Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemothera... by Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo

“…This clinical trial will focus on a well-defined patient group with metastatic disease limited to the liver as the target organ, with a maximum of three metastases. Discussion METAPANC is the first international, randomized, controlled, open-label, multicentre, phase III clinical trial for curative intended surgical therapy of oligometastatic pancreatic cancer in Europe and America. …”
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Interactions of Self-Assembled <i>Bletilla Striata</i> Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles by Guangyuan Zhang, Jin Qiao, Xin Liu, Yuran Liu, Ji Wu, Long Huang, Danyang Ji, Qingxiang Guan

“…Docetaxel levels of DTX-loaded BSPs-SA nanoparticles in some organs changed, and more docetaxel accumulated in the liver, spleen, and the tumor compared with Duopafei^®. …”
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Pepper as a phytogenic additive in finishing lambs diets by Suellem Fernanda Pedrosa Zanin, Luiz Juliano Valério Geron, Alexandre Lima de Souza, Fagton de Mattos Negrão, André Gustavo Leão, Anderson de Moura Zanine, Daniele de Jesus Ferreira, Jocilaine Garcia, Nelcino Francisco de Paula, Luciano da Silva Cabral

“…The intake of DM, crude protein (CP), organic matter (OM), and neutral detergent fiber (NDF) in g/day decreased linearly (P < 0.05). …”
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Evaluation of mental disorder related to colposcopy procedure during the COVID period: A cross-sectional study by Ilaria Bochicchio, Martina Catalano, Giovanni Deiana, Giandomenico Roviello, Pasquale Marino, Fabrizia Calenda, Alessandro R Lettini, Francesca Sanseverino

“…Background: The Coronavirus Disease (COVID-19) has had a significant impact on healthcare organizations, leading to a reduction in screening. The pandemic period has caused important psychological repercussions in the most fragile patients. …”
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A Heterogeneously Integrated 256-Element 5G Phased Array: Design, Assembly, Test by Bodhisatwa Sadhu, Arun Paidimarri, Atom O. Watanabe, Duixian Liu, Xiaoxiong Gu, Christian W. Baks, Yujiro Tojo, Yoshiharu Fujisaku, Isabel De Sousa, Yo Yamaguichi, Ning Guan, Alberto Valdes-Garcia

“…The design is based on a 64-element antenna-in-package tile designed using an organic substrate. This work represents one of the earliest examples of a heterogeneously integrated mmWave phased array module where each tile uses chips in three different substrate technologies to perform beamforming, frequency conversion, filtering, combining/splitting, and supply decoupling functions. …”
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Higher AVCO2 and Lactate Gradient Combined with SOFA Score as a Mortality Predictor during the 6-Hours of Resuscitation of Septic Shock by Morteza Talebi Doluee, Sahar Azam Ghasemzadeh, Ahmad Bagheri Moghadam, Zahra Abbasishaye, Davood Soroosh, Elnaz Vafadar Moradi

“… Background: Sepsis is a severe and life-threatening condition leading to widespread inflammation and organ dysfunction. It is a medical emergency that requires immediate attention and treatment. …”
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Concerning the issue of early diagnostics of low tannin content in faba bean seeds (<i>Vicia faba</i> L.) by S. M. Mamedova, V. S. Popov, A. E. Solovyeva, I. N. Perchuk, L. L. Malyshev, M. A. Vishnyakova

“…Different combinations of the studied morphological features associated with the coloration of the studied organs were found. A high positive correlation between the levels of anthocyanins and tannins (r = 0.79) was identified as well as a direct connection of the high value of these traits with the presence of a dark extrafloral nectary on stipules and anthocyanin in seedlings. …”
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Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease by Bei Zhang, Ruijie Zhang, Huiming Ren, Qiongfeng Guan, Weinv Fan, Liyuan Han

“…Material and methods We aggregated data from three genome-wide association studies (International Parkinson’s Disease Genomics Consortium, Parkinson’s Research: The Organized Genetics Initiative and GenePD, and FinnGen) to extract single-nucleotide polymorphisms (SNPs) associated with circulating concentrations of TMAO, choline, carnitine, and betaine. …”
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Synchronous clonally related anaplastic large cell lymphoma and malignant histiocytosis by Mirvate Harb, Tom Abrassart, Laurent Dewispeleare, Pierre Sidon, Natacha Dirckx, Anne-laure Trepant, Julie Castiaux, Pierre Heimann, Jean-Francois Emile, Hussein Farhat

“…Patient died in the intensive care unit from a multiple-organ failure related to lymphohistiocytic hemophagocytosis. …”
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ENDOPROSTHESIS OF THE SHOULDER JOINT IN METASTATIC LESIONS OF THE PROXIMAL HUMERUS DURING IMMUNOSUPPRESSIVE THERAPY by M. V. Ivanova, V. Yu. Karpenko, A. V. Bukharov, V. A. Derzhavin

“…The frequency of complications in patients who undergo total joint replacement after organ transplantation can be significantly reduced by the correction of metabolic disorders, the purpose of broad-spectrum antibiotics in the perioperative period and careful rehabilitation. …”
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Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome by Fabiana Boncimino, Ludovica D’Auria, Kristina Todorova, Sabina Y. van der Zanden, Jacques Neefjes, Anna Mandinova, Caterina Missero, Stefano Sol

“…A chemical analog of Doxorubicin, diMe-Doxorubicin, which exhibits lower tissue and organ toxicity, was also found to be effective in promoting the disaggregation of mutant p63 and rescuing its transcriptional activity. …”
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Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase by Roy J. Rodriguez Carrero, Cody T. Lloyd, Janhavi Borkar, Shounak Nath, Liviu M. Mirica, Satish Nair, Squire J. Booker, William Metcalf

“…Here, we show that two different MgmA homologs are able to methylate MCR in vivo when expressed in Methanosarcina acetivorans, an organism that does not normally possess this PTM. M. acetivorans strains expressing MgmA showed small, but significant, reductions in growth rates and yields on methylotrophic substrates. …”
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Exploring the exoproteome of the parasitic nematode Anisakis simplex (s. s.) and its impact on the human host – an in vitro cross-talk proteomic approach by Robert Stryiński, Robert Stryiński, Ewa Fiedorowicz, Jesús Mateos, Aneta Andronowska, Elżbieta Łopieńska-Biernat, Mónica Carrera

“…IntroductionAnisakis simplex sensu stricto (s. s.) is one of the most widespread parasitic nematodes of marine organisms, with humans as accidental hosts. While many studies have explored nematode biology and host interactions, the role of extracellular vesicles (EVs) as signaling molecules in parasitic nematodes is less understood.Materials and methodsTherefore, the proteins present in the EVs of A. simplex (s. s.) …”
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DRomics, a workflow to exploit dose-response omics data in ecotoxicology by Delignette-Muller, Marie Laure, Siberchicot, Aurélie, Larras, Floriane, Billoir, Elise

“…Coupled to dose-response experimental designs, they allow a non-targeted assessment of organism responses at the molecular level along an exposure gradient. …”
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Crop protection by RNA interference: a review of recent approaches, current state of developments and use as of 2013 by Kirsten Germing, Cecilia Andrea Díaz Navarrete, Andreas Schiermeyer, Udo Hommen, Luise Zühl, Sebastian Eilebrecht, Elke Eilebrecht

“…Abstract RNAi-based applications aim to inhibit the expression of specific essential genes in target organisms by uptake and processing of double-stranded RNA and subsequent degradation of target gene mRNA. …”
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Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies by Niloofar Javid, Ali Asadipour, Ehsan Salarkia, Mohammad Amin Langarizadeh, Fatemeh Sharifi, Mohammad Mahdavi, Bagher Amirheidari, Aida Iraji, Hojjat Rezaiezadeh, Gholamreza Hassanpour, Yaghoub Pourshojaei

“…Abstract Leishmaniasis is a parasitic disease caused by protozoan organisms belonging to the Leishmania genus, affecting many individuals worldwide, with the burden surpassing one million cases. …”
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Molecular Mechanisms Underlying Substance Transport, Signal Transduction, and Anti-Stress Regulation, as Well as Anti-Alkaline Regulation via <i>Bursicon</i> in the Cerebral Gangli... by Meiyao Wang, Jun Zhou, Jiachun Ge, Gangchun Xu, Yongkai Tang

“…In particular, the brain (cerebral ganglion for crustaceans) serves as a vital regulatory organ in response to environmental stress; (2) Methods: In this study, a comparative transcriptome approach was employed to investigate the key regulatory genes and molecular regulatory mechanisms in the cerebral ganglion of <i>E. sinensis</i> under alkaline stress. (3) Results: The results demonstrated that the cerebral ganglion of <i>E. sinensis</i> exhibited a positive response to acute alkaline stress. …”
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Development and Testing of a Patient Outcome Measure for Interprofessional Tuberculosis Care: A Delphi Study by Bau D. Ardyansyah, Reinie Cordier, Margo Brewer, Dave Parsons

“…The final instrument consists of 44 items organized into five domains. All items were relevant to the construct being measured and deemed understandable, and significant concerns related to TB care were comprehensively addressed in the instrument. …”
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Hydrophobic deep eutectic solvents as novel, sustainable aids for intracellular protein release from Saccharomyces cerevisiae by Tjalling Gijsbert Tjalsma, Yannick Patrice Didion, Ziran Su, Magdalena Malankowska, Pablo Torres-Montero, José Luis Martínez, Manuel Pinelo

“…However, traditional downstream processing of intracellular compounds often depends on organic solvents and harsh processing conditions. …”
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A novel roseosiphovirus infecting dinoroseobacter shibae DFL12T represents a new genus by Nana Wei, Longfei Lu, Yingying Li, Bo Ding, Lanlan Cai, Yunlan Yang

“…Despite their importance, phages infecting organisms of the Roseobacter clade remain poorly understood. …”
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