Early mortality, epidemiological and clinical factors in seriously ill patients treated in Intermediate Care Units by Osmani Pérez Ortiz, Angel Antonio Urbay Ruíz, Elaine Teresa Gutiérrez Pérez, Lis Marlyn Rodríguez García, Ivette Irene Molina Linares, Ernesto Conyedo Vergel

“…The diagnosis at admission of upper digestive bleeding and intraventricular hemorrhage was more closely related to early mortality, and septic shock and multiple organ dysfunction were determining complications as well.…”
Get full text

Nanocomplex hyaluronic acid/ganciclovir@ZIF-8 for ganciclovir efficient delivery and targeted anti-KSHV treatment by Fangling Li, Chengjing Liu, Wenyi Gu, Qianhe Xu, Dongmei Li, Dongdong Cao, Zhiyong Liu

“…By encapsulating GCV into metal–organic skeleton material zeolitic imidazolate framework-8 (ZIF-8) and further modification of hyaluronic acid (HA), the nanomedical delivery system of GCV (HA/GCV@ZIF-8) has been developed for efficient GCV delivery and targeted anti-KSHV treatment. …”
Get full text

INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW by Auria Ekanti Pratiwi, Oki Suwarsa, Achadiyani, Nur Atik

“…Result: We found that IVC influenced inflammatory biomarkers such as CRP, d-dimer, ferritin, and several inflammatory cytokines, mortality, length of stay, oxygenation, organ and immune system function but showed no significant difference between the control group. …”
Get full text

Genome-scale evolution in local populations of wild chimpanzees by Takashi Hayakawa, Takushi Kishida, Yasuhiro Go, Eiji Inoue, Eri Kawaguchi, Tomoyuki Aizu, Hinako Ishizaki, Atsushi Toyoda, Asao Fujiyama, Tetsuro Matsuzawa, Chie Hashimoto, Takeshi Furuichi, Kiyokazu Agata

“…Overall, our analytical framework offers ecological insights into chimpanzees and may be applicable to other organisms.…”
Get full text

Local structural–functional coupling with counterfactual explanations for epilepsy prediction by Jiashuang Huang, Shaolong Wei, Zhen Gao, Shu Jiang, Mingliang Wang, Liang Sun, Weiping Ding, Daoqiang Zhang

“…Specifically, we first construct structural and functional connections using diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI) data, subsequently organizing them into a multimodal brain network. Then, we extract subgraphs from these multimodal brain networks and select them based on their frequencies to generate local SC–FC coupling patterns. …”
Get full text

Hydrogen production by methane decomposition over Ni-doped activated carbons: effect of the activation method by Mahmoudi, Marwa, Dufour, Anthony, Bettahar, Mohammed El-Miloud, Medjahdi, Ghouti, Ouederni, Abdelmottaleb, Gadiou, Roger

“…TEM characterization revealed the formation of well-organized carbon nano-onions surrounding Ni particles on the physically activated carbon. …”
Get full text

Early transcriptomic changes at the skin interface during Powassan virus transmission by Ixodes scapularis ticks by Dakota N. Paine, Dakota N. Paine, Meghan Hermance, Saravanan Thangamani, Saravanan Thangamani, Saravanan Thangamani

“…As obligate hematophagous organisms, ticks transmit pathogens like POWV at the tick bite site, specifically during the initial stages of feeding. …”
Get full text

A review of metabolic calorimetric applications in plant stress, waste management, and diagnostics by Michael Bayode, Ifeoluwaposi Ogundana, Oluwatosin Ogundare, Elizabeth Awodire, Patience Abbah, Israel Onifade, Adeola Adeyolanu, Stephen Okunade, Samuel Ogboye, Michael Elabiyi

“…Biologically exothermic reactions—which involve biotransformation mechanisms during composting, wastewater reuse, and organic sludge stability as physiochemical attributes of solid and liquid wastes via changes in heat release—influence plant dynamic stress variables. …”
Get full text

Arterial Hypertension and Interleukins: Potential Therapeutic Target or Future Diagnostic Marker? by Daniela Maria Tanase, Evelina Maria Gosav, Smaranda Radu, Anca Ouatu, Ciprian Rezus, Manuela Ciocoiu, Claudia Florida Costea, Mariana Floria

“…Increased serum level of proinflammatory cytokines such as IL-1β, IL-6, IL-8, IL-17, IL-23, TGFβ, and TNFα in hypertensive patients has been associated with either increased blood pressure values and/or end-organ damage. Moreover, some cytokines (i.e., IL-6) seem to determine a hypertensive response to angiotensin II, regardless of blood pressure values. …”
Get full text

Context effects on repair of 5′‐overhang DNA double‐strand breaks induced by Cas12a in Arabidopsis by Sébastien Lageix, Miguel Hernandez, Maria E. Gallego, Jérémy Verbeke, Yannick Bidet, Sandrine Viala, Charles I. White

“…Abstract Sequence‐specific endonucleases have been key to the study of the mechanisms and control of DNA double‐strand break (DSB) repair and recombination, and the availability of CRISPR‐Cas nucleases over the last decade has driven rapid progress in the understanding and application of targeted recombination in many organisms, including plants. We present here an analysis of recombination at targeted chromosomal 5′ overhang DSB generated by the FnCas12a endonuclease in the plant, Arabidopsis thaliana. …”
Get full text

The landscape of cell regulatory and communication networks in the human dental follicle by Jia-Ning Liu, Jia-Ning Liu, Jiong-Yi Tian, Lu Liu, Lu Liu, Yuan Cao, Yuan Cao, Xiao Lei, Xiao Lei, Xiao-Hui Zhang, Xiao-Hui Zhang, Zi-Qi Zhang, Zi-Qi Zhang, Jun-Xi He, Jun-Xi He, Chen-Xi Zheng, Chao Ma, Sheng-Feng Bai, Bing-Dong Sui, Fang Jin, Ji Chen, Ji Chen

“…IntroductionThe dental follicle localizes the surrounding enamel organ and dental papilla of the developing tooth germ during the embryonic stage. …”
Get full text

Speciation studies of potentially toxic elements within the vicinity of major dumpsites in Ile-Ife, Osun State, Nigeria by Oluwakemi O. Tovide, John A.O. Oyekunle, Odunayo T. Ore, Bukola A. Oyebode, Elizabeth O. Moseri, Abolanle S. Adekunle, Oluwasegun Oluwarotimi, Aderemi O. Ogunfowokan, Adebayo O. Eludoyin

“…The speciation analysis indicated that the water-soluble, exchangeable, and carbonate fractions contained more than 80 % of the metals, implying high solubility and bioavailability. The organic and residual fractions had minimal metal forms. …”
Get full text

A Giant Parasitic Leiomyoma with Blood Supply from Omental Branches: A Case Report by Mustafa Ulubay, Fahri Burçin Fıratlıgil, Uğur Keskin, Ulaş Fidan, Nuri Yiğit, Rıza Efendi Karaca, Ali Ergün

“…It is crucial to maintain specific diagnosis, careful imaging and serious planning in preoperative preparations.Although parasitic leiomyomas are rarely seen cases, because of abnormal vascularization and adhesion to other organs, one should be careful in preoperative examinations and sufficient blood supply should be maintained in case of bleeding. …”
Get full text

TSC complex decrease the expression of mTOR by regulated miR-199b-3p by Na Zhao, Qiuhong Xiong, Ping Li, Guangxin Chen, Han Xiao, Changxin Wu

“…Genetic variations in either TSC1 or TSC2 cause tuberous sclerosis complex (TSC) disease which is a rare autosomal dominant disorder resulting in impairment of multiple organ systems. In this study, besides a reported variation, c.2509_2512del (p.Asn837Valfs*11, p.N837fs) in TSC1, we found a de novo TSC2 variation c.1113delG (p.Gln371Hisfs*18, p.Q371fs), which these two mutation influence the formation of TSC complex. …”
Get full text

Current practices and key challenges associated with the adoption of resilient, circular, and sustainable food supply chain for smallholder farmers to mitigate food loss by Jessika Milagros Vásquez Neyra, Jessika Milagros Vásquez Neyra, Mirza Marvel Cequea, Valentina Gomes Haensel Schmitt

“…Participants were selected through purposive sampling, focusing on farmers who apply organic agricultural techniques. Data were analyzed using content analysis techniques supported by ATLAS.ti 23 software to identify patterns in practices and challenges.ResultsThe findings reveal that farmers operate within short supply chains, without intermediaries, applying intuitive practices aligned with circular economy principles, including Rethink, Redesign, Reduce, Replace, Reuse, Repurpose, and Recycle, but excluding Recovery. …”
Get full text

Selected Biomarkers Correlate with the Origin and Severity of Sepsis by Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran

“…Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.…”
Get full text

Nasal Carriage of Methicillin-Resistant Staphylococcus aureus among Health Care Workers in Tertiary and Regional Hospitals in Dar es Salam, Tanzania by Agricola Joachim, Sabrina J. Moyo, Lillian Nkinda, Mtebe Majigo, Sima Rugarabamu, Elizabeth G. Mkashabani, Elia J. Mmbaga, Naboth Mbembati, Said Aboud, Eligius F. Lyamuya

“…Methicillin-resistant Staphylococcus aureus (MRSA) among health care workers (HCWs) increases the risk of spreading the organism in hospital settings. A cross-sectional study was conducted between June and October 2016 among HCWs in tertiary and regional hospitals in Dar es Salaam, Tanzania, to determine the MRSA nasal carriage rate. …”
Get full text

Psychological, psychiatric, and behavioral sciences measurement scales: best practice guidelines for their development and validation by Alberto Stefana, Stefano Damiani, Umberto Granziol, Umberto Provenzani, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Eric A. Youngstrom, Eric A. Youngstrom, Eric A. Youngstrom, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli

“…This article presents a guide to scope, organize, and clarify the process of scale development and validation for psychological and psychiatric use by integrating current methodological literature with the authors’ real-world experience. …”
Get full text

Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100 by Maghraby Gamal Mohamed El, Elzayat Ehab Mostafa, Alanazi Fars Kaed

“…Solid matrix of the drug and Eudragit S 100 was prepared by dissolving the drug and polymer in acetone. The organic solvent was then evaporated and the deposited solid matrix was micronized, sieved and dispersed in alginate solution to obtain candidate formulations. …”
Get full text

Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy by Krupal B. Patel, Anthony C. Nichols, Kevin Fung, John Yoo, S. Danielle MacNeil

“…Abstract Objectives For early stage supraglottic squamous cell carcinoma (SCC), single modality treatment either in the form of primary organ preservation surgery alone or radiation alone is recommended. …”
Get full text