Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary by Michaela Quintero, Linda C. Samuelson

“…Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of niche factors required to maintain intestinal stem cells and to direct their proliferation and differentiation. …”
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Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment by Chengyang Zhu, Zun Fan, Zhijie Cheng, Jun Yin, Lei Qin, Xin Zhao

“…The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack of intrinsic bioactivities to orchestrate the intricate regenerative process. To tackle this deficiency, nature-derived microneedles (NMs) composed of silk methacrylate and snail mucus are developed in this study. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Moreover, we showed that it is vimentin on the plasma membrane of recipient cells that orchestrates HCV cell–cell transmission. Consequently, vimentin antibody, either applied individually or in combination with HCV neutralizing antibody, exerts pronounced inhibition of HCV cell–cell transmission. …”
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Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells by Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang, George E. Sandusky, Yunlong Liu, Mateusz Opyrchal, Sha Cao, Jun Wan, Chi Zhang, Xinna Zhang

“…Abstract Colorectal cancer (CRC) cells display remarkable adaptability, orchestrating metabolic changes that confer growth advantages, pro‐tumor microenvironment, and therapeutic resistance. …”
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A computational tool to infer enzyme activity using post-translational modification profiling data by Dehui Kong, Aijun Zhang, Ling Li, Zuo-Fei Yuan, Yingxue Fu, Long Wu, Ashutosh Mishra, Anthony A. High, Junmin Peng, Xusheng Wang

“…Abstract Enzymes play a pivotal role in orchestrating complex cellular responses to external stimuli and environmental changes through signal transduction pathways. …”
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Regulation of calcium homeostasis in endoplasmic reticulum–mitochondria crosstalk: implications for skeletal muscle atrophy by Xuexin Li, Xin Zhao, Zhengshan Qin, Jie Li, Bowen Sun, Li Liu

“…Calcium is vital for both regulating muscle excitation–contraction coupling and for the development, maintenance, and regeneration of muscle cells. The orchestrated release of calcium from the endoplasmic reticulum (ER) is mediated by receptors such as the ryanodine receptor (RYR) and inositol 1,4,5-trisphosphate receptor (IP3R), which is crucial for skeletal muscle contraction. …”
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Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts by Mengmeng Xing, Fei Wang, Ruowen Chu, He Wang, Yuyao Sun, Meng Qian, Huan Jiang, Adam C. Midgley, Guohao Dai, Qiang Zhao

“…Recent advances in vascular biology highlight the pivotal role of COUP‐TFII in orchestrating endothelial identity, angiogenesis, safeguarding against atherosclerosis, and mitigating vascular calcification. …”
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Optimization strategies for multi‐block structured CFD simulation based on Sunway TaihuLight by Xiaojing Lv, Wenhao Leng, Zhao Liu, Chengsheng Wu, Fang Li, Jiuxiu Xu

“…In this article, we proposed several optimization strategies to improve the computing efficiency of multi‐block structured CFD simulation based on Sunway TaihuLight super computing system, including: (1) a load balancing decomposition approach combined with recursive segmentation of undirected graphs and block mapping for multi‐structured blocks, (2) two‐level parallelism that utilizes MPI + OpenACC2.0* hybrid parallel paradigms with various performance optimizations such as data preprocessing, reducing unnecessary loops of subroutine calls, collapse, and tile syntax, memory access optimization between the main memory and local data memory (LDM), and (3) a carefully orchestrated pipeline and register communication strategy between computing processor elements (CPEs) to tackle the dependence of LU‐SGS (Lower‐Upper Symmetric Gauss–Seidel). …”
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PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways by Julian Müller, Florian P. Bayer, Mathias Wilhelm, Maximilian G. Schuh, Bernhard Kuster, Matthew The

“…Abstract Post-translational modifications (PTMs) play pivotal roles in regulating cellular signaling, fine-tuning protein function, and orchestrating complex biological processes. Despite their importance, the lack of comprehensive tools for studying PTMs from a pathway-centric perspective has limited our ability to understand how PTMs modulate cellular pathways on a molecular level. …”
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The FvABF3-FvALKBH10B-FvSEP3 cascade regulates fruit ripening in strawberry by Renkun Tang, Xiaoyu Duan, Leilei Zhou, Guangtong Gao, Jinying Liu, Yuying Wang, Xingfeng Shao, Guozheng Qin

“…Abstract Fruit ripening is a highly-orchestrated process that requires the fine-tuning and precise control of gene expression, which is mainly governed by phytohormones, epigenetic modifiers, and transcription factors. …”
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Reinforced Cost-Sensitive Graph Network for Detecting Fraud Leaders in Telecom Fraud by Peiwen Gao, Zhihua Li, Dibin Zhou, Liang Zhang

“…The primary reason for this inadequacy is the inability of previous methods to detect “fraud leaders” within fraudulent groups. These leaders orchestrate scams through intermediaries rather than directly engaging in fraudulent activities. …”
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Oxidative stress-driven enhanced iron production and scavenging through Ferroportin reorientation worsens anemia in antimony-resistant Leishmania donovani infection. by Souradeepa Ghosh, Krishna Vamshi Chigicherla, Shirin Dasgupta, Yasuyuki Goto, Budhaditya Mukherjee

“…Higher iron utilization by LD-R leads to subsequent iron insufficiency, compensated by increased erythrophagocytosis through the breakdown of SIRPα-CD47 surveillance, orchestrated by a complex interplay of two proteases, Furin and ADAM10. …”
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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…At the heart of this interaction lies the PERIOD proteins (PERs), pivotal to the circadian clock, influencing the timing of physiological and behavioral processes and impacting oxidative stress, immune functionality, and tumorigenesis. PER1 orchestrates the cooperation of the enzyme GPX1, modulating mitochondrial dynamics in sync with daily rhythms and oxidative stress, thus regulating the mechanisms managing energy substrates. …”
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Feasibility and Limits of Magnetically Labeling Primary Cultured Rat T Cells with Ferumoxides Coupled with Commonly Used Transfection Agents by Cedric Berger, Martin Rausch, Philipp Schmidt, Markus Rudin

“…Macrophages are effectors of the immune response, their appearance being orchestrated by activated T lymphocytes. Therefore, tracking of labeled T lymphocytes, which initiate the immune process, should enable earlier detection of tissue inflammation. …”
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Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila by Lisa Zipper, Bernat Corominas-Murtra, Tobias Reiff

“…Upon mating, endocrine signals orchestrate a 30% net increase of absorptive epithelium. …”
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CLASSIFICATION OF SOCIAL PROTEST IN CONTEMPORARY JAPAN by D. V. Streltsov

“…The author identifies five types of politically orchestrated social protest: ideological, socio-class, problem centered, conservative and local. …”
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Humanitarian Diplomacy in Action: Examining Muhammadiyah as a Model for Faith-Based Organizational Engagement by Rahmawati Husein, Bachtiar Dwi Kurniawan, Nawang Kurniawati

“…This study parses the organization’s activities into four core dimensions, as stated by Minear and Smith (2007): the orchestration of presence, the negotiation of access, the mobilization of advocacy, and the oversight of programmatic assistance. …”
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MONet: cancer driver gene identification algorithm based on integrated analysis of multi-omics data and network models by Yingzan Ren, Tiantian Zhang, Jian Liu, Fubin Ma, Jiaxin Chen, Ponian Li, Guodong Xiao, Chuanqi Sun, Yusen Zhang

“…Cancer progression is orchestrated by the accrual of mutations in driver genes, which endow malignant cells with a selective proliferative advantage. …”
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HISTORICAL DEVELOPMENT OF THE ORANYAN CULTURAL FESTIVAL IN NEW OYO: A STRATEGIC MEASURE TO PRESERVE YORÙBÁ ANTIQUITIES IN THE 21ST CENTURY by OYEDOKUN MOJEED OYETUNJI, AKANBI SHOLA AHMED, ADEYEMI KAMIL HAMZAH

“…The cultural festivals of Oyo Yorùbá are diverse, but the Oranyan festival is unique in New Oyo because of its global acceptance orchestrated by His Royal Highness, the Alaafin of Oyo, the late Oba Lamidi Adeyemi Olayiwola III. …”
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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…Development of multicellular organisms requires well-orchestrated interplay between cell-intrinsic transcription factors and cell-cell signaling. …”
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