A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats by Lorea Iturri, Emmanuel Jouglar, Cristèle Gilbert, Julie Espenon, Marjorie Juchaux, Yolanda Prezado

“…We need to conduct further work to determine the optimal RT-IT combination and schedule for ICI injection and MBRT irradiation.…”
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Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review by Lou’i Al-Husinat, Shrouq Obeidat, Saif Azzam, Yara Al-Gwairy, Fatima Obeidat, Sarah Al Sharie, Deema Haddad, Fadi Haddad, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Giustino Varrassi

“…Future research should prioritize long-term clinical trials to establish optimal dosing, efficacy, and safety, aiding in the development of informed guidelines for safe cannabis use in chronic pain management. …”
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Effects of management of plastic and straw mulching management on crop yield and soil salinity in saline-alkaline soils of China: A meta-analysis by Ying Song, Jineng Sun, Mingjun Cai, Jinyu Li, Meizhen Bi, Mingxiu Gao

“…Notably, the impact of these mulching practices on both crop yield and soil salinity became insignificant when the experimental duration exceeded 2 years. For optimal results, black plastic mulch should be used to cover the entire ground surface when employing PM, while SM should be applied as surface mulch. …”
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The impact of channel density, inverse solutions, connectivity metrics and calibration errors on OPM-MEG connectivity analysis: A simulation study by Shengjie Qi, Xinda Song, Le Jia, Hongyu Cui, Yuchen Suo, Tengyue Long, Zhendong Wu, Xiaolin Ning

“…Hence, a calibration workflow for accurate sensor parameters, such as the gain and direction of the sensitive axis, before commencing OPM-MEG measurement and a careful choice of different method combinations play crucial roles in ensuring that OPMs yield optimal results for functional connectivity analysis. …”
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Urethra-sparing prostate cancer radiotherapy: Current practices and future insights from an international survey by Jennifer Le Guévelou, Paul Sargos, Piet Ost, Filippo Alongi, Stefano Arcangeli, Alejandro Berlin, Pierre Blanchard, Anna Bruynzeel, Olivier Chapet, Alan Dal Pra, Robert T. Dess, Matthias Guckenberger, Andrew Loblaw, Amar U. Kishan, Barbara Alicja Jereczek-Fossa, David Pasquier, Mohamed Shelan, Shankar Siva, Alison C. Tree, Costantinos Zamboglou, Stephane Supiot, Vedang Murthy, Thomas Zilli

“…The lack of consensus on specific urethral dose constraints and optimal sparing techniques underscores the need for further research to standardize practices in this field.…”
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Hybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the Potentialities of Resveratrol-Loaded Lipid Nanoparticles and Hydroxyapatite to Promote... by Viviana De Caro, Giada Tranchida, Cecilia La Mantia, Bartolomeo Megna, Giuseppe Angellotti, Giulia Di Prima

“…<b>Results</b>: PEG-based nanocomposites emerged as optimal and, following HXA insertion, the resulting powders revealed adequate bulk properties, making them useful as a pharmaceutical intermediate to produce ≈59 mm³ mini-tablets, compliant with the post-extraction socket. …”
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Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery by Syrine Abdeljaoued, Alexandre Doussot, Marie Kroemer, Emilien Laloy, Jean René Pallandre, Antoine El Kaddissi, Laurie Spehner, Myriam Ben Khelil, Adeline Bouard, Virginie Mougey, Ugo Chartral, Angélique Vienot, Julien Viot, Zaher Lakkis, Franck Monnien, Romain Loyon, Christophe Borg

“…In this study, we identified a population of CD103+CD69+ TRM cells exhibiting the characteristics of tumor reactivity and correlated with better patients’ prognosis, with potential implications in optimal therapeutic strategies determination.…”
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Assessing subtle changes in arid land river basin ecological quality: A study utilizing the PIE engine platform and RSEI by Aizemaitijiang Maimaitituersun, Han Yang, Nuerbiye Aobuliaisan, Kamuran Maimaitiaili, Ouyang Chenyu

“…Subsequently, the Sen’s slope analysis and Mann-Kendall (M−K) trend test were employed to analyze the level of EQ changes in the Urumqi River Basin (URB). Finally, the Optimal Parameters-based Geographical Detector (OPGD) model was utilized to quantitatively assess the driving factors of EQ changes and discuss their underlying reasons. …”
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The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes by Zeynep Seyhanli, Burak Bayraktar, Mevlut Bucak, Gulsan Karabay, Betul Tokgoz Cakir, Can Ozan Ulusoy, Gizem Aktemur, Selver Ozge Sefik, Serap Topkara Sucu, Sevki Celen, Ali Turhan Caglar

“…The analysis involved determining the optimal Resolvin D1 cut-off levels for predicting composite adverse neonatal outcomes in GDM using receiver operating characteristic curve (ROC) analysis. …”
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Silver (Ag) doped graphitic carbon nitride (g-C3N4)/biochar composite photocatalyst for improved photocatalytic degradation of ciprofloxacin (CIP) by Ijlal Idrees, Muhammad Zafar, Malik Adeel Umer, Fahad Rehman, Abdul Razzaq, Seongwan Kim, Yunsook Yang, Woo Young Kim

“…The photocatalytic performance is optimized by varying the content of Ag dopant in the composite photocatalyst. …”
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Histology Assessment of Chitosan–Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles by Carlos David Grande-Tovar, Jorge Ivan Castro Castro, Lemy Vanessa Barba-Rosado, Paula A. Zapata, Daniel Insuasty, Carlos-Humberto Valencia-Llano

“…Combining these polymers optimizes their advantages while adding metal oxide nanoparticles like calcium oxide (CaO NPs) enhances antimicrobial properties by damaging bacterial membranes. …”
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Development of the PRECIOUS Short-Form (PRECIOUS-SF) quality of care measure for children with serious illnesses by Felicia Jia Ler Ang, Yin Bun Cheung, Mihir Gandhi, Rahul Malhotra, Truls Ostbye, Chetna Malhotra, Cristelle Chu-Tian Chow, Poh Heng Chong, Zubair Amin, Teresa Shu Zhen Tan, Eric Finkelstein

“…Abstract Background Rising number of children with complex medical conditions necessitate regular healthcare quality evaluation to achieve optimal outcomes. To address the need for a periodic and quick assessment of quality of care in serious childhood illnesses, we developed a short version of previously validated 45-item PaRental Experience with care for Children with serIOUS illnesses (PRECIOUS) measure. …”
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Evidence-based exercise recommendations to improve functional mobility in older adults - A study protocol for living systematic review and meta-analysis [version 2; peer review: 2... by Claudia Volecker-Rehage, Uros Marusic, Bettina Wollesen, Antoine Langeard, Tamar Yellon, Anna Wunderlich, Vera Belkin, Guoping Qian, Eleftheria Giannouli, Zbigniew Ossowski, Rafael A. Bernades, Yael Netz, Rajesh Sighdel

“…They provide a foundation for structuring an optimal exercise training program. If possible, we will also compare interventions from the different categories (eg. cardiovascular, resistance, motor-coordinative, multicomponent or mind-body exercise) as a network analysis and report the influence of moderator variables. …”
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Low dose ATG-Fresenius for GVHD prophylaxis: a comparative study with ATG-Thymoglobulin by Itai Falicovich, Boaz Nachmias, Shlomo Elias, Eran Zimran, Adir Shaulov, Polina Stepensky, Batia Avni, Sigal Grisariu

“…BackgroundAnti-Thymocyte Globulin (ATG) is commonly used to prevent graft-versus-host disease (GVHD), but the optimal dosage and type of ATG remains to be determined.ObjectiveWe compared retrospectively the safety and efficacy outcomes of allogeneic transplantation using low-dose ATG-Fresenius (15mg/kg) and ATG-Thymoglobulin (10mg/kg) for GVHD prevention.Study designNinety-eight patients were included, with 46 in the ATG-T group and 52 in the ATG-F group. …”
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Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] by Eunice Lobo, Jyothi S. Menon, Deepa R., Supriya Bhavnani, Onno CP van Schayck, Shweta Dixit, Prashanth Nuggehalli Srinivas, Aditi Roy, Sumathi Swaminathan, Ruby Gupta, Poornima Prabhakaran, Prashanth Thankachan, Giridhara Rathnaiah Babu, Debarati Mukherjee, Siddhartha Mandal, Gauri Divan

“…Background Over 250 million children are developing sub-optimally due to their exposure to early life adversities. …”
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From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi by Asanka Madhushan, Dulan Bhanuka Weerasingha, Evgeny Ilyukhin, Paul W. J. Taylor, Amila Sandaruwan Ratnayake, Jian-Kui Liu, Sajeewa S. N. Maharachchikumbura

“…Although halting pathogen evolution is impractical, its pace can be slowed by managing selective pressures, optimizing farming practices, and enforcing quarantine regulations. …”
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Photon sensor-based monitoring of spatial variations in canopy FIPAR for crop growth assessment by Jian Wang, Zhenggui Zhang, Xin Li, Lu Feng, Xiaofei Li, Minghua Xin, Shiwu Xiong, Yingchun Han, Shijie Zhang, Xiaoyu Zhi, Beifang Yang, Guoping Wang, Yaping Lei, Zhanbiao Wang, Yabing Li

“…Crop growth monitoring technology holds great potential to enable timely management adjustments, optimize resource use, and support sustainable agriculture practices, achieving efficient intelligent agriculture for data-driven cultivation. …”
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A quantitative amplitude of vagus nerve obtained by intraoperative neuromonitoring predicts postoperative vocal cord paralysis among patients in thyroid/parathyroid surgery as a se... by Hiroshi Katoh, MD, FACS, Riku Okamoto, MD, Kanako Naito, MD, Tomoya Mitsuma, MD, Mariko Kikuchi, MD, Takaaki Tokito, MD, Takeshi Naitoh, MD, FACS, Naoki Hiki, MD, Yusuke Kumamoto, MD, Takafumi Sangai, MD

“…The remaining 728 RLNs were evaluated. The optimal cut-offs of amplitudes or ratios of amplitude decrease on VCP were determined and evaluated. …”
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Effects of Dietary Iron Levels on the Production Performance, Nutrient Digestibility, Blood Biochemistry, and Meat and Fur Quality of Growing Rex Rabbits by Jiali Chen, Jiyuan Wang, Lei Liu, Fuchang Li

“…Specifically, 40 mg/kg Fe (diet Fe content of 49.1 mg/kg) improved growth performance, nutrient digestibility, and fur quality, while 80 mg/kg Fe (diet Fe content at 85.6 mg/kg) was optimal for enhancing meat quality.…”
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Waste ceramic powder for sustainable concrete production as supplementary cementitious material by Yasin Onuralp Özkılıç, Yasin Onuralp Özkılıç, Alireza Bahrami, Yusuf Güzel, Ali Sinan Soğancı, Memduh Karalar, Essam Althaqafi, Ali İhsan Çelik, Özer Zeybek, P. Jagadesh

“…This is very significant because it represents one of the key issues in calculating the optimal quantity of WCP in relation to both the strength and the amount of WCP utilized. …”
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