Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection by Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid

“…The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is not yet established, and the reported survival rates vary. …”
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Studying Alzheimer’s disease through an integrative serum metabolomic and lipoproteomic approach by Alessia Vignoli, Giovanni Bellomo, Federico Paolini Paoletti, Claudio Luchinat, Leonardo Tenori, Lucilla Parnetti

“…A panel of 26 metabolites and 112 lipoprotein-related parameters was quantified and the logistic LASSO regression algorithm was employed to identify the optimal combination of metabolites-lipoproteins and their ratios to discriminate the groups of interest. …”
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Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review by Claire Goodman, Tom Dening, Neil H Chadborn, Maria Zubair, Lídia Sousa, John R F Gladman, Adam, L Gordon

“…Objectives Comprehensive geriatric assessment (CGA) may be a way to deliver optimal care for care home residents. We used realist review to develop a theory-driven account of how CGA works in care homes.Design Realist review.Setting Care homes.Methods The review had three stages: first, interviews with expert stakeholders and scoping of the literature to develop programme theories for CGA; second, iterative searches with structured retrieval and extraction of the literature; third, synthesis to refine the programme theory of how CGA works in care homes.We used the following databases: Medline, CINAHL, Scopus, PsychInfo, PubMed, Google Scholar, Greylit, Cochrane Library and Joanna Briggs Institute.Results 130 articles informed a programme theory which suggested CGA had three main components: structured comprehensive assessment, developing a care plan and working towards patient-centred goals. …”
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Prevalence of diabetic retinopathy and its associated factors among adults in East African countries: A systematic review and meta-analysis. by Habtamu Wagnew Abuhay, Tigabu Kidie Tesfie, Meron Asmamaw Alemayehu, Muluken Chanie Agimas, Getaneh Awoke Yismaw, Gebrie Getu Alemu, Nebiyu Mekonnen Derseh, Bantie Getnet Yirsaw

“…Therefore, comprehensive diabetes management focusing on optimal glycemic control and healthy weight maintenance is essential to mitigate the problems. …”
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Effect of increased protein intake before pre-event on muscle fatigue development and recovery in female athletes by Taghread Ahmed Elsayed Ahmed, Heba Ali Ibrahim Seleem, Ghada Mohamed Youssef Elsayed, Marwa Ahmed Fadl Kholif, Rania Mohammed Abduljawad, Nour Taha Ebrahem Housen, Naglaa Mohamed Roby Sofy, Hager Abdel Hady

“…Background: Protein plays a vital role in facilitating muscle growth and also plays an important part in the optimal repair and recovery of the muscle after exercise. …”
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Deep learning model based prediction of vehicle CO2 emissions with eXplainable AI integration for sustainable environment by Gazi Mohammad Imdadul Alam, Sharia Arfin Tanim, Sumit Kanti Sarker, Yutaka Watanobe, Rashedul Islam, M. F. Mridha, Kamruddin Nur

“…The proposed model was optimized by hyperparameter tuning and achieved excellent performance metrics, such as a high R-squared value of 0.9938 and a low Mean Squared Error (MSE) of 0.0002. …”
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Suboptimal Blood Pressure Control, Associated Factors, and Choice of Antihypertensive Drugs among Type 2 Diabetic Patients at KCMC, Tanzania by Gabriel W. Mbwete, Kajiru G. Kilonzo, Elichilia R. Shao, Nyasatu G. Chamba

“…The early initiation of ACE-I or ARBs among the diabetic patients will improve the optimal BP control.…”
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1990–2041 Global burden of Burkitt lymphoma with 20 years forecast: A systematic analysis using the global burden disease of study of 2021 by Chengyun Dou, Yidan Sang, Hongbo Zhu, Chuangjie Cao

“…Hopefully, this study will help optimize the prevention, diagnosis, treatment, and management of Burkitt lymphoma to reduce the disease burden.…”
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Bit selection method based on the rock drillability characteristics and principal component analysis of rock-breaking indicators by Yang Hu, Xian Xinlong, Zhou Penggao, Li Zhen, Wei Ruihua, Liang Junqiao, Xiong Shilong

“…Based on the principal component method, the actual drilling data of the drill bit in each layer are analyzed, and the high-efficiency drill bit model is optimized. Corresponding to the rock mechanics and anti-drilling characteristic parameters of the drilled formation, a database of high-efficiency drill bit models for drilling in the southern margin of the Junggar Basin was established. …”
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Impact of remnant cholesterol on acute ischemic stroke prognosis: a nationwide cohort analysis stratified by non-alcoholic fatty liver disease status by Sili Jiang, Aoming Jin, Aoming Jin, Wenli Xing, Jing Jing, Jing Jing

“…Future studies are needed to determine the optimal target levels of RC in NAFLD patients.…”
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Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review [version 1; peer review: 2 approved] by Mamata Hebbal, Albandri Mohammed Alowid, Praveen Jodalli, Shahad Saad Alkait, Ghadeer Ghalab Almutairi, Fatimah Salim Almufarji

“…Future research, including long-term clinical trials, is warranted to elucidate optimal dosage regimens and therapeutic approaches for the routine application of SDF in managing dental caries.…”
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Biological characteristics of bream (Abramis brama Linnaeus, 1758) of the Kremenchuk Reservoir as an object of commercial fishery by N. Rudyk-Leuska, O. Buzevych, M. Leuskyi, I. Burjak

“…The distribution of fishing effort by size and age groups of bream in the Kremenchuk reservoir during the study period did not fully correspond to the optimal values ​​in terms of specific accumulation of ichthyomas, which requires appropriate adjustment of the qualitative characteristics of the fish stock in this reservoir. …”
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Determining Factors and Zootechnical Output of Biosecurity Practices in Fish Farms in the Wouri Division, Cameroon by Fonkwa Georges, Makombu Judith Georgette, Kamdem Alex Henri, Kametieu Djamou Franck, Nack Jacques, Awah-Ndukum Julius, Tomedi Eyango Minette, Tchoumboue Joseph

“…Fish farming is an income-generating activity that still requires socioeconomic, technical, and institutional efforts for optimal productivity. The Cameroonian government should emphasize on the education, training, and capacity building of farmers on biosecurity practices to minimise the introduction, establishment, and spread of diseases.…”
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The synergistic effects of recycled polyethylene terephthalate fiber and fly ash on the ductility of one-part geopolymer stabilized soft soil by Zihan Zhou, Guo Hu, Qiang Zhu, Chuanqin Yao, Jun Wu

“…Nonetheless, the combination of PET fiber and FA significantly improved the ductility behavior of OPG-stabilized soft soil. The optimal FA content was 10 %, with the ideal PET fiber length and content being 9 mm and 1.5 %, respectively. …”
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Sequential or simultaneous-integrated boost in early-stage breast cancer patients: trade-offs between skin toxicity and risk of compromised coverage by Changyou Zhong, Minfeng Huang, Haidong Yu, Jun Yuan, Ruilian Xie, Zhenzhen Lai, Shanzhou Niu, Chunbo Tang

“…Results The s-SIB had optimal target coverage and lower high-dose volume, but it increased the risk of compromised coverage to tumor bed. …”
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Colorimetric and Naked-Eye Detection of Inorganic Arsenic in Water using BF2-Curcumin and Silica Nanoparticle-BF2-Curcumin Sheets by Farshid Ghorbani, Sheyda Mohammadi Isaabad

“…In the first step, this reagent was optimized with consideration of four concentrations: 15, 20, 25 and 30 µM (in 60% ethanol). …”
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Establishing trust through home visits during pregnancy: a realist evaluation of a Danish breastfeeding support intervention by Anne Kristine Gadeberg, Ingrid Maria Susanne Nilsson, Ulla Christensen, Marie Honoré Jacobsen, Henriette Knold Rossau, Sarah Fredsted Villadsen

“…In realist terms, our central mechanism of change, the establishment of trust, had optimal conditions for success in the contextual setting of the pregnancy home visit where there was time, peace, undisturbed conversations, mental capacity to reflection, and a perceived more even power balance between the family and the health visitor which resulted in a range of positive outcomes. …”
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Prevalence and Risk Factors of Work-Related Upper Extremity Disorders among University Teaching Staff in Ethiopia, 2021: An Institution-Based Cross-Sectional Study by Amensisa Hailu Tesfaye, Tesfaye Hambisa Mekonnen, Mekuriaw Alemayehu, Giziew Abere

“…The manifestation of upper extremity disorder was affected by working hours per day, physical activity, and job satisfaction. Optimizing working hours, having a group regular exercise, and proper management of workplace conditions related to job satisfaction are recommended to lessen the condition.…”
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Bridging the gap: attitudes and practices toward complementary and alternative medicine among oncology patients and healthcare professionals in Croatia by Ljerka Armano, Vanja Vasiljev, Tomislav Rukavina, Denis Juraga, Aleksandar Racz, Aleksandar Racz, Vanja Tešić, Vanja Tešić, Vanja Tešić

“…The findings underscore the need for targeted education for healthcare professionals, development of CAM management guidelines in oncology, and fostering open dialogue between patients and providers to optimize outcomes. Longitudinal research is recommended to explore CAM’s impact on clinical outcomes.…”
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Mathematical analysis of steady-state solutions in compartment and continuum models of cell polarization by Zhenzhen Zheng, Ching-Shan Chou, Tau-Mu Yi, Qing Nie

“…Through both analysis and simulations, we find that stronger positive feedback, reduced diffusion, and a shallower ligand gradient all result in more steady-state solutions, although most of these are not optimally aligned with the gradient. We explore in the different settings the relationship between the number of steady-state solutions and the extent and accuracy of the polarization. …”
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