Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB by So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang

“…Abstract The circadian clock orchestrates behavior and physiology through the oscillation of key clock proteins like PERIOD (PER). …”
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Understanding Genetic Regulation of Sex Differentiation in Hermaphroditic Fish by Junchao Fang, Guanglve Li, Wenyin Luo, Qiaomu Hu

“…Furthermore, it examines the regulatory genes and associated signaling pathways that orchestrate sex determination and differentiation. By systematically synthesizing these research advancements, this paper endeavors to offer a comprehensive and profound insight into the intricate mechanisms governing sex differentiation in sequential hermaphroditic fish.…”
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Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy by Xiangrui Zhang, Lihan Zhang, Beibei Li, Qingchao Wang, Peixin Chen, Ranran Shi, Xiuman Zhou, Xiaoshuang Niu, Wenjie Zhai, Yahong Wu, Wenhui Shen, Xiaowen Zhou, Wenshan Zhao

“…Abstract Background Poliovirus receptor (PVR) and its receptor system, including TIGIT, CD226, and CD96, play a pivotal role in orchestrating tumor immune evasion. Upon engagement with PVR on tumor cells, CD96 exerts inhibitory effects on the function of T cells and NK cells, thereby fostering tumor immune evasion. …”
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T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration by Haixing Wang, Yashi Li, Haoxin Li, Xu Yan, Zhaowei Jiang, Lu Feng, Wenhui Hu, Yinuo Fan, Sien Lin, Gang Li

“…Numerous immune cell types, including macrophages, T cells, and neutrophils are involved in fracture healing by orchestrating a series of events that modulate bone formation and remodeling. …”
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Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer by Jiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu

“…Abstract Hypoxia-inducible factors (HIFs) are essential transcription factors that orchestrate cellular responses to oxygen deprivation. …”
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Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary by Michaela Quintero, Linda C. Samuelson

“…Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of niche factors required to maintain intestinal stem cells and to direct their proliferation and differentiation. …”
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Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment by Chengyang Zhu, Zun Fan, Zhijie Cheng, Jun Yin, Lei Qin, Xin Zhao

“…The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack of intrinsic bioactivities to orchestrate the intricate regenerative process. To tackle this deficiency, nature-derived microneedles (NMs) composed of silk methacrylate and snail mucus are developed in this study. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Moreover, we showed that it is vimentin on the plasma membrane of recipient cells that orchestrates HCV cell–cell transmission. Consequently, vimentin antibody, either applied individually or in combination with HCV neutralizing antibody, exerts pronounced inhibition of HCV cell–cell transmission. …”
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Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells by Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang, George E. Sandusky, Yunlong Liu, Mateusz Opyrchal, Sha Cao, Jun Wan, Chi Zhang, Xinna Zhang

“…Abstract Colorectal cancer (CRC) cells display remarkable adaptability, orchestrating metabolic changes that confer growth advantages, pro‐tumor microenvironment, and therapeutic resistance. …”
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A computational tool to infer enzyme activity using post-translational modification profiling data by Dehui Kong, Aijun Zhang, Ling Li, Zuo-Fei Yuan, Yingxue Fu, Long Wu, Ashutosh Mishra, Anthony A. High, Junmin Peng, Xusheng Wang

“…Abstract Enzymes play a pivotal role in orchestrating complex cellular responses to external stimuli and environmental changes through signal transduction pathways. …”
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Regulation of calcium homeostasis in endoplasmic reticulum–mitochondria crosstalk: implications for skeletal muscle atrophy by Xuexin Li, Xin Zhao, Zhengshan Qin, Jie Li, Bowen Sun, Li Liu

“…Calcium is vital for both regulating muscle excitation–contraction coupling and for the development, maintenance, and regeneration of muscle cells. The orchestrated release of calcium from the endoplasmic reticulum (ER) is mediated by receptors such as the ryanodine receptor (RYR) and inositol 1,4,5-trisphosphate receptor (IP3R), which is crucial for skeletal muscle contraction. …”
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Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts by Mengmeng Xing, Fei Wang, Ruowen Chu, He Wang, Yuyao Sun, Meng Qian, Huan Jiang, Adam C. Midgley, Guohao Dai, Qiang Zhao

“…Recent advances in vascular biology highlight the pivotal role of COUP‐TFII in orchestrating endothelial identity, angiogenesis, safeguarding against atherosclerosis, and mitigating vascular calcification. …”
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Optimization strategies for multi‐block structured CFD simulation based on Sunway TaihuLight by Xiaojing Lv, Wenhao Leng, Zhao Liu, Chengsheng Wu, Fang Li, Jiuxiu Xu

“…In this article, we proposed several optimization strategies to improve the computing efficiency of multi‐block structured CFD simulation based on Sunway TaihuLight super computing system, including: (1) a load balancing decomposition approach combined with recursive segmentation of undirected graphs and block mapping for multi‐structured blocks, (2) two‐level parallelism that utilizes MPI + OpenACC2.0* hybrid parallel paradigms with various performance optimizations such as data preprocessing, reducing unnecessary loops of subroutine calls, collapse, and tile syntax, memory access optimization between the main memory and local data memory (LDM), and (3) a carefully orchestrated pipeline and register communication strategy between computing processor elements (CPEs) to tackle the dependence of LU‐SGS (Lower‐Upper Symmetric Gauss–Seidel). …”
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PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways by Julian Müller, Florian P. Bayer, Mathias Wilhelm, Maximilian G. Schuh, Bernhard Kuster, Matthew The

“…Abstract Post-translational modifications (PTMs) play pivotal roles in regulating cellular signaling, fine-tuning protein function, and orchestrating complex biological processes. Despite their importance, the lack of comprehensive tools for studying PTMs from a pathway-centric perspective has limited our ability to understand how PTMs modulate cellular pathways on a molecular level. …”
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The FvABF3-FvALKBH10B-FvSEP3 cascade regulates fruit ripening in strawberry by Renkun Tang, Xiaoyu Duan, Leilei Zhou, Guangtong Gao, Jinying Liu, Yuying Wang, Xingfeng Shao, Guozheng Qin

“…Abstract Fruit ripening is a highly-orchestrated process that requires the fine-tuning and precise control of gene expression, which is mainly governed by phytohormones, epigenetic modifiers, and transcription factors. …”
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Reinforced Cost-Sensitive Graph Network for Detecting Fraud Leaders in Telecom Fraud by Peiwen Gao, Zhihua Li, Dibin Zhou, Liang Zhang

“…The primary reason for this inadequacy is the inability of previous methods to detect “fraud leaders” within fraudulent groups. These leaders orchestrate scams through intermediaries rather than directly engaging in fraudulent activities. …”
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Oxidative stress-driven enhanced iron production and scavenging through Ferroportin reorientation worsens anemia in antimony-resistant Leishmania donovani infection. by Souradeepa Ghosh, Krishna Vamshi Chigicherla, Shirin Dasgupta, Yasuyuki Goto, Budhaditya Mukherjee

“…Higher iron utilization by LD-R leads to subsequent iron insufficiency, compensated by increased erythrophagocytosis through the breakdown of SIRPα-CD47 surveillance, orchestrated by a complex interplay of two proteases, Furin and ADAM10. …”
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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…At the heart of this interaction lies the PERIOD proteins (PERs), pivotal to the circadian clock, influencing the timing of physiological and behavioral processes and impacting oxidative stress, immune functionality, and tumorigenesis. PER1 orchestrates the cooperation of the enzyme GPX1, modulating mitochondrial dynamics in sync with daily rhythms and oxidative stress, thus regulating the mechanisms managing energy substrates. …”
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Feasibility and Limits of Magnetically Labeling Primary Cultured Rat T Cells with Ferumoxides Coupled with Commonly Used Transfection Agents by Cedric Berger, Martin Rausch, Philipp Schmidt, Markus Rudin

“…Macrophages are effectors of the immune response, their appearance being orchestrated by activated T lymphocytes. Therefore, tracking of labeled T lymphocytes, which initiate the immune process, should enable earlier detection of tissue inflammation. …”
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Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila by Lisa Zipper, Bernat Corominas-Murtra, Tobias Reiff

“…Upon mating, endocrine signals orchestrate a 30% net increase of absorptive epithelium. …”
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