Hormonal Changes in Menopause and Orexin-A Action by Giovanni Messina, Andrea Viggiano, Vincenzo De Luca, Antonietta Messina, Sergio Chieffi, Marcellino Monda

“…Orexins are hypothalamic neuropeptides recently discovered, involved in the regulation of feeding behaviour, sleep-wakefulness rhythm, and neuroendocrine homeostasis. …”
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Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…While there are many existing treatments such as benzodiazepines, melatonin agonists, TCAs, and atypical antipsychotics used to target various receptors involved in normal induction and maintenance of sleep, Suvorexant is an antagonist that specifically targets orexin receptors. Recent clinical studies suggest that Suvorexant is both clinically safe and effective. …”
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Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration by Xing Xiao, Gagik Yeghiazaryan, Fynn Eggersmann, Anna Lena Cremer, Heiko Backes, Peter Kloppenburg, Anne Christine Hausen

Subjects: “…orexin…”
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Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease by Yan Wu, Narayan R. Bhat, Meng Liu

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Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway by Xiaocen Chang, Yuyan Zhao, Lei Guo

“…Orexin-A is a neuropeptide that orchestrates diverse central and peripheral processes. …”
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Role of Hypothalamus in Acupuncture’s Effects by Ryan Bae, Hyung Kyu Kim, Baoji Lu, Jing Ma, Juping Xing, Hee Young Kim

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Daridorexant for the Treatment of Insomnia by Christopher L Robinson, Rajesh Supra, Evan Downs, Saurabh Kataria, Katelyn Parker, Alan D. Kaye, Omar Viswanath, Ivan Urits

“…Pharmacotherapy for insomnia falls into four classes based on mechanism of action: benzodiazepine receptor agonists (BZRAs), histamine receptor antagonists, melatonin receptor agonists, and dual orexin receptor antagonists (DORAs). # Recent Findings Daridorexant is a dual orexin type 1 and types 2 (OX~1~ and OX~2~) receptor antagonist that was recently approved by the US FDA for the treatment of adults suffering from insomnia. …”
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Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats by Miwa Nahata, Yayoi Saegusa, Yumi Harada, Naoko Tsuchiya, Tomohisa Hattori, Hiroshi Takeda

“…However, melanin-concentrating hormone (MCH) and prepro-orexin mRNA expression in the hypothalamus of GERD rats was similar to that in sham-operated rats. …”
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