Nisin Z Production by Wild Strains of Lactococcus lactis Isolated from Brazilian (Italian Type) Fermented Sausage by Margarete Alice Fontes Saraiva, Dagim Jirata Birri, Dag Anders Brede, Maria Cristina Baracat-Pereira, Marisa Vieira de Queiroz, Ingolf F Nes, Célia Alencar de Moraes

“…PCR product sequence analysis confirmed that the structural genes of bacteriocins produced by the five isolates are identical to the lantibiotic nisin Z. Optimal nisin Z production was achieved in tryptone and casein peptone, at pH 6.0 or 6.5. …”
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Identification and Immunological Characterization of Cuproptosis Related Genes in Preeclampsia Using Bioinformatics Analysis and Machine Learning by Tiantian Yu, Guiying Wang, Xia Xu, Jianying Yan

“…Subsequently, the RF model was deemed the most optimal model for the identification of PE with a large area under the curve (AUC = 0.733). …”
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Change in seed viability of commercial maize hybrids during storage by Perić Sanja, Stevanović Milan, Mladenović Marko, Popović Aleksandar, Kovačević Aleksandar, Grčić Nikola

“…A major challenge in corn seed production and processing is maintaining optimal storage conditions to preserve germination and vigor over time. …”
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User and Developer Views on Using AI Technologies to Facilitate the Early Detection of Skin Cancers in Primary Care Settings: Qualitative Semistructured Interview Study by Owain Tudor Jones, Natalia Calanzani, Suzanne E Scott, Rubeta N Matin, Jon Emery, Fiona M Walter

“…ConclusionsThis study is one of the first to examine the views of a wide range of stakeholders on the use of AI technologies to facilitate early diagnosis of skin cancer. The optimal approach and position in the diagnostic pathway for these technologies have not yet been determined. …”
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The Role of Lifestyle Factors in Controlling Blood Pressure among Hypertensive Patients in Two Health Facilities in Urban Ghana: A Cross-Sectional Study by Emefa Modey Amoah, Darlene Esinam Okai, Adom Manu, Amos Laar, Joseph Akamah, Kwasi Torpey

“…Area under the receiver-operator curves (AUROC) was used to identify lifestyle factors predicting optimal blood pressure control among patients diagnosed with hypertension. …”
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Timing of Type I Open Distal Radius Fracture Fixation Does Not Affect Early Complication Rates by Eric R. Taleghani, MD, James Rex, MD, Samuel Gerak, BA, John Velasquez, MS, Kathryn Rost, BS, Sonu A. Jain, MD, FACS

“…Purpose: There is limited published evidence regarding the optimal management of type I open fractures of the distal radius. …”
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Pre-gestational diabetes in a young woman with a pathogenic INSR missense mutation, p.(Met1180Lys) by Emma L Prehn, Mairéad Crowley, David Fennell, Brendan T Kinsley, Kevin Colclough, Maria M Byrne

“…This case highlights the importance of genetic testing to establish optimal diabetes treatment.…”
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Do Maternal Vitamin D Levels Influence Vitamin D Levels in Preterm Neonates? by M. Panda, J. McIntosh, T. Chaudhari, A. L. Kent

“…Routine screening of maternal VitD and their preterm neonates along with individualized supplementation regimens in mothers and preterm infants may optimize VitD status and reduce risk of ongoing VitD deficiency/insufficiency.…”
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A COMPARATIVE STUDY ON THE EFFECT OF SISAL FIBRE AND WASTE PLASTIC STRIPS IN STRUCTURAL STRENGTH IMPROVEMENT OF TROPICAL BLACK CLAY by YOHANNA PAUL, BADAMASI ABDULRAHMAN, ISHOLA KAZEEM, ODOH KELVIN CHUKWUEBUKA, ABDULKADIR MOHAMMED NYAKO, FWANGSHAK GAYUS MIJE

“…Based on the results, BCS/waste plastic strips improved the soil more than BCS/sisal fibre treated soil and is recommended at optimal 2% waste plastic strips for geotechnical engineering application such as road payment. …”
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A New Strain of Preponderant Amphitriploid Carassius Clone Juvenile With Integrated Genomes Partly From White Crucian Carp (C. auratus cuvieri) Requires Low Dietary Protein by Xing Wang, Dong Han, Junyan Jin, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie

“…The dietary protein requirement of the new Carassius clone was as low as 21.38% for growth. The optimal dietary protein for high FE was 39.62% and should be less than 30.56% to maintain the maximum protein retention. …”
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Receipt of long-acting injectable antiretroviral therapy among people with HIV in Southern US states: an assessment using electronic health records and claims data by Yiyang Liu, Rebecca J. Fisk-Hoffman, Maitri Patel, Robert L. Cook, Mattia Prosperi

“…About 8% of LAI ART recipients did not have optimal care engagement the year before LAI ART initiation; one in five recipients had a diagnosis of alcohol or substance use disorder in lifetime. …”
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Outcome-Based Education sebagai Pendekatan Transformasi dalam Pengajaran Kewirausahaan: Studi Kasus di Perguruan Tinggi by Hanafiah Hanafiah, Otisia Arinindyah, Wakhida Nurhayati, Nurhidayah Nurhidayah, Zawirrahmi Zawirrahmi

“…Kendala yang ditemukan meliputi keterbatasan sumber daya, kebutuhan akan perangkat evaluasi yang lebih inovatif, dan komunikasi yang kurang optimal antara dosen dan mahasiswa terkait tujuan pembelajaran berbasis OBE. …”
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Designing an intervention to improve cognitive evaluations in primary care by Kyra S. O’Brien, Kristin Harkins, MaryAnne Peifer, Melanie Kleid, Cameron Coykendall, Judy Shea, Jason Karlawish, Robert E. Burke

“…Abstract Background Early diagnosis is crucial to the optimal management of patients with cognitive impairment due to Alzheimer’s disease (AD) or AD-related dementias. …”
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Effects of Dietary Vitamin C on the Growth Performance, Biochemical Parameters, and Antioxidant Activity of Coho Salmon Oncorhynchus kisutch (Walbaum, 1792) Postsmolts by Cong-mei Xu, Hai-rui Yu, Ling-yao Li, Min Li, Xiang-yi Qiu, Xiao-qian Fan, Yan-lin Fan, Ling-ling Shan

“…Polynomial analysis showed that the optimal VC levels in the diet of coho salmon postsmolts were 188.10, 190.68, 224.68, 132.83, 156.57, 170.12, 171.00, 185.50, 142.77, and 93.08 mg/kg on the basis of specific growth rate (SGR), feed conversion ratio (FCR), liver VC concentration, catalase (CAT), hepatic superoxide dismutase (SOD) activities, malondialdehyde (MDA) content, and serum total antioxidative capacity (T-AOC), AKP, AST, and ALT activities, respectively. …”
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Comparing the cost-benefit of breast cancer screening programs in rural and urban areas across four economic zones in China: a Markov modeling analysis by Dachuang Zhou, Kejia Zhou, Wenjuan Wang, Hanqiao Shao, Hongliu Zhang, Wenxi Tang

“…These findings highlight the necessity of universal screening and the importance of optimizing strategies based on regional economic development and epidemiological characteristics. …”
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Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment effic... by Nakaba Okamura, Ayano Katagiri, Tomoya Komori, Kei Kawanabe, Hirofumi Koike, Yukiko Sahashi, Rie Kubota

“…These findings suggest that formulary management can be a valuable strategy for optimizing antibiotic use while maintaining clinical outcomes and contributing to improved antimicrobial stewardship in healthcare settings. …”
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Enhancing Older Adults’ Lives Through Positive Aging Perception, Quality-of-Life Enhancement, and Social Support to Drive Acceptance and Readiness Toward Indoor Assistive Technolog... by Ka Po Wong, Pei-Lee Teh, Weng Marc Lim, Shaun Wen Huey Lee

“…Among demographic variables, educational level significantly impacted gerontechnology confidence (P=.004) while ethnicity influenced optimism (P=.003). ConclusionsThis study sheds light on key factors affecting older adults’ acceptance and readiness to adopt indoor assistive technologies. …”
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The usage of personalized scheme of fentanyl administration during coronary artery stenting by D.О. Dziuba

“…Its usage is safe (due to the optimal parameters of gas exchange and hemodynamics and fewer side effects, such as nausea and residual sedation) and effective (due to the lower level of stress markers and less frequent complaints of pain of various origins) than when the routine technique was used.…”
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“I’m living in a ‘no’ world now…”- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symp... by Helene L. Elliott-Button, Miriam J. Johnson, Ann Hutchinson, David C. Currow, Joseph Clark

“…Breathlessness adversely impacts physical and psychological wellbeing. (2) Barriers to optimal health-seeking and identification of chronic breathlessness. …”
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An In Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration by Qiyun Wang, Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Bingjie Qiu, Xiaosi Chen, Xiao Lin, Yao Nie

“…Conclusions. We have optimized glucose concentrations to model diabetic retinal endothelial (25-50 mM) or neuronal (50-100 mM) dysfunction in vitro, which have a wide range of downstream applications.…”
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