Gain-of-Function Mutations in STAT1: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies by Sanem Eren Akarcan, Ezgi Ulusoy Severcan, Neslihan Edeer Karaca, Esra Isik, Guzide Aksu, Mélanie Migaud, Ferda Evin Gurkan, Elif Azarsiz, Anne Puel, Jean-Laurent Casanova, Necil Kutukculer

“…HSCT should be considered as an early treatment option before permanent organ damage leading to morbidity and mortality develops. …”
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Neurons with larval synaptic targets pioneer the later nervous system in the annelid Malacoceros fuliginosus by Anna Seybold, Anna Seybold, Suman Kumar, Suman Kumar, Sharat Chandra Tumu, Harald Hausen, Harald Hausen

“…One of the prominent larval characteristics of numerous planktonic marine organisms is the epidermal ciliation used for swimming and steering, which disappears during metamorphosis. …”
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Rectal cancer with severe distal spreading by A. A. Nevolskikh, T. P. Berezovskaya, N. A. Gorban, L. M. Kondrashova, L. N. Titova

“…Presented clinical case testifies necessity of careful preoperative investigation of patients with local spread of rectal tumors with obligatory application of magnetic-resonance tomography of small pelvis organs. In the case of prolonged radiological (chemoradiation) therapy careful investigation is required in 6–8 wks after the termination of radiation therapy, before surgical intervention. …”
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Mixed forest conversion from moso bamboo forests in wetland parks increases understory species diversity and improves soils by Yuhua Ma, Duanyang Xu, Ziming Huang, Fengyu Xu, Mengqin Xiang, Jingya Wei, Han Sheng, Zhen Wu, Luis Carlos Ramos Aguila, Lei Zhang, Wei Wang, Xu Li

“…The contents of soil carbon, nitrogen and organic matter in mixed forest were significantly higher than P. massoniana forests and P. pubescens forests (P < 0.05). …”
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Optically driven microtools with an antibody‐immobilised surface for on‐site cell assembly by Shuntaro Mori, Takumi Ito, Hidekuni Takao, Fusao Shimokawa, Kyohei Terao

“…Abstract To enable the accurate reproduction of organs in vitro, and improve drug screening efficiency and regenerative medicine research, it is necessary to assemble cells with single‐cell resolution to form cell clusters. …”
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Early Diagnosis of Alzheimer&#x2019;s Disease Using Adaptive Neuro K-Means Clustering Technique by Karan Kumar, Shweta Agrawal, Isha Suwalka, Celestine Iwendi, Cresantus N. Biamba

“…The approach integrates the Adaptive Moving Self-Organizing Map (AMSOM), a neural network technique for unsupervised training and tissue segmentation, with K-means clustering and Principal Component Analysis (PCA) for feature selection. …”
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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential by Masayo Aoki, Hiroaki Aoki, Rajesh Ramanathan, Nitai C. Hait, Kazuaki Takabe

“…The S1P concentration gradient between various tissues promotes S1PR1-dependent migration of T cells from secondary lymphoid organs into the lymphatic and blood circulation. S1P suppresses T cell egress from and promotes retention in inflamed peripheral tissues. …”
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Peritoneal Breach as an Indication for Exploratory Laparotomy in Penetrating Abdominal Stab Injury: Operative Findings in Haemodynamically Stable Patients by Jasmina Kevric, Victor Aguirre, Kate Martin, Dinesh Varma, Mark Fitzgerald, Charles Pilgrim

“…The operative diagnoses included nonperitoneal-breaching injuries, intraperitoneal penetration without organ damage, or intraperitoneal injury with organ damage. …”
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Severe Tuberculosis Requiring Intensive Care: A Descriptive Analysis by Raquel Pacheco Duro, Paulo Figueiredo Dias, Alcina Azevedo Ferreira, Sandra Margarida Xerinda, Carlos Lima Alves, António Carlos Sarmento, Lurdes Campos dos Santos

“…Most risk factors for mortality were related to organ failure, but others could be attributed to delay in the diagnostic and therapeutic approach, important targets for intervention.…”
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Management Practices and Effectiveness of Universities at Lifelong Learning Realization by I. A. Korshunov, N. N. Shirkova, E. S. Szhenov, I. A. Efremov, G. A. Chakhoyan

“…They contribute to increasing the role of higher education organizations in the implementation of lifelong learning programs and ensure the financial stability of organizations. …”
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Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset by Shamshul Ansari, Hari Prasad Nepal, Rajendra Gautam, Sony Shrestha, Puja Neopane, Moti Lal Chapagain

“…Acinetobacter species (9.5%) was the predominant Gram-negative organism followed by Klebsiella pneumoniae (7.7%). …”
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Diagnosis of Methyl Malonicaciduria from 2013 to 2018 by Alina Concepción Álvarez, Ivette Camayd Viera, Norma Elena de León Ojeda, Alina García García, Laritza Martínez Rey, Daniel Quintana Hernández

“…<strong>Foundation:</strong> methylmalonic aciduria is one of the most frequent organic acidurias and groups together a set of genetic defects, characterized by the excretion of elevated levels of urinemethyl malonic acid. …”
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Liquid Chromatography-Mass Spectrometry-Based Untargeted Metabolomics Analysis of Differential Metabolites in Three Types of Boza Made from Different Raw Materials by WANG Qi, GAO Yan, XUE Juanjuan, ZENG Jun, HUO Xiangdong, ZHAO Zhongkai

“…These differential metabolites mainly included lipids and lipid-like molecules, organic acids and their derivatives, organic heterocyclic compounds, phenylpropanoids, and polyketones. …”
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Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation by Anthony D. Foster, Diego Vicente, Jonathan J. Sexton, Luke Johnston, Nick Clark, Crystal Leonhardt, Eric A. Elster, Thomas A. Davis, Matthew J. Bradley

“…This study examined whether the administration of the T-cell sequestration agent, FTY720, following hind limb tourniquet-induced skeletal muscle IRI in a rat model would attenuate systemic inflammation and multiple end organ injury. Sprague-Dawley rats were subjected to 1 hr of ischemia via application of a rubber band tourniquet. …”
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Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis by Kazuhiko Umazume, Jun Suzuki, Yoshihiko Usui, Yoshihiro Wakabayashi, Hiroshi Goto

“…The 10 patients comprised 8 males and 2 females, with mean age of 71.2 years. The causative organisms were bacteria in 6 eyes and fungi in 4 eyes. …”
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Toxicity of Per- and polyfluoroalkyl substances in elutriates prepared with estuarine and freshwater sediments by Paige M. Krupa, Guilherme R. Lotufo, Jonna Boyda, Nicolas L. Melby, Ashley N. Kimble

“…PFAS partitioning to sediment and organic matter was observed to increase with carbon chain length. …”
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Characteristics and microscopic mechanisms of smoke emissions of OMMT/SBS-modified asphalt by Wanhong Yang, Zhenghao Zhang, Xiaolong Yang, Xiaofan Jia, Yixin Jiang

“…The smoke suppression performance of asphalt can be substantially improved using organic nano-montmorillonite (OMMT)/styrene–butadiene–styrene (SBS) block modifiers. …”
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Marked spatial heterogeneity of macro-benthic communities along a shallow-mesophotic depth gradient in Reunion Island by Ludovic Hoarau, François Guilhaumon, Sophie Bureau, Perrine Mangion, Priscille Labarrère, Lionel Bigot, Pascale Chabanet, Lucie Penin, Mehdi Adjeroud

“…We recorded a transition of light-dependent communities towards heterotrophic organisms between shallow and upper mesophotic zones at 30–45 m, and a community shift in the lower mesophotic zone at 75 m. …”
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Safety evaluation of the food enzyme protein‐glutamine γ‐glutamyltransferase from the non‐genetically modified Streptomyces mobaraensis strain AE‐BTG by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Giulio diPiazza, Yi Liu

“…The food enzyme was free from viable cells of the production organism. It is intended to be used in nine food manufacturing processes. …”
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Safety evaluation of the food enzym endo‐1,4‐β‐xylanase from the genetically modified Bacillus subtilis strain AR‐153 by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Giulio diPiazza, Yi Liu

“…The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in four food manufacturing processes. …”
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