yao Wu, Yao Wu, Xin Yan, Mingjun Sun, Xiaohan Guo, Jiaqi Li, Xiangxiang Sun, Xiangxiang Sun, Mengda Liu, Mengda Liu, Haobo Zhang, Haobo Zhang, Wenlong Nan, Weixing Shao, Fangkun Wang, Xiaoxu Fan, Xiaoxu Fan, Shufang Sun

“…IntroductionBrucellosis, an infectious zoonotic disease caused by members of the genus Brucella, results in chronic multi-organ injury. Improving the specificity and sensitivity of serological methods for diagnosing brucellosis necessitates the development of novel diagnostic antigens. …”
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