Efficacy and safety of once-weekly semaglutide monotherapy in a young subject with Prader-Willi syndrome, obesity, and type 2 diabetes: a case report by Elisa Dinoi, Giuseppe Daniele, Giuseppe Daniele, Angela Michelucci, Fulvia Baldinotti, Fabrizio Campi, Piero Marchetti, Stefano Del Prato, Angela Dardano, Angela Dardano

“…At 24-month follow-up, glycemic control remained optimal (HbA1c 38 mmol/mol) with further BW reduction (71 kg). …”
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Advancing Pediatric Surgery: The Use of HoloLens 2 for 3D Anatomical Reconstructions in Preoperative Planning by Marco Di Mitri, Annalisa Di Carmine, Simone D’Antonio, Benedetta Maria Capobianco, Cristian Bisanti, Edoardo Collautti, Sara Maria Cravano, Francesca Ruspi, Michele Libri, Tommaso Gargano, Mario Lima

“…Background: In pediatric surgery, a comprehensive knowledge of the child’s anatomy is crucial to optimize surgical outcomes and minimize complications. …”
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DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer by Qianqian Zhao, Jie Zhong, Ping Lu, Xiao Feng, Ying Han, Chenqi Ling, Wenke Guo, Weijin Zhou, Fudong Yu

“…The present study is aimed at optimizing candidate genes by integrating platinum-chemotherapy expression data and PPAR family genes with their targets. …”
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Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review by Xiaowei Zhao, Yuqi Zhao, Guoyu Ding, Xue Li, Xiaoyue Zhang, Yanli Leng, Hongmei Wang

“…Advanced diagnostic methods, like PRM and MBW, may improve early detection and help optimize the management of pulmonary dysfunction, ultimately improving long‐term outcomes for pediatric patients.…”
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Retrieval of Land Surface Temperature From Passive Microwave Observations Using CatBoost-Based Adaptive Feature Selection by Yang Dai, Yingbao Yang, Xin Pan, Penghua Hu, Xiangjin Meng, Fanggang Li, Zhenwei Wang

“…Next, for each group, we ranked the feature sets according to their importance and employed the recursive feature elimination (RFE) method for feature selection. Finally, the optimized feature sets were used in the CatBoost algorithm to construct the PMW-LST retrieval model. …”
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Development of the Dutch translational knowledge agenda for inherited metabolic diseases by I. J. Hieltjes, J. H. van derLee, M. C. Groenendijk, G. vanHaaften, P. M. vanHasselt, R. J. Lunsing, G. J. J. vanProoijen, E. M. deRuiter, F. J. vanSpronsen, N. M. Verhoeven‐Duif, A. deVreugd, M. Wagenmakers, H. Zweers, H. Dekker, H. R. Waterham, C. D. vanKarnebeek, R. J. A. Wanders, R. A. Wevers

“…The resulting top 10 research questions cover multiple themes, i.e. prediction of disease progression, development of novel tools, mechanistic insights, improved diagnostics, therapeutic integration of multi‐omics techniques, assessment of impact on daily life, expanding treatment avenues, optimal study designs, effect of lifestyle interventions, and data utilization using FAIR principles. …”
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Existent state and removal rate of silver in lead-silver slag during the melt-vaporization process by Shen Y.-Y., Zhao X.-S., Zhang F.-J., Ma W.-X., Wang X.-F., Du X.-Y.

“…The existing Ag state in the soot was analyzed, the influence of the reaction temperature, the carbon ratio, and the reaction time on the removal rate of the silver was investigated, and the process conditions were optimized using reaction surface methodology. Silver chloride, silver metal, silver sulfide, silver oxide, and silver sulfate are the main silver phases in lead-silver slag, of which silver chloride and silver sulfide are the main phases. …”
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Shift in the profile and prognostic implications in invasive fungal rhinosinusitis: experience of 10 years in a tertiary center by Raúl Mellidez-Acosta, Lidia Torres-García, Miguel Saro-Buendía, Natalia Jaramillo-Ángel, Javier Cabrera-Guijo, Catalina Bancalari-Díaz, Noelia Muñoz-Fernández, Lucas Fito-Martorell, Miguel Armengot-Carceller, Alfonso García-Piñero

“…Abstract Background Despite appropriate treatment, mortality of acute invasive fungal rhinosinusitis remains exceedingly high, surpassing 50%. Evidence on how to optimize its management is still limited. We present a case series from our institution aiming to fill the knowledge gap. …”
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Advanced perspective on heavily phosphorus-doped diamond layers via optical emission spectroscopy by Kil-dong Sung, Stefan Andrei Irimiciuc, Michal Novotný, Zdeněk Weiss, Pavel Hubík, Jaromír Kopeček, Martin Vondráček, Vincent Mortet

“…This novel growth approach offers valuable insights for optimizing PDD synthesis, enabling more efficient phosphorus incorporation for electronic, electrochemical, and quantum applications.…”
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Sensitivity and specificity of the Patient Health Questionnaire (PHQ-9, PHQ-8, PHQ-2) and General Anxiety Disorder scale (GAD-7, GAD-2) for depression and anxiety diagnosis: a cros... by David Villarreal-Zegarra, Juan Carlos Bazo-Alvarez, Juan Barrera-Begazo, Sharlyn Otazú-Alfaro, Nikol Mayo-Puchoc, Jeff Huarcaya-Victoria

“…For a similar contrast against the gold standard, the other optimal cut-off points were: ≥7 for the PHQ-8 and ≥2 for the PHQ-2. …”
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Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting by I.V. Shklianka, O.J. Zharinov, К.O. Mikhaliev, O.A. Epanchintseva

“…Therefore, there is a great need to determine the optimal dosage, the timing of the appointment and suspension of treatment with statins in patients with stable ischemic heart disease being prepared for coronary artery bypass grafting surgery.…”
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The line Rico is the earliest maturing accession in the VIR collection of spring bread wheat by B. V. Rigin, E. V. Zuev, A. S. Andreeva, Z. S. Pyzhenkova, I. I. Matvienko

“…Background. To optimize the process of bread wheat breeding for earliness and environmental adaptability, searching for new source material is a crucial task. …”
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Maternal and Perinatal Outcome of Triplet Pregnancies in a Tertiary Care Hospital in North India: A Prospective Observational Study by Sabreen Wani, Fiza Amin, Shagufta Yasmeen Rather

“…Thus, early diagnosis, adequate antenatal care, counselling, and perinatal care and support can help to ensure optimal outcomes. …”
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Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Comme... by Dingwei Dai, Ali Samiian, Joaquim Fernandes, Henriette Coetzer

“…**Discussion:** Highly prevalent multiple comorbidities and psychiatric disorders should be considered in the context of clinical decision-making to optimize ET management. **Conclusions:** This study represents the largest observational study to report ET disease and economic burdens in a real-world setting. …”
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Outcome of dual implantation in distal end femur fractures among patients attending a tertiary care hospital in Karnataka by Kumar SVA, Vishnuprasad SH, Vittal V, Diwakar P, Zai SAK

“…Conclusion: For distal femur fractures, particularly Muller's type-C2 and C3, Dual implants, such as dual plates or plate with nail, offer favorable clinical outcomes, acceptable knee motion, high union rates, and optimal supra patella area reconstruction, and thus can be recommended as a standard procedure for managing complex distal femur injuries. …”
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Impact of vancomycin area under the curve in early or later phase on efficacy and nephrotoxicity in patients with enterococcal bloodstream infections: a multicenter study by Piyawadee Tangvichitrerk, Dhitiwat Changpradub, Jatapat Hemapanpairoa, Piraporn Juntanawiwat, Wichai Santimaleeworagun

“…Abstract Background The optimal pharmacokinetic and pharmacodynamic (PK/PD) parameters of vancomycin that can improve outcomes in enterococcal infections remain controversial. …”
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Adverse events associated with the delivery of telerehabilitation: A scoping review protocol. by Thomas Yau, McKyla McIntyre, Josh Chan, Damanveer Bhogal, Angie Andreoli, Mark Bayley, Carl Froilan D Leochico, Ailene Kua, Meiqi Guo, Sarah Munce

“…This will help to identify key limitations for optimizing telerehabilitation delivery by allowing for the development of key risk-mitigation measures and quality indicators. …”
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Characteristics of velopharyngeal dysfunction in 22q11.2 deletion syndrome: a retrospective case-control study by Sebastiano Failla, Peng You, Chandheeb Rajakumar, Anne Dworschak-Stokan, Philip C. Doyle, Murad Husein

“…These findings may guide further efforts directed toward understanding the dynamic velopharyngeal characteristics of this population and potentially optimize surgical management and functional outcomes.…”
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Technoeconomic Feasibility of Wind and Solar Generation for Off-Grid Hyperscale Data Centres by William Rollinson, Andrew Urquhart, Murray Thomson

“…WindPRO 4.0 software is used to find optimal configurations with wind and solar generation, backed up by battery storage and onsite gas generation. …”
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Motor Unit Sampling From Intramuscular Micro-Electrode Array Recordings by Agnese Grison, Jaime Ibanez Pereda, Dario Farina

“…Through systematic offline analyses of these recordings, we tested different electrode configurations to identify optimal setups for accurately capturing motor unit activity. …”
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