Spatiotemporal dynamics of early oogenesis in pigs by Wei Ge, Yi-Lin Niu, Yu-Kang Li, Li Li, Han Wang, Wen-Wen Li, Tian Qiao, Yan-Ni Feng, Yu-Qing Feng, Jing Liu, Jun-Jie Wang, Xiao-Feng Sun, Shun-Feng Cheng, Lan Li, Wei Shen

“…Notably, in vitro culture of ovarian tissues verifies that intercellular NOTCH signaling and extracellular matrix (ECM) proteins played crucial roles in initiating meiotic and oogenic programs, highlighting an underappreciated role of ovarian microenvironments in orchestrating germ cell fates. Conclusions Overall, our work provides insight into the spatial characteristics of early oogenesis and the regulatory role of ovarian microenvironments in germ cell fate within a spatial context.…”
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ALIGNING STRATEGIC OBJECTIVES TO CORPORATE GOVERNANCE OBJECTIVES IN CONSTRUCTION PROFESSIONAL SERVICE FIRMS by Frank Boateng, De-Graft Owusu-Manu, Michael Adesi, Erika Parn, David John Edwards

“…This imbalance has culminated in several high-profile corporate scandals orchestrated by top management – consequently, this research seeks to establish a nexus between strategic corporate objectives and corporate governance objectives within construction professional service firms. …”
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Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1 by Ziyi Wang, Hao Wang, Xuejiao Chen, Sheng Han, Yulin Zhu, Hanhua Wang, Feng Cheng, Liyong Pu

“…The innate immunity regulated by liver macrophages orchestrates the cascade of IR inflammation and acts as a bridge. …”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger oxidative stress through enhanced ROS production in hepatocytes and Kupffer cells, leading to mitochondrial dysfunction and lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation of endotoxins like LPS, which activate inflammatory pathways through TLR4 signaling and promote oxidative stress via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB and Nrf2 serve as crucial mediators in the gut-liver axis, with NF-κB regulating inflammatory responses and Nrf2 orchestrating antioxidant defenses; (4) Oxidative stress-induced damage to intestinal barrier function creates a destructive feedback loop, further exacerbating liver inflammation and disease progression. …”
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Calponin 3 Regulates Myoblast Proliferation and Differentiation Through Actin Cytoskeleton Remodeling and YAP1-Mediated Signaling in Myoblasts by Mai Thi Nguyen, Quoc Kiet Ly, Thanh Huu Phan Ngo, Wan Lee

“…These findings reveal that CNN3 is essential for myogenic differentiation, playing a key role in regulating actin remodeling and cellular localization of YAP1 to orchestrate the proliferation and differentiation in myogenic progenitor cells. …”
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Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine by Izadiyan Z, Misran M, Kalantari K, Webster TJ, Kia P, Basrowi NA, Rasouli E, Shameli K

“…The integration of immunotherapeutic agents within liposomes marks a paradigm shift, enabling the design of ‘immuno-modulatory hubs’ capable of orchestrating precise immune responses while facilitating theranostic applications. …”
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HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop by Qiaohui Gao, Zhenghua Ren, Shengyuan Jiao, Juan Guo, Xia Miao, Jin Wang, Junye Liu

“…But we know little about how the hypoxia factors and microRNAs orchestrate to regulate hallmarks of cervical cancer cells. …”
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CSE-8, a filamentous fungus-specific Shr3-like chaperone, facilitates endoplasmic reticulum exit of chitin synthase CHS-3 (class I) in Neurospora crassa by Samantha Verónica González-Téllez, Meritxell Riquelme

“…Chitin is a crucial structural polysaccharide in fungal cell walls, essential for maintaining cellular plasticity and integrity. Its synthesis is orchestrated by chitin synthases (CHS), a major family of transmembrane proteins. …”
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MODIFICAREA PEISAJULUI AMENINȚĂRILOR CIBERNETICE DATORITĂ IMPLICĂRII GRUPĂRILOR DE CYBERCRIME ÎN RĂZBOIUL RUSO-UCRAINEAN by Claudia-Alecsandra GABRIAN

“…There were identified changes in malware-as-a-service and ransomware-as-a-service attacks, as well as changes in cybercriminal tactics and methods to orchestrate an attack. Also, when we refer to ransomware, LockBit, and CL0P groups are currently the most important cybercrime groups that carry out major cyber-attacks on countries from Europe. …”
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Biosynthetic pathway for leukotrienes is stimulated by lipopolysaccharide and cytokines in pig endometrial stromal cells by Barbara Jana, Aneta Andronowska, Jarosław Całka, Aleksandra Mówińska

“…These functional interactions could be one of the mechanisms responsible for local orchestrating events in inflamed and healthy endometrium.…”
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Discovering a Young State: Foreign Sports Delegations in the USSR during the 1920s by A. M. Glushich

“…It explores the planning of their itineraries and leisure activities, aiming to understand how Soviet sports leaders, during the early stages of state formation, skillfully concealed various shortcomings (especially economic and infrastructural) and highlighted sports and cultural triumphs to craft a positive global image of the USSR through what was ostensibly a non-political institution.Soviet physical education leaders did not shy away from inviting foreign teams to the country; instead, they actively welcomed all interested parties who could manage the journey. An ideally orchestrated visit seamlessly integrated four key elements: sports (the competitions), culture (theater, cinema, sightseeing), daily life (direct interaction with Soviet workers), and team recreation. …”
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A digital leap in the evolution of continuous professional development for teachers by M. Ghobrini, R. E. A. Ghobrini, F. Benaicha

“…Results: The research provides a comprehensive overview of the CPD process and a cost-effective scalable CPD-centric system based on six key elements: e-platforms, e-meetings, archiving, certification, website and organization that orchestrates and streamlines the entire process. This CPD-driven system offers guidelines for institutions and policymakers looking to replicate this system in their educational contexts, with the goal of upgrading teachers’ pedagogical expertise. …”
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Zwischen Traditionalismus und Modernisierung: Musikausbildung in Russland by Irina Susidko, Pavel Lutsker

“…This position remains firmly established in the training of all musical specialities: pianists, orchestral musicians, musicologists, ethnomusicologists, musicians on folk instruments and even pop musicians. …”
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The development and maintenance of immunity against visceral leishmaniasis by Rahul Tiwari, Awnish Kumar, Vishal Kumar Singh, Rajneesh, Shashi Bhushan Chauhan, Shyam Sundar, Susanne Nylén, Christian Engwerda, Rajiv Kumar

“…CD4+ T helper (Th) cells orchestrate immune responses in leishmaniasis and IFNγ+ Tbet+ CD4+ T (Th1) cells are required for the activation of phagocytes to kill captured or resident parasites, while other Th cell subset, including FoxP3+ natural regulatory T cells and Th2 cells can promote disease progression by suppressing the activities of Th1 cells. …”
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Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine by Marina Agueda-Oyarzabal, Marie S. Isidor, Kaja Plucińska, Lars R. Ingerslev, Oksana Dmytriyeva, Patricia S.S. Petersen, Sara Laftih, Axel B. Pontoppidan, Jo B. Henningsen, Kaja Rupar, Erin L. Brown, Thue W. Schwartz, Romain Barrès, Zachary Gerhart-Hines, Camilla C. Schéele, Brice Emanuelli

“…We therefore aimed to study brown adipocyte-derived secreted factors that may be involved in adipocyte function and/or may orchestrate intercellular communications. For this, mRNA levels in mature adipocytes from mouse adipose depots were assessed using RNA sequencing upon chronic cold acclimation, and bioinformatic analysis was used to identify secreted factors. …”
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Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization by Jainabbi Irshad Ahmed Patel, Jagadeesha Poyya, Apeksha Padakannaya, Namrata Manjunath Kurdekar, Ajay Sathayanarayan Khandagale, Chandrashekhar Gajanan Joshi, Santosh R. Kanade, Kapaettu Satyamoorthy

“…A key player in this process is the HIF-1α signaling cascade, meticulously regulated by Prolyl Hydroxylase Domain 2 (PHD2), which orchestrates cellular responses to varying oxygen levels. …”
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Ultraviolet B (UVB) Radiation Induces Skin Alterations, Emperipolesis and Decreases the Erythroid-to-myeloid Ratio in Rats by Verda Farida, Dion Adiriesta Dewananda, Muhammad Novrizal Abdi Sahid, Siti Isrina Oktavia Salasia

“…The inflammation process is orchestrated by many cell types, including immune cells. …”
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Evolutionary analysis of genes associated with the sense of balance in semi-aquatic mammals by Yuehuan Dong, Qinguo Wei, Guolei Sun, Xiaodong Gao, Tianshu Lyu, Lidong Wang, Shengyang Zhou, Xibao Wang, Yongquan Shang, Lupeng Shi, Honghai Zhang

“…Particularly, genes such as SLC26A2, SOX10, MYCN, and OTX1 are implicated in collectively orchestrating morphological adaptations in the semicircular canals to suit semi-aquatic environments. …”
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High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response by Tianzhu Tao, Lulong Bo, Teng Li, Longbao Shi, Hui Zhang, Bo Ye, Yuhai Xu, Qingqing Ma, Xiaoming Deng, Guorong Zhang

“…B7 family members and ligands have been identified as critical checkpoints in orchestrating the immune response during sepsis. V-domain Ig suppressor of T cell activation (VISTA) is a new inhibitory immune checkpoint involved in restraining T cell response. …”
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Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis by Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia, Dianhao Guo

“…Results Our study identified enhancer-specific activation within epithelial cells orchestrated by the three-dimensional structure of chromatin that regulates SERPINH1 transcription, and promotes the epithelial-mesenchymal transition (EMT) and metastasis of ESCC. …”
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