A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster by Yuto Yoshinari, Takashi Nishimura, Taishi Yoshii, Shu Kondo, Hiromu Tanimoto, Tomoe Kobayashi, Makoto Matsuyama, Ryusuke Niwa

“…Collectively, our findings unravel the crosstalk of gut hormone and neuronal pathways that orchestrate physiological responses to prevent and adapt to dietary protein overload.…”
Get full text

Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

“…Recombinase A (RecA) and the transcriptional repressor LexA are the key players that orchestrate this process, determining either the silencing or the active transcription of the genes under their control. …”
Get full text

Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications by Muhammad Sufyan bin Masroni, Evelyn Siew-Chuan Koay, Victor Kwan Min Lee, Siok Bian Ng, Soo Yong Tan, Karen Meiling Tan, Marco Archetti, Sai Mun Leong

“…Against the backdrop of existing knowledge on various social organisms found in nature, we explore the mechanisms underlying the manifestation of altruism within breast tumors, revealing a complex interplay of seemingly counteracting cancer signaling pathways and processes that orchestrate the delicate balance between cost and benefit underlying altruistic cooperation. …”
Get full text

UV-induced reorganization of 3D genome mediates DNA damage response by Veysel Oğulcan Kaya, Ogün Adebali

“…Abstract While it is well-established that UV radiation threatens genomic integrity, the precise mechanisms by which cells orchestrate DNA damage response and repair within the context of 3D genome architecture remain unclear. …”
Get full text

Ethical Implications and Ramifications in the Case of Truong My Lan by Edgar Manuel Cambaza

“… This article examines the ethical and systemic failures surrounding the massive financial fraud orchestrated by Vietnamese real estate tycoon Truong My Lan. …”
Get full text

Linguistic Misogyny as a Parodic Device: Valspeak Markers in Jimmy Fallon’s “Ew!” by Pierre Habasque

“…Second, the main goal of the sketch is to make the audience laugh, and its parodic power partly relies on the fact that semantic bleaching is used to orchestrate a loss of meaning in the discourse of the two characters. …”
Get full text

After Arizona: Military Musicians in the Second World War by Rosemary Peters

“…L’histoire de l’USS Arizona — et de son orchestre, noyé avec le cuirassé lors de l’attaque surprise des forces japonaises — étant bien connue, je m’appuie sur cet exemple comme point de départ afin de contextualiser la situation des musiciens militaires après les événements de Pearl Harbor, en décembre 1941. …”
Get full text

The crucial role of 5hmC in neuroprotection and repair after cerebrovascular injury by Yanina Tsenkina

“…Within the complex realm of epigenetic modifications, hydroxymethylation emerges as a crucial factor in orchestrating mechanisms for neuroprotection and repair following such injuries. …”
Get full text

Two Chancellors: Metternich and Nesselrode by E. P. Kudryavtseva

“…According to estimates of historians, Nesselrode was just an obedient apprentice of the Austrian Chancellor who orchestrated the whole European policy. Adherence to the principles of conservatism and The Holy Alliance resulted in nothing but misfortunes of Russian foreign policy and its submission to the «European Idea». …”
Get full text

NFP:enabling network function parallelism in NFV by Jun BI, Chen SUN, Heng YU

“…Software-based sequential service chains in network function virtualization (NFV) could introduce significant performance overhead.Current acceleration efforts for NFV mainly target on optimizing each component of the sequential service chain.However,based on the statistics from real world enterprise networks,it was observed that 53.8% network function (NF) pairs could work in parallel.In particular,41.5% NF pairs could be parallelized without causing extra resource overhead.NFP was presented,a high performance framework,that innovatively enabled network function parallelism to improve NFV performance.NFP consisted of three logical components.Firstly,NFP provided a policy specification scheme for operators to intuitively describe sequential or parallel NF chaining intents.Secondly,NFP orchestrator intelligently identified NF dependency and automatically compiled the policies into high performance service graphs.Thirdly,NFP infrastructure performed light-weight packet copying,distributed parallel packet delivery,and load-balanced merging of packet copies to support NF parallelism.An NFP prototype based on DPDK in Linux containers was implemented.The evaluation results show that NFP achieves significant latency reduction for real world service chains.…”
Get full text

In the Name of the British People: Words and Democracy in Three Post-Brexit Films by Nicole Cloarec

“…In each case, albeit with obvious stylistic differences, both mise en scène and montage give a proper dialectical dimension to the film discourse insofar as the narratives are built on a series of ruptures or contrasts that are orchestrated into an organic whole.…”
Get full text

MLOps Components, Tools, Process, and Metrics: A Systematic Literature Review by Adrian P. Wozniak, Mateusz Milczarek, Joanna Wozniak

“…While some tools originate from DevOps practices, others, such as Model Orchestrators, Feature Stores, and Model Repositories, are unique to MLOps. …”
Get full text

Can more able CEOs reduce the gap between internal and external CSR disclosures? by Irfan Kazim, Fangjun Wang, Dongfang Nie, Muhammad Jameel Hussain

“…From a practical standpoint, our findings emphasize the pivotal role of capable CEOs in orchestrating consistent CSR narratives that resonate internally and externally. …”
Get full text

Visualizing stepwise evolution of carbon hybridization from sp 3 to sp 2 and to sp by Wei Xiong, Guang Zhang, De-Liang Bao, Jianchen Lu, Lei Gao, Yusen Li, Hui Zhang, Zilin Ruan, Zhenliang Hao, Hong-Jun Gao, Long Chen, Jinming Cai

“…Abstract Regulating carbon hybridization states lies at the heart of engineering carbon materials with tailored properties but orchestrating the sequential transition across three states has remained elusive. …”
Get full text

Predicting immunotherapy efficacy in endometrial cancer: focus on the tumor microenvironment by Liubov A. Tashireva, Irina V. Larionova, Irina V. Larionova, Nikita A. Ermak, Anastasia A. Maltseva, Ekaterina I. Livanos, Anna Yu. Kalinchuk, Marina N. Stakheyeva, Larisa A. Kolomiets

“…The tumor microenvironment can orchestrate an immunosuppressive milieu, attenuating the immune response and facilitating tumor progression. …”
Get full text

Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response by Tomás Lombardo, Guillermo A. Blanco

“…Phagocytosis of self and non-self particles shed from the clot occurs at the clot neighbourhood, demonstrating that clotting is the initial phase of a well-orchestrated dual haemostatic and immune cellular response.…”
Get full text

Dysregulated Functions of Lung Macrophage Populations in COPD by Theodore S. Kapellos, Kevin Bassler, Anna C. Aschenbrenner, Wataru Fujii, Joachim L. Schultze

“…Innate immune cells play a pivotal role in the disease’s progression, and in particular, lung macrophages exploit their prevalence and strategic localisation to orchestrate immune responses. To date, alveolar and interstitial resident macrophages as well as blood monocytes have been described in the lungs of patients with COPD contributing to disease pathology by changes in their functional repertoire. …”
Get full text

Interplay between Extracellular Matrix and Neutrophils in Diseases by Yanyan Zhu, Yumeng Huang, Qian Ji, Shengqiao Fu, Jia Gu, Ningzheng Tai, Xu Wang

“…Neutrophils are the most abundant immune cells in circulation and play key roles in orchestrating a complex series of events during inflammation. …”
Get full text

Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments by Huihui Li, Yanmei Cui, Yule Hu, Mengran Zhao, Kuanyu Li, Xiaoyun Pang, Fei Sun, Bing Zhou

“…Abstract Iron is a potent biochemical, and accurate homeostatic control is orchestrated by a network of interacting players at multiple levels. …”
Get full text

Cell migration in dense microenvironments by de Freitas Nader, Guilherme Pedreira, García-Arcos, Juan Manuel

“…Moreover, there is a link between regimes of nuclear envelope unfolding and different cellular behaviors, from orchestrated signaling cascades to cellular perturbations and damage.…”
Get full text